The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Calreticulin: non‐endoplasmic reticulum functions in physiology and disease
Open accessAbstract
Calreticulin (CRT), when localized to the endoplasmic reticulum (ER), has important functions in directing proper conformation of proteins and glycoproteins, as well as in homeostatic control of cytosolic and ER calcium levels. There is also steadily accumulating evidence for diverse roles for CRT localized outside the ER, including data suggesting important roles for CRT localized to the outer cell surface of a variety of cell types, in the cytosol, and in the extracellular matrix (ECM). Furthermore, the addition of exogenous CRT rescues numerous CRT‐driven functions, such as adhesion, migration, phagocytosis, and immunoregulatory functions of CRT‐null cells. Recent studies show that topically applied CRT has diverse and profound biological effects that enhance cutaneous wound healing in animal models. This evidence for extracellular bioactivities of CRT has provided new insights into this classically ER‐resident protein, despite a lack of knowledge of how CRT exits from the ER to the cell surface or how it is released into the extracellular milieu. Nonetheless, it has become clear that CRT is a multicompartmental protein that regulates a wide array of cellular responses important in physiological and pathological processes, such as wound healing, the immune response, fibrosis, and cancer.—Gold, L. I., Eggleton, P., Sweetwyne, M. T., Van Duyn, L. B., Greives, M. R., Naylor, S.‐M., Michalak, M., Murphy‐Ullrich, J. E. Calreticulin: non‐endoplamic reticulum functions in physiology and disease. FASEB J. 24, 665–683 (2010). www.fasebj.org
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Calreticulin exposure dictates the immunogenicity of cancer cell death
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Cytokines in immunogenic cell death: Applications for cancer immunotherapy
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Metadata
- Authors
- Gold, L. I., Eggleton, P., Sweetwyne, M. T., Van Duyn, L. B., Greives, M. R., Naylor, S., Michalak, M., & Murphy‐Ullrich, J. E.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2009-11-25
- Volume
- 24
- Issue
- 3
- Pages
- 665-683
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2155315999
- Cited by
- 382
- References
- 150
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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