Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age‐related muscle dysfunction

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879

What is the cause of the ageing atrophy?

Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,142

Strength, power and related functional ability of healthy people aged 65-89 years.

SKELTON, D. A., GREIG, C. A., DAVIES, J. M., & YOUNG, A. (1994) · Age and Ageing · doi:10.1093/ageing/23.5.371 · Cited by 934

Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

Marber, M. S., Mestril, R., H, S., Sayen, M. R., Yellon, D. M., & DILLMANN, W. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117815 · Cited by 843

Contractile properties of skeletal muscles from young, adult and aged mice.

Brooks, S. V., & Faulkner, J. A. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017279 · Cited by 777 · cited 4×

Aging of human muscle: structure, function and adaptability

Porter, M. M., Vandervoort, A. A., & Lexell, J. E. (1995) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1995.tb00026.x · Cited by 565

Muscle transplantation between young and old rats: age of host determines recovery

Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417

Injury to skeletal muscle fibers of mice following lengthening contractions

McCully, K. K., & Faulkner, J. A. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.1.119 · Cited by 408

Nitric oxide release is present from incubated skeletal muscle preparations

Balon, T. W., & Nadler, J. L. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.6.2519 · Cited by 406

HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise

Salo, D. C., Donovan, C. M., & Davies, K. J. A. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90119-n · Cited by 357

Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers

Stary, C. M., & Hogan, M. C. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01060.2015 · Cited by 6

Knockout of Hsp70 Genes Modulates Age-Related Transcriptomic Changes in Leg Muscles and Reduces the Locomotion Speed and Lifespan of Drosophila melanogaster

Kukushkina, I. V., Makhnovskii, P. A., Zgoda, V. G., Kurochkina, N. S., & Popov, D. V. (2024) · Molecular Biology · doi:10.1134/s0026893324020109 · Cited by 5

HSP72 expression is specific to skeletal muscle contraction type

Bonello, J.-P., & Locke, M. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-00997-x · Cited by 5

Effects of hyperbaric environment on endurance and metabolism are exposure time‐dependent in well‐trained mice

Suzuki, J. (2021) · Physiological Reports · doi:10.14814/phy2.14780 · Cited by 5

Protection of heart and skeletal muscle by heat shock proteins

Tupling, A. R. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h08-066 · Cited by 5

Muscle diseases and aging

Oflazer, P. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)86018-0 · Cited by 4

Skeletal Muscle Aging

Broome, C. S., Vasilaki, A., & McArdle, A. (2003) · Springer eBooks · doi:10.1007/978-94-017-0673-5_3 · Cited by 5

Differential Regulation of Smac/DIABLO and Hsp-70 during Brain Maturation

Stoka, V., Türk, V., & Bredesen, D. E. (2007) · NeuroMolecular Medicine · doi:10.1007/s12017-007-8007-9 · Cited by 4

Intermittent dilution of dietary digestible lysine lowers the incidence of white striping by suppressing the growth, lipid synthesis, and muscle damage in broiler chickens

Ahsan, U., İpek, E., ÖZDEMİR, Ö. S., Aydın, A. K., Raza, I., Çalık, A., Kuter, E., Özsoy, Ş. Y., & Cengiz, Ö. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12140 · Cited by 4

Hormetic Interventions in Aging

Rattan, S. I. S. (2008) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2008.30.43 · Cited by 4

Ovariectomy alters lengthening contraction induced heat shock protein expression

Locke, M., & Salerno, S. A. (2020) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2019-0212 · Cited by 4

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Jackson, M. J. (2025) · Experimental Physiology · doi:10.1113/ep092458 · Cited by 3

Older mice show decreased regeneration of neuromuscular junctions following lengthening contraction-induced injury

Paul, T. A., Macpherson, P. C. D., Janetzke, T. L., Davis, C. S., Jackson, M. J., McArdle, A., & Brooks, S. V. (2023) · GeroScience · doi:10.1007/s11357-023-00774-w · Cited by 3

Senescence inhibits the chaperone response to thermal stressPreprint

Llewellyn, J., Mallikarjun, V., Appleton, E., Osipova, M., Gilbert, H. T. J., Richardson, S. M., Hubbard, S. J., & Swift, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.15.448532 · Cited by 3

Redox control of signalling responses to contractile activity and aging in skeletal muscle

Jackson, M. J. (2023) · Redox Experimental Medicine · doi:10.1530/rem-23-0014 · Cited by 2

Skeletal Muscle Heat Shock Protein Content and the Repeated Bout Effect

Locke, M., & Bruccoleri, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074017 · Cited by 2

