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The Impact of Familial Adenomatous Polyposis on the Tumorigenesis and Mortality at the Several Organs: Its Rational Treatment
Open accessAbstract
The authors reviewed the case records of 1050 familial adenomatous polyposis (FAP) patients who were registered at their institution. The organ-specific morbidity and mortality rates of malignant tumor in FAP patients were compared with those of the general population of Japan, and the prognosis after rectum-preserving operation also was calculated. The cumulative prevalence of colorectal carcinoma at the age of 44 years was 0.52 for men and 0.61 for women. The observed/expected morbidity ratio was 20.9 (95% confidence interval, 10.8-36.6) for thyroid carcinoma, 3.08 (2.03-7.75) for gastric carcinoma, and 295 (263-330) for colorectal carcinoma. The observed/expected mortality ratios was 250 (112-447) for periampullary and small intestinal carcinoma, 3.43 (1.77-6.0) for gastric carcinoma, and 210 (183-241) for colorectal carcinoma. The risk of rectal carcinoma after ileorectal anastomosis was 13% (8.5-17.5%) at 10 years and 37% at 20 years. The results clarified the impact of FAP on the carcinogenesis in several organs as a whole including preserved rectum, and suggested a direction of the rational treatment of FAP.
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Cited by
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662
van der Post, R. S., Vogelaar, I. P., Carneiro, F., Guilford, P., Huntsman, D., Hoogerbrugge, N., Caldas, C., Chelcun Schreiber, K. E., Hardwick, R. H., Ausems, M. G. E. M., et al. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103094 · Cited by 561
Extra-Intestinal Manifestations of Familial Adenomatous Polyposis
Groen, E. J., Roos, A., Muntinghe, F. L., Enting, R. H., de Vries, J., Kleibeuker, J. H., Witjes, M. J. H., Links, T. P., & van Beek, A. P. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9981-3 · Cited by 261
HARACH, H. R., WILLIAMS, G. T., & WILLIAMS, E. D. (1994) · Histopathology · doi:10.1111/j.1365-2559.1994.tb01374.x · Cited by 259
Gastrointestinal manifestations of endocrine disease
Maser, C. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i20.3174 · Cited by 42
Metadata
- Authors
- Iwama, T., Mishima, Y., & Utsunomiya, J.
- Venue
- Annals of Surgery
- Published
- 1993-02
- Volume
- 217
- Issue
- 2
- Pages
- 101-108
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2060266620
- Cited by
- 247
- References
- 0
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Impact of Familial Adenomatous Polyposis on the Tumorigenesis and Mortality at the Several Organs: Its Rational Treatment. https://app.cochat.ai/papers/10.1097/00000658-199302000-00002
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- Iwama, T., Mishima, Y., & Utsunomiya, J. (1993). The Impact of Familial Adenomatous Polyposis on the Tumorigenesis and Mortality at the Several Organs: Its Rational Treatment. Annals of Surgery. https://doi.org/10.1097/00000658-199302000-00002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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