Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321 · see citing works

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138 · see citing works

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913 · see citing works

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063 · see citing works

TGF-β signalling from cell membrane to nucleus through SMAD proteins

Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697 · see citing works

The Transforming Growth Factor-Beta Family

Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041 · see citing works

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911 · see citing works

Mutations in the p53 gene occur in diverse human tumour types

Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hosteller, R., Cleary, K. R., Signer, S. H., Davidson, N. E., Baylin, S., Devilee, P., et al. (1989) · Nature · doi:10.1038/342705a0 · Cited by 2,730 · see citing works

Cell Cycle Control and Cancer

Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,523 · see citing works

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

Miyashita, T., Krajewski, S., Krajewska, M., Wang, H., Lin, H., Liebermann, D. A., Hoffman‐Liebermann, B., & Reed, J. C. (1994) · PubMed · Cited by 2,143 · see citing works

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., & Oren, M. (1991) · Nature · doi:10.1038/352345a0 · Cited by 2,079 · see citing works

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works

p53 function and dysfunction

Vogelstein, B. (1992) · Cell · doi:10.1016/0092-8674(92)90421-8 · Cited by 1,862 · see citing works

A novel form of Epstein-Barr virus latency in normal B cells in vivo

Miyashita, E. M., Yang, B., Lam, K. M. C., Crawford, D., & Thorley‐Lawson, D. A. (1995) · Cell · doi:10.1016/0092-8674(95)90513-8 · Cited by 1,591 · see citing works

TGFβ signals through a heteromeric protein kinase receptor complex

Wrana, J. L., Attisano, L., Cárcamo, J. M., Zentella‐Dehesa, A., Doody, J. F., Laiho, M., Wang, X.-F., & Massagué, J. (1992) · Cell · doi:10.1016/0092-8674(92)90395-s · Cited by 1,528 · see citing works

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

Knudson, C. M., Tung, K. S. K., Tourtellotte, W. G., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Science · doi:10.1126/science.270.5233.96 · Cited by 1,480 · see citing works

p53 Status and the Efficacy of Cancer Therapy in Vivo

Lowe, S. W., Bodis, S. B., McClatchey, A. I., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E., & Jacks, T. (1994) · Science · doi:10.1126/science.7973635 · Cited by 1,470 · see citing works

Life, death, and the pursuit of apoptosis.Preprint

White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,300 · see citing works

Is a p53-Regulated Inhibitor of G2/M Progression

Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251 · see citing works

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180 · see citing works

KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene

Wu, G. S., Burns, T. F., McDonald, E. R., Jiang, W., Meng, R., Krantz, I. D., Kao, G., Gan, D.-D., Zhou, J.-Y., Muschel, R. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1097-141 · Cited by 1,081 · see citing works

Transcriptional Activators of TGF-β Responses: Smads

Derynck, R., Zhang, Y. E., & Feng, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81696-7 · Cited by 1,035 · see citing works

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

Datto, M., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y., & Wang, X. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5545 · Cited by 945 · see citing works

Molecular regulation of apoptosis: Genetic controls on cell death

Williams, G. T., & Smith, C. A. (1993) · Cell · doi:10.1016/0092-8674(93)90457-2 · Cited by 914 · see citing works

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

Lagna, G., Hata, A., Hemmati‐Brivanlou, A., & Massagué, J. (1996) · Nature · doi:10.1038/383832a0 · Cited by 905 · see citing works

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

Chen, C. A., & Okayama, H. (1990) · PubMed · Cited by 898 · see citing works

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

Yeh, W., de la Pompa, J. L., McCurrach, M. E., Shu, H., Elia, A., Shahinian, A., Ng, M. S. W., Wakeham, A. C., Khoo, W., Mitchell, K., et al. (1998) · Science · doi:10.1126/science.279.5358.1954 · Cited by 886 · see citing works

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

Rossé, T., Olivier, R., Monney, L., Rager, M., Conus, S., Fellay, I., Jansen, B., & Borner, C. (1998) · Nature · doi:10.1038/35160 · Cited by 870 · see citing works

Induction of the growth inhibitor IGF-binding protein 3 by p53

Buckbinder, L., Talbott, R. L., Velasco-Miguel, S., Takenaka, I. M., Faha, B., Seizinger, B. R., & Kley, N. (1995) · Nature · doi:10.1038/377646a0 · Cited by 869 · see citing works

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

Massagué, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81296-9 · Cited by 836 · see citing works

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation.

Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M., & Massague, J. (1990) · Cell · doi:10.1016/0092-8674(90)90251-9 · Cited by 797 · see citing works

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

Weinstein, D. C., Altaba, A. R. I., Chen, W. S., Hoodless, P. A., Prezioso, V. R., Jessell, T. M., & Darnell, J. E., Jr. (1994) · Cell · doi:10.1016/0092-8674(94)90523-1 · Cited by 783 · see citing works

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

Bett, A. J., Haddara, W. M. R., PREVEC, L., & Graham, F. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8802 · Cited by 742 · see citing works

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

Owen‐Schaub, L. B., Zhang, W. K., Cusack, J. C., Angelo, L. S., Santee, S. M., Fujiwara, T., Roth, J. A., Deisseroth, A., Zhang, W., Kruzel, E., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3032 · Cited by 731 · see citing works

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

Brown, J. M., & Wouters, B. G. (1999) · PubMed · Cited by 696 · see citing works

DPC4 gene in various tumor types.

