p38MAPK: stress responses from molecular mechanisms to therapeutics

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647 · see citing works

The selectivity of protein kinase inhibitors: a further update

Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I. V., Arthur, J. S. C., Alessi, D. R., & Cohen, P. (2007) · Biochemical Journal · doi:10.1042/bj20070797 · Cited by 2,522 · see citing works

The p38 signal transduction pathway Activation and function

Ono, K., & Han, J. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(99)00071-6 · Cited by 1,571 · see citing works

Differential regulation and properties of MAPKs

Raman, M., Chen, W., & Cobb, M. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210392 · Cited by 1,430 · see citing works

p38 MAP-Kinases pathway regulation, function and role in human diseases

Cuenda, A., & Rousseau, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.010 · Cited by 1,397 · see citing works

Dickkopf-1 is a master regulator of joint remodeling

Diarra, D., Stolina, M., Polzer, K., Zwerina, J., Ominsky, M. S., Dwyer, D., Korb, A., Smolen, J. S., Hoffmann, M. H., Scheinecker, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1538 · Cited by 1,296 · see citing works

MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits

Kaminska, B. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.08.017 · Cited by 1,285 · see citing works

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,213 · see citing works

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

Kumar, S., Boehm, J. C., & Lee, J. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1177 · Cited by 1,199 · see citing works

Systematic Review of the Literature

Wool, C. (2011) · Advances in Neonatal Care · doi:10.1097/anc.0b013e31821bd92d · Cited by 1,021 · see citing works

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

Hanger, D. P., Anderton, B. H., & Noble, W. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.01.003 · Cited by 965 · see citing works

p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain

Jin, S., Zhuang, Z.-Y., Woolf, C. J., & Ji, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04017.2003 · Cited by 854 · see citing works

Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

Junttila, M. R., Li, S., & Westermarck, J. (2008) · The FASEB Journal · doi:10.1096/fj.06-7859rev · Cited by 826 · see citing works

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases

Owens, D. M., & Keyse, S. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210412 · Cited by 777 · see citing works

Mapk signal specificity: The right place at the right time

Murphy, L. O., & Blenis, J. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.03.009 · Cited by 707 · see citing works

Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury

Hains, B. C., & Waxman, S. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0003-06.2006 · Cited by 641 · see citing works

Oxidative stress: the vulnerable β-cell

Lenzen, S. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360343 · Cited by 535 · see citing works

Activation of p38 mitogen‐activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

Tsuda, M., Mizokoshi, A., Shigemoto‐Mogami, Y., Koizumi, S., & Inoue, K. (2003) · Glia · doi:10.1002/glia.10308 · Cited by 520 · see citing works

A CD36-dependent signaling cascade is necessary for macrophage foam cell formation

Rahaman, S. O., Lennon, D. J., Febbraio, M., Podrez, E. A., Hazen, S. L., & Silverstein, R. L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.007 · Cited by 506 · see citing works

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

Muslin, A. J. (2008) · Clinical Science · doi:10.1042/cs20070430 · Cited by 496 · see citing works

Mechanism of p38 MAP kinase activation in vivoPreprint

Brancho, D., Tanaka, N., Jaeschke, A., Ventura, J., Kelkar, N., Tanaka, Y., Kyuuma, M., Takeshita, T., Flavell, R. A., & Davis, R. J. (2003) · Genes & Development · doi:10.1101/gad.1107303 · Cited by 490 · see citing works

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

Jiang, Y., Gram, H., Zhao, M. F., New, L., Gu, J., Feng, L., Padova, F. D., Ulevitch, R. J., & Han, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30122 · Cited by 489 · see citing works

Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

Kummer, J. L., Rao, P., & Heidenreich, K. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20490 · Cited by 468 · see citing works

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

Bulavin, D. V., Demidov, O. N., Saito, S., Kauraniemi, P., Dudgeon, C., Amundson, S. A., Ambrosino, C., Sauter, G., Nebreda, Á. R., Anderson, C. W., et al. (2002) · Nature Genetics · doi:10.1038/ng894 · Cited by 437 · see citing works

The complexity of mitogen-activated protein kinases (MAPKs) made simple

Krishna, M., & Narang, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8170-7 · Cited by 432 · see citing works

Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.

