Muscle transplantation between young and old rats: age of host determines recovery
Abstract
As compared with age-matched controls, extensor digitorum longus (EDL) muscles autografted in young rats regenerated significantly greater mass (1.8 times) and developed greater maximum contractile force (2.6 times) than EDL muscles autografted in old rats. A cross-age transplantation study showed that the mass and maximum force of old muscles grafted into young hosts were not significantly different from those of young muscles grafted into the same young hosts. Conversely, young muscle grafted into old hosts regenerated no better than old muscles grafted into the same old hosts. We conclude 1) that chronological age alone is not a factor that limits the intrinsic ability of a muscle to regenerate and 2) that the poor regeneration of muscles in old animals is a function of the environment for regeneration provided by the old host.
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Heterochronic grafting experiments first indicated that the chronological age of the muscle microenvironment strongly affects muscle regenerative capacity.
“Grafting experiments, in which portions of intact muscle tissues are heterochronically transplanted between young and aged mice, provided the first indication that the chronological age of the muscle microenvironment exerts a profound influence on muscle regenerative capacity32.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [32]
Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments, whereas signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs.
“Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments143,144. By contrast, signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs145.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [143]
Skeletal muscle possesses the remarkable ability to repair and regenerate after injury or damage; however, this ability is impaired with aging.
“Skeletal muscle possesses the remarkable ability to repair and regenerate after an injury or damage; however, this ability is impaired with aging (4–7).”
From Phytoecdysteroids Accelerate Recovery of Skeletal Muscle Function Following in vivo Eccentric Contraction-Induced Injury in Adult and Old Mice (2021) · cites this paper as [6]
Cites
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683 · see citing works
Skeletal muscle satellite cells: Changes in proliferation potential as a function of age
Schultz, E., & Lipton, B. H. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90105-1 · Cited by 335 · see citing works
Age‐related differences in absolute numbers of skeletal muscle satellite cells
Gibson, M. C., & Schultz, E. (1983) · Muscle & Nerve · doi:10.1002/mus.880060807 · Cited by 321 · see citing works
Snow, M. H. (1977) · The Anatomical Record · doi:10.1002/ar.1091880206 · Cited by 223 · see citing works
The effects of aging on satellite cells in skeletal muscles of mice and rats
Snow, M. H. (1977) · Cell and Tissue Research · doi:10.1007/bf00220299 · Cited by 201 · see citing works
Edström, L., & Larsson, L. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016773 · Cited by 152 · see citing works
Reinnervation of long-term denervated rat muscle freely grafted into an innervated limb
Carlson, B. M., & Faulkner, J. A. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90077-5 · Cited by 83 · see citing works
Self-citationThe Influence of Age on the Course of Reinnervation of Muscle
Drahota, Z., & GUTMANN, E. (2009) · Gerontologia · doi:10.1159/000211047 · Cited by 49 · see citing works
A rapid silver impregnation for central and peripheral nerve fibers in paraffin and frozen sections
Goshgarian, H. G. (1977) · Experimental Neurology · doi:10.1016/0014-4886(77)90065-6 · Cited by 46 · see citing works
Womble, M. D., & Carlson, B. M. (1986) · American Journal of Anatomy · doi:10.1002/aja.1001760208 · Cited by 26 · see citing works
Self-citationIncreased phenylalanine incorporation in regenerating skeletal muscle grafts
Schwartz, J., Wiesen, J. F., Carlson, B. M., Yamasaki, L., Moore, M., & Womble, M. D. (1986) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y86-030 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691 · see citing works
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works
Myogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,646 · see citing works
The aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851 · see citing works
No place like home: anatomy and function of the stem cell niche
Jones, D. L., & Wagers, A. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2319 · Cited by 794 · see citing works
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719 · see citing works