Schutte, M. E. M., Hruban, R. H., Hedrick, L., Cho, K. R., Nadasdy, G. M., Weinstein, C. L., Bova, G. S., Isaacs, W. B., Cairns, P., Nawroz, H., et al. (1996) · PubMed · Cited by 672 · see citing works

TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway

Hocevar, B. A., Brown, T. L., & Howe, P. H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1345 · Cited by 671 · see citing works

SMADs: mediators and regulators of TGF-β signaling

Kretzschmar, M., & Massagué, J. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80069-5 · Cited by 467 · see citing works

Identification of AML-1 and the (8;21) Translocation Protein (AML-1/ETO) as Sequence-Specific DNA-Binding Proteins: theruntHomology Domain is Required for DNA Binding and Protein-Protein Interactions

Meyers, S., Downing, J. R., & Hiebert, S. W. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6336 · Cited by 462 · see citing works

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexesPreprint

Liu, F., Pouponnot, C., & Massagué, J. (1997) · Genes & Development · doi:10.1101/gad.11.23.3157 · Cited by 445 · see citing works

Functional Analysis of the Transforming Growth Factor βResponsive Elements in the WAF1/Cip1/p21 Promoter

Datto, M., Yu, Y., & Wang, X. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28623 · Cited by 429 · see citing works

Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y.-N., Campbell, A., Sudha, T., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.322 · Cited by 429 · see citing works

Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily

Ladias, J. A. A., & Karathanasis, S. K. (1991) · Science · doi:10.1126/science.1899293 · Cited by 367 · see citing works

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

Zhang, Y. E., Musci, T. J., & Derynck, R. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00123-0 · Cited by 310 · see citing works

Cloning and Characterization of a Novel Member of the Transforming Growth Factor-β/Bone Morphogenetic Protein Family

Paralkar, V. M., Vail, A. L., GRASSER, W. A., Brown, T. A., Xu, H., Vukičević, S., Ke, H. Z., Qi, H., Owen, T. A., & Thompson, D. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13760 · Cited by 289 · see citing works

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

Liebermann, D. A., Hoffman, B., & Steinman, R. A. (1995) · PubMed · Cited by 282 · see citing works

Solution structure of the tetrameric minimum transforming domain of p53

Lee, W., Harvey, T. S., Yin, Y., Yau, P., Litchfield, D. W., & Arrowsmith, C. H. (1994) · Nature Structural & Molecular Biology · doi:10.1038/nsb1294-877 · Cited by 265 · see citing works

Coupling gene expression to cAMP signalling: role of CREB and CREM

Sassone‐Corsi, P. (1998) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00093-9 · Cited by 242 · see citing works

Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin

Brancolini, C., Lazarević, D., Rodriguez, J., & Schneider, C. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.3.759 · Cited by 236 · see citing works

PLAB, a novel placental bone morphogenetic protein

Hromas, R., Hufford, M. B., Sutton, J., Xu, D., Li, Y., & Lu, L. (1997) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(97)00122-x · Cited by 233 · see citing works

Characterization of the stress-inducing effects of homocysteine

Outinen, P. A., Sood, S. K., LIAW, P. C. Y., Sarge, K. D., Maeda, N., Hirsh, J., Ribau, J. C. O., Podor, T. J., Weitz, J. I., & Austin, R. C. (1998) · Biochemical Journal · doi:10.1042/bj3320213 · Cited by 232 · see citing works

The Lymphoid Transcription Factor LyF-1 Is Encoded by Specific, Alternatively Spliced mRNAs Derived from the Ikaros Gene

Hahm, K., Ernst, P., Lo, K., Kim, G. S., Turck, C. W., & Smale, S. T. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7111 · Cited by 224 · see citing works

Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta

Lawton, L. N., Bonaldo, M. F., Jelenc, P. C., Qiu, L., Baumes, S. A., Marcelino, R. A., de Jesus, G. M., Wellington, S., Knowles, J. A., Warburton, D., et al. (1997) · Gene · doi:10.1016/s0378-1119(97)00485-x · Cited by 209 · see citing works

The state of the STATs: recent developments in the study of signal transduction to the nucleus

Horvath, C. M., & Darnell, J. E., Jr. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80067-1 · Cited by 204 · see citing works

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

Massagué, J., & Weis‐Garcia, F. (1996) · PubMed · Cited by 196 · see citing works

Cancer therapy and p53

Lowe, S. W. (1995) · Current Opinion in Oncology · doi:10.1097/00001622-199511000-00013 · Cited by 194 · see citing works

Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF-7

Hishikawa, K., Oemar, B. S., Tanner, F. C., Nakaki, T., Lüscher, T. F., & Fujii, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37461 · Cited by 178 · see citing works

A novel p53‐inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

Israeli, D., Tessler, E., Haupt, Y., Elkeles, A., Wilder, S., Amson, R. B., Telerman, A., & Oren, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.14.4384 · Cited by 172 · see citing works

Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice

Sirito, M., Lin, Q., Deng, J. M., Behringer, R. R., & Sawadogo, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3758 · Cited by 163 · see citing works

The MEK Pathway Is Required for Stimulation of p21WAF1/CIP1 by Transforming Growth Factor-β

Hu, P. P.-C., Shen, X., Huang, D., Liu, Y. I., Counter, C. M., & Wang, X.-F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35381 · Cited by 157 · see citing works

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding

Zhan, Q., Chen, I. T., Antinore, M. J., & Fornace, A. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2768 · Cited by 154 · see citing works

DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells

de Winter, J. P., Roelen, B. A. J., ten Dijke, P., van der Burg, B., & Raaij, A. J. M. V. D. E.-V. (1997) · Oncogene · doi:10.1038/sj.onc.1201017 · Cited by 133 · see citing works

p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta.