She, Q., Bode, A. M., Ma, W., Chen, N. Y., & Dong, Z. (2001) · PubMed · Cited by 393 · see citing works

Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic <i>ras</i> -Induced Premature Senescence

Wang, W., Chen, J. X., Liao, R., Deng, Q., Zhou, J. J., Huang, S., & Sun, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3389-3403.2002 · Cited by 376 · see citing works

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

Roulston, A., Reinhard, C., Amiri, P., & Williams, L. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10232 · Cited by 371 · see citing works

p38 MAP kinase: a convergence point in cancer therapy

Olson, J. M., & Hallahan, A. R. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.007 · Cited by 335 · see citing works

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

Ananieva, O., Darragh, J., Johansen, C., Carr, J. M., McIlrath, J. M., Park, J. M., Wingate, A. D., Monk, C. E., Toth, R. L., Santos, S. G., et al. (2008) · Nature Immunology · doi:10.1038/ni.1644 · Cited by 329 · see citing works

Development in Motion: Helper T Cells at Work

Reiner, S. L. (2007) · Cell · doi:10.1016/j.cell.2007.03.019 · Cited by 312 · see citing works

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

Ventura, J., Tenbaum, S. P., Perdiguero, E., Huth, M., Guerra, C. E., Barbacid, M., Pasparakis, M., & Nebreda, Á. R. (2007) · Nature Genetics · doi:10.1038/ng2037 · Cited by 306 · see citing works

Current Advances on Different Kinases Involved in Tau Phosphorylation, and Implications in Alzheimers Disease and Tauopathies

Ferrer, I., Gómez‐Isla, T., Puig, B., Freixes, M., Ribé, E. M., Dalfó, E., & Ávila, J. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772713 · Cited by 302 · see citing works

p38 MAP Kinase's Emerging Role as a Tumor Suppressor

Bulavin, D. V., & Fornace, A. J. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)92005-2 · Cited by 290 · see citing works

Minocycline as a Neuroprotective Agent

Stirling, D. P., Koochesfahani, K. M., Steeves, J. D., & Tetzlaff, W. (2005) · The Neuroscientist · doi:10.1177/1073858405275175 · Cited by 280 · see citing works

The Potential of Adiponectin in Driving Arthritis

Ehling, A., Schäffler, A., Herfarth, H. H., Tarner, I. H., Anders, S., Distler, O., Paul, G., Distler, J. H. W., Gay, S., Schölmerich, J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4468 · Cited by 279 · see citing works

Feedback control of the protein kinase TAK1 by SAPK2a/p38α

Cheung, P., Campbell, D. G., Nebreda, Á. R., & Cohen, P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg552 · Cited by 278 · see citing works

The pathways to tumor suppression via route p38

Han, J., & Sun, P. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.06.007 · Cited by 267 · see citing works

Adiponectin Enhances IL-6 Production in Human Synovial Fibroblast via an AdipoR1 Receptor, AMPK, p38, and NF-κB Pathway

Tang, C., Chiu, Y., Tan, T., Yang, R., & Fu, W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5483 · Cited by 244 · see citing works

Eotaxin and eosinophil recruitment: implications for human disease

Rankin, S. M., Conroy, D. M., & Williams, T. J. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01635-4 · Cited by 242 · see citing works

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cellsPreprint

Puri, P., Wu, Z., Zhang, P., Wood, L. D., Bhakta, K. S., Han, J., Feramisco, J. R., Karin, M., & Wang, J. Y. J. (2000) · Genes & Development · doi:10.1101/gad.14.5.574 · Cited by 242 · see citing works

p38 Pathway Kinases as Anti-inflammatory Drug Targets

Schindler, J. F., Monahan, J. B., & Smith, W. G. (2007) · Journal of Dental Research · doi:10.1177/154405910708600902 · Cited by 228 · see citing works

The Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinases MK2 and MK3 Cooperate in Stimulation of Tumor Necrosis Factor Biosynthesis and Stabilization of p38 MAPK

Ronkina, N., Kotlyarov, A., Dittrich‐Breiholz, O., Kracht, M., Hitti, E., Milarski, K. L., Askew, R., Marušić, S., Lin, L.-L., Gaestel, M., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01456-06 · Cited by 217 · see citing works

p38 MAPK in Development and Cancer

Bradham, C. A., & McClay, D. R. (2006) · Cell Cycle · doi:10.4161/cc.5.8.2685 · Cited by 210 · see citing works

Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies

Ferrer, I., Blanco, R. E., Carmona, M., & Puig, B. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100016 · Cited by 207 · see citing works

Targeting protein kinases for the development of anti-inflammatory drugs

Cohen, P. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.015 · Cited by 207 · see citing works

Tumor Necrosis Factor-induced Toxic Liver Injury Results from JNK2-dependent Activation of Caspase-8 and the Mitochondrial Death Pathway

Wang, Y., Singh, R., Lefkowitch, J. H., Rigoli, R. M., & Czaja, M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512953200 · Cited by 206 · see citing works

The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin

Johansen, C., Kragballe, K., Westergaard, M., et al. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06304.x · Cited by 205 · see citing works

TNFR1-induced NF-κB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells

Zhou, Z., Connell, M. C., & MacEwan, D. J. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2006.12.013 · Cited by 202 · see citing works

Inhibition of p38: Has the fat lady sung?

Genovese, M. C. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24264 · Cited by 192 · see citing works

Phosphorylation of Sodium Channel Na v 1.8 by p38 Mitogen-Activated Protein Kinase Increases Current Density in Dorsal Root Ganglion Neurons

Hudmon, A., Choi, J., Tyrrell, L., Black, J. A., Rush, A. M., Waxman, S. G., & Dib‐Hajj, S. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4403-07.2008 · Cited by 180 · see citing works

Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human α-defensins from neutrophils

Zheng, Y., Niyonsaba, F., Ushio, H., Nagaoka, I., Ikeda, S., Okumura, K., & Ogawa, H. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08196.x · Cited by 175 · see citing works

Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies

Ferrer, I., Blanco, R. E., Carmona, M., Puig, B., Barrachina, M., Gómez, C., & Ambrosio, S. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100015 · Cited by 172 · see citing works

MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity

Culbert, A. A., Skaper, S. D., Howlett, D. R., Evans, N. A., Facci, L., Soden, P. E., Seymour, Z. M., Guillot, F., Gaestel, M., & Richardson, J. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513646200 · Cited by 170 · see citing works

Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF- B- and p38 MAPK-dependent signalling pathways

Kim, H.-R., Cho, M.-L., Kim, K.-W., Juhn, J.-P., Hwang, S.-Y., Yoon, C.-H., Park, S.-H., Lee, S., & Kim, H.-Y. (2006) · Rheumatology · doi:10.1093/rheumatology/kel159 · Cited by 170 · see citing works

IL‐18 enhances IFN‐γ‐induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes

Kanda, N., Shimizu, T., Tada, Y., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200636420 · Cited by 169 · see citing works

Role of MAPKs in development and differentiation: lessons from knockout mice

Aouadi, M., Binétruy, B., Caron, L., MARCHAND‐BRUSTEL, Y. L., & Bost, F. (2006) · Biochimie · doi:10.1016/j.biochi.2006.06.003 · Cited by 157 · see citing works

Activation of Src-Family Kinases in Spinal Microglia Contributes to Mechanical Hypersensitivity after Nerve Injury

Katsura, H., Obata, K., Mizushima, T., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1771-06.2006 · Cited by 149 · see citing works

Involvement of the p38 mitogen‐activated protein kinase cascade in hepatocellular carcinoma

Iyoda, K., Sasaki, Y., Horimoto, M., Toyama, T., Yakushijin, T., Sakakibara, M., Takehara, T., Fujimoto, J., Hori, M., Wands, J. R., et al. (2003) · Cancer · doi:10.1002/cncr.11425 · Cited by 148 · see citing works

MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced Arthritis

Hegen, M., Gaestel, M., Nickerson‐Nutter, C. L., Lin, L., & Telliez, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1913 · Cited by 147 · see citing works

Cell cycle regulation by p38 MAP kinases

Ambrosino, C., & Nebreda, Á. R. (2001) · Biology of the Cell · doi:10.1016/s0248-4900(01)01124-8 · Cited by 147 · see citing works

Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence.

