ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high‐fat diet and impairs adipocyte function and differentiation
Open accessAbstract
ADP‐ribosyltransferase Diphtheria toxinlike 1 [ARTD1; formerly called poly‐ADP‐ribose polymerase 1 (PARP1)] is a chromatin‐associated enzyme involved in regulating metabolic homeostasis. The liver is at the core of glucose and lipid metabolism and is significantly affected by obesity and the metabolic syndrome. Here, we show that when fed a high‐fat diet (HFD), mice lacking ARTD1 developed exacerbated hepatic steatosis. ARTD1 –/– mice had a 19% higher liver weight than wild‐type (WT) animals and exhibited a significantly increased serum concentration of cholesterol (38%) and impaired glucose tolerance. In addition, adipocyte function and size were significantly reduced in ARTD1 –/– mice fed an HFD (7794 μm 2 for WT and 5579 μm 2 for ARTD1 –/– mice). The significantly reduced adipogenic differentiation of adipose‐derived stromal cells (ASCs) isolated from ARTD1 –/– mice (28 vs. 11% Oil red O‐positive cells in WT and ARTD1 –/– ASCs, respectively) suggested that impaired adipogenesis as the underlying cause for this adipose tissue malfunction. This function of ARTD1 was specific for adipogenesis, since osteogenic differentiation was not affected by the ARTD1 deletion. In summary, we show that ARTD1 –/– mice fed an HFD display impaired adipogenesis and show exacerbated hepatic steatosis, which can have important implications for nonalcoholic fatty liver disease.—Erener, S., Mirsaidi, A., Hesse, M., Tiaden, A. N., Ellingsgaard, H., Kostadinova, R., Donath, M. Y., Richards, P. J., Hottiger, M. O. ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high‐fat diet and impairs adipocyte function and differentiation. FASEB J. 26, 2631‐2638 (2012). www.fasebj.org
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PARP-1 activity promotes adipogenesis.
“Consistent with this, PARP-1 activity was found to enhance adipogenesis (Erener et al., 2012).”
From Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle (2014) · cites this paper as Erener et al., 2012
Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,669 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Nonalcoholic Fatty Liver Disease
Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G., & Melchionda, N. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1844 · Cited by 2,581 · see citing works
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210 · see citing works
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,259 · see citing works
Diet-Induced Type II Diabetes in C57BL/6J Mice
Surwit, R. S., Kuhn, C. M., Cochrane, C., McCubbin, J. A., & Feinglos, M. N. (1988) · Diabetes · doi:10.2337/diab.37.9.1163 · Cited by 1,211 · see citing works
Lipid-induced insulin resistance: unravelling the mechanism
Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189 · see citing works
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
Murcia, J. M., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M. P., Oliver, F. J., Masson, M., Dierich, A., LeMeur, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7303 · Cited by 1,058 · see citing works
Nguyen, P., Leray, V., Diez, M., Serisier, S., Bloc’h, J. L., Siliart, B. S., & Dumon, H. (2008) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2007.00752.x · Cited by 972 · see citing works
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.004 · Cited by 837 · see citing works
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
Krishnakumar, R., & Kraus, W. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.017 · Cited by 836 · see citing works
Evaluating the glucose tolerance test in mice
Andrikopoulos, S., Blair, A. R., DeLuca, N., Fam, B. C., & Proietto, J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90617.2008 · Cited by 824 · see citing works
Toward a unified nomenclature for mammalian ADP-ribosyltransferases
Hottiger, M. O., Hassa, P. O., Lüscher, B., Schuler, H., & Koch‐Nolte, F. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.12.003 · Cited by 814 · see citing works
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.Preprint
Wang, Z. Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M. R., & Wagner, E. F. (1995) · Genes & Development · doi:10.1101/gad.9.5.509 · Cited by 774 · see citing works
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
Hassa, P. O., Haenni, S. S., Elser, M., & Hottiger, M. O. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-05 · Cited by 682 · see citing works
Adipose Tissue Dysfunction in Obesity
Blüher, M. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1192044 · Cited by 657 · see citing works
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
Vidal‐Puig, A., Jimenez‐Liñan, M., Lowell, B. B., Hamann, A., Hu, E., Spiegelman, B. M., Flier, J. S., & Moller, D. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118703 · Cited by 656 · see citing works
Paul, O. H. (2007) · Frontiers in bioscience · doi:10.2741/2909 · Cited by 587 · see citing works
Sethi, J. K., & Vidal‐Puig, A. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700005-jlr200 · Cited by 558 · see citing works
Jones, J. R., Barrick, C. J., Kim, K., Lindner, J., Blondeau, B., Fujimoto, Y., Shiota, M., Kesterson, R. A., Kahn, B. B., & Magnuson, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306743102 · Cited by 487 · see citing works
Qiao, L., & Shao, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607215200 · Cited by 378 · see citing works
Non-alcoholic fatty liver: another feature of the metabolicsyndrome?
