The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
Abstract
Mitogen-activated protein kinase (MAPK) pathways constitute a large modular network that regulates a variety of physiological processes, such as cell growth, differentiation, and apoptotic cell death. The function of the ERK pathway has been depicted as survival-promoting, in essence by opposing the proapoptotic activity of the stress-activated c-Jun NH(2)-terminal kinase (JNK)/p38 MAPK pathways. However, recently published work suggests that extracellular regulated kinase (ERK) pathway activity is suppressed by JNK/p38 kinases during apoptosis induction. In this review, we will summarize the current knowledge about JNK/p38-mediated mechanisms that negatively regulate the ERK pathway. In particular, we will focus on phosphatases (PP2A, MKPs) as inhibitors of ERK pathway activity in regulating apoptosis. A model proposed in this review places the negative regulation of the ERK pathway in a central position for the cellular decision-making process that determines whether cells will live or die in response to apoptosis-promoting signals. In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation).
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“The p38 pathway has been reported to interfere with ERK activity during apoptosis (see 88 for review); thus, ERK activity was assayed in these genotypes by measuring phospho-ERK levels.”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [88]
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1 retracted
A Regulatory Role for p38δ MAPK in Keratinocyte Differentiation
Efimova, T., Broome, A., & Eckert, R. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302759200 · Cited by 135
RetractedMutations of the BRAF gene in human cancer
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961 · cited 1×
“The most classical JNK substrate is the transcription factor c-Jun, from which JNK derived its name (2, 5, 33).”
BackgroundProtein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
Hunter, T. R. (1995) · Cell · doi:10.1016/0092-8674(95)90405-0 · Cited by 2,961
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Roberts, P. J., & Der, C. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210422 · Cited by 2,788
Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,540
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- 10.1042/bj3530417 · DOI
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Mechanisms and functions of p38 MAPK signalling
Cuadrado, A., & Nebreda, Á. R. (2010) · Biochemical Journal · doi:10.1042/bj20100323 · Cited by 1,720
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p38MAPK: stress responses from molecular mechanisms to therapeutics
Coulthard, L. R., White, D. E., Jones, D. L., McDermott, M. F., & Burchill, S. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.005 · Cited by 691
Metadata
- Authors
- Junttila, M. R., Li, S., & Westermarck, J.
- Affiliations
- Åbo Akademi University (FI)
- University of Helsinki (FI)
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2007-11-26
- Volume
- 22
- Issue
- 4
- Pages
- 954-965
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2003060606
- Cited by
- 826
- References
- 138
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 24 · 2023: 19 · 2022: 32 · 2021: 48 · 2020: 28 · 2019: 36 · 2018: 42 · 2017: 41 · 2016: 58 · 2015: 49 · 2014: 76 · 2013: 72 · 2012: 74
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- ERK signaling, phosphatase, protein phosphatase 2A, apoptosis, cell survival
- MeSH terms
- Animals, Cell Survival, Humans, Models, Biological, Phosphoprotein Phosphatases, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System
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