The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Mechanical stress activates the nuclear factor‐kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy
Abstract
The ex vivo effects of passive mechanical stretch on the activation of nuclear factor‐kappaB (NF‐κB) pathways in skeletal muscles from normal and mdx mouse, a model of Duchenne muscular dystrophy (DMD), were investigated. The NF‐κB/DNA binding activity of the diaphragm muscle was increased by the application of axial mechanical stretch in a time‐dependent manner. The increased activation of NF‐κB was associated with a concomitant increase in I‐kappaB (IκB) kinase activity and the degradation of IκBμ protein. Pretreatment of the muscles with nifedipine (a Ca 2+ channel blocker) and gadolinium(III) chloride (a stretch‐activated channel blocker) did not alter the level of activation of NF‐κB, ruling out involvement of Ca 2+ influx through these channels. Furthermore, N‐acetyl cysteine, a free radical inhibitor, blocked the mechanical stretch‐induced NF‐κB activation, suggesting the involvement of free radicals. Compared with normal diaphragm, the basal level of NF‐κB activity was higher in muscles from mdx mice, and it was further enhanced in mechanically stretched muscles. Furthermore, activation of NF‐κB and increased expression of inflammatory cytokines IL‐1 β and tumor necrosis factor β in the mdx mouse precede the onset of muscular dystrophy. Our results show that mechanical stretch activates the classical NF‐κB pathway and this pathway could be predominately active in DMD. FASEB J. 17, 386–396 (2003)
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Dystrophin: the protein product of the Duchenne muscular dystrophy locus
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NF-κB at the crossroads of life and death
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Signal transduction by tumor necrosis factor and its relatives
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Dystrophin protects the sarcolemma from stresses developed during muscle contraction
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The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation
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The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy
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Nuclear factor-?B: its role in health and disease
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Self-citationThe Molecular Bases of Training Adaptation
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Metadata
- Authors
- Kumar, A., & Boriek, A. M.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2003-03
- Volume
- 17
- Issue
- 3
- Pages
- 386-396
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1985266648
- Cited by
- 301
- References
- 54
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
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