Stem cells, ageing and the quest for immortality
Rando, T. A. (2006) · Nature · doi:10.1038/nature04958 · Cited by 695 · see citing works
The Skeletal Muscle Satellite Cell: The Stem Cell That Came in From the Cold
Zammit, P. S., Partridge, T. A., & Yablonka‐Reuveni, Z. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6r6995.2006 · Cited by 684 · see citing works
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627 · see citing works
Bernet, J. D., Doles, J. D., Hall, J. K., Kelly Tanaka, K., Carter, T. A., & Olwin, B. B. (2014) · Nature Medicine · doi:10.1038/nm.3465 · Cited by 573 · see citing works
Role of Inflammation in Muscle Homeostasis and Myogenesis
Costamagna, D., Costelli, P., Sampaolesi, M., & Penna, F. (2015) · Mediators of Inflammation · doi:10.1155/2015/805172 · Cited by 532 · see citing works
Skeletal muscle satellite cells
Schultz, E., & McCormick, K. M. (1994) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0030904 · Cited by 526 · see citing works
Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation
Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.12.012 · Cited by 507 · see citing works
Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle
Shefer, G., de Mark, D. P. V., Richardson, J. B., & Yablonka‐Reuveni, Z. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.022 · Cited by 506 · see citing works
Muscle stem cells in development, regeneration, and diseasePreprint
Shi, X., & Garry, D. J. (2006) · Genes & Development · doi:10.1101/gad.1419406 · Cited by 502 · see citing works
Intrinsic and extrinsic mechanisms regulating satellite cell function
Dumont, N. A., Wang, Y. X., & Rudnicki, M. A. (2015) · Development · doi:10.1242/dev.114223 · Cited by 491 · see citing works
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476 · see citing works
The p53 network: cellular and systemic DNA damage responses in aging and Cancer
Reinhardt, H. C., & Schumacher, B. (2012) · Trends in Genetics · doi:10.1016/j.tig.2011.12.002 · Cited by 458 · see citing works
The central role of muscle stem cells in regenerative failure with aging
Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437 · see citing works
Wosczyna, M. N., Konishi, C. T., Carbajal, E. E. P., Wang, T. T., Walsh, R. A., Gan, Q., Wagner, M. W., & Rando, T. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.074 · Cited by 438 · see citing works
Petrella, J. K., Kim, J.-S., Mayhew, D. L., Cross, J. M., & Bamman, M. M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01215.2007 · Cited by 435 · see citing works
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness
Ryall, J. G., Schertzer, J. D., & Lynch, G. S. (2008) · Biogerontology · doi:10.1007/s10522-008-9131-0 · Cited by 423 · see citing works
Wagers, A. J., & Conboy, I. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.021 · Cited by 416 · see citing works
Tissue-specific stem cells: Lessons from the skeletal muscle satellite cell
Brack, A. S., & Rando, T. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.04.001 · Cited by 409 · see citing works
Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works
Regeneration of Mammalian Skeletal Muscle: Basic Mechanisms and Clinical Implications
Ciciliot, S., & Schiaffino, S. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883453 · Cited by 384 · see citing works
Atrogin-1, MuRF-1, and sarcopenia
Gumucio, J. P., & Mendias, C. L. (2012) · Endocrine · doi:10.1007/s12020-012-9751-7 · Cited by 368 · see citing works
Satellite cells in human skeletal muscle plasticity
Snijders, T., Nederveen, J. P., McKay, B. R., Joanisse, S., Verdijk, L. B., van Loon, L. J. C., & Parise, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00283 · Cited by 359 · see citing works
Petrella, J. K., Kim, J.-S., Cross, J. M., Kosek, D. J., & Bamman, M. M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2006 · Cited by 356 · see citing works
When stem cells grow old: phenotypes and mechanisms of stem cell aging
Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 331 · see citing works
A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging
Collins, C. A., Zammit, P. S., Ruiz, A. P., Morgan, J. E., & Partridge, T. A. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0372 · Cited by 320 · see citing works
Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works
Analysis of 100 Cases of Free-Muscle Transplantation for Facial Paralysis
Terzis, J. K., & Noah, M. E. (1997) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199706000-00016 · Cited by 296 · see citing works
