Cited by 417Muscle Physiology and DisordersTissue Engineering and Regenerative MedicineNerve injury and regeneration

Muscle transplantation between young and old rats: age of host determines recovery

Carlson, B. M., Faulkner, J. A.·1989·American Journal of Physiology-Cell Physiology

Abstract

As compared with age-matched controls, extensor digitorum longus (EDL) muscles autografted in young rats regenerated significantly greater mass (1.8 times) and developed greater maximum contractile force (2.6 times) than EDL muscles autografted in old rats. A cross-age transplantation study showed that the mass and maximum force of old muscles grafted into young hosts were not significantly different from those of young muscles grafted into the same young hosts. Conversely, young muscle grafted into old hosts regenerated no better than old muscles grafted into the same old hosts. We conclude 1) that chronological age alone is not a factor that limits the intrinsic ability of a muscle to regenerate and 2) that the poor regeneration of muscles in old animals is a function of the environment for regeneration provided by the old host.

Integrity signals

Registry

Crossref · 10.1152/ajpcell.1989.256.6.c1262

Cites

11 of 11 references verified0 citation errors · 0 not checkable

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  • Heterochronic grafting experiments first indicated that the chronological age of the muscle microenvironment strongly affects muscle regenerative capacity.

    “Grafting experiments, in which portions of intact muscle tissues are heterochronically transplanted between young and aged mice, provided the first indication that the chronological age of the muscle microenvironment exerts a profound influence on muscle regenerative capacity32.”
  • Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments, whereas signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs.

    “Extrinsic signals from old niches appear to dominate over intrinsic function of young stem cells in transplantation experiments143,144. By contrast, signals from young niches may have only limited rejuvenation effects on old stem cells, at least for HSCs145.”

    From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [143]

  • Skeletal muscle possesses the remarkable ability to repair and regenerate after injury or damage; however, this ability is impaired with aging.

    “Skeletal muscle possesses the remarkable ability to repair and regenerate after an injury or damage; however, this ability is impaired with aging (4–7).”

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Authors
Carlson, B. M., & Faulkner, J. A.
Affiliations
University of Michigan (US)
Venue
American Journal of Physiology-Cell Physiology
Published
1989-06-01
Volume
256
Issue
6
Pages
C1262-C1266
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
OpenAlex
W2323748919
Cited by
417
References
11
Citations by year
2026: 7 · 2025: 4 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 18 · 2018: 8 · 2017: 21 · 2016: 19 · 2015: 22 · 2014: 23 · 2013: 25 · 2012: 22
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Cell Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG-06157)
  • National Eye Institute (EY-05813)
  • National Institute of Dental and Craniofacial Research (DE 07687)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
muscle transplantation, muscle regeneration, aging, host age, extensor digitorum longus, autograft, muscle mass, age-related muscle loss
MeSH terms
Aging, Animals, Isometric Contraction, Male, Microscopy, Electron, Muscle Contraction, Muscles, Rats, Inbred Strains, Transplantation, Autologous, Muscle Development, Rats

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