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Endotoxemia and Bacteremia During Hemorrhagic Shock The Link Between Trauma and Sepsis?
Open accessAbstract
Previous investigations of a treated model of hemorrhagic shock in the rat indicated the frequent occurrence of bacteremia that appeared to derive from the gut. This paper determines the incidence of bacteremia and endotoxemia during the acute shock period and compares this with similar observations in humans in varying degrees of shock. Studies in 26 rats indicated that bacteremia and endotoxemia was present in 50% and 87%, respectively, by the end of 2 hours at a mean arterial pressure of 30 mmHg. Observations in 50 patients admitted to the trauma unit showed that positive bacterial blood cultures were present in 56% when the admission systolic blood pressure was 80 mmHg or less (p less than 0.01 compared with either of the other groups). Endotoxemia was noticed in two such patients. Direct access of bacteria and endotoxin to the blood stream may occur during hemorrhagic or traumatic shock and is the probable cause of subsequent sepsis in traumatized patients when no other source is apparent.
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Citations
Cited by
Multiple Organ Failure Pathophysiology and Potential Future Therapy
DEITCH, E. A. (1992) · Annals of Surgery · doi:10.1097/00000658-199208000-00002 · Cited by 1,380
MOORE, F. A., FELICIANO, D. V., ANDRASSY, R. J., MCARDLE, A. H., McL. BOOTH, F. V., MORGENSTEIN-WAGNER, T. B., KELLUM, J. M., WELLING, R. E., & MOORE, E. E. (1992) · Annals of Surgery · doi:10.1097/00000658-199208000-00008 · Cited by 1,379
The indigenous gastrointestinal microflora
Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153
The prevalence of gut translocation in humans
Sedman, P. C., Macfle, J., Sagar, P., Mitchell, C. J., May, J., Mancey-Jones, B., & Johnstone, D. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90110-4 · Cited by 362
Endotoxemia: Methods of detection and clinical correlates
Hurley, J. C. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.2.268 · Cited by 318
Metadata
- Authors
- RUSH, B. F., SORI, A. J., MURPHY, T. F., SMITH, S., FLANAGAN, J. J., & MACHIEDO, G. W.
- Venue
- Annals of Surgery
- Published
- 1988-05
- Volume
- 207
- Issue
- 5
- Pages
- 549-554
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2043652442
- Cited by
- 384
- References
- 0
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- green
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- RUSH, B. F., SORI, A. J., MURPHY, T. F., SMITH, S., FLANAGAN, J. J., & MACHIEDO, G. W. (1988). Endotoxemia and Bacteremia During Hemorrhagic Shock The Link Between Trauma and Sepsis? Annals of Surgery. https://doi.org/10.1097/00000658-198805000-00009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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