The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β‐amyloid
Abstract
Alzheimer's disease (AD) is characterized by the presence of neurofibrillary tangles and amyloid plaques, which are abnormal protein deposits. The major constituent of the plaques is the neurotoxic β‐amyloid peptide (Aβ); the genetics of familial AD support a direct role for this peptide in AD. Aβ neurotoxicity is linked to hydrogen peroxide formation. Aβ coordinates the redox active transition metals, copper and iron, to catalytically generate reactive oxygen species. The chemical mechanism underlying this process is not well defined. With the use of density functional theory calculations to delineate the chemical mechanisms that drive the catalytic production of H 2 O 2 by Aβ/Cu, tyrosine10 (Y10) was identified as a pivotal residue for this reaction to proceed. The relative stability of tyrosyl radicals facilitates the electron transfers that are required to drive the reaction. Confirming the theoretical results, mutation of the tyrosine residue to alanine inhibited H 2 O 2 production, Cu‐induced radicalization, dityrosine cross‐linking, and neurotoxicity.
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Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y.-S., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00317-8 · Cited by 1,447
Self-citationGong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., & Klein, W. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834302100 · Cited by 1,061
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Self-citationAllan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity
Huang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D. A., Hanson, G. R., Stokes, K. C., Leopold, M., Multhaup, G., Goldstein, L. E., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37111 · Cited by 762
Self-citationWater-soluble Aβ(N-40, N-42) oligomers in normal and Alzheimer disease brains
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Cited by
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185
Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729
Oxidative Stress and Neurotoxicity
Sayre, L. M., Perry, G., & Smith, M. A. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700210j · Cited by 867
Metals in Alzheimer's and Parkinson's Diseases
Barnham, K. J., & Bush, A. I. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2008.02.019 · Cited by 695
Self-citationAdlard, P. A., Cherny, R. A., Finkelstein, D. I., Gautier, E., Robb, E., Cortes, M., Volitakis, I., Liu, X., Smith, J. P., Perez, K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.018 · Cited by 672
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Metadata
- Authors
- Barnham, K. J., Haeffner, F., Ciccotosto, G. D., Curtain, C. C., Tew, D., Mavros, C., Beyreuther, K., Carrington, D., Masters, C. L., Cherny, R. A., Cappai, R., & Bush, A. I.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 18
- Issue
- 12
- Pages
- 1427-1429
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2171092661
- Cited by
- 263
- References
- 8
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barnham, K. J., Haeffner, F., Ciccotosto, G. D., Curtain, C. C., Tew, D., Mavros, C., Beyreuther, K., Carrington, D., Masters, C. L., Cherny, R. A., Cappai, R., & Bush, A. I. (2004). Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β‐amyloid. The FASEB Journal. https://doi.org/10.1096/fj.04-1890fje
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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