The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Hydrogen sulfide protects neurons from oxidative stress
Abstract
Hydrogen sulfide (H 2 S), which is a well‐known toxic gas, is found in relatively high concentrations in the brain. Although a neuromodulatory role of H 2 S has been demonstrated, little is known of its other biological functions. Here we show that H 2 S protects primary cultures of neurons from death in a well‐studied model of oxidative stress caused by glutamate, a process called oxidative glutamate toxicity—or oxytosis. We found that H 2 S increases the glutathione levels, which normally decrease during the cell death cascade, by enhancing the activity of γ‐ glutamylcysteine synthetase and up‐regulating cystine transport. Cystine (cysteine) is the rate‐ limiting substrate of glutathione synthesis. These observations reveal that H 2 S protects neurons from oxytosis by increasing the production of the antioxidant glutathione.
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Citations
Cites
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Self-citationThe vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
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An antioxidant function for DMSP and DMS in marine algae
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Cited by
Hydrogen sulfide chemical biology: pathophysiological roles and detection
Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.002 · Cited by 480
Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models
Hu, L., Lu, M., Tiong, C. X., Dawe, G. S., Hu, G., & Bian, J. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00543.x · Cited by 365
Chemical foundations of hydrogen sulfide biology
Li, Q., & Lancaster, J. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.001 · Cited by 334
Hydrogen sulfide in physiology and diseases of the digestive tract
Singh, S., & Lin, H. (2015) · Microorganisms · doi:10.3390/microorganisms3040866 · Cited by 260
H2S and its role in redox signaling
Kabil, O., Motl, N., & Banerjee, R. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.01.002 · Cited by 240
Metadata
- Authors
- Kimura, Y., & Kimura, H.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2004-05-20
- Volume
- 18
- Issue
- 10
- Pages
- 1165-1167
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2078739145
- Cited by
- 874
- References
- 35
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
