IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857 · see citing works

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784 · see citing works

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154 · see citing works

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., Ito, S., Yang, C., Wang, P., Xiao, M.-T., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.014 · Cited by 2,875 · see citing works

Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

Ardenkjær‐Larsen, J. H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M. H., Servin, R., Thaning, M., & Golman, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733835100 · Cited by 2,870 · see citing works

Tumor cell metabolism: cancer's Achilles' heel

Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337 · see citing works

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.020 · Cited by 2,020 · see citing works

Primary Bioassay of Human Tumor Stem Cells

Hamburger, A. W., & Salmon, S. E. (1977) · Science · doi:10.1126/science.560061 · Cited by 1,650 · see citing works

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1- 13 C]Pyruvate

Nelson, S. J., Kurhanewicz, J. V., Vigneron, D. B., Larson, P. E. Z., Harzstark, A. L., Ferrone, M., Criekinge, M. V., Chang, J. W., Bok, R., Park, I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006070 · Cited by 1,289 · see citing works

Glioma-Derived Mutations in <i>IDH1</i> Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Zhao, S., Lin, Y., Xu, W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., et al. (2009) · Science · doi:10.1126/science.1170944 · Cited by 1,119 · see citing works

Targeting metabolic transformation for cancer therapy

Tennant, D. A., Durán, R. V., & Gottlieb, E. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2817 · Cited by 1,057 · see citing works

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

Choi, C., Ganji, S. K., DeBerardinis, R. J., Hatanpaa, K. J., Rakheja, D., Kovacs, Z., Yang, X.-L., Mashimo, T., Raisanen, J. M., Marin-Valencia, I., et al. (2012) · Nature Medicine · doi:10.1038/nm.2682 · Cited by 839 · see citing works

Choline metabolism in malignant transformation

Glunde, K., Bhujwalla, Z. M., & Ronen, S. M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3162 · Cited by 826 · see citing works

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

Koivunen, P., Lee, S., Duncan, C. G., Lopez, G., Lu, G., Ramkissoon, S., Losman, J. A., Joensuu, P., Bergmann, U., Gross, S., et al. (2012) · Nature · doi:10.1038/nature10898 · Cited by 727 · see citing works

Metabolic Modulation of Glioblastoma with Dichloroacetate

Michelakis, E. D., Sutendra, G., Dromparis, P., Webster, L., Haromy, A., Niven, E. B., Maguire, C., Gammer, T.-L., Mackey, J. R., Fulton, D. S., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000677 · Cited by 722 · see citing works

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681 · see citing works

Real-time metabolic imaging

Golman, K., Zandt, R. I. ‘., & Thaning, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601319103 · Cited by 661 · see citing works

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

Seltzer, M. J., Bennett, B. D., Joshi, A. D., Gao, P., Thomas, A. G., Ferraris, D. V., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Rabinowitz, J. D., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1666 · Cited by 513 · see citing works

IDH1andIDH2Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

Yang, H., Ye, D., Guan, K., & Xiong, Y. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1773 · Cited by 459 · see citing works

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

Reitman, Z. J., Jin, G., Karoly, E. D., Spasojevic, I., Yang, J., Kinzler, K. W., He, Y., Bigner, D. D., Vogelstein, B., & Yan, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019393108 · Cited by 449 · see citing works

Detection of 2-Hydroxyglutarate in <i>IDH</i> -Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

Andronesi, O. C., Kim, G. S., Gerstner, E., Batchelor, T., Tzika, A. A., Fantin, V. R., Vander Heiden, M. G., & Sorensen, A. G. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002693 · Cited by 438 · see citing works

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy

Pope, W. B., Prins, R. M., Albert Thomas, M., Nagarajan, R., Yen, K. E., Bittinger, M. A., Salamon, N., Chou, A. P., Yong, W. H., Soto, H., et al. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0737-8 · Cited by 318 · see citing works

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

Sasaki, M., Knobbe, C. B., Itsumi, M., Elia, A. J., Harris, I. S., Chio, I. I. C., Cairns, R. A., McCracken, S., Wakeham, A., Haight, J., et al. (2012) · Genes &amp; Development · doi:10.1101/gad.198200.112 · Cited by 296 · see citing works

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism

Grassian, A. R., Parker, S. J., Davidson, S. M., Divakaruni, A. S., Green, C. R., Zhang, X., Slocum, K. L., Pu, M., Lin, F., Vickers, C., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0772-t · Cited by 280 · see citing works

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

Roche, T. E., & Hiromasa, Y. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6380-z · Cited by 265 · see citing works