Windhorst, R. A., Cohen, S. H., Hathi, N. P., McCarthy, P. J., Ryan, R. E., Yan, H., Baldry, I. K., Driver, S. P., Frogel, J. A., Hill, D. T., et al. (2011) · The Astrophysical Journal Supplement Series · doi:10.1088/0067-0049/193/2/27 · Cited by 298 · see citing works
Williamson, D., Gallagher, P. M., Harber, M. P., Hollon, C. J., & Trappe, S. W. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.036673 · Cited by 290 · see citing works
McArdle, A., H. Dillmann, W., Mestril, R., A. Faulkner, J., & J. Jackson, M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0395fje · Cited by 274 · see citing works
Self-citationMiller, K. J., Thaloor, D., Matteson, S., & Pavlath, G. K. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.1.c174 · Cited by 274 · see citing works
Effects of ageing on the motor unit
Larsson, L., & Ansved, T. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)98601-z · Cited by 274 · see citing works
Stem Cell Review Series: Aging of the skeletal muscle stem cell niche
Gopinath, S. D., & Rando, T. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00399.x · Cited by 262 · see citing works
Age‐associated Changes in the Response of Skeletal Muscle Cells to Exercise and Regenerationa
Grounds, M. D. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09894.x · Cited by 264 · see citing works
IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle
Chakravarthy, M. V., Davis, B. S., & Booth, F. W. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.4.1365 · Cited by 262 · see citing works
Emerging models and paradigms for stem cell ageing
Jones, D. L., & Rando, T. A. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-506 · Cited by 256 · see citing works
Day, K., Shefer, G., Shearer, A., & Yablonka-Reuveni, Z. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.01.006 · Cited by 254 · see citing works
Pericytes at the intersection between tissue regeneration and pathology: Figure 1
Birbrair, A., Zhang, T., Wang, Z., Messi, M. L., Mintz, A., & Delbono, O. (2014) · Clinical Science · doi:10.1042/cs20140278 · Cited by 243 · see citing works
Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses
Carlson, M. E., Conboy, M. J., Hsu, M., Barchas, L., Jeong, J., Agrawal, A., Mikels, A. J., Agrawal, S., Schaffer, D. V., & Conboy, I. M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00517.x · Cited by 244 · see citing works
Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
Conboy, I. M., & Rando, T. A. (2012) · Cell Cycle · doi:10.4161/cc.20437 · Cited by 239 · see citing works
Intrinsic Changes and Extrinsic Influences of Myogenic Stem Cell Function During Aging
Brack, A. S., & Rando, T. A. (2007) · Stem Cell Reviews · doi:10.1007/s12015-007-9000-2 · Cited by 238 · see citing works
Regulation of muscle growth in neonates
Davis, T. A., & Fiorotto, M. L. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef9f · Cited by 237 · see citing works
Mechanisms of skeletal muscle aging: insights from <i>Drosophila</i> and mammalian models
Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012559 · Cited by 238 · see citing works
Loss of stem cell regenerative capacity within aged niches
Carlson, M. E., & Conboy, I. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00286.x · Cited by 233 · see citing works
Owino, V., Yang, S. Y., & Goldspink, G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02825-3 · Cited by 227 · see citing works
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
Mera, P., Laue, K., Wei, J., Berger, J. M., & Karsenty, G. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.07.002 · Cited by 223 · see citing works
Ono, Y., Boldrin, L., Knopp, P., Morgan, J. E., & Zammit, P. S. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.005 · Cited by 217 · see citing works
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works
Thaloor, D., Miller, K. J., Gephart, J., Mitchell, P. O., & Pavlath, G. K. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.2.c320 · Cited by 213 · see citing works
Shefer, G., Rauner, G., Yablonka‐Reuveni, Z., & Benayahu, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013307 · Cited by 211 · see citing works
Age-related changes in skeletal muscle: changes to life-style as a therapy
McCormick, R., & Vasilaki, A. (2018) · Biogerontology · doi:10.1007/s10522-018-9775-3 · Cited by 210 · see citing works
Bone and skeletal muscle: neighbors with close ties
DiGirolamo, D. J., Kiel, D. P., & Esser, K. A. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1969 · Cited by 193 · see citing works
“(94,95) Interestingly, despite the many indications of intrinsic defects in both myofibers and satellite cells with age, early work by Carlson and Faulkner(96) clearly demonstrated that the aged environment exerts a dominant effect on the regenerative capacity of muscle.”
