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Lysosome-related organelles
Abstract
Lysosomes are membrane-bound cytoplasmic organelles involved in intracellular protein degradation. They contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most of the properties of lysosomes are shared with a group of cell type-specific compartments referred to as 'lysosome-related organelles', which include melanosomes, lytic granules, MHC class II compartments, platelet-dense granules, basophil granules, azurophil granules, and Drosophila pigment granules. In addition to lysosomal proteins, these organelles contain cell type-specific components that are responsible for their specialized functions. Abnormalities in both lysosomes and lysosome-related organelles have been observed in human genetic diseases such as the Chediak-Higashi and Hermansky-Pudlak syndromes, further demonstrating the close relationship between these organelles. Identification of genes mutated in these human diseases, as well as in mouse and Drosophila: pigmentation mutants, is beginning to shed light on the molecular machinery involved in the biogenesis of lysosomes and lysosome-related organelles.
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“By integrating transcriptomic profiling, gene perturbation, cryo-TEM, and comparative evolutionary analyses, we reveal that iridosome biogenesis depends on a similar molecular machinery that governs the formation of canonical LROs such as melanosomes, platelet dense granules, and Weibel-Palade bodies (31, 32) (Fig. 4E).”
From Lysosome-related organelles orchestrate guanine crystal formation in pigment cells (2026) · cites this paper as [31]
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Raposo, G., Tenza, D., Murphy, D. M., Berson, J. F., & Marks, M. S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.809 · Cited by 451
Pmel17 initiates premelanosome morphogenesis within multivesicular bodies
Berson, J. F., Harper, D. C., Tenza, D., Raposo, G., & Marks, M. S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.11.3451 · Cited by 326
H. BRILLIANT, M. (2001) · Pigment Cell Research · doi:10.1034/j.1600-0749.2001.140203.x · Cited by 193
Zanzottera, E. C., Messinger, J. D., Ach, T., Smith, R. T., Freund, K. B., & Curcio, C. A. (2015) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-16431 · Cited by 164
Two-way traffic on the road to plasma membrane repair
Idone, V., Tam, C., & Andrews, N. W. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.09.001 · Cited by 138
Metadata
- Authors
- DELL'ANGELICA, E. C.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2000-07-01
- Volume
- 14
- Issue
- 10
- Pages
- 1265-1278
- ISSN
- 1530-6860
- Cited by
- 174
- References
- 0
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