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

Sutendra, G., & Michelakis, E. D. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00038 · Cited by 263 · see citing works

Real‐time assessment of Krebs cycle metabolism using hyperpolarized C magnetic resonance spectroscopy

Schroeder, M., Atherton, H. J., Ball, D. R., Cole, M. A., Heather, L. C., Griffin, J. L., Clarke, K., Radda, G. K., & Tyler, D. J. (2009) · The FASEB Journal · doi:10.1096/fj.09-129171 · Cited by 221 · see citing works

Lactate dehydrogenase A silencing in IDH mutant gliomas

Chesnelong, C., Chaumeil, M. M., Blough, M. D., Al-Najjar, M., Stechishin, O. D., Chan, J. A., Pieper, R. O., Ronen, S. M., Weiss, S., Luchman, H. A., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/not243 · Cited by 210 · see citing works

An in vivo patient-derived model of endogenous IDH1-mutant glioma

Luchman, H. A., Stechishin, O. D. M., Dang, N. H., Blough, M. D., Chesnelong, C., Kelly, J. J., Nguyen, S. A., Chan, J. A.-W., Weljie, A. M., Cairncross, J. G., et al. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor207 · Cited by 194 · see citing works

Magnetic Resonance of 2-Hydroxyglutarate in IDH1 -Mutated Low-Grade Gliomas

Elkhaled, A., Jalbert, L. E., Phillips, J. J., Yoshihara, H. A. I., Parvataneni, R., Srinivasan, R., Bourne, G., Berger, M. S., Chang, S. M., Cha, S., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002796 · Cited by 180 · see citing works

Noninvasive Detection of Target Modulation following Phosphatidylinositol 3-Kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

Ward, C. S., Venkatesh, H. S., Chaumeil, M. M., Brandes, A., Criekinge, M. V., Dafni, H., Sukumar, S., Nelson, S. J., Vigneron, D. B., Kurhanewicz, J. V., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2251 · Cited by 152 · see citing works

Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

Sanchez, W. Y., McGee, S. L., Connor, T., Mottram, B. M., Wilkinson, A., Whitehead, J. P., Vučković, S., & Catley, L. P. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.120 · Cited by 144 · see citing works

IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo

Bralten, L. B. C., Kloosterhof, N. K., Balvers, R. K., Sacchetti, A., Lapre, L., Lamfers, M. L. M., Leenstra, S., de Jonge, H. R., Kros, J. M., Jansen, E. E. W., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22390 · Cited by 141 · see citing works

Non-invasive in vivo assessment of IDH1 mutational status in glioma

Chaumeil, M. M., Larson, P. E. Z., Yoshihara, H. A. I., Danforth, O. M., Vigneron, D. B., Nelson, S. J., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2013) · Nature Communications · doi:10.1038/ncomms3429 · Cited by 139 · see citing works

Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation

Ohka, F., Ito, M., Ranjit, M., Senga, T., Motomura, A., Motomura, K., Saito, K., Kato, K., Kato, Y., Wakabayashi, T., et al. (2014) · Tumor Biology · doi:10.1007/s13277-014-1784-5 · Cited by 121 · see citing works

Hominoid-specific enzyme GLUD2 promotes growth of IDH1 R132H glioma

Chen, R., Nishimura, M. C., Kharbanda, S., Peale, F., Deng, Y., Daemen, A., Forrest, W. F., Kwong, M., Hedehus, M., Hatzivassiliou, G., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409653111 · Cited by 112 · see citing works

Oligodendroglioma cell lines containing t(1;19)(q10;p10)

Kelly, J. J., Blough, M. D., Stechishin, O. D. M., Chan, J. A.-W., Beauchamp, D. R., Perizzolo, M., Demetrick, D. J., Steele, L., Auer, R. N., Hader, W. J., et al. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq031 · Cited by 94 · see citing works

Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia

Reitman, Z. J., Duncan, C. G., Poteet, E. C., Winters, A., Yan, L., Gooden, D. M., Spasojević, I., Boros, L. G., Yang, S.-H., & Yan, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.575183 · Cited by 90 · see citing works

Assessment of therapeutic response and treatment planning for brain tumors using metabolic and physiological MRI

Nelson, S. J. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1669 · Cited by 87 · see citing works

Hyperpolarized [1-13C] Glutamate: A Metabolic Imaging Biomarker of IDH1 Mutational Status in Glioma