Haq, R., Brenton, J. D., Takahashi, M. T., Finan, D., Finkielsztein, A., Damaraju, S., Rottapel, R. K., & Zanke, B. W. (2002) · PubMed · Cited by 143 · see citing works

Differential tissue expression and activation of p38 MAPK α, β, γ, and δ isoforms in rheumatoid arthritis

Korb, A., Tohidast-Akrad, M., Cetin, E., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22080 · Cited by 140 · see citing works

Protein Expression of TNF-α in Psoriatic Skin Is Regulated at a Posttranscriptional Level by MAPK-Activated Protein Kinase 2

Johansen, C., Funding, A. T., Otkjær, K., Kragballe, K., Jensen, U. B., Madsen, M. W., Binderup, L., Skak‐Nielsen, T., Fjording, M. S., & Iversen, L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1431 · Cited by 139 · see citing works

Nerve Conduction Blockade in the Sciatic Nerve Prevents but Does Not Reverse the Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia in the Rat Spared Nerve Injury Model

Wen, Y., Suter, M. R., Kawasaki, Y., Huang, J. L., Pertin, M., Kohno, T., Berde, C. B., Décosterd, I., & Ji, R. (2007) · Anesthesiology · doi:10.1097/01.anes.0000270759.11086.e7 · Cited by 137 · see citing works

Spinal p38β isoform mediates tissue injury‐induced hyperalgesia and spinal sensitization

Svensson, C. I., Fitzsimmons, B., Azizi, S., Powell, H. C., Hua, X., & Yaksh, T. L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02996.x · Cited by 134 · see citing works

Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38δ at Thr50 promotes microtubule assembly

Feijoo, C., Campbell, D. G., Jakes, R., Goedert, M., & Cuenda, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.01655 · Cited by 133 · see citing works

IL-17A Induces Eotaxin-1/CC Chemokine Ligand 11 Expression in Human Airway Smooth Muscle Cells: Role of MAPK (Erk1/2, JNK, and p38) Pathways

Rahman, M. S., Yamasaki, A., Yang, J., Shan, L., Halayko, A. J., & GOUNNI, A. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.4064 · Cited by 133 · see citing works

The p38 Kinases MKK4 and MKK6 Suppress Metastatic Colonization in Human Ovarian Carcinoma

Hickson, J. A., Huo, D., Griend, D. J. V., Lin, A., Rinker-Schaeffer, C. W., & Yamada, S. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3676 · Cited by 132 · see citing works

Activation of p38 MAPK is a key step in tumor necrosis factor–mediated inflammatory bone destruction

Zwerina, J., Hayer, S., Redlich, K., Bobacz, K., Kollias, G., Smolen, J. S., & Schett, G. A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21626 · Cited by 132 · see citing works

Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38

Svensson, C. I., Schäfers, M., Jones, T. L., et al. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.12.064 · Cited by 131 · see citing works

Regulation of Peripheral Inflammation by Spinal p38 MAP Kinase in Rats

Boyle, D. L., Jones, T. L., Hammaker, D. R., Svensson, C. I., Rosengren, S., Albani, S., Sorkin, L. S., & Firestein, G. S. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030338 · Cited by 130 · see citing works

p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells

Junttila, M. R., Ala‐aho, R., Jokilehto, T., Peltonen, J. T. K., Kallajoki, M. A., Grenman, R. A., Jaakkola, P., Westermarck, J. K., & Kähäri, V. (2007) · Oncogene · doi:10.1038/sj.onc.1210332 · Cited by 127 · see citing works

Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways

Ip, W., Wong, C. K., & Lam, C. W. K. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03085.x · Cited by 125 · see citing works

Mitogen-Activated Protein Kinase p38 Mediates Reduced Nerve Conduction Velocity in Experimental Diabetic Neuropathy

Price, S. A., Agthong, S., Middlemas, A. B., & Tomlinson, D. R. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1851 · Cited by 123 · see citing works

Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: A MLK-3-MKK7-dependent mechanism

Muniyappa, H., & Das, K. C. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.003 · Cited by 114 · see citing works

Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice

Lim, A. K. H., Nikolic‐Paterson, D. J., Ma, F. Y., Ozols, E., Thomas, M. C., Flavell, R. A., Davis, R. J., & Tesch, G. H. (2008) · Diabetologia · doi:10.1007/s00125-008-1215-5 · Cited by 113 · see citing works