Heat Shock Proteins, Exercise, and Aging

Huey, K. A., Vieira‐Potter, V. J., & Woods, J. A. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_22 · Cited by 2

Low-intensity treadmill exercise enhances fast recovery from bupivacaine-induced muscle injury in rats

Kim, K.-J., Jun, T.-W., Kim, H. K., Kim, C., & Song, W. J. (2013) · Integrative Medicine Research · doi:10.1016/j.imr.2013.09.005 · Cited by 2

Overexpression of HSP70 attenuates sarcopenia by suppressing the expression of miR‐133b

Nascimento, T. L., Mestril, R., & Miyabara, E. H. (2020) · JCSM Rapid Communications · doi:10.1002/rco2.12 · Cited by 2

Mechanisms of decline in muscle quality in sarcopenia

Yamada, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00007-7 · Cited by 2

Skeletal muscle aging

Close, G. L., Haggan, P., & McArdle, A. (2007) · Reviews in Clinical Gerontology · doi:10.1017/s0959259808002360 · Cited by 2

MicroAge mission: experimental design and hardware for a bespoke culture system supporting tissue-engineered skeletal muscle

Jones, S. W., Shigdar, S. M., Temple, J., Tollitt, B. R., Janvier, A. J., Mutter, F., Henstock, J. R., Ohana, J., Turner, D. A., McArdle, C., et al. (2026) · npj Microgravity · doi:10.1038/s41526-026-00579-z · Cited by 2

Potential Cytoprotective Effects of Heat Shock Proteins to Skeletal Muscle

Vardiman, J. P., Gallagher, P. M., & Siedlik, J. A. (2015) · Heat shock proteins · doi:10.1007/978-3-319-17211-8_7 · Cited by 1

Skeletal muscle fiber plasticity: Heat shock proteins and satellite cell activation

Oishi, Y., & Ogata, T. (2012) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.1.473 · Cited by 1

Role of Melatonin Supplementation During Strenuous Exercise

Díaz‐Castro, J., Pulido‐Moran, M., Moreno‐Fernández, J., Kajarabille, N., Hijano, S., & Ochoa, J. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805094-1.00010-1 · Cited by 1

Heat Shock Proteins Involved in Neuromuscular Pathologies

Merino‐Jiménez, C., García-Cruz, C., Aragón, J., Siqueiros‐Márquez, L., & Montáñez, C. (2019) · Heat shock proteins · doi:10.1007/978-3-030-03952-3_21 · Cited by 1

Interventions in Aging and Age-Related Diseases: The Present and the Future

(2006) · AGE · doi:10.1007/s11357-006-9011-y · Cited by 1

Reactive oxygen species in age-related musculoskeletal decline: implications for nutritional intervention

Jackson, M. J. (2024) · Proceedings of The Nutrition Society · doi:10.1017/s0029665124004877 · Cited by 1

Proteomic and Biochemical Profiling of Aged Skeletal Muscle

O’Connell, K. M., Doran, P., Gannon, J. M., Donoghue, P. M., & Ohlendieck, K. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_12 · Cited by 1

Protein Oxidation in Some Age‐Related Diseases

Grune, T., Karademir-Yilmaz, B., & Jung, T. (2012) · Wiley eBooks · doi:10.1002/9781118493038.ch4 · Cited by 1

Muscular Pain Mechanisms: Brief Review with Special Consideration of Delayed-Onset Muscle Soreness

Mizumura, K. (2008) · Springer eBooks · doi:10.1007/978-4-431-73242-6_12 · Cited by 1

Degradation of ribosome and chaperone proteins is attenuated during the Differentiation of Replicatively Aged C2C12 MyoblastsPreprint

Brown, A. D., Stewart, C. E., & Burniston, J. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.18.464830 · Cited by 1

Unravelling disease mechanisms in juvenile dermatomyositis

Elst, E. F. (2007) · Utrecht University Repository (Utrecht University)

Role of Contraction-Induced Injury in Age-Related Muscle Wasting and Weakness

Faulkner, J. A., Mendias, C. L., Davis, C. S., & Brooks, S. V. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_16

Critical illness myopathy : understanding different effects on muscle fibre function

Ogilvie, H. (2015) · Figshare

Estratégias alternativas de implementação do efeito protetor contra o dano muscular

Delgado, L. E., & de Lima, L. C. R. (2014) · Conexões · doi:10.20396/conex.v12i3.2160

Influência das HSPs (heat shock proteins) e do mTORC-1 (mammalian target of rapamycin complex 1) na regeneração de músculos esqueléticos.