Chaumeil, M. M., Larson, P. E. Z., Woods, S. M., Cai, L., Eriksson, P., Robinson, A. E., Lupo, J., Vigneron, D. B., Nelson, S. J., Pieper, R. O., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0680 · Cited by 87 · see citing works

IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma

Esmaeili, M., Hamans, B. C., Navis, A. C., van Horssen, R., Bathen, T. F., Gribbestad, I. S., Leenders, W. P. J., & Heerschap, A. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0008 · Cited by 86 · see citing works

Metabolic Reprogramming in Mutant IDH1 Glioma Cells

Izquierdo-García, J. L., Viswanath, P., Eriksson, P., Chaumeil, M. M., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118781 · Cited by 84 · see citing works

A comparative study of short‐ and long‐TE 1H MRS at 3 T for in vivo detection of 2‐hydroxyglutarate in brain tumors

Choi, C., Ganji, S., Hulsey, K., Madan, A., Kovács, Z. Z., Dimitrov, I. E., Zhang, S., Pichumani, K., Mendelsohn, D. B., Mickey, B., et al. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2943 · Cited by 83 · see citing works

Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase

Izquierdo-García, J. L., Cai, L. M., Chaumeil, M. M., Eriksson, P., Robinson, A. E., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108289 · Cited by 73 · see citing works

Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2‐13C]pyruvate

Park, J. M., Josan, S., Grafendorfer, T., Yen, Y., Hurd, R. E., Spielman, D. M., & Mayer, D. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2935 · Cited by 70 · see citing works

Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells

Lodi, A., Woods, S. M., & Ronen, S. M. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2848 · Cited by 64 · see citing works

Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis

Prabhu, A. H., Sarcar, B., Miller, C. R., Kim, S.-H., Nakano, I., Forsyth, P. A., & Chinnaiyan, P. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nou369 · Cited by 41 · see citing works

Studies of the metabolism of human breast cancer spheroids by NMR

Ronen, S. M., & Degani, H. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910120217 · Cited by 38 · see citing works

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

Kurhanewicz, J. V., Vigneron, D. B., Ardenkjær‐Larsen, J. H., Bankson, J. A., Brindle, K. M., Cunningham, C. H., Gallagher, F. A., Keshari, K. R., Kjær, A., Laustsen, C., et al. (2018) · Neoplasia · doi:10.1016/j.neo.2018.09.006 · Cited by 441 · see citing works

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

Stacpoole, P. W. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx071 · Cited by 408 · see citing works

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works

Metabolic Reprogramming in Glioma

Strickland, M., & Stoll, E. A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00043 · Cited by 350 · see citing works

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

Ye, D., Guan, K.-L., & Xiong, Y. (2018) · Trends in Cancer · doi:10.1016/j.trecan.2017.12.005 · Cited by 242 · see citing works

The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment

Hayes, C., Donohoe, C. L., Davern, M., & Donlon, N. E. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.12.021 · Cited by 215 · see citing works

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

Clark, O., Yen, K. E., & Mellinghoff, I. K. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1333 · Cited by 205 · see citing works

Isocitrate Dehydrogenase Mutation and ( <i>R</i> )-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development

Dang, L., & Su, S.-S. M. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044732 · Cited by 204 · see citing works

Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair

Lu, Y., Kwintkiewicz, J., Liu, Y., Tech, K., Frady, L. N., Su, Y.-T., Bautista, W., Moon, S. I., Macdonald, J. M., Ewend, M. G., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2773 · Cited by 203 · see citing works

The Roles of 2-Hydroxyglutarate

Du, X., & Hu, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651317 · Cited by 152 · see citing works

Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

Zhou, W., & Wahl, D. R. (2019) · Cancers · doi:10.3390/cancers11091231 · Cited by 146 · see citing works

Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways

Fack, F., Tardito, S., Hochart, G., Oudin, A., Zheng, L., Fritah, S., Golebiewska, A., Nazarov, P. V., Bernard, A., Hau, A., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707729 · Cited by 144 · see citing works

Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches

Navarro, C., Ortega, Á., Santeliz, R., Garrido, B., Chacín, M., Galbán, N., Vera, I., Sanctis, J. B. D., & Bermúdez, V. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061303 · Cited by 152 · see citing works

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

Gagné, L. M., Boulay, K., Topisirović, I., Huot, M., & Mallette, F. A. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.06.002 · Cited by 141 · see citing works

New insights into molecules and pathways of cancer metabolism and therapeutic implications

Tang, Z., Xu, Z., Zhu, X. M., & Zhang, J. (2020) · 癌症：英文版 · doi:10.1002/cac2.12112 · Cited by 99 · see citing works