BackgroundResultInfluentialMolecular and cell biology of skeletal muscle regeneration
Grounds, M. D., & Yablonka‐Reuveni, Z. (1993) · Springer eBooks · doi:10.1007/978-94-011-1528-5_9 · Cited by 192 · see citing works
Prospective Isolation of Skeletal Muscle Stem Cells with a Pax7 Reporter
Bosnakovski, D., Xu, Z., Li, W., Thet, S., Cleaver, O., Perlingeiro, R. C. R., & Kyba, M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1017 · Cited by 187 · see citing works
Danoviz, M. E., & Yablonka‐Reuveni, Z. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-343-1_2 · Cited by 182 · see citing works
The role of systemic inflammation in age‐related muscle weakness and wasting
Degens, H. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.01018.x · Cited by 188 · see citing works
Suetta, C., Frandsen, U., Mackey, A. L., Jensen, L., Hvid, L. G., Bayer, M. L., Petersson, S. J., Schrøder, H. D., Andersen, J. L., Aagaard, P., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.257121 · Cited by 182 · see citing works
Factors contributing to neuromuscular impairment and sarcopenia during aging
Edström, E., Altun, M., Bergman, E., Johnson, H., Kullberg, S., Ramírez-León, V., & Ulfhake, B. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.05.040 · Cited by 181 · see citing works
Role of satellite cells in muscle growth and maintenance of muscle mass
Pallafacchina, G., Blaauw, B., & Schiaffino, S. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.02.002 · Cited by 173 · see citing works
Divergent Roles of Inflammation in Skeletal Muscle Recovery From Injury
Howard, E. E., Pasiakos, S. M., Blesso, C. N., Fussell, M. A., & Rodriguez, N. R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00087 · Cited by 176 · see citing works
Stem Cell Aging in Skeletal Muscle Regeneration and Disease
Yamakawa, H., Kusumoto, D., Hashimoto, H., & Yuasa, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051830 · Cited by 178 · see citing works
Heterogeneity in the muscle satellite cell population
Biressi, S., & Rando, T. A. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.09.003 · Cited by 168 · see citing works
The ins and outs of muscle stem cell aging
Brack, A. S., & Muñoz-Cánoves, P. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0072-z · Cited by 166 · see citing works
Skeletal muscle satellite cell populations in healthy young and older men and women
Roth, S. M., Martel, G. F., Ivey, F. M., Lemmer, J. T., Metter, E. J., Hurley, B. F., & Rogers, M. A. (2000) · The Anatomical Record · doi:10.1002/1097-0185(200012)260:4 · Cited by 164 · see citing works
Muscle stem cell aging: regulation and rejuvenation
Sousa-Victor, P., García-Prat, L., Serrano, A. L., Perdiguero, E., & Muñoz-Cánoves, P. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.03.006 · Cited by 163 · see citing works
The Skeletal Muscle Satellite Cell
Yablonka‐Reuveni, Z. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155411426780 · Cited by 164 · see citing works
Skeletal muscle regeneration and impact of aging and nutrition
Domingues-Faria, C., Vasson, M.-P., Goncalves-Mendes, N., Boirie, Y., & Walrand, S. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.004 · Cited by 157 · see citing works
Impact of ageing on muscle cell regeneration.
Carosio, S., Berardinelli, M., Aucello, M., & Musarò, A. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2009.08.001 · Cited by 156 · see citing works
Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2013) · The FEBS Journal · doi:10.1111/febs.12221 · Cited by 152 · see citing works
An Overview About the Biology of Skeletal Muscle Satellite Cells
Forcina, L., Miano, C., Pelosi, L., & Musarò, A. (2019) · Current Genomics · doi:10.2174/1389202920666190116094736 · Cited by 151 · see citing works
Regenerative decline of stem cells in sarcopenia
Sousa-Victor, P., & Muñoz-Cánoves, P. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.02.002 · Cited by 147 · see citing works
Satellite cell depletion in degenerative skeletal muscle
Jejurikar, S. S., & Kuzon, W. M. (2003) · APOPTOSIS · doi:10.1023/a:1026127307457 · Cited by 149 · see citing works
Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats
Marsh, D. R., Criswell, D. S., Carson, J. A., & Booth, F. W. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.4.1270 · Cited by 144 · see citing works
Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting
Jo, E., Lee, S.-R., Park, B., & Kim, J. (2012) · Aging Clinical and Experimental Research · doi:10.1007/bf03654825 · Cited by 145 · see citing works
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00646.x · Cited by 143 · see citing works
Replicative aging down‐regulates the myogenic regulatory factors in human myoblasts
