The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Disruption of the taurine transporter gene ( taut ) leads to retinal degeneration in mice
Abstract
Taurine is involved in cell volume homeostasis, antioxidant defense, protein stabilization, and stress responses. High levels of intracellular taurine are maintained by a Na + ‐dependent taurine transporter (TAUT) in the plasma membrane. In view of the immunomodulatory and cytoprotective effects of taurine, a mouse model with a disrupted gene coding for the taurine transporter (taut‐/‐ mice) was generated. These mice show markedly decreased taurine levels in a variety of tissues, a reduced fertility, and loss of vision due to severe retinal degeneration. In particular, the retinal involvement identifies the taurine transporter as an important factor for the development and maintenance of normal retinal functions and morphology.
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Cites
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
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Cited by
Jong, C. J., Azuma, J., & Schaffer, S. (2012) · Amino Acids · doi:10.1007/s00726-011-0962-7 · Cited by 461
Taurine: new implications for an old amino acid
Schuller-Levis, G. B., & Park, E. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00611-6 · Cited by 425
Taurine and its chloramine: Modulators of immunity
Schuller-Levis, G. B., & Park, E. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000010440.37629.17 · Cited by 219
Taurine: A Regulator of Cellular Redox Homeostasis and Skeletal Muscle Function
Seidel, U., Huebbe, P., & Rimbach, G. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800569 · Cited by 176
Functions of Maternally-Derived Taurine in Fetal and Neonatal Brain Development
Tochitani, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1079-2_2 · Cited by 41
Metadata
- Authors
- Heller-Stilb, B., van Roeyen, C., Rascher, K., Hartwig, H.-G., Huth, A., Seeliger, M. W., Warskulat, U., & Häussinger, D.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2001-12-28
- Volume
- 16
- Issue
- 2
- Pages
- 1-18
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2004616733
- Cited by
- 226
- References
- 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heller-Stilb, B., van Roeyen, C., Rascher, K., Hartwig, H.-G., Huth, A., Seeliger, M. W., Warskulat, U., & Häussinger, D. (2002). Disruption of the taurine transporter gene ( taut ) leads to retinal degeneration in mice. The FASEB Journal. https://doi.org/10.1096/fj.01-0691fje
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