Fuchs, E. J., Mckenna, K. A., & Bedi, A. (1997) · PubMed · Cited by 132 · see citing works

[20] Analysis of altered gene expression by differential display

Liang, P., Bauer, D., Averboukh, L., Warthoe, P., Rohrwild, M., Müller, H., Strauss, M., & Pardee, A. B. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)54022-9 · Cited by 129 · see citing works

Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect.

Nishizaki, M., Fujiwara, T., Tanida, T., HIZUTA, A., Nishimori, H., Tokino, T., Nakamura, Y., Bouvet, M., Roth, J., & Tanaka, N. (1999) · PubMed · Cited by 118 · see citing works

Human cDNA Encoding a Novel TGF- Superfamily Protein Highly Expressed in Placenta

Yokoyama-Kobayashi, M., Saeki, M., Sekine, S., & Kato, S. (1997) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021798 · Cited by 116 · see citing works

Tamoxifen induces TGF-beta 1 activity and apoptosis of human MCF-7 breast cancer cells in vitro.

Chen, H., Tritton, T. R., Kenny, N., Absher, M. P., & Chiu, J. (1996) · PubMed · doi:10.1002/(sici)1097-4644(19960401)61:1%3c9::aid-jcb2%3e3.0.co;2-z · Cited by 107 · see citing works

Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.

Katayose, D., Gudas, J. M., Nguyen, H., Srivastava, S., Cowan, K. H., & Seth, P. K. (1995) · PubMed · Cited by 106 · see citing works

Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3

Towatari, M., May, G. E., Marais, R., Perkins, G. R., Marshall, C. J., Cowley, S. A., & Enver, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4101 · Cited by 101 · see citing works

A novel p53‐inducible gene coding for a microtubule‐localized protein with G2‐phase‐specific expression

Utrera, R., Collavin, L., Lazarević, D., Delia, D., & Schneider, C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5015 · Cited by 97 · see citing works

Mechanism and Function of Signaling by the TGFβ Superfamily

Hoodless, P. A., & Wrana, J. L. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80481-6_10 · Cited by 82 · see citing works

Tamoxifen induces TGF-β1 activity and apoptosis of human MCF-7 breast cancer cells in vitro

Chen, H., Tritton, T. R., Kenny, N., Absher, M. P., & Chiu, J. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960401)61:1 · Cited by 77 · see citing works

DNA damage, p53 and anticancer therapies

Milner, J. (1995) · Nature Medicine · doi:10.1038/nm0995-879 · Cited by 68 · see citing works

Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck.

Frank, D. K., Frederick, M. J., Liu, T. J., & Clayman, G. L. (1998) · PubMed · Cited by 50 · see citing works

Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells.

Peled, A., Zipori, D., & Rotter, V. (1996) · PubMed · Cited by 48 · see citing works

ICE-like protease (caspase) is involved in transforming growth factor β1-mediated apoptosis in FaO rat hepatoma cell line

Choi, K. S., Lim, I. K., Brady, J. N., & Kim, S. (1998) · Hepatology · doi:10.1002/hep.510270215 · Cited by 46 · see citing works

A role for CdxA in gut closure and intestinal epithelia differentiation

Frumkin, A., Pillemer, G., Haffner, R., Tarcic, N., Gruenbaum, Y., & Fainsod, A. (1994) · Development · doi:10.1242/dev.120.2.253 · Cited by 43 · see citing works

Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress

Frenkel, J., Sherman, D., Fein, A., Schwartz, D., Almog, N., Kapon, A., Goldfinger, N., & Rotter, V. (1999) · Oncogene · doi:10.1038/sj.onc.1202518 · Cited by 39 · see citing works

Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells.

Yount, G. L., Levine, K. S., Kuriyama, H., Haas-Kogan, D. A., & Israel, M. A. (1999) · PubMed · Cited by 35 · see citing works

Tumor Suppressor Gene Smad4/DPC4, Its Downstream Target Genes, and Regulation of Cell Cyclea

Chiao, P. J., Hunt, K. K., Grau, A. M., Abramian, A., Fleming, J. B., ZHANG, W., Breslin, T. M., Abbruzzese, J. L., & Evans, D. B. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09507.x · Cited by 33 · see citing works

The evaluation of adenoviral p53-mediated bystander effect in gene therapy of cancer

Rizk, N. P., Chang, M. Y., Kouri, C. E., Seth, P. K., Kaiser, L. R., Albelda, S. Μ., & Amin, K. M. (1999) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700059 · Cited by 31 · see citing works

Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer

Li, P.-X., Ngo, D., Brade, A. M., & Klamut, H. J. (1999) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700005 · Cited by 19 · see citing works

Therapeutic potential of recombinant p53 overexpression in breast cancer cells expressing endogenous wild-type p53

Pei-xiang, L., Bui, T., Gray, D. M., & Klamut, H. J. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1005961705860 · Cited by 13 · see citing works

DNA-Binding Activity of Wild-Type p53 Protein is Mediated by the Central Part of the Molecule and Controlled by Its C Terminus

Wolkowicz, R., Peled, A., Elkind, B., & Rotter, V. (1998) · Cancer Detection and Prevention · doi:10.1046/j.1525-1500.1998.00003.x · Cited by 13 · see citing works

Molecular targets to overcome radioresistance.

