The indigenous gastrointestinal microflora

Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians

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Colonization resistance of the digestive tract in conventional and antibiotic-treated mice

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Translocation of Certain Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Nodes and Other Organs in a Gnotobiotic Mouse Model

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Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: A prospective study

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Human intestinal microflora in health and disease

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Human intestinal flora

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Endotoxemia and Bacteremia During Hemorrhagic Shock The Link Between Trauma and Sepsis?

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INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT

Dubos, R. J., Schaedler, R. W., Costello, R. L., & Hoet, P. P. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.122.1.67 · Cited by 319 · see citing works

Survival and Implantation of <i>Escherichia coli</i> in the Intestinal Tract

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Simple Intestinal Obstruction Causes Bacterial Translocation in Man

Deitch, E. A. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410060065013 · Cited by 279 · see citing works

Comparison of Translocation Rates of Various Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Node

Steffen, E. K., Berg, R. D., & Deitch, E. A. (1988) · Journal of Infectious Diseases · doi:10.1093/infdis/157.5.1032 · Cited by 234 · see citing works

The normal microbial flora of man

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Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery

Ambrose, N. S., Johnson, M., Burdon, D. W., & Keighley, M. R. B. (1984) · British journal of surgery · doi:10.1002/bjs.1800710821 · Cited by 195 · see citing works

EXPERIMENTAL ENTERIC SHIGELLA AND VIBRIO INFECTIONS IN MICE AND GUINEA PIGS

Freter, R., & Hentges, W. T. T. A. O. D. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.104.3.411 · Cited by 193 · see citing works

Microbial ecology of the gut

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Bacterial Translocation in Patients with Colorectal Cancer

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Staphylococci and Infection Immunity

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Revised Estimates for the Number of Human and Bacteria Cells in the Body

Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Inflammatory bowel disease: cause and immunobiology

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Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

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The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

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Interactions between commensal intestinal bacteria and the immune system

Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,607 · see citing works

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584 · see citing works

The population genetics of commensal Escherichia coli

Tenaillon, O., Skurnik, D., Picard, B., & Denamur, É. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2298 · Cited by 1,536 · see citing works

T HE G UT B ACTERIA OF I NSECTS : Nonpathogenic Interactions

Dillon, R. J., & Dillon, V. M. (2004) · Annual Review of Entomology · doi:10.1146/annurev.ento.49.061802.123416 · Cited by 1,412 · see citing works

Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing

Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255 · see citing works

Scaling laws predict global microbial diversity

Locey, K. J., & Lennon, J. T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521291113 · Cited by 1,184 · see citing works

Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens

Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,234 · see citing works

Deciphering diversity indices for a better understanding of microbial communities

Kim, B.-R., Shin, J., Guevarra, R. B., Lee, J. H., Kim, D. W., Seol, K.-H., Lee, J.-H., Kim, H. B., & Isaacson, R. E. (2017) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1709.09027 · Cited by 1,012 · see citing works

Developmental microbial ecology of the neonatal gastrointestinal tract

Mackie, R. I., Sghir, A., & Gaskins, H. R. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1035s · Cited by 1,360 · see citing works

Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children

Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works

Brain-gut-microbe communication in health and disease

Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works

Antioxidant Properties of Probiotic Bacteria

Wang, Y., Wu, Y., Wang, Y., Xu, H., 梅小强, Yu, D., Wang, Y., & Li, W. (2017) · Nutrients · doi:10.3390/nu9050521 · Cited by 930 · see citing works

Effects of gut microbes on nutrient absorption and energy regulation

Krajmalnik‐Brown, R., Ilhan, Z., Kang, D., & DiBaise, J. K. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533611436116 · Cited by 852 · see citing works

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

Bansal, T., Alaniz, R. C., Wood, T. K., & Jayaraman, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906112107 · Cited by 868 · see citing works

Overview of gut flora and probiotics

Holzapfel, W. H., Haberer, P., Snel, J., Schillinger, U., & Veld, J. H. J. H. I. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00044-0 · Cited by 887 · see citing works

Inulin-Type Fructans: Functional Food Ingredients

Roberfroid, M. B. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2493s · Cited by 880 · see citing works

Honor thy symbionts

Xu, J., & Gordon, J. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734063100 · Cited by 856 · see citing works

Environmental Escherichia coli: ecology and public health implications—a review

Jang, J., Hur, H., Sadowsky, M., Byappanahalli, M., Yan, T., & Ishii, S. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13468 · Cited by 755 · see citing works

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation

Prockop, D. J., & Youn Oh, J. (2012) · Molecular Therapy · doi:10.1038/mt.2011.211 · Cited by 816 · see citing works

Biogeochemical processes and geotechnical applications: progress, opportunities and challenges

DeJong, J. T., Soga, K., Kavazanjian, E., Burns, S. E., van Paassen, L. A., QABANY, A. A., Aydilek, A. H., Bang, S., Burbank, M. B., Caslake, L. F., et al. (2013) · Géotechnique · doi:10.1680/geot.sip13.p.017 · Cited by 827 · see citing works