Antioxidants in brain tumors: current therapeutic significance and future prospects

Qi, X., Jha, S. K., Jha, N. K., Dewanjee, S., Dey, A., Deka, R., Pritam, P., Ramgopal, K., Liu, W.-T., & Hou, K. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01668-9 · Cited by 100 · see citing works

The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1 -Mutant Cancers and Potentiates NAD+ Depletion–Mediated Cytotoxicity

Tateishi, K., Higuchi, F., Miller, J. J., Koerner, M. V. A., Lelic, N., Shankar, G. M., Tanaka, S., Fisher, D. E., Batchelor, T. T., Iafrate, A. J., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2263 · Cited by 98 · see citing works

Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress

Gelman, S. J., Naser, F. J., Mahieu, N. G., McKenzie, L. D., Dunn, G. P., Chheda, M. G., & Patti, G. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.050 · Cited by 95 · see citing works

Poly(ADP-ribose) Glycohydrolase Inhibition Sequesters NAD+ to Potentiate the Metabolic Lethality of Alkylating Chemotherapy in IDH-Mutant Tumor Cells

Nagashima, H., Lee, C. K., Tateishi, K., Higuchi, F., Subramanian, M. P., Rafferty, S., Melamed, L., Miller, J. J., Wakimoto, H., & Cahill, D. P. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0226 · Cited by 89 · see citing works

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

Garrett, M. C., Sperry, J., Braas, D., Yan, W., Le, T. M., Mottahedeh, J., Ludwig, K., Eskin, A., Qin, Y., Levy, R., et al. (2018) · Cancer & Metabolism · doi:10.1186/s40170-018-0177-4 · Cited by 83 · see citing works

Friend or foe—IDH1 mutations in glioma 10 years on

Huang, L. E. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz134 · Cited by 82 · see citing works

Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells

Badur, M. G., Muthusamy, T., Parker, S. J., Ma, S., McBrayer, S. K., Cordes, T., Magaña, J. H., Guan, K., & Metallo, C. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.074 · Cited by 82 · see citing works

First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism

Chung, B. T., Chen, H., Gordon, J. W., Mammoli, D., Sriram, R., Autry, A. W., Page, L. M. L., Chaumeil, M. M., Shin, P., Slater, J. M., et al. (2019) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2019.106617 · Cited by 84 · see citing works

Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression

Zhang, Q., Lou, Y., Bai, X., & Liang, T. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i31.3500 · Cited by 80 · see citing works

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation

Zhou, L., Wang, Z., Hu, C., Zhang, C., Kovatcheva‐Datchary, P., Yu, D., Liu, S., Ren, F., Wang, X., Li, Y., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00663 · Cited by 73 · see citing works

Emerging Technologies to Image Tissue Metabolism

Ntziachristos, V., Pleitez, M. A., Aime, S., & Brindle, K. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.004 · Cited by 74 · see citing works

The Tricarboxylic Acid Cycle at the Crossroad Between Cancer and Immunity

Scagliola, A., Mainini, F., & Cardaci, S. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7974 · Cited by 73 · see citing works

The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat

Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 68 · see citing works

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

Khurshed, M., Molenaar, R. J., Lenting, K., Leenders, W. P. J., & Noorden, C. J. F. V. (2017) · Oncotarget · doi:10.18632/oncotarget.17106 · Cited by 68 · see citing works

Hyperpolarized 13C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

Chaumeil, M. M., Radoul, M., Najac, C., Eriksson, P., Viswanath, P., Blough, M. D., Chesnelong, C., Luchman, H. A., Cairncross, J. G., & Ronen, S. M. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.06.018 · Cited by 67 · see citing works

PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival

Batsios, G., Viswanath, P., Subramani, E., Najac, C., Gillespie, A. M., Santos, R. D., Molloy, A. R., Pieper, R. O., & Ronen, S. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-47021-x · Cited by 60 · see citing works

Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases

Yang, G., Xia, Y., & Ren, W. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1703-2 · Cited by 55 · see citing works

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations

Hvinden, I. C., Cadoux-Hudson, T. A. D., Schofield, C. J., & McCullagh, J. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100469 · Cited by 59 · see citing works

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

Viswanath, P., Radoul, M., Izquierdo-García, J. L., Ong, W. Q., Luchman, H. A., Cairncross, J. G., Huang, B., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2926 · Cited by 54 · see citing works