Cortez‐Pinto, H., Camilo, M., Baptista, A., Oliveira, A. G., & de Moura, M. C. (1999) · Clinical Nutrition · doi:10.1016/s0261-5614(99)80015-6 · Cited by 299 · see citing works
Wang, F., & Tong, Q. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-06-0647 · Cited by 289 · see citing works
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
di Fagagna, F. D., Hande, M. P., Tong, W., Lansdorp, P. M., Wang, Z.-Q., & Jackson, S. P. (1999) · Nature Genetics · doi:10.1038/12680 · Cited by 256 · see citing works
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
Bai, P., Cantó, C., Brunyánszki, A., Huber, A., Szántó, M., Cen, Y., Yamamoto, H., Houten, S. M., Kiss, B., Oudart, H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.013 · Cited by 250 · see citing works
Histone ADP-ribosylation in DNA repair, replication and transcription
Messner, S., & Hottiger, M. O. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.001 · Cited by 197 · see citing works
Samper, E., Goytisolo, F. A., Murcia, J. M., González‐Suárez, E., Cigudosa, J. C., de MURCIA, G., & Blasco, M. A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103049 · Cited by 86 · see citing works
Poly(ADP-Ribose)Polymerase-1 (PARP1) Controls Adipogenic Gene Expression and Adipocyte Function
Erener, S., Hesse, M., Kostadinova, R. M., & Hottiger, M. O. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1163 · Cited by 75 · see citing works
Mirsaidi, A., Kleinhans, K. N., Rimann, M., Tiaden, A. N., Stauber, M., Rudolph, K. L., & Richards, P. J. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.440 · Cited by 73 · see citing works
PARP1 deficiency exacerbates diet-induced obesity in mice
Devalaraja-Narashimha, K. B., & Padanilam, B. J. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0402 · Cited by 64 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648 · see citing works
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works
Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases
Rosenthal, F., Feijs, K. L. H., Frugier, E., Bonalli, M., Forst, A. H., Imhof, R., Winkler, H. C., Fischer, D., Caflisch, A., Hassa, P. O., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2521 · Cited by 317 · see citing works
The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease
Bai, P., & Cantó, C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.016 · Cited by 312 · see citing works
PARP-1 and gene regulation: Progress and puzzles
Kraus, W. L., & Hottiger, M. O. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.005 · Cited by 255 · see citing works
Pirinen, E., Cantó, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.002 · Cited by 254 · see citing works
“, 2011), likely favoring fat storage over burning (Erener et al., 2012).”
BackgroundCrosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes
Cantó, C., Sauve, A. A., & Bai, P. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.01.004 · Cited by 246 · see citing works
Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics
Hottiger, M. O. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034506 · Cited by 224 · see citing works
PARPs in lipid metabolism and related diseases
Szántó, M., Gupte, R., Kraus, W. L., Pacher, P., & Bai, P. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101117 · Cited by 184 · see citing works
New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases
Ryu, K. W., Kim, D.-S., & Kraus, W. L. (2015) · Chemical Reviews · doi:10.1021/cr5004248 · Cited by 147 · see citing works
Jubin, T., Kadam, A. A., Jariwala, M., Bhatt, S., Sutariya, S., Gani, A. R., Gautam, S., & Begum, R. (2016) · Cell Proliferation · doi:10.1111/cpr.12268 · Cited by 130 · see citing works
Poly (ADP-Ribose) Polymerase-1 Is a Key Mediator of Liver Inflammation and Fibrosis
Mukhopadhyay, P., Rajesh, M., Cao, Z., Horváth, B., Park, O., Wang, H., Erdélyi, K., Holovac, E., Wang, Y., Liaudet, L., et al. (2013) · Hepatology · doi:10.1002/hep.26763 · Cited by 125 · see citing works