Weichselbaum, R. R., Beckett, M. A., Hallahan, D. E., Kufe, D. W., & Vokes, E. E. (1992) · PubMed · Cited by 12 · see citing works

Cyclooxygenase‐independent actions of cyclooxygenase inhibitors

Tegeder, I., Pfeilschifter, J. M., & Geißlinger, G. (2001) · The FASEB Journal · doi:10.1096/fj.01-0390rev · Cited by 748 · see citing works

Activation of p53 by MEG3 Non-coding RNA

Zhou, Y., Zhong, Y., Wang, Y., Zhang, X., Batista, D. L., Gejman, R., Ansell, P. J., Zhao, J. C., Weng, C., & Klibanski, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702029200 · Cited by 654 · see citing works

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanismsPreprint

Rohde, M., Daugaard, M., Jensen, M. H., Helin, K., Nylandsted, J., & Jäättelä, M. (2005) · Genes & Development · doi:10.1101/gad.305405 · Cited by 417 · see citing works

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

Tsai, V. W.-W., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.018 · Cited by 414 · see citing works

Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities

Baek, S. J., Kim, K. S., Nixon, J. B., Wilson, L. C., & Eling, T. E. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.901 · Cited by 402 · see citing works

Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties

Yoon, J., & Baek, S. J. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.5.585 · Cited by 382 · see citing works

Expression Profiling of Serous Low Malignant Potential, Low-Grade, and High-Grade Tumors of the Ovary

Bonome, T., Lee, J.-Y., Park, D.-C., Radonovich, M., Pise-Masison, C. A., Brady, J. N., Gardner, G. J., Hao, K., Wong, W. H., Barrett, J. C., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2240 · Cited by 315 · see citing works

Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

Koopmann, J., Buckhaults, P., Brown, D. A., ZAHURAK, M. L., Sato, N., Fukushima, N., Sokoll, L. J., Chan, D. W., Yeo, C. J., Hruban, R. H., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0165 · Cited by 274 · see citing works

MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.

Brown, D. A., Ward, R. L., Buckhaults, P., Liu, T., Romans, K. E., Hawkins, N. J., Bauskin, A. R., Kinzler, K. W., Vogelstein, B., & Breit, S. N. (2003) · PubMed · Cited by 265 · see citing works

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study

Brown, D. A., Breit, S. N., Buring, J. E., Fairlie, W. D., Bauskin, A. R., Liu, T., & Ridker, P. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09093-1 · Cited by 258 · see citing works

GDF15: a hormone conveying somatic distress to the brain

Lockhart, S. M., Saudek, V., & O’Rahilly, S. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa007 · Cited by 256 · see citing works

Hepatokines and metabolism: Deciphering communication from the liver

Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works

Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer

Bauskin, A. R., Brown, D. A., Kuffner, T., Johnen, H., Luo, X. W., Hunter, M., & Breit, S. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4067 · Cited by 251 · see citing works

The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism

Breit, S. N., Johnen, H., Cook, A. D., Tsai, V. W. W., Mohammad, M. G., Kuffner, T., Zhang, H. P., Marquis, C. P., Jiang, L., Lockwood, G., et al. (2011) · Growth Factors · doi:10.3109/08977194.2011.607137 · Cited by 247 · see citing works

The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?

Breit, S. N., Brown, D. A., & Tsai, V. W.-W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022020-045449 · Cited by 228 · see citing works

Involvement of growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in oxLDL-induced apoptosis of human macrophages in vitro and in arteriosclerotic lesions

Schlittenhardt, D., Schober, A., Strelau, J., Bonaterra, G. A., Schmiedt, W., Unsicker, K., Metz, J., & Kinscherf, R. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0986-3 · Cited by 224 · see citing works

Concise Review: Growth Differentiation Factor 15 in Pathology: A Clinical Role?

Corre, J., Hébraud, B., & Bourin, P. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0055 · Cited by 209 · see citing works

Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine‐1 in cancer

Mimeault, M., & Batra, S. K. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22196 · Cited by 208 · see citing works

Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age‐related disorders

Fujita, Y., Taniguchi, Y., Shinkai, S., Tanaka, M., & Ito, M. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12724 · Cited by 199 · see citing works

Growth differentiation factor 15 (GDF15): a survival protein with therapeutic potential in metabolic diseases

Baek, S. J., & Eling, T. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.008 · Cited by 194 · see citing works

Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53

Baek, S. J., Wilson, L. C., & Eling, T. E. (2002) · Carcinogenesis · doi:10.1093/carcin/23.3.425 · Cited by 194 · see citing works

GDF15, an emerging key player in human aging

Conte, M., Giuliani, C., Chiariello, A., Iannuzzi, V., Franceschi, C., & Salvioli, S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101569 · Cited by 189 · see citing works

Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia

Baek, S. J., Okazaki, R., Lee, S.-H., Martinez, J., Kim, J.-S., Yamaguchi, K., Mishina, Y., Martin, D. W., Shoieb, A., Mcentee, M. F., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.09.015 · Cited by 175 · see citing works

GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

Roth, P., Junker, M., Tritschler, I., Mittelbronn, M. G. A., Dombrowski, Y., Breit, S. N., Tabatabai, G., Wick, W., Weller, M., & Wischhusen, J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0705 · Cited by 175 · see citing works

Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells.