The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons

Poon, A., Saini, H. K., Sethi, S., O’Sullivan, G. A., Plun‐Favreau, H., Wray, S., Dawson, L. A., & McCarthy, J. M. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.03.030 · Cited by 48 · see citing works

Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies

Zhao, N., Huang, Y., Wang, Y.-H., Muir, R. K., Chen, Y.-C., Wei, J., Hooshdaran, N., Viswanath, P., Seo, Y., Ruggero, D., et al. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.252460 · Cited by 46 · see citing works

Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease

Badur, M. G., & Metallo, C. M. (2017) · Metabolic Engineering · doi:10.1016/j.ymben.2017.11.013 · Cited by 44 · see citing works

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

Viswanath, P., Radoul, M., Izquierdo-García, J. L., Luchman, H. A., Cairncross, J. G., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2018) · Cancer & Metabolism · doi:10.1186/s40170-018-0178-3 · Cited by 46 · see citing works

Magnetic Resonance (MR) Metabolic Imaging in Glioma

Chaumeil, M. M., Lupo, J., & Ronen, S. M. (2015) · Brain Pathology · doi:10.1111/bpa.12310 · Cited by 44 · see citing works

Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites

Hesketh, R. L., & Brindle, K. M. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.03.004 · Cited by 44 · see citing works

Reprogramming of glucose metabolism: The hallmark of malignant transformation and target for advanced diagnostics and treatments

Tang, Q., Wu, S., Zhao, B., Li, Z., Zhou, Q., Yu, Y., Yang, X., Wang, R., Wang, X., Wu, W., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117257 · Cited by 42 · see citing works

Magnetic resonance spectroscopy for the study of cns malignancies

Ruiz‐Rodado, V., Brender, J., Cherukuri, M. K., Gilbert, M. R., & Larion, M. (2020) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2020.11.001 · Cited by 37 · see citing works

Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells

Viswanath, P., Chaumeil, M. M., & Ronen, S. M. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00060 · Cited by 38 · see citing works

From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas

Sun, X., & Turcan, Ş. (2021) · Cells · doi:10.3390/cells10051225 · Cited by 37 · see citing works

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Viswanath, P., Najac, C., Izquierdo-García, J. L., Pankov, A., Hong, C., Eriksson, P., Costello, J., Pieper, R. O., & Ronen, S. M. (2016) · Oncotarget · doi:10.18632/oncotarget.9006 · Cited by 35 · see citing works

TCA cycle-derived oncometabolites in cancer and the immune microenvironment

Sarkar, S., Chang, C.-I., Jean, J., & Wu, M. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01186-y · Cited by 37 · see citing works

MicroRNA Regulation of Glycolytic Metabolism in Glioblastoma

Alfardus, H., McIntyre, A., & Smith, S. J. (2017) · BioMed Research International · doi:10.1155/2017/9157370 · Cited by 33 · see citing works

Non-invasive assessment of telomere maintenance mechanisms in brain tumors

Viswanath, P., Batsios, G., Mukherjee, J., Gillespie, A. M., Larson, P. E. Z., Luchman, H. A., Phillips, J. J., Costello, J., Pieper, R. O., & Ronen, S. M. (2021) · Nature Communications · doi:10.1038/s41467-020-20312-y · Cited by 34 · see citing works

Regulative Roles of Metabolic Plasticity Caused by Mitochondrial Oxidative Phosphorylation and Glycolysis on the Initiation and Progression of Tumorigenesis

Niu, N., Ye, J., Hu, Z., Zhang, J., & Wang, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087076 · Cited by 32 · see citing works

Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells

Han, A., Bennett, N. E., MacDonald, A., Johnstone, M. E., Whelan, J. N., & Donohoe, D. R. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25287 · Cited by 31 · see citing works

IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway

Li, K., Ouyang, L., He, M., Luo, M., Cai, W., Tu, Y., Pi, R., & Liu, A. (2017) · Oncotarget · doi:10.18632/oncotarget.15868 · Cited by 31 · see citing works

Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

Peeters, T. H., Lenting, K., Breukels, V., van Lith, S. A. M., van den Heuvel, C. N. A. M., Molenaar, R. J., van Rooij, A., Wevers, R. A., Span, P. N., Heerschap, A., et al. (2019) · Cancer & Metabolism · doi:10.1186/s40170-019-0198-7 · Cited by 32 · see citing works

Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation

Fujiwara, H., Tateishi, K., Misumi, K., Hayashi, A., Igarashi, K., Kato, H., Nakatsuka, T., Suzuki, N., Yamamoto, K., Kudo, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55211-w · Cited by 31 · see citing works

MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma

Molloy, A. R., Najac, C., Viswanath, P., Lakhani, A., Subramani, E., Batsios, G., Radoul, M., Gillespie, A. M., Pieper, R. O., & Ronen, S. M. (2020) · Theranostics · doi:10.7150/thno.47317 · Cited by 31 · see citing works

IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment—Current State and Future Perspectives

Crispo, F., Pietrafesa, M., Condelli, V., Maddalena, F., Bruno, G., Piscazzi, A., Sgambato, A., Esposito, F., & Landriscina, M. (2020) · Molecules · doi:10.3390/molecules25163754 · Cited by 32 · see citing works

Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294

McGee, K. P., Hwang, K., Sullivan, D. C., Kurhanewicz, J. V., Hu, Y., Wang, J., Li, W., Debbins, J. P., Paulson, E. S., Olsen, J. R., et al. (2021) · Medical Physics · doi:10.1002/mp.14884 · Cited by 31 · see citing works

From the (Epi)Genome to Metabolism and Vice Versa; Examples from Hematologic Malignancy

Karagianni, P., Giannouli, S., & Voulgarelis, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126321 · Cited by 32 · see citing works

Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma

Yang, R., Zhao, Y., Gu, Y., Yang, Y., Gao, X., Yuan, Y., Xiao, L., Zhang, J., Sun, C., Yang, H. K., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01439-0 · Cited by 28 · see citing works

In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-13C]glycine

Batsios, G., Najac, C., Cao, P., Viswanath, P., Subramani, E., Saito, Y., Gillespie, A. M., Yoshihara, H. A. I., Larson, P. E. Z., Sando, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63160-y · Cited by 28 · see citing works

MR Molecular Imaging of Brain Cancer Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

Najac, C., & Ronen, S. M. (2016) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000104 · Cited by 27 · see citing works

Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Mörén, L., Perryman, R., Crook, T., Langer, J. K., O’Neill, K., Syed, N., & Antti, H. (2018) · BMC Cancer · doi:10.1186/s12885-018-4040-3 · Cited by 27 · see citing works

mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma

Liu, Y., Lu, Y., Li, A., Celiku, O., Han, S., Qian, M., & Yang, C. (2020) · Cancers · doi:10.3390/cancers12040787 · Cited by 26 · see citing works

Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment

Subramani, E., Radoul, M., Najac, C., Batsios, G., Molloy, A. R., Hong, D., Gillespie, A. M., Santos, R. D., Viswanath, P., Costello, J., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1314 · Cited by 25 · see citing works

In vivo brain MR spectroscopy in gliomas: clinical and pre-clinical chances

Padelli, F., Mazzi, F., Erbetta, A., Chiapparini, L., Doniselli, F. M., Palermo, S., Aquino, D., Bruzzone, M. G., & Cuccarini, V. (2022) · Clinical and Translational Imaging · doi:10.1007/s40336-022-00502-y · Cited by 25 · see citing works

Cancer metabolism in a snapshot: MRS(I)

Julià‐Sapé, M., Candiota, A. P., & Arús, C. (2019) · NMR in Biomedicine · doi:10.1002/nbm.4054 · Cited by 25 · see citing works

Metabolic profiling of human gliomas assessed with NMR

Lee, J. E., Jeun, S. S., Kim, S. H., Yoo, C. Y., Baek, H., & Yang, S. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.07.078 · Cited by 25 · see citing works

Illuminating the cross-talk between tumor metabolism and immunity in IDH-mutated cancers

Leca, J., Fortin, J., & Mak, T. W. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.11.013 · Cited by 23 · see citing works

Glioblastoma Metabolomics—In Vitro Studies

Jaroch, K., Modrakowska, P., & Bojko, B. (2021) · Metabolites · doi:10.3390/metabo11050315 · Cited by 23 · see citing works

One-Carbon Metabolism Associated Vulnerabilities in Glioblastoma: A Review

Ghannad‐Zadeh, K., & Das, S. (2021) · Cancers · doi:10.3390/cancers13123067 · Cited by 23 · see citing works

Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma

Clark, P. M., Mai, W. X., Cloughesy, T. F., & Nathanson, D. A. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0613-6 · Cited by 21 · see citing works

Lactic Acidosis in Prostate Cancer: Consider the Warburg Effect

van der Mijn, J. C., Kuiper, M. J., Siegert, C. E. H., Wassenaar, A. E., van Noesel, C. J. M., & Ogilvie, A. C. (2017) · Case Reports in Oncology · doi:10.1159/000485242 · Cited by 20 · see citing works