MAPKs: new targets for neurodegeneration

Harper, S. J., & Wilkie, N. M. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.2.187 · Cited by 111 · see citing works

p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury

Xu, J., Xin, W., Wei, X., et al. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.11.016 · Cited by 110 · see citing works

Interleukin‐31 induces cytokine and chemokine production from human bronchial epithelial cells through activation of mitogen‐activated protein kinase signalling pathways: implications for the allergic response

Ip, W., Wong, C. K., Li, M. L. Y., Li, P. W., Cheung, P. F., & Lam, C. W. K. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02668.x · Cited by 110 · see citing works

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis

Inoue, T., Boyle, D. L., Corr, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509188103 · Cited by 110 · see citing works

Critical role of nuclear factor‐κB and stress‐activated protein kinases in steroid unresponsiveness

Bantel, H., Schmitz, M. L., Raible, A., Gregor, M., & Schulze‐Osthoff, K. (2002) · The FASEB Journal · doi:10.1096/fj.02-0223fje · Cited by 107 · see citing works

IL-17 enhances IL-1β-mediated CXCL-8 release from human airway smooth muscle cells

Dragon, S., Rahman, M. S., Yang, J., Unruh, H. W., Halayko, A. J., & GOUNNI, A. S. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00306.2006 · Cited by 107 · see citing works

The p38 MAP kinase signaling pathway in Alzheimer's disease

Johnson, G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00268-1 · Cited by 106 · see citing works

IL-17A acts via p38 MAPK to increase stability of TNF-α-induced IL-8 mRNA in human ASM

Henness, S., van Thoor, E., Ge, Q., Armour, C. L., Hughes, J. M., & Ammit, A. J. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00367.2005 · Cited by 98 · see citing works

Interleukin‐18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways

Amin, M. A., Mansfield, P. J., Pákozdi, A., Campbell, P. L., Ahmed, S., Martinez, R. J., & Koch, A. E. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22705 · Cited by 97 · see citing works

MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation

Gorska, M. M., Liang, Q., Stafford, S. J., Goplen, N., Dharajiya, N. G., Guo, L., Sur, S. A., Gaestel, M., & Alam, R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062621 · Cited by 97 · see citing works

Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation

Zheng, Y., Niyonsaba, F., Ushio, H., Ikeda, S., Nagaoka, I., Okumura, K., & Ogawa, H. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02782.x · Cited by 93 · see citing works

Characterization of epithelial IL-8 response to inflammatory bowel disease mucosal E. coli and its inhibition by mesalamine

Subramanian, S., Rhodes, J. M., Hart, A. C., Tam, B., Roberts, C. L., Smith, S. L., CORKILL, J. E., Winstanley, C., Virji, M., & Campbell, B. J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20296 · Cited by 91 · see citing works

Cell Cycle Arrest and Reversion of Ras-Induced Transformation by a Conditionally Activated Form of Mitogen-Activated Protein Kinase Kinase Kinase 3

Ellinger-Ziegelbauer, H. C., Kelly, K., & Siebenlist, U. K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3857 · Cited by 85 · see citing works

Overexpression of Mitogen-activated Protein Kinase Kinase 6 in the Heart Improves Functional Recovery from Ischemia in Vitro and Protects against Myocardial Infarction in Vivo

Martindale, J. J., Wall, J. A., Martinez-Longoria, D. M., Aryal, P., Rockman, H. A., Guo, Y., Bolli, R., & Glembotski, C. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406690200 · Cited by 85 · see citing works

Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation

Pruitt, K., Pruitt, W. M., Bilter, G. K., Westwick, J. K., & Der, C. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203964200 · Cited by 84 · see citing works

Positive crosstalk between ERK and p38 in melanoma stimulates migration and in vivo proliferation

Estrada, Y. D., Dong, J., & Ossowski, L. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2008.00520.x · Cited by 84 · see citing works

Targeting p38-MAPK in the ischaemic heart: kill or cure?