Introducing inulin-type fructans

Roberfroid, M. B. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041350 · Cited by 799 · see citing works

The Link between Phylogeny and Virulence in <i>Escherichia coli</i> Extraintestinal Infection

Picard, B., Garcia, J. S., Gouriou, S., Duriez, P., Brahimi, N., Bingen, E., Elion, J., & Denamur, E. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.546-553.1999 · Cited by 794 · see citing works

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works

Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice

Madsen, K. L., Doyle, J. S. G., Jewell, L. D., Tavernini, M. M., & Fedorak, R. N. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70013-2 · Cited by 761 · see citing works

Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases

Tlaskalová‐Hogenová, H., Štëpánková, R., Hudcovic, T., Tučková, L., Cukrowská, B., Lodinová‐Žádníková, R., Kozáková, H., Rossmann, P., Bártová, J., Sokol, D., et al. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.02.005 · Cited by 755 · see citing works

Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine

Kayama, H., Okumura, R., & Takeda, K. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-070119-115104 · Cited by 765 · see citing works

Ecological Role of Lactobacilli in the Gastrointestinal Tract: Implications for Fundamental and Biomedical Research

Walter, J. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00753-08 · Cited by 756 · see citing works

The oral microbiome: Role of key organisms and complex networks in oral health and disease

Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works

A Primer on Metagenomics

Wooley, J., Godzik, A., & Friedberg, I. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000667 · Cited by 719 · see citing works

War and peace at mucosal surfaces

Sansonetti, P. J. (2004) · Nature reviews. Immunology · doi:10.1038/nri1499 · Cited by 680 · see citing works

Chylomicrons promote intestinal absorption of lipopolysaccharides

Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662 · see citing works

Creating and Maintaining the Gastrointestinal Ecosystem: What We Know and Need To Know from Gnotobiology

Falk, P. G., Hooper, L. V., Midtvedt, T., & Gordon, J. I. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1157-1170.1998 · Cited by 643 · see citing works

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

Moreira, A. P. B., Teixeira, T. F. S., Machado, A. B. F., Pelúzio, M. D. C. G., & Alfenas, R. D. C. G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001213 · Cited by 654 · see citing works

Exercise Modifies the Gut Microbiota with Positive Health Effects

Monda, V., Villano, I., Messina, A., Valenzano, A., Esposito, T., Moscatelli, F., Viggiano, A., Cibelli, G., Chieffi, S., Monda, M., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3831972 · Cited by 654 · see citing works

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Gurbatri, C. R., Lia, I., Vincent, R., Coker, C., Castro, S., Treuting, P. M., Hinchliffe, T. E., Arpaia, N., & Danino, T. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax0876 · Cited by 647 · see citing works

Evaluation of the Efficacy of a Probiotic Containing Lactobacillus, Bifidobacterium, Enterococcus, and Pediococcus Strains in Promoting Broiler Performance and Modulating Cecal Microflora Composition and Metabolic Activities

Mountzouris, K. C., Tsirtsikos, P., Kalamara, E., Nitsch, S., Schatzmayr, G., & Fegeros, K. (2007) · Poultry Science · doi:10.1093/ps/86.2.309 · Cited by 634 · see citing works

The QseC sensor kinase: A bacterial adrenergic receptor

Clarke, M. B., Hughes, D. T., Zhu, C., Boedeker, E. C., & Sperandio, V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604343103 · Cited by 621 · see citing works

Gut Microbiota and Its Possible Relationship With Obesity

DiBaise, J. K., Zhang, H., Crowell, M. D., Krajmalnik‐Brown, R., Decker, G. A., & Rittmann, B. E. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.4.460 · Cited by 598 · see citing works

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

Paulos, C. M., Wrzesinski, C., Kaiser, Hinrichs, C. S., Chieppa, M., Cassard, L., Palmer, D. C., Boni, A., Muranski, P., Yu, Z., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32205 · Cited by 586 · see citing works

Review article: yeast as probiotics – <i>Saccharomyces boulardii</i>

CZERUCKA, D., PICHE, T., & RAMPAL, P. (2007) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2007.03442.x · Cited by 587 · see citing works

Microbial Ecology along the Gastrointestinal Tract

Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 586 · see citing works

Epithelial crosstalk at the microbiota–mucosal interface

Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574 · see citing works

PCR detection, identification to species level, and fingerprinting of Campylobacter jejuni and Campylobacter coli direct from diarrheic samples

Linton, D., Lawson, A., Owen, R. J., & Stanley, J. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.10.2568-2572.1997 · Cited by 570 · see citing works

Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity

Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563 · see citing works

Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells*

Yan, F., & Polk, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207050200 · Cited by 599 · see citing works

Advances and Trends in Omics Technology Development

Dai, X., & Shen, L. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.911861 · Cited by 567 · see citing works

