The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Pancreaticoduodenectomy (Whipple Resections) in Patients Without Malignancy: Are They All `Chronic Pancreatitis'?
Abstract
Pancreaticoduodenectomy (Whipple resection) has evolved into a safe procedure in major high-volume medical centers for the treatment of pancreatic adenocarcinoma and refractory chronic pancreatitis. However, some Whipple resections performed for a clinical suspicion of malignancy reveal only benign disease on pathologic examination. We evaluated the frequency of such Whipple resections without tumor in a large series of pancreaticoduodenectomies and classified the diverse pancreatic and biliary tract diseases present in these specimens. Of 442 Whipple resections performed during 1999-2001, 47 (10.6%) were negative for neoplastic disease and, in 40 cases, had been performed for a clinical suspicion of malignancy. Most Whipple resections revealed benign pancreatic disease, including 8 (17%) alcohol-associated chronic pancreatitis, 4 (8.5%) gallstone-associated pancreatitis, 1 (2.1%) pancreas divisum, 6 (12.8%) "ordinary" chronic pancreatitis of unknown etiology, and 11 (23.4%) lymphoplasmacytic sclerosing pancreatitis. In particular, patients with lymphoplasmacytic sclerosing pancreatitis were all thought to harbor malignancy, whereas only 13 of 19 (68.4%) of Whipple resections showing histologically "ordinary" forms of chronic pancreatitis were performed for a clinical suspicion of malignancy. Benign biliary tract disease, including three cases of primary sclerosing cholangitis, two cases of choledocholithiasis-associated chronic biliary tract disease, and four fibroinflammatory strictures isolated to the intrapancreatic common bile duct, was a common etiology for clinically suspicious Whipple resections (22.5% of cases). Pancreatic intraepithelial neoplasia (PanIN) was a common finding among all pancreata, whether involved by pancreatitis or histologically normal. Overall, PanIN 1A/1B was present in 68.1%, PanIN 2 in 40.4%, and PanIN 3 in just 2.1%. These findings indicate that "benign but clinically suspicious" Whipple resections are relatively common in high-volume centers (9.2%) and reveal a diverse group of clinicopathologically distinctive pancreatic and biliary tract disease.
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Cites
High Serum IgG4 Concentrations in Patients with Sclerosing Pancreatitis
Hamano, H., Kawa, S., Horiuchi, A., Unno, H., Furuya, N., Akamatsu, T., Fukushima, M., Nikaido, T., Nakayama, K., Usuda, N., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441005 · Cited by 2,705
Resected adenocarcinoma of the pancreas—616 patients: results, outcomes, and prognostic indicators
Sohn, T. A., Yeo, C. J., Cameron, J. L., Koniaris, L., Kaushal, S., Abrams, R. A., Sauter, P. K., Coleman, J., Hruban, R. H., & Lillemoe, K. D. (2000) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(00)80105-5 · Cited by 1,485
Self-citationYoshida, K., Toki, F., Takeuchi, T., Watanabe, S.-I., Shiratori, K., & Hayashi, N. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02285209 · Cited by 1,430
(2011) · Hepatogastroenterology · doi:10.5754/hge11453 · Cited by 1,254
Chronic pancreatitis: Diagnosis, classification, and new genetic developments
Etemad, B., & Whitcomb, D. C. (2001) · Gastroenterology · doi:10.1053/gast.2001.22586 · Cited by 1,212
Hruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126
Self-citationMutations of the Cystic Fibrosis Gene in Patients with Chronic Pancreatitis
Sharer, N., Schwarz, M., Malone, G., Howarth, A., Painter, J., Super, M., & Braganza, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809033391001 · Cited by 954
Kawaguchi, K., Koike, M., Tsuruta, K., Okamoto, A., Tabata, I., & Fujita, N. (1991) · Human Pathology · doi:10.1016/0046-8177(91)90087-6 · Cited by 633
Okazaki, K., Uchida, K., Ohana, M., Nakase, H., Uose, S., Inai, M., Matsushima, Y., Katamura, K., Ohmori, K., & Chiba, T. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70264-2 · Cited by 538
Importance of Hospital Volume in the Overall Management of Pancreatic Cancer
Sosa, J. A., Bowman, H. M., Gordon, T. A., Bass, E. B., Yeo, C. J., Lillemoe, K. D., Pitt, H. A., Tielsch, J. M., & Cameron, J. L. (1998) · Annals of Surgery · doi:10.1097/00000658-199809000-00016 · Cited by 505
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Cited by
Hruban, R. H., Takaori, K., Klimstra, D. S., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Biankin, S. A., Compton, C., Fukushima, N., Furukawa, T., et al. (2004) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000126675.59108.80 · Cited by 1,091
Self-citationBasturk, O., Hong, S.-M., Wood, L. D., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Brosens, L. A. A., Fukushima, N., Goggins, M., Hruban, R. H., et al. (2015) · American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000533 · Cited by 864
Self-citationCornell, L. D., Chicano, S. L., Deshpande, V., Collins, A. B., Selig, M. K., Lauwers, G. Y., Barisoni, L., & Colvin, R. B. (2007) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318059b87c · Cited by 200
Moutinho-Ribeiro, P., Iglesias-Garcia, J., Gaspar, R., & Macedo, G. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.09.027 · Cited by 29
Metadata
- Authors
- Abraham, S. C., Wilentz, R. E., Yeo, C. J., Sohn, T. A., Cameron, J. L., Boitnott, J. K., & Hruban, R. H.
- Venue
- The American Journal of Surgical Pathology
- Published
- 2003-01
- Volume
- 27
- Issue
- 1
- Pages
- 110-120
- ISSN
- 0147-5185 (ISSN-L)
- OpenAlex
- W2072429788
- Cited by
- 334
- References
- 19
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Abraham, S. C., Wilentz, R. E., Yeo, C. J., Sohn, T. A., Cameron, J. L., Boitnott, J. K., & Hruban, R. H. (2003). Pancreaticoduodenectomy (Whipple Resections) in Patients Without Malignancy: Are They All `Chronic Pancreatitis'? The American Journal of Surgical Pathology. https://doi.org/10.1097/00000478-200301000-00012
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