Respiratory infections caused by non-typeable Haemophilus influenzae.
Abstract
PURPOSE OF REVIEW: This review will consider recent developments in the clinical aspects of infections due to non-typeable Haemophilus influenzae. In addition, newer developments in the areas of mechanisms of pathogenesis, host pathogen interaction, immune responses and efforts toward vaccine development will be reviewed briefly. RECENT FINDINGS: Non-typeable H. influenzae continues to be a common cause of otitis media in infants and children, sinusitis in children and adults, pneumonia in adults, and lower respiratory tract infection in adults with chronic obstructive pulmonary disease. While the rate of beta-lactamase production by isolates of H. influenzae varies geographically, most regions show a rate of 20-35% of isolates producing beta-lactamase. Recent studies have highlighted the possible role of bacterial biofilms formed by H. influenzae as a cause of otitis media. Several lines of evidence indicate that H. influenzae causes intracellular infection in the lower respiratory tract in chronic obstructive pulmonary disease and this observation has important implications in understanding the human immune response to the bacterium. Lipooligosaccharide is an important virulence factor for H. influenzae and research is generating new information on the complex role of this molecule in colonization and infection of the respiratory tract. Several surface molecules are under active evaluation as vaccine antigens. SUMMARY: Non-typeable H. influenzae is an important cause of respiratory tract infections in children and adults. Most strains are susceptible to amoxicillin/clavulanate, fluoroquinolones and the newer macrolides. Research in the next decade promises substantial progress in the challenge of developing vaccines for nontypeable H. influenzae.
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H. influenzae serotype B was a major cause of invasive disease.
“H. influenzae serotype B was a major cause of invasive disease (Wenger, 1998; Murphy, 2003; Chin et al., 2005; Brouwer et al., 2010)”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Murphy, 2003
Cites
New Strains of Bacteria and Exacerbations of Chronic Obstructive Pulmonary Disease
Sethi, S., Evans, N., Grant, B. J. B., & Murphy, T. F. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012561 · Cited by 1,046 · see citing works
Self-citationCommunity‐Acquired Pneumonia in Adults: Guidelines for Management
Bartlett, J. G., Breiman, R. F., Mandell, L. A., & File, T. M. (1998) · Clinical Infectious Diseases · doi:10.1086/513953 · Cited by 862 · see citing works
Patel, I. S. (2002) · Thorax · doi:10.1136/thorax.57.9.759 · Cited by 689 · see citing works
Bacterial Infection in Chronic Obstructive Pulmonary Disease in 2000: a State-of-the-Art Review
Sethi, S., & Murphy, T. F. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.2.336-363.2001 · Cited by 595 · see citing works
Self-citationMucosal Biofilm Formation on Middle-Ear Mucosa in the Chinchilla Model of Otitis Media
Ehrlich, G. D. (2002) · JAMA · doi:10.1001/jama.287.13.1710 · Cited by 333 · see citing works
Molecular Analysis of Bacterial Pathogens in Otitis Media With Effusion
Post, J. C. (1995) · JAMA · doi:10.1001/jama.1995.03520440052036 · Cited by 293 · see citing works
Nouira, S., Marghli, S., Belghith, M., Ouanes-Besbes, L., Elatrous, S., & Abroug, F. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07097-0 · Cited by 281 · see citing works
Shuto, T., Xu, H., Wang, B., Han, J., Kai, H., Gu, X., Murphy, T. F., LIM, D. J., & Li, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151236098 · Cited by 258 · see citing works
Self-citationCandidate's Thesis: Direct Evidence of Bacterial Biofilms in Otitis Media
Post, J. C. (2001) · The Laryngoscope · doi:10.1097/00005537-200112000-00001 · Cited by 243 · see citing works
Thornsberry, C., Sahm, D. F., Kelly, L. J., Critchley, I. A., Jones, M. E., Evangelista, A. T., & Karlowsky, J. A. (2002) · Clinical Infectious Diseases · doi:10.1086/324525 · Cited by 222 · see citing works
