The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Real‐time assessment of Krebs cycle metabolism using hyperpolarized C magnetic resonance spectroscopy
Open accessAbstract
The Krebs cycle plays a fundamental role in cardiac energy production and is often implicated in the energetic imbalance characteristic of heart disease. In this study, we measured Krebs cycle flux in real time in perfused rat hearts using hyperpolarized magnetic resonance spectroscopy (MRS). [2‐ 13 C]Pyru‐ vate was hyperpolarized and infused into isolated perfused hearts in both healthy and postischemic metabolic states. We followed the enzymatic conversion of pyruvate to lactate, acetylcarnitine, citrate, and glutamate with 1 s temporal resolution. The appearance of 13 C‐labeled glutamate was delayed compared with that of other metabolites, indicating that Krebs cycle flux can be measured directly. The production of 13 C‐ labeled citrate and glutamate was decreased postischemia, as opposed to lactate, which was significantly elevated. These results showed that the control and fluxes of the Krebs cycle in heart disease can be studied using hyperpolarized [2‐ 13 C]pyruvate.— Schroeder, M. A., Atherton, H. J., Ball, D. R., Cole, M. A., Heather, L. C., Griffin, J. L., Clarke, K., Radda, G. K., Tyler, D. J. Real‐time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEBJ. 23, 2529–2538 (2009)
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Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Atherton, H. J., Bailey, N. J., Zhang, W., Taylor, J., Major, H., Shockcor, J., Clarke, K., & Griffin, J. L. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00060.2006 · Cited by 159
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Cited by
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
Keshari, K. R., & Wilson, D. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60124b · Cited by 358
Metabolomics as a tool for cardiac research
Griffin, J. L., Atherton, H., Shockcor, J., & Atzori, L. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.138 · Cited by 278
Self-citationIDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
Izquierdo-Garcia, J. L., Viswanath, P., Eriksson, P., Cai, L., Radoul, M., Chaumeil, M. M., Blough, M., Luchman, H. A., Weiss, S., Cairncross, J. G., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0840 · Cited by 123
Sonnay, S., Gruetter, R., & Duarte, J. M. N. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00288 · Cited by 74
Metadata
- Authors
- Schroeder, M. A., Atherton, H. J., Ball, D. R., Cole, M. A., Heather, L. C., Griffin, J. L., Clarke, K., Radda, G. K., & Tyler, D. J.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2009-03-27
- Volume
- 23
- Issue
- 8
- Pages
- 2529-2538
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2129716919
- Cited by
- 221
- References
- 2
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Schroeder, M. A., Atherton, H. J., Ball, D. R., Cole, M. A., Heather, L. C., Griffin, J. L., Clarke, K., Radda, G. K., & Tyler, D. J. (2009). Real‐time assessment of Krebs cycle metabolism using hyperpolarized C magnetic resonance spectroscopy. The FASEB Journal. https://doi.org/10.1096/fj.09-129171
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