Luo, X., Ryu, K. W., Kim, D.-S., Nandu, T. S., Medina, C. J., Gupte, R., Gibson, B. A., Soccio, R. E., Yu, Y., Gupta, R. K., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.11.015 · Cited by 109 · see citing works
Jokinen, R., Pirnes-Karhu, S., Pietiläinen, K. H., & Pirinen, E. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.011 · Cited by 103 · see citing works
Huang, K., Du, M., Tan, X., Yang, L., Li, X., Jiang, Y., Wang, C., Zhang, F., Zhu, F., Cheng, M., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.11.020 · Cited by 102 · see citing works
Exploring the emerging complexity in transcriptional regulation of energy homeostasis
Lempradl, A. M., Pospisilik, J. A., & Penninger, J. M. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3941 · Cited by 94 · see citing works
Wang, S., Yang, F., Shang, L., Zhang, Y., Zhou, Y., & Shi, X. (2019) · Phytotherapy Research · doi:10.1002/ptr.6417 · Cited by 91 · see citing works
Szántó, M., & Bai, P. (2020) · Genes & Development · doi:10.1101/gad.334284.119 · Cited by 88 · see citing works
Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis
Huang, D. Y., Camacho, C. V., Setlem, R., Ryu, K. W., Parameswaran, B., Gupta, R. K., & Kraus, W. L. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.08.002 · Cited by 70 · see citing works
Musso, G., Saba, F., Cassader, M., & Gambino, R. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101238 · Cited by 67 · see citing works
Metabolic roles of poly(ADP-ribose) polymerases
Vida, A., Márton, J., Mikó, E., & Bai, P. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.12.009 · Cited by 66 · see citing works
ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange
Lehmann, M., Pirinen, E., Mirsaidi, A., Kunze, F. A., Richards, P. J., Auwerx, J. H., & Hottiger, M. O. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1260 · Cited by 52 · see citing works
Sakthianandeswaren, A., Parsons, M. J., Mouradov, D., MacKinnon, R. N., Catimel, B., Liu, S., Palmieri, M., Love, C. G., Jorissen, R. N., Li, S., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0909 · Cited by 51 · see citing works
PARP10 (ARTD10) modulates mitochondrial function
Márton, J., Fodor, T., Nagy, L., Vida, A., Kis, G. N., Brunyánszki, A., Antal, M., Lüscher, B., & Bai, P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0187789 · Cited by 49 · see citing works
A Double-Edged Sword: The Two Faces of PARylation
Kang, M., Park, S., Park, S., Lee, H. G., & Park, J. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179826 · Cited by 46 · see citing works
Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels
Szántó, M., Brunyánszki, A., Márton, J., Vámosi, G., Nagy, L., Fodor, T., Kiss, B., Virág, L., Gergely, P., & Bai, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.006 · Cited by 42 · see citing works
Robaszkiewicz, A., Qu, C., Wiśnik, E., Płoszaj, T., Mirsaidi, A., Kunze, F. A., Richards, P. J., Cinelli, P., Mbalaviele, G., & Hottiger, M. O. (2016) · Scientific Reports · doi:10.1038/srep21131 · Cited by 42 · see citing works
MacroH2A1.1 cooperates with EZH2 to promote adipogenesis by regulating Wnt signaling
Wan, D., Liu, C., Sun, Y., Wang, W., Huang, K., & Zheng, L. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx027 · Cited by 40 · see citing works
Poly ADP-ribose polymerase-1: Beyond transcription and towards differentiation
Jubin, T., Kadam, A. A., Gani, A. R., Singh, M., Dwivedi, M., & Begum, R. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.07.027 · Cited by 37 · see citing works
Kuenzler, M., Nuss, K. M. R., Karol, A. A., Schär, M. O., Hottiger, M. O., Raniga, S., Kenkel, D., von Rechenberg, B., & Zumstein, M. A. (2017) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2016.11.009 · Cited by 29 · see citing works
Möhrle, D., Reimann, K., Wolter, S., Wolters, M., Varakina, K., Mergia, E., Eichert, N., Geisler, H.-S., Sandner, P., Ruth, P., et al. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.108548 · Cited by 27 · see citing works
Adverse effects of weight loss: Are persistent organic pollutants a potential culprit?