Bandi, V., Apicella, M. A., Mason, E. O., Murphy, T. F., Siddiqi, A., Atmar, R. L., & Greenberg, S. B. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.11.2104093 · Cited by 195 · see citing works
Self-citationDabernat, H., Delmas, C., Seguy, M., Pelissier, R., Faucon, G., Bennamani, S., & Pasquier, C. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.7.2208-2218.2002 · Cited by 187 · see citing works
Nursing Home–Acquired Pneumonia
Mylotte, J. M. (2002) · Clinical Infectious Diseases · doi:10.1086/344281 · Cited by 187 · see citing works
Murphy, T. F., & Kirkham, C. (2002) · BMC Microbiology · doi:10.1186/1471-2180-2-7 · Cited by 176 · see citing works
Self-citationWang, B., LIM, D. J., Han, J., Kim, Y. S., Basbaum, C. B., & Li, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107484200 · Cited by 125 · see citing works
Bacteriologic Findings Associated with Chronic Bacterial Maxillary Sinusitis in Adults
Finegold, S. M., Flynn, M. J., Rose, F. V., Jousimies-Somer, H. R., Jakielaszek, C., McTeague, M., Wexler, H. M., Berkowitz, E. M., & Wynne, B. (2002) · Clinical Infectious Diseases · doi:10.1086/341899 · Cited by 124 · see citing works
Post, J. C., Aul, J. J., White, G. J., Wadowsky, R. M., Zavoral, T., Tabari, R., Kerber, B., Doyle, W. J., & Ehrlich, G. D. (1996) · American Journal of Otolaryngology · doi:10.1016/s0196-0709(96)90005-8 · Cited by 119 · see citing works
The Haemophilus influenzae Hap Autotransporter Binds to Fibronectin, Laminin, and Collagen IV
Fink, D. L., Green, B. A., & Geme, J. W. S. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.4902-4907.2002 · Cited by 116 · see citing works
Molecular and cellular determinants of non-typeable Haemophilus influenzae adherence and invasion
Geme, J. W. S. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00180.x · Cited by 115 · see citing works
Jones, P. A., Samuels, N. M., Phillips, N. J., Munson, R. S., Bozue, J. A., Arseneau, J. A., Nichols, W. A., Zaleski, A., Gibson, B. W., & Apicella, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110986200 · Cited by 107 · see citing works
Otitis Media in Children. I. The Systemic Immune Response to Nontypable Hemophilus influenzae
Faden, H. S., Bernstein, J. M., Brodsky, L., Stanievich, J. F., Krystofik, D., Shuff, C., Hong, J. J., & Ogra, P. L. O. (1989) · The Journal of Infectious Diseases · doi:10.1093/infdis/160.6.999 · Cited by 103 · see citing works
Jono, H., Shuto, T., Xu, H., Kai, H., LIM, D. J., Gum, J. R., Kim, Y. S., Yamaoka, S., Feng, X., & Li, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206883200 · Cited by 98 · see citing works
Turner, D., Leibovitz, E., Aran, A. A., Piglansky, L., RAIZ, S., Leiberman, A., & Dagan, R. (2002) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200207000-00013 · Cited by 96 · see citing works
Shurin, P. A., Pelton, S. I., Tager, I. B., & Kasper, D. L. (1980) · The Journal of Pediatrics · doi:10.1016/s0022-3476(80)80182-x · Cited by 92 · see citing works
Peerbooms, P. G. H., Engelen, M. N., Stokman, D. A. J., BENTHEM, B. H. B. V., van Weert, M.-L., Bruisten, S. M., van Belkum, A., & Coutinho, R. A. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.8.2832-2836.2002 · Cited by 89 · see citing works
Bacteriology of Acute and Chronic Frontal Sinusitis
Brook, I. (2002) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.128.5.583 · Cited by 82 · see citing works
Abe, Y., Murphy, T. F., Sethi, S., Faden, H. S., Dmochowski, J., Harabuchi, Y., & Thanavala, Y. M. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.7.2109009 · Cited by 78 · see citing works
Self-citationTalbot, G. H., Kennedy, D. W., Scheld, W. M., Granito, K., & for the Endoscopy Study Group (2001) · Clinical Infectious Diseases · doi:10.1086/323813 · Cited by 78 · see citing works
Starner, T. D., Swords, W. E., Apicella, M. A., & McCray, P. B. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.5287-5289.2002 · Cited by 74 · see citing works
Ueyama, T., Kurono, Y., Shirabe, K., Takeshita, M., & Mogi, G. (1995) · Journal of Clinical Microbiology · doi:10.1128/jcm.33.7.1835-1838.1995 · Cited by 73 · see citing works
Fan, X., Goldfine, H., Lysenko, E., & Weiser, J. N. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02571.x · Cited by 71 · see citing works