Liu, T., Bauskin, A. R., Zaunders, J. J., Brown, D. A., Pankhurst, S., Russell, P. J., Breit, S. N., & Panhurst, S. (2003) · PubMed · Cited by 174 · see citing works

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1

Albertoni, M., Shaw, P., Nozaki, M., Godard, S., Tenan, M., Hamou, M., Fairlie, D. W., Breit, S., Paralkar, V., de Tribolet, N., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205610 · Cited by 173 · see citing works

GDF15 promotes EMT and metastasis in colorectal cancer

Li, C., Wang, J., Kong, J., Tang, J., Wu, Y., Xu, E., Zhang, H., & Lai, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6205 · Cited by 170 · see citing works

Identification of Serum Biomarkers for Colorectal Cancer Metastasis Using a Differential Secretome Approach

Xue, H., Lü, B., Zhang, J., Wu, M., Huang, Q., Wu, Q., Sheng, H., Wu, D., Hu, J., & Lai, M. (2009) · Journal of Proteome Research · doi:10.1021/pr9008817 · Cited by 169 · see citing works

Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells

Baek, S. J. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh255 · Cited by 169 · see citing works

Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein

Baek, S. J., Kim, J., Moore, S. M., Lee, S., Martinez, J. M., & Eling, T. E. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.005108 · Cited by 162 · see citing works

Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA

Kim, J.-S., Lee, C. S., Bonifant, C. L., Ressom, H. W., & Waldman, T. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00537-06 · Cited by 159 · see citing works

Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system.

Lee, D. H., Yang, Y. D., Lee, S. J., Kim, K. Y., Koo, T. H., Shin, S. M., Song, K. S., Lee, Y. H., Kim, Y. J., Lee, J. J., et al. (2003) · PubMed · Cited by 161 · see citing works

Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation.

Yang, H. S., Filipovic, Z., Brown, D. A., Breit, S. N., & Vassilev, L. T. (2003) · PubMed · Cited by 157 · see citing works

The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer

Wang, X., Baek, S. J., & Eling, T. E. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.025 · Cited by 154 · see citing works

The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome

Bauskin, A. R., Brown, D. A., Junankar, S. R., Rasiah, K., Eggleton, S. A., Hunter, M. I., Liu, T., Smith, D., Kuffner, T., Pankhurst, G. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3827 · Cited by 154 · see citing works

Macrophage Inhibitory Cytokine 1: A New Prognostic Marker in Prostate Cancer

Brown, D. A., Lindmark, F., Stattin, P. E., Bälter, K. A., Adami, H., Zheng, S. L., Xu, J., Isaacs, W. B., Grönberg, H., Breit, S. N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-3126 · Cited by 152 · see citing works

Expression of growth differentiation factor‐15/ macrophage inhibitory cytokine‐1 (GDF‐15/MIC‐1) in the perinatal, adult, and injured rat brain

Schober, A., Bottner, M. B., Strelau, J., Kinscherf, R., Bonaterra, G. A., Barth, M., Schilling, L., Fairlie, W. D., Breit, S. N., & Unsicker, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1333 · Cited by 151 · see citing works

Molecular Cloning and Characterization of Human Nonsteroidal Anti-inflammatory Drug-activated Gene Promoter

Baek, S. J., Horowitz, J. M., & Eling, T. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101814200 · Cited by 147 · see citing works

Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene EGR-1

Baek, S. J., Kim, J., Nixon, J. B., DiAugustine, R. P., & Eling, T. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305295200 · Cited by 145 · see citing works

TIM-3 Is Expressed in Melanoma Cells and Is Upregulated in TGF-Beta Stimulated Mast Cells

Wiener, Z., Kőhalmi, B., Pócza, P., Jeager, J., Tölgyesi, G., Tóth, S., Görbe, É., Papp, Z., & Falus, A. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700616 · Cited by 139 · see citing works

Growth differentiation factor 15 in erythroid health and disease

Tanno, T., Noel, P., & Miller, J. L. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328337b52f · Cited by 139 · see citing works

Growth Differentiation Factor-15 Prevents Low Potassium-induced Cell Death of Cerebellar Granule Neurons by Differential Regulation of Akt and ERK Pathways

Subramaniam, S., Strelau, J., & Unsicker, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210037200 · Cited by 134 · see citing works

Growth Differentiation Factor 15 in Heart Failure: An Update

Wollert, K. C., & Kempf, T. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0113-9 · Cited by 128 · see citing works

