The DOI matches its Crossref record; 316 of the 316 references it cites were found in a registry or an index.
Oxidative Stress and Neurotoxicity
Open accessAbstract
There is increasing awareness of the ubiquitous role of oxidative stress in neurodegenerative disease states. A continuing challenge is to be able to distinguish between oxidative changes that occur early in the disease from those that are secondary manifestations of neuronal degeneration. This perspective highlights the role of oxidative stress in Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and multiple sclerosis, neurodegenerative and neuroinflammatory disorders where there is evidence for a primary contribution of oxidative stress in neuronal death, as opposed to other diseases where oxidative stress more likely plays a secondary or by-stander role. We begin with a brief review of the biochemistry of oxidative stress as it relates to mechanisms that lead to cell death, and why the central nervous system is particularly susceptible to such mechanisms. Following a review of oxidative stress involvement in individual disease states, some conclusions are provided as to what further research should hope to accomplish in the field.
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1 retracted
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RetractedChemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
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Protein Oxidation in Aging, Disease, and Oxidative Stress
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Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Copper, iron and zinc in Alzheimer's disease senile plaques
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Oxidative stress in Parkinson's disease
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Aβ Oligomers – a decade of discovery
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Cited by
Assessment of antioxidant capacity in vitro and in vivo
Niki, E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.016 · Cited by 873
Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents
Magesh, S., Chen, Y., & Hu, L. (2012) · Medicinal Research Reviews · doi:10.1002/med.21257 · Cited by 760
“174 Some naturally occurring coumarin derivatives, such as 4-methyl daphnetin (9),175 imperatorin (10),176 auraptene (11),176 and poncimarin (12),177 are reported to have ARE-mediated enzyme induction activities via Keap1-Nrf2-ARE pathway.”
BackgroundDash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 700
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
Braidy, N., Guillemin, G. J., Mansour, H., Chan-Ling, T., Poljak, A., & Grant, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019194 · Cited by 594
RetractedManoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8590578 · Cited by 523
Metadata
- Authors
- Sayre, L. M., Perry, G., & Smith, M. A.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-12-04
- Volume
- 21
- Issue
- 1
- Pages
- 172-188
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2124603205
- Cited by
- 867
- References
- 316
- FWCI
- 16.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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