The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Long-term Course of Patients with Persistent Hypercalcitoninemia After Apparent Curative Primary Surgery for Medullary Thyroid Carcinoma
Open accessAbstract
Thirty-one patients with persistent hypercalcitoninemia after seemingly adequate primary operation for medullary thyroid carcinoma (MTC) were followed for a mean period of 11.9 years after operation. Ten patients had sporadic MTC and the remaining patients were members of families with multiple endocrine neoplasia (MEN)--either MEN 2A (15 patients) or MEN 2B (six patients). Overall 5- and 10-year survival rates were 90% and 86%, respectively. Only four patients died at the completion of the study: two of MTC and two of unrelated causes. Eleven patients (35.5%) underwent surgical re-exploration after demonstration of recurrent disease clinically or radiologically. In no patient did the calcitonin level return to normal after re-exploration. The presence of more than three metastatic nodes at the time of initial operation was a statistically significant (p = 0.003) predictor for disease recurrence. Factors approaching statistical significance were patients younger than age 35 (p = 0.06) and the percentage of cells in the S phase of cell division (0.07). This data supports a conservative surgical philosophy in the management of the patient with persistent hypercalcitoninemia after resection of MTC.
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Cites
Evidence for Calcitonin—A New Hormone from the Parathyroid That Lowers Blood Calcium
COPP, D. H., CAMERON, E. C., CHENEY, B. A., DAVIDSON, A. G. F., & HENZE, K. G. (1962) · Endocrinology · doi:10.1210/endo-70-5-638 · Cited by 697
Cited by
Elisei, R., Bottici, V., Luchetti, F., Di Coscio, G., Romei, C., Grasso, L., Miccoli, P., Iacconi, P., Basolo, F., Pinchera, A., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030550 · Cited by 537
Scollo, C., Baudin, E., Travagli, J.-P., Caillou, B., Bellon, N., Leboulleux, S., & Schlumberger, M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021713 · Cited by 369
AACE/AAES MEDICAL/SURGICAL Guidelines for Clinical Practice: Management of Thyroid Carcinoma
Cobin, R. H., Gharib, H., Bergman, D. A., Clark, O. H., Cooper, D. S., Daniels, G. H., Dickey, R. A., Duick, D. S., Garber, J. R., Hay, I. D., et al. (2001) · Endocrine Practice · doi:10.4158/ep.7.3.202 · Cited by 365
Self-citationLeboulleux, S., Baudin, E., Travagli, J., & Schlumberger, M. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02037.x · Cited by 281
for the German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hematology; and the German Thyroid Cancer Patient Support Organization Ohne Schilddrüse leben e.V., Dralle, H., Musholt, T. J., Schabram, J., Steinmüller, T., Frilling, A., Simon, D., Goretzki, P. E., Niederle, B., Scheuba, C., et al. (2013) · Langenbeck's Archives of Surgery · doi:10.1007/s00423-013-1057-6 · Cited by 279
Metadata
- Authors
- VAN HEERDEN, J. A., GRANT, C. S., GHARIB, H., HAY, I. D., & ILSTRUP, D. M.
- Venue
- Annals of Surgery
- Published
- 1990-10
- Volume
- 212
- Issue
- 4
- Pages
- 395-401
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2044683004
- Cited by
- 259
- References
- 1
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Long-term Course of Patients with Persistent Hypercalcitoninemia After Apparent Curative Primary Surgery for Medullary Thyroid Carcinoma. https://app.cochat.ai/papers/10.1097/00000658-199010000-00002
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- VAN HEERDEN, J. A., GRANT, C. S., GHARIB, H., HAY, I. D., & ILSTRUP, D. M. (1990). Long-term Course of Patients with Persistent Hypercalcitoninemia After Apparent Curative Primary Surgery for Medullary Thyroid Carcinoma. Annals of Surgery. https://doi.org/10.1097/00000658-199010000-00002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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