NF-κB at the crossroads of life and death

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766 · see citing works

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745 · see citing works

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · see citing works

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950 · see citing works

Suppression of TNF-α-Induced Apoptosis by NF-κB

Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581 · see citing works

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,581 · see citing works

Inhibition of death receptor signals by cellular FLIP

Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548 · see citing works

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828 · see citing works

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E. M., Zon, L. I., Kyriakis, J. M., et al. (1996) · Nature · doi:10.1038/380075a0 · Cited by 1,767 · see citing works

Signal transduction by tumor necrosis factor and its relatives.

Baud, V., & Karin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02064-5 · Cited by 1,741 · see citing works

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728 · see citing works

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

Asea, A. A. A., Kraeft, S., Kurt‐Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R. W., Koo, G. C., & Calderwood, S. K. (2000) · Nature Medicine · doi:10.1038/74697 · Cited by 1,621 · see citing works

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

Ohashi, K., Burkart, V., Flohé, S. B., & Kolb, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.558 · Cited by 1,607 · see citing works

A receptor for phosphatidylserine-specific clearance of apoptotic cells

Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491 · see citing works

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

Baldwin, A. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11991 · Cited by 1,427 · see citing works

IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases

Deveraux, Q. L., Roy, N., Stennicke, H. R., Arsdale, T. V., Zhou, Q., Srinivasula, S. M., Alnemri, E. S., Salvesen, G. S., & Reed, J. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2215 · Cited by 1,390 · see citing works

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361 · see citing works

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., et al. (1997) · Nature · doi:10.1038/386517a0 · Cited by 1,316 · see citing works

Cross-Talk between Two Cysteine Protease Families

Nakagawa, T., & Yuan, J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.4.887 · Cited by 1,164 · see citing works

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

Sha, W. C., Liou, H.-C., TUOMANEN, E. I., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90415-8 · Cited by 1,158 · see citing works

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

Listen, P., Roy, N., Tamai, K., Lefebvre, C. A., Baird, S. D., Cherton-Horvat, G., Farahani, R., McLean, M., lkeda, J.-E., MacKenzie, A., et al. (1996) · Nature · doi:10.1038/379349a0 · Cited by 1,005 · see citing works

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

Li, Q., Antwerp, D. V., Mercurio, F., Lee, K., & Verma, I. M. (1999) · Science · doi:10.1126/science.284.5412.321 · Cited by 963 · see citing works

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

Li, Z., Chu, W., Hu, Y., Delhase, M., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1839 · Cited by 927 · see citing works

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

Delhase, M., Hayakawa, M., Chen, Y., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.309 · Cited by 852 · see citing works

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosisPreprint

Lin, Y., Devin, A., Rodriguez, Y., & Liu, Z.-G. (1999) · Genes & Development · doi:10.1101/gad.13.19.2514 · Cited by 835 · see citing works

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

Zhong, H., Suyang, H., Erdjument‐Bromage, H., Tempst, P., & Ghosh, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80222-6 · Cited by 828 · see citing works

Structural Basis for the Inhibition of Caspase-3 by XIAP

Riedl, S. J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C. C., Fesik, S. W., Liddington, R., & Salvesen, G. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00274-4 · Cited by 793 · see citing works

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x L

Chen, C., Edelstein, L. C., & Gélinas, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2687-2695.2000 · Cited by 760 · see citing works

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

Deveraux, Q. L., Leo, E., Stennicke, H. R., Welsh, K., Salvesen, G. S., & Reed, J. C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5242 · Cited by 751 · see citing works

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743 · see citing works

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosisPreprint

Zong, W.-X., Edelstein, L., Chen, C.-L., Bash, J., & Gélinas, C. (1999) · Genes & Development · doi:10.1101/gad.13.4.382 · Cited by 738 · see citing works

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732 · see citing works

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

Chu, Z.-L., McKinsey, T. A., Liu, L., Gentry, J. J., Malim, M. H., & Ballard, D. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10057 · Cited by 732 · see citing works

Inhibition of JNK activation through NF-κB target genes

Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721 · see citing works

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

Sizemore, N., Leung, S., & Stark, G. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4798 · Cited by 650 · see citing works

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

Madrid, L. V., Wang, C.-Y., D, D. C. G., Schottelius, A. J. G., Baldwin, A. S., & Mayo, M. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1626-1638.2000 · Cited by 634 · see citing works

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

Takahashi, R., Deveraux, Q. L., Tamm, I., Welsh, K., Assa‐Munt, N., Salvesen, G. S., & Reed, J. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.7787 · Cited by 608 · see citing works

NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

Wang, C.-Y., D, D. C. G., Mayo, M. W., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.5923 · Cited by 586 · see citing works

Structural Basis of Caspase-7 Inhibition by XIAP

Chai, J., Shiozaki, E. N., Srinivasula, S. M., Wu, Q. Y., Dataa, P., Alnemri, E. S., & Shi, Y. (2001) · Cell · doi:10.1016/s0092-8674(01)00272-0 · Cited by 582 · see citing works

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

Kreuz, S., Siegmund, D., Scheurich, P., & Wajant, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3964-3973.2001 · Cited by 579 · see citing works

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

Tamatani, M., Ho, Y., Matsuzaki, H., Ogawa, S., Okado, H., Miyake, S., Mizuno, T., & Tohyama, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8531 · Cited by 549 · see citing works

Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease

Orth, K., Xu, Z., Mudgett, M. B., et al. (2000) · Science · doi:10.1126/science.290.5496.1594 · Cited by 549 · see citing works

Nuclear Factor (NF)-κB–regulated X-chromosome–linked <i>iap</i> Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J. A., Binder, B. R., & Lipp, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.211 · Cited by 532 · see citing works

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

Lee, H. H., Dadgostar, H., Cheng, Q., Shu, J., & Cheng, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9136 · Cited by 522 · see citing works

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

Yeh, W.-C., Itie, A., Elia, A. J., Ng, M., Shu, H.-B., Wakeham, A., Mirtsos, C., Suzuki, N., Bonnard, M., Goeddel, D. V., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80214-9 · Cited by 515 · see citing works

Modulation of cell death by Bcl-x L through caspase interaction

Clem, R. J., Cheng, E. H. Y., Karp, C. L., Kirsch, D. G., Ueno, K., Takahashi, A., Kastan, M. B., Griffin, D. E., Earnshaw, W. C., Veliuona, M. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.554 · Cited by 514 · see citing works

Structural Basis of Caspase Inhibition by XIAP

Huang, Y., Park, Y. C., Rich, R. L., Segal, D., Myszka, D. G., & Wu, H. (2001) · Cell · doi:10.1016/s0092-8674(01)00273-2 · Cited by 480 · see citing works

Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages

Freire-de-Lima, C. G., Nascimento, D. O., Soares, M. B. P., Bozza, P. T., Castro-Faria-Neto, H. C., Mello, F. G. D., DosReis, G. A., & Lopes, M. F. (2000) · Nature · doi:10.1038/35003208 · Cited by 455 · see citing works

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

Natoli, G., Costanzo, A., Ianni, A., Templeton, D. J., Woodgett, J. R., Balsano, C., & Levrero, M. (1997) · Science · doi:10.1126/science.275.5297.200 · Cited by 452 · see citing works

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

Lee, S. Y., Reichlin, A., Santana, A., Sokol, K. A., Nussenzweig, M. C., & Choi, Y. (1997) · Immunity · doi:10.1016/s1074-7613(00)80390-8 · Cited by 445 · see citing works

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

Franzoso, G., Carlson, L. M., Poljak, L., Shores, E. W., Epstein, S. L., Leonardi, A., Grinberg, A., Tran, T., Scharton‐Kersten, T., Anver, M. R., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.2.147 · Cited by 425 · see citing works

Characterization of XIAP-Deficient Mice

Harlin, H., Reffey, S. B., Duckett, C. S., Lindsten, T., & Thompson, C. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3604-3608.2001 · Cited by 422 · see citing works

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

Shu, H., Takeuchi, M., & Goeddel, D. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13973 · Cited by 418 · see citing works

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

Wu, M. X., Ao, Z., Prasad, K. V. S., Wu, R., & Schlossman, S. F. (1998) · Science · doi:10.1126/science.281.5379.998 · Cited by 414 · see citing works

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosisPreprint

Grumont, R. J., Rourke, I. J., & Gerondakis, S. (1999) · Genes & Development · doi:10.1101/gad.13.4.400 · Cited by 403 · see citing works

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

Shu, H., Halpin, D. R., & Goeddel, D. V. (1997) · Immunity · doi:10.1016/s1074-7613(00)80450-1 · Cited by 399 · see citing works

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

Makris, C., Godfrey, V., Krähn‐Senftleben, G., Takahashi, T., Roberts, J. L., Schwarz, T., Feng, L., Johnson, R. S., & Karin, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80262-2 · Cited by 393 · see citing works

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2 .