Conte, T. C. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2009.tde-26012010-111321

Reactive Oxygen Species Generation and Skeletal Muscle Wasting – Implications for Sarcopenia

McArdle, A., & Jackson, M. J. (2010) · Springer eBooks · doi:10.1007/978-90-481-9713-2_14

Papel da proteína de choque térmico 70 induzível (HSP70) na atrofia muscular e subsequente recuperação.

Nascimento, T. L. (2012) · doi:10.11606/d.42.2012.tde-17042013-085753

Abstracts

Valis, K., & Neuzil, J. (2009) · Free Radical Research · doi:10.1080/10715760903128886

training in mouse skeletal and cardiac muscle -crystallin responses to inflammation and exercise

Huey, K. A., Meador, B. M., Haseler, L. J., Headrick, J. P., Budiono, B. P., Hoe, L. E. S., Peart, J. N., Sabapathy, S., & Ashton, K. J. (2015)

following acute nondamaging treadmill exercise heat shock protein families in human skeletal muscle Time course and differential responses of the major

Drust, B., Griffiths, D., Campbell, I. T., Evans, L., Kayani, A. C., McArdle, A., Morton, J. P., MacLaren, D. P. M., Cable, N. T., Bongers, T., et al. (2015)

reloadingand attenuates oxidative damage following Intermittent hyperthermia enhances skeletal muscle

Selsby, J. T., Rother, S., Tsuda, S., Quindry, J. C., DODD, S. L., Fujimoto, M., Nakai, A., Ohira, Y., Yoshioka, T., Yasuhara, K., et al. (2015)

Calorie Restriction, Exercise, and Colon Cancer Prevention: A Mechanistic Perspective

Rogers, C. J., Colbert, L. H., Perkins, S. N., & Hursting, S. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7551-5_5

Análise proteômica das respostas agudas e crônicas ao exercício de endurance no músculo esquelético de ratos

Gandra, P. G. (2010) · doi:10.47749/t/unicamp.2010.772569

Morphological and Apoptotic Alterations in Skeletal Muscle of Mice Deficient in Apoptosis Repressor with Caspase Recruitment Domain

Mitchell, A. (2012) · UWSpace (University of Waterloo)

Mobilização neural: avaliação molecular e comportamental em ratos Wistar após indução de dor neuropática.

dos Santos, F. M. (2015) · doi:10.11606/t.42.2015.tde-05102015-150313

Transcriptome changes associated with muscle and intramuscular connective tissue growth in cull cows under different recovery gain rates

Fausto, D. A. (2016) · doi:10.11606/t.11.2016.tde-28032016-115422

The Role of Small Heat Shock Protein 20 and Its Phosphorylation in the Regulation of Cardiac Function and Ischemia/Reperfusion Injury

Jiang, Q. (2010) · OhioLink ETD Center (Ohio Library and Information Network)

Heat shock proteins and endogenous antioxidants in skeletal muscle: acute responses to exercise and adaptations to training

Cumming, K. T. (2014) · BIBSYS Brage (BIBSYS (Norway))

A Comparison of Heat Shock Protein Expression in Rat Skeletal Muscle After Lengthening or Shortening Contractions

Holwerda, A. M. (2013) · TSpace (University of Toronto)

Characterization of the Cellular Stress Response in Skeletal Muscle Following Lengthening Contractions

Pollock‐Tahiri, E. (2015) · TSpace (University of Toronto)

Determinación de la cinética del daño en el ADN de leucocitos de sangre periférica en equinos sometidos a esfuerzo físico de alta intensidad

Muriel, M. G. (2016) · doi:10.35537/10915/59227

Does Creatine Supplementation Reduce Lengthening Contraction Induced Muscle Damage

Robinson, N. (2017) · TSpace (University of Toronto)

The Effect of Estrogen Deprivation on the Cellular Stress Response following Muscle Damage

Salerno, S. A. (2017) · TSpace (University of Toronto)

Heat Shock Protein Response to Overuse Injuries

Barbe, M. F., Salvadeo, D. M., & Hilliard, B. A. (2018) · Heat shock proteins · doi:10.1007/978-3-319-74715-6_11

Influência das proteínas de choque térmico na resposta regenerativa de músculos esqueléticos de camundongos idosos.

