The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Sulfide, the first inorganic substrate for human cells
Abstract
Hydrogen sulfide (H 2 S) is produced inside the intestine and is known as a poison that inhibits cellular respiration at the level of cytochrome oxidase. However, sulfide is used as an energetic substrate by many photo‐ and chemoautotrophic bacteria and by animals such as the lugworm Arenicola marina. The concentrations of sulfide present in their habitats are comparable with those present in the human colon. Using permeabilized colonic cells to which sulfide was added by an infusion pump we show that the maximal respiratory rate of colonocyte mitochondria in presence of sulfide compares with that obtained with succinate or L‐alpha‐glycerophosphate. This oxidation is accompanied by mitochondrial energization. In contrast, other cell types not naturally exposed to high concentration of sulfide showed much lower oxidation rates. Mitochondria showed a very high affinity for sulfide that permits its use as an energetic substrate at low micromolar concentrations, hence, below the toxic level. However, if the supply of sulfide exceeds the oxidation rate, poisoning renders mitochondria inefficient and our data suggest that an anaerobic mechanism involving partial reversion of Krebs cycle already known in invertebrates takes place. In conclusion, this work provides additional and compelling evidence that sulfide is not only a toxic compound. According to our study, sulfide appears to be the first inorganic substrate for mammalian cells characterized thus far.—Goubern, M., Andriamihaja, M., Nübel, T., Blachier, F., Bouil‐laud, F. Sulfide, the first inorganic substrate for human cells. FASEB J. 21, 1699–1706 (2007)
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Cites
Two's company, three's a crowd: can H 2 S be the third endogenous gaseous transmitter?
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The Emerging Roles of Hydrogen Sulfide in the Gastrointestinal Tract and Liver
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Evidence That Hydrogen Sulfide Is a Genotoxic Agent
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ANIMAL ADAPTATIONS FOR TOLERANCE AND EXPLOITATION OF POISONOUS SULFIDE
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Cited by
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways
Mishanina, T. V., Libiad, M., & Banerjee, R. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1834 · Cited by 615
Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host
Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.005 · Cited by 548
Self-citationMicrobial pathways in colonic sulfur metabolism and links with health and disease
Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00448 · Cited by 544
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Akaike, T., Ida, T., Wei, F.-Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01311-y · Cited by 544
Metadata
- Authors
- Goubern, M., Andriamihaja, M., Nübel, T., Blachier, F., & Bouillaud, F.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2007-02-21
- Volume
- 21
- Issue
- 8
- Pages
- 1699-1706
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2026465800
- Cited by
- 422
- References
- 38
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
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