Lin, E. Y., Orlofsky, A., Berger, M. S., & Prystowsky, M. B. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.4.1979 · Cited by 335 · see citing works

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

Ravi, R. K., Bedi, G. C., Engstrom, L., Zeng, Q., Mookerjee, B., Gélinas, C., Fuchs, E. J., & Bedi, A. (2001) · Nature Cell Biology · doi:10.1038/35070096 · Cited by 313 · see citing works

The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators

Dechend, R., Hirano, F., Lehmann, K. E., Heissmeyer, V., Ansieau, S., Wulczyn, F. G., Scheidereit, C., & Leutz, A. (1999) · Oncogene · doi:10.1038/sj.onc.1202717 · Cited by 313 · see citing works

Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein

Mills, S. D., Boland, A., Sory, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12638 · Cited by 312 · see citing works

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

Doi, T. S., Marino, M. W., Takahashi, T., Yoshida, T., Sakakura, T., Old, L. J., & Obata, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2994 · Cited by 299 · see citing works

Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

Alcamo, E., Mizgerd, J. P., Horwitz, B. H., Bronson, R. T., Beg, A. A., Scott, M. L., Doerschuk, C. M., Hynes, R. O., & Baltimore, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1592 · Cited by 259 · see citing works

Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis

Lenczowski, J. M., Domínguez, L., Eder, A. M., King, L. B., Zacharchuk, C., & Ashwell, J. D. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.170 · Cited by 245 · see citing works

The anti‐apoptotic activities of Rel and RelA required during B‐cell maturation involve the regulation of Bcl‐2 expression

Grossmann, M., O’Reilly, L. A., Gugasyan, R., Strasser, A., Adams, J. M., & Gerondakis, S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6351 · Cited by 227 · see citing works

RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100

Solan, N. J., Miyoshi, H., Carmona, E. M., Bren, G. D., & Payá, C. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109619200 · Cited by 224 · see citing works

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survivalPreprint

Duckett, C. S., & Thompson, C. B. (1997) · Genes & Development · doi:10.1101/gad.11.21.2810 · Cited by 224 · see citing works

The NF-κB Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes

Khoshnan, A., Tindell, C., Laux, I., Bae, D. J., Bennett, B. L., & Nel, A. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1743 · Cited by 221 · see citing works

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

Mitchell, T. C., Hildeman, D. A., Kedl, R. M., Teague, T. K., Schaefer, B. C., White, J., Zhu, Y., Kappler, J. W., & Marrack, P. (2001) · Nature Immunology · doi:10.1038/87692 · Cited by 221 · see citing works

Induction of Bcl-xLExpression by Human T-Cell Leukemia Virus Type 1 Tax through NF-κB in Apoptosis-Resistant T-Cell Transfectants with Tax

Tsukahara, T., Kannagi, M., Ohashi, T., Kato, H., Arai, M., Núñez, G., Iwanaga, Y., Yamamoto, N., Ohtani, K., Nakamura, M., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.7981-7987.1999 · Cited by 213 · see citing works

IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis

Senftleben, U., Li, Z., Baud, V., & Karin, M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00104-2 · Cited by 208 · see citing works

Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 Gene

Hamasaki, A., Sendo, F., Nakayama, K., Ishida, N., Negishi, I., Nakayama, K., & Hatakeyama, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.1985 · Cited by 199 · see citing works

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

Horwitz, B. H., Scott, M. L., Cherry, S. R., Bronson, R. T., & Baltimore, D. (1997) · Immunity · doi:10.1016/s1074-7613(00)80451-3 · Cited by 190 · see citing works

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop

Levkau, B., Scatena, M., Giachelli, C. M., Ross, R., & Raines, E. W. (1999) · Nature Cell Biology · doi:10.1038/12050 · Cited by 188 · see citing works

High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation

Lavon, I., Goldberg, I., Amit, S., Landsman, L., Jung, S., Tsuberi, B., Barshack, I., Kopolovic, J., Galun, E., Bujard, H., et al. (2000) · Nature Medicine · doi:10.1038/75057 · Cited by 182 · see citing works

Genotoxic‐Stress‐Response Genes and Growth‐Arrest Genes

Fornace, A. J., Jackman, J., Hollander, M. C., Hoffman‐Liebermann, B., & Liebermann, D. A. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38657.x · Cited by 181 · see citing works

The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-κB and c-Jun N-terminal Kinase

Schwenzer, R., Siemienski, K., Liptay, S., Schubert, G., Peters, N., Scheurich, P., Schmid, R. M., & Wajant, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19368 · Cited by 168 · see citing works

Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases

Fujita, N., Nagahashi, A., Nagashima, K., Rokudai, S., & TSURUO, T. (1998) · Oncogene · doi:10.1038/sj.onc.1202065 · Cited by 160 · see citing works

Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro

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