Chronic Obstructive Pulmonary Disease
Murphy, T. F., & Sethi, S. (2002) · Drugs & Aging · doi:10.2165/00002512-200219100-00005 · Cited by 70 · see citing works
Self-citationTreatment of Acute Otitis Media Consensus Recommendations
Hoberman, A., Marchant, C. D., Kaplan, S. L., & Feldman, S. (2002) · Clinical Pediatrics · doi:10.1177/000992280204100602 · Cited by 70 · see citing works
Ghaffar, F., Muniz, L. S., Katz, K., Smith, J. L., Shouse, T., Davis, P., & McCracken, G. H. (2002) · Clinical Infectious Diseases · doi:10.1086/340054 · Cited by 66 · see citing works
Survival of nontypeable Haemophilus influenzae in macrophages
Craig, J. E., Cliffe, A. R., Garnett, K. E., & High, N. J. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10820.x · Cited by 63 · see citing works
Marco, F., García-de-Lomas, J., Garcı́a-Rey, C., Bouza, E., Aguilar, L., Fernández-Mazarrasa, C., & The Spanish Surveillance Group for Respiratory Pathogens (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.3226-3228.2001 · Cited by 62 · see citing works
Diagnosis and treatment of upper respiratory tract infections in the primary care setting
Fendrick, A. M., Saint, S. K., Brook, I., Jacobs, M. R., Pelton, S. I., & Sethi, S. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80137-5 · Cited by 61 · see citing works
Cutter, D., Mason, K. W., Howell, A. P., Fink, D. L., Green, B. A., & Geme, J. W. S. (2002) · The Journal of Infectious Diseases · doi:10.1086/344233 · Cited by 60 · see citing works
Management of acute bacterial rhinosinusitis
Conrad, D. A., & Jenson, H. B. (2002) · Current Opinion in Pediatrics · doi:10.1097/00008480-200202000-00015 · Cited by 58 · see citing works
Karlowsky, J. A., Critchley, I. A., Blosser-Middleton, R. S., Karginova, E. A., Jones, M. E., Thornsberry, C., & Sahm, D. F. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.3.1063-1066.2002 · Cited by 55 · see citing works
Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain 1003
Månsson, M., Hood, D. W., Li, J., Richards, J. C., Moxon, E. R., & Schweda, E. K. H. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02707.x · Cited by 54 · see citing works
Pettigrew, M. M., Foxman, B., Marrs, C. F., & Gilsdorf, J. R. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3551-3556.2002 · Cited by 50 · see citing works
Marchisio, P., Gironi, S., Esposito, S., Schito, G. C., MANNELLI, S., & Principi, N. (2001) · Journal of Medical Microbiology · doi:10.1099/0022-1317-50-12-1095 · Cited by 48 · see citing works
Swords, W. E., Chance, D. L., Cohn, L. A., Shao, J., Apicella, M. A., & Smith, A. L. (2002) · Infection and Immunity · doi:10.1128/iai.70.8.4661-4668.2002 · Cited by 47 · see citing works
Glycine is a common substituent of the inner core in Haemophilus influenzae lipopolysaccharide
Li, J., Bauer, S. H. J., Mansson, M., Moxon, E. R., Richards, J. C., & Schweda, E. K. H. (2001) · Glycobiology · doi:10.1093/glycob/11.12.1009 · Cited by 46 · see citing works
Molecular analysis of bacterial pathogens in otitis media with effusion
Post, J. C. (1995) · JAMA · doi:10.1001/jama.273.20.1598 · Cited by 43 · see citing works
Shao, J., Zhang, J., Kowal, P., Lu, Y., & Wang, P. G. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00615-0 · Cited by 38 · see citing works
Bauer, S. H. J., Månsson, M., Hood, D. W., Richards, J. C., Moxon, E. R., & Schweda, E. K. H. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00242-7 · Cited by 38 · see citing works
Cox, A. D., Hood, D. W., Martin, A., Makepeace, K., Deadman, M. E., Li, J., Brisson, J., Moxon, E. R., & Richards, J. C. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03090.x · Cited by 36 · see citing works
Cox, A. D., Masoud, H., Thibault, P., Brisson, J., van der Zwan, M., Perry, M. B., & Richards, J. C. (2001) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02459.x · Cited by 33 · see citing works
Schweda, E. K. H., Li, J., Moxon, E. R., & Richards, J. C. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00002-2 · Cited by 33 · see citing works
Colonization rate of bacteria in the throat of healthy infants
