Microbial pathways in colonic sulfur metabolism and links with health and disease

Carbonero, Franck; Benefiel, Ann C.; Alizadeh-Ghamsari, Amir H.; Gaskins, H. Rex

doi:10.3389/fphys.2012.00448

Cited by 544Gut microbiota and healthSulfur Compounds in BiologyGastrointestinal motility and disorders

Microbial pathways in colonic sulfur metabolism and links with health and disease

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Carbonero, Franck, Benefiel, Ann C., Alizadeh-Ghamsari, Amir H., Gaskins, H. Rex·2012·Frontiers in Physiology

DOI 10.3389/fphys.2012.00448PMC PMC3508456

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Abstract

Sulfur is both crucial to life and a potential threat to health. While colonic sulfur metabolism mediated by eukaryotic cells is relatively well studied, much less is known about sulfur metabolism within gastrointestinal microbes. Sulfated compounds in the colon are either of inorganic (e.g., sulfates, sulfites) or organic (e.g., dietary amino acids and host mucins) origin. The most extensively studied of the microbes involved in colonic sulfur metabolism are the sulfate-reducing bacteria (SRB), which are common colonic inhabitants. Many other microbial pathways are likely to shape colonic sulfur metabolism as well as the composition and availability of sulfated compounds, and these interactions need to be examined in more detail. Hydrogen sulfide is the sulfur derivative that has attracted the most attention in the context of colonic health, and the extent to which it is detrimental or beneficial remains in debate. Several lines of evidence point to SRB or exogenous hydrogen sulfide as potential players in the etiology of intestinal disorders, inflammatory bowel diseases (IBDs) and colorectal cancer in particular. Generation of hydrogen sulfide via pathways other than dissimilatory sulfate reduction may be as, or more, important than those involving the SRB. We suggest here that a novel axis of research is to assess the effects of hydrogen sulfide in shaping colonic microbiome structure. Clearly, in-depth characterization of the microbial pathways involved in colonic sulfur metabolism is necessary for a better understanding of its contribution to colonic disorders and development of therapeutic strategies.

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H2S is likely to contribute to colorectal cancer development, as colonic detoxification of H2S is reduced in patients with colorectal cancer and H2S induces colonic mucosal hyperproliferation.
“H2S is likely to contribute to CRC development, as colonic detoxification of H2S is also reduced in patients with CRC; it also induces colonic mucosal hyperproliferation.102”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [102]
At least 50% of intestinal H2S is derived from a set of commensal Proteobacteria, called the sulfate-reducing bacteria (SRB), either by cysteine degradation or a dissimilatory sulfate reduction reaction.
“At least 50% of intestinal H2S is derived from a set of commensal Proteobacteria, called the sulfate-reducing bacteria (SRB), either by cysteine degradation or a dissimilatory sulfate reduction reaction[345].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [345]

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Scanlan P. D. Shanahan F. Marchesi J. R. (2009). Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals. FEMS Microbiol. Ecol. 69, 213– 221 10.1111/j.1574-6941.2009.00709.x 19496818 · DOI

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Authors: Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R.
Affiliations: University of Illinois Urbana-Champaign (US)
Corresponding author: Gaskins, H. Rex
ORCID: Carbonero, Franck
Gaskins, H. Rex
Venue: Frontiers in Physiology
Publisher: Frontiers Media SA
Published: 2012
Volume: 3
Pages: 448-448
ISSN: 1664-042X (ISSN-L)
DOI: 10.3389/fphys.2012.00448
PMC: PMC3508456
OpenAlex: W2156602527
Cited by: 544
References: 160
Citations by year: 2026: 50 · 2025: 45 · 2024: 50 · 2023: 43 · 2022: 58 · 2021: 58 · 2020: 50 · 2019: 39 · 2018: 36 · 2017: 43 · 2016: 28 · 2015: 20 · 2014: 11 · 2013: 12
FWCI: 5.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Physiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: sulfate-reducing bacteria, hydrogen sulfide, colonic microbiome, sulfite, sulfate, mucin, dietary amino acids, inflammatory bowel disease, colorectal cancer, microbial pathways

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Microbial pathways in colonic sulfur metabolism and links with health and disease

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