Identification of vasodilator‐stimulated phosphoprotein (VASP) as an HIF‐regulated tissue permeability factor during hypoxia
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Increased tissue permeability is commonly associated with hypoxia of many origins. Since hypoxia‐inducible factor (HIF) represents a predominant hypoxia signaling mechanism, we compared hyp‐oxia‐elicited changes in tissue barrier function in mice conditionally lacking intestinal epithelial hypoxia‐inducible factor‐1α (hifla). Somewhat surprisingly, these studies revealed that mutant hifla mice were protected from hypoxia‐induced increases in intestinal permeability in vivo. Guided by microarray analysis of tissues derived from these mutant hifla mice, we identified HIF‐1‐dependent repression of vasodilator‐stimulated phosphoprotein (VASP), a molecule known to be important in the control of cytoskeletal dynamics, including barrier function. Studies at the mRNA and protein level confirmed hypoxia‐elicited repression of VASP in murine tissue, cultured epithelia and endothelia, as well as human saphenous vein ex vivo. Targeted repression of VASP by siRNA recapitulated our findings with hypoxia and directed overexpression of VASP abolished hypoxia‐induced barrier dysfunction. Studies in the cloned human VASP promoter revealed hypoxia‐dependent transcriptional repression, and functional studies by chromatin immunoprecipitation (ChIP) and site‐directed mutagenesis revealed hypoxia‐dependent binding of HIF‐1α to the human VASP promoter. These studies identify HIF‐1‐dependent repression of VASP as a control point for hypoxia‐regulated barrier dysfunction.—Rosenberger, P., Khoury, J., Kong, T., Weissmuller, T., Robinson, A. M., Colgan, S. P. Identification of vasodilator‐stimulated phosphoprotein (VASP) as an HIF‐regulated tissue permeability factor during hypoxia. FASEB J. 21, 2613–2621 (2007)
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HIF regulates the expression of a family of barrier protective factors including intestinal trefoil factor, the mucins and actin cytoskeletal crosslinkers.
“For example, HIF regulates the expression of a family of barrier protective factors including intestinal trefoil factor4, the mucins31 and actin cytoskeletal crosslinkers45.”
From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [45]
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- Authors
- Rosenberger, P., Khoury, J., Kong, T., Weissmüller, T., Robinson, A. M., & Colgan, S. P.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Colorado Denver (US)
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2007-04-05
- Volume
- 21
- Issue
- 10
- Pages
- 2613-2621
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC4049288
- OpenAlex
- W2087677532
- Cited by
- 57
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2017: 1 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 2
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL060569)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK050189)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- VASP, hypoxia-inducible factor-1α, HIF-1, intestinal permeability, hypoxia, transcriptional repression, cytoskeletal dynamics, endothelial barrier, epithelial barrier function, saphenous vein
- MeSH terms
- Vasodilator-Stimulated Phosphoprotein, Animals, Cell Membrane Permeability, Endothelium, Vascular, Humans, Microfilament Proteins, Phosphoproteins, RNA, Messenger, Cell Hypoxia, Cell Adhesion Molecules, DNA Primers, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice, Hypoxia-Inducible Factor 1, alpha Subunit
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