Berkovitch, M., Bulkowstein, M., Zhovtis, D., Greenberg, R., Nitzan, Y., Barzilay, B., & Boldur, I. (2002) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/s0165-5876(01)00635-8 · Cited by 32 · see citing works
Jones, M. E., Karlowsky, J. A., Blosser-Middleton, R. S., Critchley, I. A., Thornsberry, C., & Sahm, D. F. (2002) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(01)00480-0 · Cited by 32 · see citing works
Hiltke, T. J., Sethi, S., & Murphy, T. F. (2002) · The Journal of Infectious Diseases · doi:10.1086/339362 · Cited by 30 · see citing works
Self-citationHotomi, M., Yamanaka, N., Shimada, J., Suzumoto, M., Ikeda, Y., Sakai, A., Arai, J., & Green, B. (2002) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/s0165-5876(02)00076-9 · Cited by 26 · see citing works
Microbiology of acute otitis media recently treated with aminopenicillins
Block, S. L., HEDRICK, J. A., Tyler, R. D., Smith, R. A., & Harrison, C. J. (2001) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200111000-00003 · Cited by 25 · see citing works
Resistant bacteria in the adenoid tissues of children with otitis media with effusion
Karlıdağ, T., Demırdağ, K., Kaygusuz, İ., Özden, M., Yalçın, Ş., & Öztürk, L. (2002) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/s0165-5876(02)00038-1 · Cited by 24 · see citing works
Novotny, L. A., Pichichero, M. E., Denoël, P., Neyt, C., Vanderschrick, S., Dequesne, G., & Bakaletz, L. O. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00306-7 · Cited by 23 · see citing works
Interaction of vitronectin with Haemophilus influenzae
Eberhard, T., & Ullberg, M. (2002) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2002.tb00627.x · Cited by 22 · see citing works
Turnak, M. R., Bandak, S. I., Bouchillon, S. K., Allen, B. S., & Hoban, D. J. (2001) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2001.00344.x · Cited by 19 · see citing works
Nasopharyngeal carriage ofHaemophilus influenzae
Das, B. K., Arora, N. K., Mathur, P., Ostwal, P., Mandal, S., Kabra, S. K., Kapil, A., Lalitha, M. K., & Thomas, K. (2002) · The Indian Journal of Pediatrics · doi:10.1007/bf02723690 · Cited by 17 · see citing works
Munson, E. L., Pfaller, M. A., Koontz, F. P., & Doern, G. V. (2002) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-001-0688-7 · Cited by 16 · see citing works
Peptide and recombinant antigens for protection against bacterial middle ear infection
Bakaletz, L. O. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00522-3 · Cited by 16 · see citing works
van Ulsen, P., van Schilfgaarde, M., Dankert, J., Jansen, H. M., & van Alphen, L. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03025.x · Cited by 15 · see citing works
Antimicrobial susceptibility of Haemophilus influenzae among children in Beijing, China, 1999-2000
Hu, Y., Yu, S., Liu, G., Gao, W., & Yang, Y. (2002) · Acta Paediatrica · doi:10.1111/j.1651-2227.2002.tb01684.x · Cited by 15 · see citing works
Casagrande, S. T., Landgraf, I. M., Kobata, A. M. M., Zanella, R. C., & Bokermann, S. (2002) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2002001100006 · Cited by 14 · see citing works
Harabuchi, H. K. Y., Kodama, H., & Faden, H. (2001) · Acta Oto-Laryngologica · doi:10.1080/00016480127372 · Cited by 14 · see citing works
Epidemiology of Major Respiratory Pathogens
Debbia, E., Schito, G. C., Zoratti, A., Gualco, L., Tonoli, E., & Marchese, A. E. (2001) · Journal of Chemotherapy · doi:10.1179/joc.2001.13.supplement-2.205 · Cited by 13 · see citing works
Modelling of endemic carriage ofHaemophilus influenzaein Aboriginal infants in Northern Australia
Smith‐Vaughan, H., McBroom, J., & Mathews, J. D. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00510.x · Cited by 13 · see citing works
Harabuchi, Y., Kodama, H., & Faden, H. S. (2001) · Acta Oto-Laryngologica · doi:10.1080/000164801317166763 · Cited by 13 · see citing works
Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis
Cripps, A. W., Foxwell, R., & Kyd, J. M. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00373-4 · Cited by 12 · see citing works
Karin Lindberg, R. G. (2001) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540110076769 · Cited by 12 · see citing works
