The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Whole Body Protein Kinetics in Severely Septic Patients: The Response to Glucose Infusion and Total Parenteral Nutrition
Open accessAbstract
Rates of whole body protein synthesis and catabolism in normal volunteers and in a group of severely septic patients were isotopically determined. In addition, the effect in the patients of either glucose infusion or total parenteral nutrition (TPN) on protein dynamics was assessed. The basal rate of net protein catabolism (NPC) was significantly higher in the septic patients than in the volunteers (p less than 0.05). The values obtained in the volunteers and patients were 1.44 +/- 0.18 and 2.20 +/- 0.10 g/kg/day, respectively. This increase in NPC was primarily due to a major increase in whole body catabolism that was partially counteracted by a modest increase in protein synthesis. When the patients were infused with glucose (4 mg/kg/min), NPC decreased significantly (p less than 0.001) to 1.96 +/- 0.08 g/kg/day, and during TPN the value was significantly lower again (p less than 0.04) (0.63 +/- 0.28 g/kg/day). In each instance the conservation of host tissue was due to an increase in protein synthesis: the accelerated rate of whole body protein catabolism continued irrespective of the nutritional status. The following conclusions were reached from these data: severely ill septic patients have an accelerated rate of NPC compared with normal volunteers, and this is primarily due to a large increase in whole body protein catabolism; TPN is an effective means of conserving host tissue in severely septic patients via the promotion of whole body protein synthesis; despite the beneficial effect of TPN in these patients, whole body protein catabolism continues unabated, and as a result, protein losses still occur at approximately one fourth the rate seen in the absence of TPN; and there is no obvious advantage in terms of protein-sparing when protein is provided in amounts exceeding 1.5 g/kg/day.
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Cites
INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*
Steele, R. (1959) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1959.tb44923.x · Cited by 1,670
Baracos, V., Rodemann, H. P., Dinarello, C. A., & Goldberg, A. L. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303103081002 · Cited by 690
Muscle Proteolysis Induced by a Circulating Peptide in Patients with Sepsis or Trauma
Clowes, G. H. A., George, B. C., Villee, C. A., & Saravis, C. A. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303103081001 · Cited by 469
Physiological and metabolic correlations in human sepsis. Invited commentary.
Jh, S., Fb, C., Coleman, B., Giovannini, I., Shetye, M., Border, & McMenamy, R. H. (1979) · PubMed · Cited by 273
Response of Protein and Urea Kinetics in Burn Patients to Different Levels of Protein Intake
WOLFE, R. R., GOODENOUGH, R. D., BURKE, J. F., & WOLFE, M. H. (1983) · Annals of Surgery · doi:10.1097/00000658-198302000-00007 · Cited by 273
Self-citationWhole body protein synthesis and catabolism in septic man
Long, C., Jeevanandam, M., Kim, B., & Kinney, J. (1977) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/30.8.1340 · Cited by 171
Shaw, J. H., Klein, S., & Wolfe, R. R. (1985) · PubMed · Cited by 142
Self-citationRegulation of enzymes involved in gluconeogenesis
Weber, G., Singhal, R. L., Stamm, N. B., Fisher, E. A., & Mentendiek, M. A. (1964) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(64)80003-0 · Cited by 136
Protein turnover in patients before and after elective orthopaedic operations
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Effects of Glucagon on General Protein Degradation and Synthesis in Perfused Rat Liver
Woodside, K. H., Ward, W. F., & Mortimore, G. E. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)79750-4 · Cited by 114
Cited by
ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
Ferrando, A. A., Lane, H. W., Stuart, C. A., Davis-Street, J., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e627 · Cited by 499
Self-citationWeijs, P. J. M., Stapel, S. N., de Groot, S. D. W., Driessen, R. H., de Jong, E., Girbes, A. R. J., Strack van Schijndel, R. J. M., & Beishuizen, A. (2012) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111415109 · Cited by 408
Overfeeding Macronutrients to Critically Ill Adults
KLEIN, C. J., STANEK, G. S., & WILES, C. E. (1998) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(98)00179-5 · Cited by 344
Metadata
- Authors
- SHAW, J. H. F., WILDBORE, M., & WOLFE, R. R.
- Venue
- Annals of Surgery
- Published
- 1987-03
- Volume
- 205
- Issue
- 3
- Pages
- 288-294
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W1987711508
- Cited by
- 277
- References
- 16
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
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- SHAW, J. H. F., WILDBORE, M., & WOLFE, R. R. (1987). Whole Body Protein Kinetics in Severely Septic Patients: The Response to Glucose Infusion and Total Parenteral Nutrition. Annals of Surgery. https://doi.org/10.1097/00000658-198703000-00012
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