Bigot, A., Jacquemin, V., Debacq‐Chainiaux, F., Butler-Browne, G. S., Toussaint, O., Furling, D., & Mouly, V. (2008) · Biology of the Cell · doi:10.1042/bc20070085 · Cited by 141 · see citing works
Prolonged absence of myostatin reduces sarcopenia
Siriett, V., Platt, L., Salerno, M. S., Ling, N., Kambadur, R., & Sharma, M. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20778 · Cited by 139 · see citing works
Claflin, D. R., Larkin, L. M., Cederna, P. S., Horowitz, J. F., Alexander, N. B., Cole, N. M., Galecki, A. T., Chen, S., Nyquist, L. V., Carlson, B. M., et al. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01119.2010 · Cited by 140 · see citing works
Self-citationThe physiopathologic role of oxidative stress in skeletal muscle
Scicchitano, B. M., Pelosi, L., Sica, G., & Musarò, A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.009 · Cited by 141 · see citing works
The role of hormones, cytokines and heat shock proteins during age-related muscle loss
Lee, C. E., McArdle, A., & Griffiths, R. D. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.05.005 · Cited by 138 · see citing works
The Basis of Muscle Regeneration
Musarò, A. (2014) · Advances in Biology · doi:10.1155/2014/612471 · Cited by 138 · see citing works
Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice
Shavlakadze, T., McGeachie, J. K., & Grounds, M. D. (2009) · Biogerontology · doi:10.1007/s10522-009-9260-0 · Cited by 135 · see citing works
The Muscle Stem Cell Niche in Health and Disease
Mashinchian, O., Pisconti, A., Moal, E. L., & Bentzinger, C. F. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.003 · Cited by 127 · see citing works
Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosis
Jejurikar, S. S., Henkelman, E., Cederna, P. S., Marcelo, C. L., Urbanchek, M. G., & Kuzon, W. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.053 · Cited by 133 · see citing works
Shiomi, K., Kiyono, T., Okamura, K., Uezumi, M., Goto, Y., Yasumoto, S., Shimizu, S., & Hashimoto, N. (2011) · Gene Therapy · doi:10.1038/gt.2011.44 · Cited by 130 · see citing works
Antagonism of Myostatin Enhances Muscle Regeneration During Sarcopenia
Siriett, V., Salerno, M. S., Berry, C., Nicholas, G., Bower, R., Kambadur, R., & Sharma, M. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300182 · Cited by 132 · see citing works
Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
Brioche, T., Pagano, A. F., Py, G., & Chopard, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.006 · Cited by 129 · see citing works
How Sex Hormones Promote Skeletal Muscle Regeneration
Velders, M., & Diel, P. R. (2013) · Sports Medicine · doi:10.1007/s40279-013-0081-6 · Cited by 129 · see citing works
Genome instability, cancer and aging
Maslov, A. Y., & Vijg, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.020 · Cited by 128 · see citing works
Extrinsic regulation of satellite cell specification
Bentzinger, C. F., von Maltzahn, J., & Rudnicki, M. A. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt27 · Cited by 126 · see citing works
Regenerative function of immune system: Modulation of muscle stem cells
Saini, J., McPhee, J. S., Al-Dabbagh, S., Stewart, C. E., & Al‐Shanti, N. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.03.006 · Cited by 129 · see citing works
Kim, J.-S., Kosek, D. J., Petrella, J. K., Cross, J. M., & Bamman, M. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00513.2005 · Cited by 128 · see citing works
Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process
Adamo, M. L., & Farrar, R. P. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.05.001 · Cited by 126 · see citing works
Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan
Regmi, S. G., Rolland, S. G. M., & Conradt, B. (2014) · Aging · doi:10.18632/aging.100639 · Cited by 124 · see citing works
- Authors
- Carlson, B. M., & Faulkner, J. A.
- Affiliations
- University of Michigan (US)
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1989-06-01
- Volume
- 256
- Issue
- 6
- Pages
- C1262-C1266
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2323748919
- Cited by
- 417
- References
- 11
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 8 · 2017: 21 · 2016: 19 · 2015: 22 · 2014: 23 · 2013: 25 · 2012: 22
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Cell Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-06157)
- National Eye Institute (EY-05813)
- National Institute of Dental and Craniofacial Research (DE 07687)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- muscle transplantation, muscle regeneration, aging, host age, extensor digitorum longus, autograft, muscle mass, age-related muscle loss
- MeSH terms
- Aging, Animals, Isometric Contraction, Male, Microscopy, Electron, Muscle Contraction, Muscles, Rats, Inbred Strains, Transplantation, Autologous, Muscle Development, Rats
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