Roles and regulation of the mucus barrier in the gut

Cornick, S., Tawiah, A., & Chadee, K. (2015) · Tissue Barriers · doi:10.4161/21688370.2014.982426 · Cited by 527 · see citing works

Gut inflammation can boost horizontal gene transfer between pathogenic and commensal <i>Enterobacteriaceae</i>

Stecher, B., Denzler, R., Maier, L., Bernet, F., Sanders, M. J., Pickard, D. J., Barthel, M., Westendorf, A. M., Krogfelt, K. A., Walker, A. W., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113246109 · Cited by 492 · see citing works

Gut Bacterial Metabolism of the Soy Isoflavone Daidzein: Exploring the Relevance to Human Health

Atkinson, C., Frankenfeld, C. L., & Lampe, J. W. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000302 · Cited by 516 · see citing works

Interactions among Strategies Associated with Bacterial Infection: Pathogenicity, Epidemicity, and Antibiotic Resistance

Martínez, J. L., & Baquero, F. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.4.647-679.2002 · Cited by 512 · see citing works

Microbiome evolution along divergent branches of the vertebrate tree of life: what is known and unknown

Colston, T. J., & Jackson, C. R. (2016) · Molecular Ecology · doi:10.1111/mec.13730 · Cited by 508 · see citing works

Caterpillars lack a resident gut microbiome

Hammer, T. J., Janzen, D. H., Hallwachs, W., Jaffe, S. P., & Fierer, N. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707186114 · Cited by 483 · see citing works

Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea.

Antharam, V. C., Li, E. C., Ishmael, A., Sharma, A., Mai, V., Rand, K. H., & Wang, G. P. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.00845-13 · Cited by 485 · see citing works

Life at the oxic–anoxic interface: microbial activities and adaptations

Brune, A., Frenzel, P. F., & Cypionka, H. (2000) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2000.tb00567.x · Cited by 478 · see citing works

Crohn's disease

Shanahan, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07284-7 · Cited by 478 · see citing works

The oralome and its dysbiosis: New insights into oral microbiome-host interactions

Radaic, A., & Kapila, Y. L. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.02.010 · Cited by 492 · see citing works

Programmable probiotics for detection of cancer in urine

Danino, T., Prindle, A. B., Kwong, G. A., Skalak, M., Li, H. Y., Allen, K. N., Hasty, J., & Bhatia, S. N. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3519 · Cited by 472 · see citing works

Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review

Yang, Q., Liang, Q., Balakrishnan, B., Belobrajdic, D. P., Feng, Q.-J., & Zhang, W. Y. (2020) · Nutrients · doi:10.3390/nu12020381 · Cited by 475 · see citing works

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

Liévin-Le Moal, V., & Servin, A. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.315-337.2006 · Cited by 568 · see citing works

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

Grangette, C., Nutten, S., Palumbo, E., Morath, S., Hermann, C., Dewulf, J., Pot, B., Härtung, T., Pascal Hols, A., & Mercenier, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504084102 · Cited by 443 · see citing works

Bacterial translocation from the gastrointestinal tract

Berg, R. D. (1995) · Trends in Microbiology · doi:10.1016/s0966-842x(00)88906-4 · Cited by 443 · see citing works

The role of the intestinal microbiota in the development of atopic disorders

Penders, J., Stobberingh, E. E., van den Brandt, P. A., & Thijs, C. T. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01462.x · Cited by 435 · see citing works

Bacterial Translocation from the Gastrointestinal Tract

Berg, R. D. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4143-1_2 · Cited by 407 · see citing works

Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour

Fetissov, S. O. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.150 · Cited by 403 · see citing works

Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720696115 · Cited by 400 · see citing works

Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity

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Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota

Espey, M. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.554 · Cited by 396 · see citing works

Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

Thompson, J. A., Oliveira, R. A., Djuković, A., Úbeda, C., & Xavier, K. B. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.049 · Cited by 390 · see citing works

Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation

KHALIF, I., QUIGLEY, E., KONOVITCH, E., & MAXIMOVA, I. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.06.008 · Cited by 382 · see citing works

Toll-Like Receptor 4 Signaling by Intestinal Microbes Influences Susceptibility to Food Allergy

Bashir, M. E. H., Louie, S., Shi, H. N., & Nagler‐Anderson, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6978 · Cited by 387 · see citing works

Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

Violi, F., Cammisotto, V., Bartimoccia, S., Pignatelli, P., Carnevale, R., & Nocella, C. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00737-2 · Cited by 384 · see citing works

Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens

Deitsch, K., Lukehart, S. A., & Stringer, J. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2145 · Cited by 377 · see citing works

Early childhood infection and atopic disorder

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A high-molecular-mass cell-surface protein from Lactobacillus reuteri 1063 adheres to mucus components The GenBank accession number for the sequence reported in this paper is AF120104.

Roos, S., & Jonsson, H. (2002) · Microbiology · doi:10.1099/00221287-148-2-433 · Cited by 376 · see citing works

Inflammatory bowel disease: Immunodiagnostics, immunotherapeutics, and ecotherapeutics

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