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

Bruzzese, F., Hägglöf, C., Leone, A., Sjöberg, E., Roca, M. S., Kiflemariam, S., Sjöblom, T., Hammarsten, P., Egevad, L., Bergh, A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2259 · Cited by 127 · see citing works

Dual Function of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Inhibition of Cyclooxygenase and Induction of NSAID-Activated Gene

Baek, S. J., Wilson, L. C., Lee, C.-H., & Eling, T. E. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.3.1126 · Cited by 127 · see citing works

MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas

Balik, V., Srovnal, J., Sulla, I. J., Kalita, O., Foltánová, T., Vaverka, M., Hrabálek, L., & Hajdúch, M. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-1038-6 · Cited by 125 · see citing works

Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3

Secchiero, P., Corallini, F., Gonelli, A., Dell’Eva, R., Vitale, M., Capitani, S., Albini, A., & Zauli, G. (2006) · Circulation Research · doi:10.1161/01.res.0000253975.76198.ff · Cited by 125 · see citing works

NSAID Activated Gene (NAG-1), a Modulator of Tumorigenesis

Eling, T. E., Baek, S. J., Shim, M., & Lee, C. H. (2006) · BMB Reports · doi:10.5483/bmbrep.2006.39.6.649 · Cited by 123 · see citing works

The Role of GDF15 as a Myomitokine

Johann, K., Kleinert, M., & Klaus, S. (2021) · Cells · doi:10.3390/cells10112990 · Cited by 121 · see citing works

Nonsteroidal anti‐inflammatory drug‐activated gene (NAG‐1) is induced by genistein through the expression of p53 in colorectal cancer cells

Wilson, L. C., Baek, S. J., Call, A., & Eling, T. E. (2003) · International Journal of Cancer · doi:10.1002/ijc.11173 · Cited by 120 · see citing works

Indole-3-carbinol and 3,3′-diindolylmethane induce expression of NAG-1 in a p53-independent manner

Lee, S., Kim, J., Yamaguchi, K., Eling, T. E., & Baek, S. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.138 · Cited by 119 · see citing works

Potential applications of MEG3 in cancer diagnosis and prognosis

He, Y., Luo, Y., Liang, B., Ye, L., Lu, G., & He, W. (2017) · Oncotarget · doi:10.18632/oncotarget.19931 · Cited by 117 · see citing works

Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells

Kim, K.-K., Lee, J. J., Yang, Y. D., You, K., & Lee, J. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn031 · Cited by 116 · see citing works

Diallyl Disulfide (DADS) Induces the Antitumorigenic NSAID-Activated Gene (NAG-1) by a p53-Dependent Mechanism in Human Colorectal HCT 116 Cells

Bottone, F. G., Baek, S. J., Nixon, J. B., & Eling, T. E. (2002) · Journal of Nutrition · doi:10.1093/jn/132.4.773 · Cited by 116 · see citing works

Growth differentiation factor-15 as a prognostic biomarker in ovarian cancer

Staff, A. C., Bock, A. J., Becker, C., Kempf, T., Wollert, K. C., & Davidson, B. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.05.032 · Cited by 115 · see citing works

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma

Wang, X., Li, Y., Tian, H.-M., Qi, J., Li, M., Fu, C., Wu, F., Wang, Y., Cheng, D., Zhao, W., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-578 · Cited by 111 · see citing works

GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

Aguilar-Recarte, D., Barroso, E., Gumà, A., Pizarro‐Delgado, J., Peña, L., Ruart, M., Palomer, X., Wahli, W., & Vázquez‐Carrera, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109501 · Cited by 109 · see citing works

Measurement of Serum Levels of Macrophage Inhibitory Cytokine 1 Combined with Prostate-Specific Antigen Improves Prostate Cancer Diagnosis

Brown, D. A., Stephan, C., Ward, R. L., Law, M. G., Hunter, M., Bauskin, A. R., Amin, J., Jung, K., Diamandis, E. P., Hampton, G. M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1331 · Cited by 109 · see citing works

Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15

Tsai, V. W.-W., Lin, S., Brown, D. A., Sainsbury, A., & Breit, S. N. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.242 · Cited by 108 · see citing works

Macrophage Inhibitory Cytokine-1 Is Overexpressed in Malignant Melanoma and Is Associated with Tumorigenicity

Boyle, G. M., Pedley, J., Martyn, A. C., Banducci, K., Strutton, G., Brown, D. A., Breit, S. N., & Parsons, P. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.270 · Cited by 108 · see citing works

Growth differentiation factor 15: A novel biomarker with high clinical potential

Desmedt, S., Desmedt, V., Vos, L. D., Delanghe, J., Speeckaert, R., & Speeckaert, M. M. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1615034 · Cited by 104 · see citing works

Expression and regulation of nonsteroidal anti-inflammatory drug–activated gene (NAG-1) in human and mouse tissue

Kim, K. S., Baek, S. J., Flake, G. P., Loftin, C. D., Calvo, B. F., & Eling, T. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.32972 · Cited by 104 · see citing works

Elevated levels of MIC‐1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome

Shnaper, S., Desbaillets, I., Brown, D. A., Murat, A., Migliavacca, E., Schluep, M., Ostermann, S., Hamou, M., Stupp, R., Breit, S. N., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24639 · Cited by 100 · see citing works

Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma

Chang, L., Wang, G., Jia, T., Zhang, L., Li, Y., Han, Y., Zhang, K., Lin, G., Zhang, R., Li, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8115 · Cited by 99 · see citing works

Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays

de Wit, N. J. W., Rijntjes, J., Diepstra, J. H. S., Kuppevelt, T. H. V., Weidle, U. H., Ruiter, D. J., & van Muijen, G. N. P. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602612 · Cited by 97 · see citing works

Regulation of growth differentiation factor 15 expression by intracellular iron

Lakhal, S., Talbot, N. P., Crosby, A., Stoepker, C., Townsend, A. R. M., Robbins, P. A., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2009) · Blood · doi:10.1182/blood-2008-07-170431 · Cited by 95 · see citing works

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

Kalli, M., Papageorgis, P., Gkretsi, V., & Stylianopoulos, T. (2018) · Annals of Biomedical Engineering · doi:10.1007/s10439-018-1997-7 · Cited by 95 · see citing works

NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells

Lim, J. H., Park, J. W., Min, D. S., Chang, J., Lee, Y. H., Park, Y. B., Choi, K. S., & Kwon, T. K. (2006) · APOPTOSIS · doi:10.1007/s10495-006-0576-9 · Cited by 95 · see citing works

Identification of Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3β Pathway

Yamaguchi, K., Lee, S., Eling, T. E., & Baek, S. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408796200 · Cited by 94 · see citing works

1,1-Bis(3′-indolyl)-1-(p-substitutedphenyl)methanes Are Peroxisome Proliferator-Activated Receptor γ Agonists but Decrease HCT-116 Colon Cancer Cell Survival through Receptor-Independent Activation of Early Growth Response-1 and Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1

Chintharlapalli, S. R., Papineni, S., Baek, S. J., Liu, S., & Safe, S. H. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.017046 · Cited by 93 · see citing works

Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis

Buendgens, L., Yagmur, E., Bruensing, J., Herbers, U., Baeck, C., Trautwein, C., Koch, A. H., & Tacke, F. (2017) · Disease Markers · doi:10.1155/2017/5271203 · Cited by 91 · see citing works

NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway

Min, K.-W., Liggett, J. L., SILVA, G. H. D. O., Wu, W., Wang, R., Shen, R.-F., Eling, T. E., & Baek, S. J. (2015) · Oncogene · doi:10.1038/onc.2015.95 · Cited by 90 · see citing works

The p53 network: p53 and its downstream genes

Shu, K., Li, B., & Wu, L. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.11.003 · Cited by 89 · see citing works

A p53-type response element in the GDF15 promoter confers high specificity for p53 activation

Osada, M., Park, H. L., Park, M. J., Liu, J.-W., Wu, G., Trink, B., & Sidransky, D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.089 · Cited by 90 · see citing works

A Retrospective Analysis of Toxicogenomics in the Safety Assessment of Drug Candidates

Foster, W. R., Chen, S.-J., He, A., Truong, A. B., Bhaskaran, V. M., Nelson, D. M., Dambach, D. M., Lehman‐McKeeman, L. D., & Car, B. D. (2007) · Toxicologic Pathology · doi:10.1080/01926230701419063 · Cited by 89 · see citing works

GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways

Urakawa, N., Utsunomiya, S., Nishio, M., Shigeoka, M., Takase, N., Arai, N., Kakeji, Y., Koma, Y., & Yokozaki, H. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.36 · Cited by 88 · see citing works

Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15

Chang, J. T., Chan, S., Lin, C., Lin, T.-Y., Wang, H., Liao, C., Wang, T., Lee, L., & Cheng, A. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0801 · Cited by 88 · see citing works

In-depth profiling and analysis of host and viral microRNAs in Japanese flounder (Paralichthys olivaceus) infected with megalocytivirus reveal involvement of microRNAs in host-virus interaction in teleost fish

Zhang, B., Zhang, J., & Sun, L. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-878 · Cited by 87 · see citing works

GDF15 is a potential predictive biomarker for TPF induction chemotherapy and promotes tumorigenesis and progression in oral squamous cell carcinoma

Yang, C., Ma, J., Zhu, D., Liu, Y., Montgomery, B. K., Wang, L. Z., Li, J., Zhang, Z. Y., Zhang, C. P., & Zhong, L. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu120 · Cited by 86 · see citing works

Growth Differentiation Factor 15 in Adverse Cardiac Remodelling: From Biomarker to Causal Player

Wesseling, M., de Poel, J. H. C., & de Jager, S. C. A. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12728 · Cited by 85 · see citing works

Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53‐dependent mechanism and inhibition of prostate cancer cell growth

Lambert, J. R., Kelly, J. A., Shim, M., Huffer, W. E., Nordeen, S. K., Baek, S. J., Eling, T. E., & Lucia, M. S. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20692 · Cited by 83 · see citing works

Changes in gene expression contribute to cancer prevention by COX inhibitors

Baek, S. J., & Eling, T. E. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.10.001 · Cited by 81 · see citing works

Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells

Ichikawa, T., Horie‐Inoue, K., Ikeda, K., Blumberg, B., & Inoue, S. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-07-0048 · Cited by 81 · see citing works

Protein Kinase C-dependent Regulation of NAG-1/Placental Bone Morphogenic Protein/MIC-1 Expression in LNCaP Prostate Carcinoma Cells