Rouhou, M. C., Karelis, A. D., St-Pierre, D. H., & Lamontagne, L. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.05.009 · Cited by 27 · see citing works
PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation
Wang, C., Xiao, J., Nowak, K., Gunasekera, K., Alippe, Y., Speckman, S., Yang, T., Kress, D., Abu‐Amer, Y., Hottiger, M. O., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3927 · Cited by 23 · see citing works
Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury
Zhang, Y., Wang, C., Tian, Y., Zhang, F., Xu, W., Li, X., Shu, Z., Wang, Y., Huang, K., & Huang, D. Y. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.08.016 · Cited by 26 · see citing works
Olaparib induces browning of in vitro cultures of human primary white adipocytes
Nagy, L., Rauch, B., Balla, N., Ujlaki, G., Kis, G. N., Abdul-Rahman, O., Kristóf, E., Sipos, A., Antal, M., Tóth, A., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.06.022 · Cited by 24 · see citing works
The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism
Hurtado-Bagès, S., Guberović, I., & Buschbeck, M. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00417 · Cited by 23 · see citing works
Inhibition of Poly(ADP-Ribose) Polymerase Increased Lipid Accumulation Through SREBP1 Modulation
Pang, J., Cui, J., Xi, C., Shen, T., Gong, H., Dou, L., Lin, Y., & Zhang, T. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493028 · Cited by 16 · see citing works
Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy
Khong, J. J., Burdon, K. P., Lu, Y., Leonardos, L., Laurie, K. J., Walsh, J. P., Gajdatsy, A., Ebeling, P. R., McNab, A. A., Hardy, T. G., et al. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18797 · Cited by 15 · see citing works
Hao, W., Jialong, Z., Jiuzhi, Y., Yang, Y. S., Lv, C., & Jin-cai, L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102347 · Cited by 13 · see citing works
Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa
Gaur, U., Tu, J., Li, D., Gao, Y., Lian, T., Sun, B., Yang, D., Fan, X., & Yang, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182306 · Cited by 12 · see citing works
PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy
Matsumoto, K., Matsumoto, Y., & Wada, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1537615 · Cited by 10 · see citing works
Role of APD-Ribosylation in Bone Health and Disease
Wang, C., & Mbalaviele, G. (2019) · Cells · doi:10.3390/cells8101201 · Cited by 9 · see citing works
Olthof, M. G. L., Hasler, A., Valdivieso, P., Flück, M., Gerber, C., Gehrke, R. S., Klein, K., von Rechenberg, B., Snedeker, J. G., & Wieser, K. (2024) · Metabolites · doi:10.3390/metabo14040187 · Cited by 1 · see citing works
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · DSpace@MIT (Massachusetts Institute of Technology)
Zhu, J., Gupte, R., Nandu, T. S., Huang, K., Kraus, W. L., & Huang, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.20.660762
The NAMPT Inhibitor FK866 Attenuates DEN-Induced Liver Fibrosis in Mice
Ren, D., Wang, S., Li, L., Fan, Z., Li, M., & Li, L. (2026) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b25-00491
Xie, B., Li, J., Huang, G., Zhao, Y., Chen, D., Wei, L., Guo, F., Florentino, R. M., Faccioli, L. A. P., Kurihara, T., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101002
Tankyrase‐2 regulates adipocyte differentiation through AMPK / mTOR signaling
Rauch, B., Ujlaki, G., Póliska, S., Murahwa, N., Kovács, P., Pettkó‐Szandtner, A., Uray, K., & Bai, P. (2026) · FEBS Journal · doi:10.1111/febs.70676
- Authors
- Erener, S., Mirsaidi, A., Hesse, M., Tiaden, A. N., Ellingsgaard, H., Kostadinova, R., Donath, M. Y., Richards, P. J., & Hottiger, M. O.
- Affiliations
- University of Zurich (CH)
- University Hospital of Basel (CH)
- Corresponding author
- Hottiger, Michael O.
- ORCID
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2012-03-16
- Volume
- 26
- Issue
- 6
- Pages
- 2631-2638
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2032276295
- Cited by
- 48
- References
- 32
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 1
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Universität Zürich
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31‐122421, 310030B‐138667)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- PARP1, hepatic steatosis, non-alcoholic fatty liver disease, high-fat diet, adipogenesis, adipose-derived stromal cells, glucose tolerance, serum cholesterol, obesity, metabolic syndrome, osteogenic differentiation
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Adipose Tissue, Animals, Cell Differentiation, Cholesterol, Fatty Liver, Liver, Male, Mice, Inbred C57BL, Osteogenesis, Poly(ADP-ribose) Polymerases, Adipocytes, Glucose Intolerance, Adipogenesis, Mice, Diet, High-Fat, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