BASSI, R., Heads, R. J., Marber, M. S., & Clark, J. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.01.002 · Cited by 83 · see citing works

A Selective p38α Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis

Medicherla, S., Jing, Y., Mangadu, R., Jiang, Y., Zhao, J. J., Almirez, R. G., Kerr, I., Stebbins, E. G., O’Young, G., Kapoun, A. M., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.098020 · Cited by 83 · see citing works

MAPKAP kinase 2‐deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

Thomas, T. A., Timmer, M., Cesnulevicius, K., Hitti, E., Kotlyarov, A., & Gaestel, M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05310.x · Cited by 81 · see citing works

Expression and localization of the activated mitogen-activated protein kinase in lesional psoriatic skin

Yu, X., Li, C., Dai, H.-Y., Cai, D., Wang, K.-Y., Xu, Y.-H., Chen, L., & Zhou, C.-L. (2007) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2007.05.002 · Cited by 78 · see citing works

MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages

Rowlett, R. M., Chrestensen, C. A., Nyce, M. R., Harp, M. G., Pelo, J. W., Cominelli, F., Ernst, P. B., Pizarro, T. T., Sturgill, T. W., & Worthington, M. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00077.2007 · Cited by 78 · see citing works

Regulation of p38 MAPK by MAPK Kinases 3 and 6 in Fibroblast-Like Synoviocytes

Inoue, T., Hammaker, D. R., Boyle, D. L., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4301 · Cited by 69 · see citing works

Expression, regulation, and signaling of the pattern‐recognition receptor nucleotide‐binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts

Ospelt, C., Brentano, F., Jüngel, A., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24226 · Cited by 69 · see citing works

Dimethylfumarate Specifically Inhibits the Mitogen and Stress-Activated Kinases 1 and 2 (MSK1/2): Possible Role for its Anti-Psoriatic Effect

Gesser, B., Johansen, C., Rasmussen, M. K., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700859 · Cited by 68 · see citing works

The Level of IgE Produced by a B Cell Is Regulated by Norepinephrine in a p38 MAPK- and CD23-Dependent Manner

Pongratz, G., McAlees, J. W., Conrad, D. H., Erbe, R. S., Haas, K. M., & Sanders, V. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2926 · Cited by 67 · see citing works

Different Mitogen-Activated Protein Kinase-Dependent Cytokine Responses in Cells of the Monocyte Lineage

Tudhope, S. J., Finney‐Hayward, T. K., Nicholson, A. G., Mayer, R. J., Barnette, M. S., Barnes, P. J., & Donnelly, L. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.127670 · Cited by 67 · see citing works

p38 MAPK Signaling in Oral-related Diseases

Patil, C. S., & Kirkwood, K. L. (2007) · Journal of Dental Research · doi:10.1177/154405910708600903 · Cited by 66 · see citing works

Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells

Kim, H. J., Oh, J. E., Kim, S. W., Chun, Y. J., & Kim, M. Y. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.10.030 · Cited by 66 · see citing works

Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold

Herberich, B., Cao, G., Chakrabarti, P., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8005417 · Cited by 61 · see citing works

Corticotropin-Releasing Hormone (CRH) Downregulates Interleukin-18 Expression in Human HaCaT Keratinocytes by Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Pathway

Park, H.-J., Kim, H. J., Lee, J. H., Lee, J. Y., Cho, B. K., Kang, J. S., Kang, H., Yang, Y. D., & Cho, D. H. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23656.x · Cited by 61 · see citing works

Bradykinin potentiates cytokine‐induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression

Brechter, A. B., & Lerner, U. H. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22445 · Cited by 61 · see citing works

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

Angell, R. M., Angell, T. D., Bamborough, P., Bamford, M. J., Chung, C., Cockerill, S. G., Flack, S. S., Jones, K. L., Lainé, D. I., Longstaff, T., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.06.028 · Cited by 58 · see citing works

IL-20 Gene Expression Is Induced by IL-1β through Mitogen-Activated Protein Kinase and NF-κB-Dependent Mechanisms

Otkjær, K., Kragballe, K., Johansen, C., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700713 · Cited by 58 · see citing works

Serum amyloid A‐induced IL‐6 production by rheumatoid synoviocytes

Koga, T., Torigoshi, T., Motokawa, S., Miyashita, T., Maeda, Y., Nakamura, M., Komori, A., Aiba, Y., Uemura, T., Yatsuhashi, H., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.01.022 · Cited by 57 · see citing works

Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats

Lim, E. J., Jeon, H., Yang, G. Y., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.05.016 · Cited by 49 · see citing works

Renal p38 MAP kinase activity in experimental diabetes

Komers, R., Lindsley, J. N., Oyama, T., Cohen, D., & Anderson, S. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700549 · Cited by 48 · see citing works

A Subtle Change in p38 MAPK Activity is Sufficient to Suppress In Vivo Tumorigenesis

Timofeev, O. N., Lee, T. Y., & Bulavin, D. V. (2004) · Cell Cycle · doi:10.4161/cc.4.1.1342 · Cited by 44 · see citing works

Differential p38 mitogen-activated protein kinase target phosphorylation in responders and nonresponders to infliximab

Waetzig, G. H., Rosenstiel, P. C., Nikolaus, S., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00979-x · Cited by 42 · see citing works

Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-α signaling

Zer, C., Sachs, G. M., & Shin, J. M. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00080.2007 · Cited by 41 · see citing works

Mitogen- and Stress-Activated Protein Kinase 2 and Cyclic AMP Response Element Binding Protein are Activated in Lesional Psoriatic Epidermis

Funding, A. T., Johansen, C., Kragballe, K., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700821 · Cited by 41 · see citing works

Amplification of the synovial inflammatory response through activation of mitogen‐activated protein kinases and nuclear factor κB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis

Harigai, M., Hara, M., Kawamoto, M., Kawaguchi, Y., Sugiura, T., Tanaka, M., Nakagawa, M., Ichida, H., Takagi, K., Higami-Ohsako, S., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20340 · Cited by 37 · see citing works

Suppressive effects of ketotifen on Th1‐ and Th2‐related chemokines of monocytes

Hung, C., Suen, J., Hua, Y., et al. (2007) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00535.x · Cited by 34 · see citing works

p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1

Stassen, M., KLEIN, M., Becker, M. A., Bopp, T., Neudörfl, C., RICHTER, C., Heib, V., KLEINHESSLING, S., Serfling, E., & Schild, H. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.019 · Cited by 34 · see citing works

IL-12-induced T-bet expression and IFNγ release in lymphocytes from asthmatics—Role of MAPkinases ERK-1/-2, p38MAPK and effect of dexamethasone

Koch, A., Raidl, M., Lux, M. P., et al. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.10.010 · Cited by 21 · see citing works

Tumour necrosis factor-α production stimulated by heat shock protein 70 and its inhibition in circulating dendritic cells and cells eluted from mucosal tissues in Crohn’s disease

Whittall, T., Wang, Y., Kelly, C. G., et al. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03010.x · Cited by 21 · see citing works

Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982

Wada, Y., Shimada, K., Kimura, T., & Ushiyama, S. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.04.010 · Cited by 16 · see citing works

Systematic review to establish the safety profiles for direct and indirect inhibitors of p38 Mitogen-activated protein kinases for treatment of cancer

Noel, J. K., Crean, S. M., Claflin, J. E., et al. (2008) · Medical Oncology · doi:10.1007/s12032-008-9039-1 · Cited by 15 · see citing works

Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase

Laufer, S., & Lehmann, F. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.01.023 · Cited by 15 · see citing works

Tumor necrosis factor-α inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways

Okuma-Yoshioka, C., Seto, H., Kadono, Y., et al. (2008) · Modern Rheumatology · doi:10.1007/s10165-008-0069-5 · Cited by 14 · see citing works

Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury

桂, 弘. (2007) · Medical Entomology and Zoology · Cited by 13 · see citing works

p38 MAP Kinase Mediated Proteoglycan Synthesis as a Target for the Prevention of Atherosclerosis

Osman, N., Ballinger, M. L., Dadlani, H., Getachew, R., Burch, M. L., & Little, P. J. (2008) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/187152908786786205 · Cited by 12 · see citing works

Perioperative pain: other

Tong, S., Daniels, S., Montano, T., et al. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.02.284 · Cited by 1 · see citing works

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763 · see citing works

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Smith, B. E., Wang, S. L., Jaime-Figueroa, S., Harbin, A., Wang, J., Hamman, B. D., & Crews, C. M. (2019) · Nature Communications · doi:10.1038/s41467-018-08027-7 · Cited by 517 · see citing works