Shim, M., & Eling, T. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414613200 · Cited by 80 · see citing works

Growth-Differentiation Factor-15 in Heart Failure

Kempf, T., & Wollert, K. C. (2009) · Heart Failure Clinics · doi:10.1016/j.hfc.2009.04.006 · Cited by 79 · see citing works

Transcriptional activation of p53 by Pitx1

Liu, D., & Lobie, P. E. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402209 · Cited by 79 · see citing works

NADPH Oxidase as a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy

Mortezaee, K., Goradel, N. H., Amini, P., Shabeeb, D., Musa, A. E., Najafi, M., & Farhood, B. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467211666181010154709 · Cited by 77 · see citing works

Elevated Plasma Growth Differentiation Factor-15 Correlates with Lymph Node Metastases and Poor Survival in Endometrial Cancer

Staff, A. C., Trovik, J., Zahl, E. A. G., Wik, E., Wollert, K. C., Kempf, T., & Salvesen, H. B. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0715 · Cited by 77 · see citing works

Predicting 5‐fluorouracil chemosensitivity of liver metastases from colorectal cancer using primary tumor specimens: Three‐gene expression model predicts clinical response

Matsuyama, R., Togo, S., Shimizu, D., Momiyama, N., Ishikawa, T., Ichikawa, Y., Endo, I., Kunisaki, C., Suzuki, H., Hayasizaki, Y., et al. (2006) · International Journal of Cancer · doi:10.1002/ijc.21843 · Cited by 76 · see citing works

The Transforming Growth Factor-β Family Members Bone Morphogenetic Protein-2 and Macrophage Inhibitory Cytokine-1 as Mediators of the Antiangiogenic Activity of N-(4-Hydroxyphenyl)Retinamide

Ferrari, N., Pfeffer, U., Dell’Eva, R., Ambrosini, C., Noonan, D. M., & Albini, A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2210 · Cited by 75 · see citing works

Gene expression profiling of the human prostate zones

van der Heul-Nieuwenhuijsen, L., Hendriksen, P. J. M., van der Kwast, T., & Jenster, G. W. (2006) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.06427.x · Cited by 74 · see citing works

Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents

Yang, M. H., Kim, J., Khan, I. A., Walker, L., & Khan, S. I. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.01.075 · Cited by 74 · see citing works

Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin–proteasome system and Cox‐2

Voutsadakis, I. A. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00032.x · Cited by 74 · see citing works

Up-regulation of Inflammatory Signalings by Areca Nut Extract and Role of Cyclooxygenase-2 −1195G>A Polymorphism Reveal Risk of Oral Cancer

Chiang, S.-L., Chen, P., Lee, C., Ko, A. M., Lee, K., Lin, Y., Ho, P., Tu, H., Wu, D., Shieh, T., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0823 · Cited by 69 · see citing works

Growth Differentiation Factor-15: Induction in Liver Injury Through p53 and Tumor Necrosis Factor-Independent Mechanisms1

Zimmers, T. A., Jin, X., Hsiao, E. C., Perez, E. A., Pierce, R. H., Chavin, K. D., & Koniaris, L. G. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.07.036 · Cited by 69 · see citing works

Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis

Rasiah, K., Kench, J. G., Gardiner‐Garden, M., Biankin, A. V., Golovsky, D., Brenner, P. C., Kooner, R., O’Neill, G., Turner, J., Delprado, W., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0752 · Cited by 69 · see citing works

Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

Pan, M., Chiou, Y.-S., Wang, Y.-J., Ho, C., & Lin, J.-K. (2011) · Food & Function · doi:10.1039/c0fo00174k · Cited by 68 · see citing works

Nonsteroidal Anti-inflammatory Drug-Activated Gene-1 Expression Inhibits Urethane-Induced Pulmonary Tumorigenesis in Transgenic Mice

Cekanova, M., Lee, S., Donnell, R. L., Sukhthankar, M., Eling, T. E., Fischer, S. M., & Baek, S. J. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0057 · Cited by 67 · see citing works

The TGF-β Superfamily Cytokine MIC-1/GDF15: Secretory Mechanisms Facilitate Creation of Latent Stromal Stores

Bauskin, A. R., Jiang, L., Luo, X., Wu, L., Brown, D. A., & Breit, S. N. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2009.0052 · Cited by 66 · see citing works

PTGF-β , a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway

Tan, M., Wang, Y., Guan, K., & Sun, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.109 · Cited by 253 · see citing works

Convergence of p53 and TGF-beta signaling networks

Dupont, S., Zacchigna, L., Adorno, M., Soligo, S., Volpin, D., Piccolo, S., & Cordenonsi, M. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.06.008 · Cited by 75 · see citing works

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

Ewan, K., Henshall-Powell, R. L., Ravani, S. A., Pajares, M. J., Arteaga, C. L., Warters, R., Akhurst, R. J., & Barcellos‐Hoff, M. H. (2002) · PubMed · Cited by 142 · see citing works

Unexpected relations

Croager, E. J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1110

Role of TAp73α in induction of apoptosis by transforming growth factor‐β in gastric cancer cells

Yamamura, Y., Lee, W. L., Goh, M. X., & Ito, Y. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.046 · Cited by 14 · see citing works