Glioblastoma metabolomics: uncovering biomarkers for diagnosis, prognosis and targeted therapy

Costantini, S., Gennaro, E. D., Fanelli, G., Bagnara, P., Argenziano, C., Maccanico, C., Paggi, M. G., Budillon, A., & Abbruzzese, C. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03497-2 · Cited by 19 · see citing works

Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations

Zhang, H., Puviindran, V., Nadesan, P., Ding, X., Shen, L., Tang, Y. J., Tsushima, H., Yahara, Y., Ban, G. I., Zhang, G., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4532 · Cited by 18 · see citing works

Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers

Liao, H., Chen, X., Wang, H., Lin, Y., Chen, L., Yuan, K., Liao, M., Jiang, H., Peng, J., Wu, Z., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-3298 · Cited by 17 · see citing works

Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma

Ruiz‐Rodado, V., Seki, T., Dowdy, T., Lita, A., Zhang, M., Han, S., Yang, C., Cherukuri, M. K., Gilbert, M. R., & Larion, M. (2020) · Cancers · doi:10.3390/cancers12061633 · Cited by 15 · see citing works

Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.

Chasapis, C. T., Makridakis, M., Damdimopoulos, A. E., Zoidakis, J., Lygirou, V., Mavroidis, M., Vlahou, A., Miranda-Vizuete, A., Spyrou, G., & Vlamis-Gardikas, A. (2019) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2019.04.018 · Cited by 14 · see citing works

Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells

Włodarczyk, A., Grot, D., Stoczyńska-Fidelus, E., & Rieske, P. (2020) · Journal of Oncology · doi:10.1155/2020/6783627 · Cited by 14 · see citing works

Functional requirement of a wild-type allele for mutant IDH1 to suppress anchorage-independent growth through redox homeostasis

Tiburcio, P. D. B., Xiao, B., Berg, S., Asper, S., Lyne, S. B., Zhang, Y., Zhu, X., Yan, H., & Huang, L. E. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1800-0 · Cited by 12 · see citing works

In-vivo magnetic resonance spectroscopy of lactate as a non-invasive biomarker of dichloroacetate activity in cancer and non-cancer central nervous system disorders

Kamson, D. O., Chinnasamy, V., Grossman, S. A., Bettegowda, C., Barker, P. B., Stacpoole, P. W., & Oeltzschner, G. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1077461 · Cited by 12 · see citing works

Exploring the crosstalk of glycolysis and mitochondrial metabolism in psychiatric disorders and brain tumours

Vlaikou, A., Nußbaumer, M., Komini, C., Lambrianidou, A., Konidaris, C., Trangas, T. T., & Filiou, M. D. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15057 · Cited by 12 · see citing works

The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches

Gruber, E., & Kats, L. M. (2023) · Biochemical Society Transactions · doi:10.1042/bst20230017 · Cited by 11 · see citing works

Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma

Kafka, A., Tomas, D., Lechpammer, M., Gabud, T., Pažanin, L., & Pećina‐Šlaus, N. (2017) · Disease Markers · doi:10.1155/2017/9253495 · Cited by 11 · see citing works

The epigenetic–metabolic interplay in gliomagenesis

Phasaludeen, B., Emerald, B. S., & Ansari, S. A. (2022) · Open Biology · doi:10.1098/rsob.210350 · Cited by 10 · see citing works

Effects of cancer-associated point mutations on the structure, function, and stability of isocitrate dehydrogenase 2

Chen, X. '., Yang, P., Qiao, Y., Ye, F., Wang, Z., Xu, M., Han, X., Song, L., Wu, Y., & Ou, W. (2022) · Scientific Reports · doi:10.1038/s41598-022-23659-y · Cited by 10 · see citing works

The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma

Javier, R. A., Wang, W., Drumm, M. R., McCortney, K., Sarkaria, J. N., & Horbinski, C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0257725 · Cited by 9 · see citing works

Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data

Lee, G., Lee, S. M., Lee, S., Jeong, C. W., Song, H., Lee, S. Y., Yun, H., Koh, Y., & Kim, H. U. (2024) · Genome biology · doi:10.1186/s13059-024-03208-8 · Cited by 9 · see citing works

C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain Tumors

Viswanath, P., Li, Y., & Ronen, S. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-27359-0_12 · Cited by 8 · see citing works

NDRG2 inhibits pyruvate carboxylase-mediated anaplerosis and combines with glutamine blockade to inhibit the proliferation of glioma cells.