Nascimento, T. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-08082018-084036

Contraction-induced elevation of heat shock protein 72 mRNA content in isolated single skeletal muscle fibers

Stary, C. M. (2006) · eScholarship (California Digital Library)

Einfluss der selektiven Inhibition pro inflammatorischer Lipoxygenasen auf die Skelettmuskulatur der ovariektomierten Ratte

Ilka, M. (2022) · doi:10.53846/goediss-9086

Faculty Opinions recommendation of Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy.

Ji, L. L. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726785722.793564355

Programme schedule for SFRR-E Berlin supplement

Vieželienė, D., Jansen, E. H. J. M., Rodovičius, H., Beekhof, P., Cremers, J., & Ivanov, L. (2008) · Free Radical Research · doi:10.1080/10715760802207914

A Network Meta-Analysis of Sarcopenia Characteristic Indicators in Different Mouse Models of Muscular DystrophyPreprint

Jiang, Q., Geng, Z., Wang, N., Long, Y., Yang, G., Wang, P., & Zhao, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4370864/v1

Knockout of Hsp70 genes modulates age-related transcriptomic changes in leg muscles, reduces locomotion speed and lifespan of Drosophila melanogaster

Kukushkina, I. V., Makhnovskii, P. A., Zgoda, V. G., Kurochkina, N. S., & Popov, D. V. (2024) · Molecular Biology · doi:10.31857/s0026898424020065

Influence of Habitual Smoking on Physiological Status, Physical Performance Adaptation and Injury Risk during Initial Military Training

Siddall, A. (2012) · The University of Bath Online Publications Store (The University of Bath) · doi:10.13140/rg.2.1.3043.6001

HSP70 in Aging

Malyshev, I. Y. (2013) · SpringerBriefs in biochemistry and molecular biology · doi:10.1007/978-94-007-5943-5_7

Altérations du muscle squelettique humain lors du vieillissement associé ou non au syndrome métabolique et identification de nouveaux marqueurs

Gueugneau, M. (2014) · theses.fr (ABES) · doi:10.70675/aa7df51fz2d39z47d8z9b67z209b59a721b4

Altérations épigénétiques des cellules souches musculaires au cours du vieillissement naturel : implications dans la sarcopénie

Bauer, D. (2017) · theses.fr (ABES) · doi:10.70675/24e5b78fz270bz4c57z9703zfd5f6ad8a002

Réponses du métabolisme mitochondrial musculaire à la chaleur lors d’une exposition aiguë ex vivo et après une acclimatation associée à un entraînement en endurance

Tardo‐Dino, P. (2020) · theses.fr (ABES) · doi:10.70675/a5f6cdd4zca04z4d90za407z31cb9a70c51e

MicroAge Mission: Effects of Microgravity and Heat Shock Protein 10 Overexpression on the Proteome of Human Tissue-Engineered Muscle Constructs - Implications for Skeletal Muscle AgeingPreprint

Jones, S. H., Hasoon, M., Adair, K., Shigdar, S. M., Hemmings, K., Henstock, J. R., Brownridge, P., McArdle, C., Neri, G., Blackler, W., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.27.721147

LNC_003296 regulates the proliferation and differentiation of ovine myoblasts by modulating the stability of Hsp70

Song, Y., Guo, X., Zhang, X., Zhang, J., Sheng, H., & Chu, M. (2026) · Veterinary Quarterly · doi:10.1080/01652176.2026.2720646

O efeito protetor contra o dano muscular: alternativas às contrações excêntricas máximas

Delgado, L. E. (2013) · Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)

Effect of lifelong overexpression of HSP70 in skeletal muscle on age‐related oxidative stress and adaptation after nondamaging contractile activity

Broome, C. S., Kayani, A. C., Palomero, J., DILLMANN, W. H., Mestril, R., Jackson, M. J., & McArdle, A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4935fje · Cited by 170

Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle cross-sectional area

Kayani, A. C., Close, G. L., DILLMANN, W. H., Mestril, R., Jackson, M. J., & McArdle, A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00334.2009 · Cited by 49

Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity

Vasilaki, A., Jackson, M. J., & McArdle, A. (2002) · Muscle & Nerve · doi:10.1002/mus.10094 · Cited by 84

Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits

Kayani, A. C., Close, G. L., Jackson, M. J., & McArdle, A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00575.2007 · Cited by 35

Enhanced Recovery from Contraction-Induced Damage in Skeletal Muscles of Old Mice Following Treatment with the Heat Shock Protein Inducer 17-(Allylamino)-17-Demethoxygeldanamycin

Kayani, A. C., Close, G. L., Broome, C. S., Jackson, M. J., & McArdle, A. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0795 · Cited by 34