The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Analysis of paradoxical observations on the association between leptin and insulin resistance
Abstract
Obesity is commonly associated with the development of insulin resistance and diabetes in humans and rodents. Insulin resistance and diabetes are observed in lipoatrophic individuals or rodent models of lipoatrophy. Here we focus on the role of leptin, the product of the obesity ( ob ) gene, in the development of insulin resistance and diabetes associated with obesity and lipoatrophy. We review the reported effects of leptin on whole body glucose metabolism and compare and contrast these with direct effects on skeletal muscle, fat and liver. This summary of paradoxical observations on the effects of leptin on glucose homeostasis and the ability of leptin to induce or improve insulin resistance suggests that a complex interplay exists between direct peripheral and centrally mediated effects of the hormone. Evidence suggesting that leptin acts as a mediator of insulin release from pancreatic β cells is reviewed. Finally, intracellular signaling mechanisms stimulated by both leptin and insulin are discussed, with potential points of cross‐talk suggested.—Ceddia, R. B., Koistinen, H. A., Zierath, J. R., Sweeney, G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J . 16, 1163–1176 (2002)
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Cites
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Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., & Hare, J. M. (2003) · Circulation · doi:10.1161/01.cir.0000083716.82622.fd · Cited by 341
Insulin Action in Adipose Tissue and Muscle in Hypothyroidism
Dimitriadis, G., Mitrou, P., Lambadiari, V., Boutati, E., Maratou, E., Panagiotakos, D. B., Koukkou, E., Tzanela, M., Thalassinos, N., & Raptis, S. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0478 · Cited by 233
Sarcopenic obesity and endocrinal adaptation with age
Sakuma, K., & Yamaguchi, A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/204164 · Cited by 189
Increased Maternal Plasma Leptin in Early Pregnancy and Risk of Gestational Diabetes Mellitus
Qiu, C., Williams, M. A., Vadachkoria, S., Frederick, I. O., & Luthy, D. A. (2004) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000113621.53602.7a · Cited by 146
Metadata
- Authors
- Ceddia, R. B., Koistinen, H. A., Zierath, J. R., & Sweeney, G.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 16
- Issue
- 10
- Pages
- 1163-1176
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1976860473
- Cited by
- 257
- References
- 25
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- closed
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