Wang, J., Sun, X. Y., Wang, J., Zhang, K., Yuan, Y., Guo, Y. H., Yao, L., Li, X., & Shen, L. (2022) · PubMed Central · Cited by 8 · see citing works

Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia

Zhu, X., Hao, J., Zhang, H., Chi, M., Wang, Y., Huang, J., Xu, R., Xincai, Z., Xin, B., Sun, X., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05366-0 · Cited by 8 · see citing works

Phosphorylated form of pyruvate dehydrogenase α1 mediates tumor necrosis factor α‑induced glioma cell migration

Yang, Z., Wang, Y., Zhang, L., Zhao, C., & Wang, D. (2021) · Oncology Letters · doi:10.3892/ol.2021.12437 · Cited by 8 · see citing works

Integrated analysis of transcriptional and metabolic responses to mitochondrial stress

Kelley, L. P., Hu, S., Boswell, S. A., Sorger, P. K., Ringel, A. E., & Haigis, M. C. (2025) · Cell Reports Methods · doi:10.1016/j.crmeth.2025.101027 · Cited by 8 · see citing works

Signaling Pathways in Gliomas

Stachyra, P., & Grzybowska-Szatkowska, L. (2025) · Genes · doi:10.3390/genes16050600 · Cited by 8 · see citing works

IDH-Mutant Gliomas

Tateishi, K., & Yamamoto, T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84543 · Cited by 7 · see citing works

Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1

Viswanath, P., & Ronen, S. M. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1077922 · Cited by 7 · see citing works

Acquisition and quantification pipeline for in vivo hyperpolarized 13C MR spectroscopy

Hong, D., Batsios, G., Viswanath, P., Gillespie, A. M., Vaidya, M. V., Larson, P. E. Z., & Ronen, S. M. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29081 · Cited by 5 · see citing works

Perfused Cells, Tissues and Organs by Magnetic Resonance Spectroscopy

Milkevitch, M., Browning, E. A., & Delikatny, E. J. (2016) · Encyclopedia of Magnetic Resonance · doi:10.1002/9780470034590.emrstm1426 · Cited by 4 · see citing works

A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator

Ye, H., Yuan, J., Wang, Z., Huang, A., Liu, X., Han, X., & Chen, Y. (2016) · Computational and Mathematical Methods in Medicine · doi:10.1155/2016/2460184 · Cited by 3 · see citing works

Untangling the web of glioblastoma treatment resistance using a multi-omic and multidisciplinary approach

Miller, D. M., Yadanapudi, K., Rai, V., Rai, S. N., Chen, J., Frieboes, H. B., Masters, A. H., McCallum, A. P., & Williams, B. J. (2023) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2023.06.010 · Cited by 3 · see citing works

Imaging Tumor MetabolismPreprint

Ruan, T., & Keshari, K. R. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041551 · Cited by 3 · see citing works

Imaging telomerase reverse transcriptase expression in oligodendrogliomas using hyperpolarized δ-[1-13C]-gluconolactone

Batsios, G., Taglang, C., Gillespie, A. M., & Viswanath, P. (2023) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdad092 · Cited by 2 · see citing works

CBIO-42DOWN REGULATION OF PYRUVATE DEHYDROGENASE ACTIVITY IS ESSENTIAL FOR CELL PROLIFERATION IN IDH1 MUTANT GLIOMA CELLS

Viswanath, P., Izquierdo-García, J. L., Eriksson, P., Cai, L., Radoul, M., Chaumeil, M. M., Blough, M. D., Luchman, H. A., Weiss, S., Cairncross, J. G., et al. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov209.42

Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1

Viswanath, P., & Ronen, S. M. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1077922 · Cited by 7 · see citing works

TM-07 * 13C MRS DETECTS METABOLIC FLUX ADAPTATION IN IDH MUTANT GLIOMA CELLS

Izquierdo-García, J. L., Eriksson, P. O., Cai, L., Chaumeil, M. M., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou278.7

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Viswanath, P., Najac, C., Izquierdo-García, J. L., Pankov, A., Hong, C., Eriksson, P., Costello, J., Pieper, R. O., & Ronen, S. M. (2016) · Oncotarget · doi:10.18632/oncotarget.9006 · Cited by 35 · see citing works

Metabolic Reprogramming in Mutant IDH1 Glioma Cells

Izquierdo-García, J. L., Viswanath, P., Eriksson, P., Chaumeil, M. M., Pieper, R. O., Phillips, J. J., & Ronen, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118781 · Cited by 84 · see citing works