Kinase inhibition in autoimmunity and inflammation

Zarrin, A. A., Bao, K., Lupardus, P., & Vucic, D. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0082-8 · Cited by 431 · see citing works

Molecular basis of MAP kinase regulation

Peti, W., & Page, R. (2013) · Protein Science · doi:10.1002/pro.2374 · Cited by 302 · see citing works

The Innate Immune System in Acute and Chronic Wounds

MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289 · see citing works

p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

Perdiguero, E., Sousa-Victor, P., Ruiz-Bonilla, V., Jardí, M., Caelles, C., Serrano, A. L., & Muñoz-Cánoves, P. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201104053 · Cited by 236 · see citing works

Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling

Galliher-Beckley, A. J., Williams, J. G., & Cidlowski, J. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05866-11 · Cited by 164 · see citing works

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

Davinelli, S., Maes, M., Corbi, G., Zarrelli, A., Willcox, D. C., & Scapagnini, G. (2016) · Immunity &amp; Ageing · doi:10.1186/s12979-016-0070-3 · Cited by 122 · see citing works

Impact of resistance exercise on ribosome biogenesis is acutely regulated by post-exercise recovery strategies

Figueiredo, V. C., Roberts, L. A., Markworth, J. F., Barnett, M. P. G., Coombes, J. S., Raastad, T., Peake, J. M., & Cameron-Smith, D. (2016) · Physiological Reports · doi:10.14814/phy2.12670 · Cited by 104 · see citing works

Erlotinib induces the human non–small‐cell lung cancer cells apoptosis via activating <scp>ROS</scp>‐dependent <scp>JNK</scp> pathways

Shan, F., Shao, Z., Jiang, S., & Cheng, Z. (2016) · Cancer Medicine · doi:10.1002/cam4.881 · Cited by 88 · see citing works

P38β MAPK Upregulates Atrogin1/MAFbx by Specific Phosphorylation of C/EBPβ

Zhang, G., & Li, Y.-P. (2012) · Skeletal Muscle · doi:10.1186/2044-5040-2-20 · Cited by 53 · see citing works

MKP-1 coordinates ordered macrophage-phenotype transitions essential for stem cell-dependent tissue repair

Perdiguero, E., Kharraz, Y., Serrano, A. L., & Muñoz-Cánoves, P. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19374 · Cited by 30 · see citing works

p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure

Xiao, Y., Wang, J., Yan, W., Zhou, K., Cao, Y., & Cai, W. (2017) · Cell Death &amp; Disease · doi:10.1038/cddis.2017.523 · Cited by 29 · see citing works

NMR Spectroscopic Investigations of the Activated p38α Mitogen‐Activated Protein Kinase

Nielsen, G., & Schwalbe, H. (2011) · ChemBioChem · doi:10.1002/cbic.201100527 · Cited by 15 · see citing works

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

Colazo, J. M., Hoogenboezem, E. N., Keech, M. C., Francini, N., Shah, V., Yu, F., Lo, J. H., Sorets, A. G., McCune, J. T., Cho, H., et al. (2023) · doi:10.1101/2023.05.31.542971 · Cited by 11 · see citing works

Crucial Roles of Effectors in Interactions between Horticultural Crops and Pathogens

Liu, T., Chen, Y., Tian, S., et al. (2023) · Horticulturae · doi:10.3390/horticulturae9020250 · Cited by 9 · see citing works

Prediction of effector proteins and their implications in pathogenicity of phytopathogenic filamentous fungi: A review

Wu, Y., Xie, L., Jiang, Y., & Li, T. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.133 · Cited by 35 · see citing works

Remote homology clustering identifies lowly conserved families of effector proteins in plant-pathogenic fungi

Jones, D., Moolhuijzen, P., & Hane, J. K. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000637 · Cited by 13 · see citing works

Controlled Trial of Propranolol in Hypertension

Zacharias, F. J., & Cowen, K. J. (1970) · BMJ · doi:10.1136/bmj.1.5694.471 · Cited by 92 · see citing works

Microbial Pathogen Effectors in Plant Disease

Pelgrom, A. J. E., & den Ackerveken, G. F. J. M. V. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0023724 · Cited by 7 · see citing works