Prevention of Otitis Media by Vaccination
Russell, F. M., & Mulholland, K. (2002) · Drugs · doi:10.2165/00003495-200262100-00002 · Cited by 10 · see citing works
Vaccine prevention of acute otitis media
Greenberg, D. P., & Hoberman, A. (2001) · Current Allergy and Asthma Reports · doi:10.1007/s11882-001-0049-8 · Cited by 8 · see citing works
Stratchounski, L. S., Кречикова, О. И., Reshedko, G., Stetsiouk, О. U., Kandalov, M. M., Egorova, O. A., BOYKO, L. M., Рябкова, Е. Л., Дмитриевна, Т. Г., & Blokhin, B. M. (2001) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(01)00391-0 · Cited by 6 · see citing works
Karma, P. H. (2002) · ORL · doi:10.1159/000057785 · Cited by 4 · see citing works
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Morris, D. E., Cleary, D. W., & Clarke, S. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01041 · Cited by 576 · see citing works
Lysenko, E. S., Ratner, A. J., Nelson, A. L., & Weiser, J. N. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010001 · Cited by 209 · see citing works
Harrison, A., Dyer, D. W., Gillaspy, A. F., Ray, W. C., Mungur, R., Carson, M. B., Zhong, H., Gipson, J. R., Gipson, M., Johnson, L. S., et al. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.13.4627-4636.2005 · Cited by 209 · see citing works
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Murphy, T. F., Bakaletz, L. O., & Smeesters, P. R. (2009) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181b6d7ec · Cited by 166 · see citing works
Self-citationLugade, A. A., Bogner, P. N., Thatcher, T. H., Sime, P. J., Phipps, R. P., & Thanavala, Y. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302584 · Cited by 147 · see citing works
Greenberg, D., Givon-Lavi, N., Broides, A., Blancovich, I., Peled, N., & Dagan, R. (2006) · Clinical Infectious Diseases · doi:10.1086/500935 · Cited by 140 · see citing works
Non-Typeable Haemophilus influenzae Invasion and Persistence in the Human Respiratory Tract
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Self-citationSharpe, S. W., Kuehn, M. J., & Mason, K. M. (2011) · Infection and Immunity · doi:10.1128/iai.05332-11 · Cited by 133 · see citing works
Taylor–Brown, A., Vaughan, L., Greub, G., Timms, P., & Polkinghorne, A. (2014) · Pathogens and Disease · doi:10.1093/femspd/ftu009 · Cited by 129 · see citing works
Hong, W., Mason, K. M., Jurcisek, J. A., Novotny, L. A., Bakaletz, L. O., & Swords, W. E. (2006) · Infection and Immunity · doi:10.1128/iai.01691-06 · Cited by 128 · see citing works
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Thornton, R. B., Rigby, P. J., Wiertsema, S. P., Filion, P. R., Langlands, J., Coates, H. L. C., Vijayasekaran, S., Keil, A. D., & Richmond, P. (2011) · BMC Pediatrics · doi:10.1186/1471-2431-11-94 · Cited by 127 · see citing works
Slevogt, H., Seybold, J., Tiwari, K. N., Hocke, A. C., Jonatat, C., Dietel, S., Hippenstiel, S., Singer, B. B., Bachmann, S., Suttorp, N., et al. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00821.x · Cited by 118 · see citing works
Ahearn, C. P., Gallo, M. C., & Murphy, T. F. (2017) · Pathogens and Disease · doi:10.1093/femspd/ftx042 · Cited by 105 · see citing works
Self-citationMoghaddam, S. J., Clement, C. G., la Garza, M. M. D., Zou, X., Travis, E. L., Young, H. W. J., Evans, C. M., Tuvim, M. J., & Dickey, B. F. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0366oc · Cited by 96 · see citing works
Wiertsema, S. P., Kirkham, L. S., Corscadden, K. J., Mowe, E. N., Bowman, J. M., Jacoby, P. A., Francis, R. W., Vijayasekaran, S., Coates, H. L. C., Riley, T. V., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.05.035 · Cited by 92 · see citing works
Binks, M., Temple, B., Kirkham, L. S., Wiertsema, S. P., Dunne, E. M., Richmond, P., Marsh, R. L., Leach, A. J., & Smith‐Vaughan, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034083 · Cited by 91 · see citing works
Ren, D., Walker, A. N., & Daines, D. A. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-263 · Cited by 84 · see citing works
Nakamura, S., Shchepetov, M., Dalia, A. B., Clark, S. E., Murphy, T. F., Sethi, S., Gilsdorf, J. R., Smith, A. L., & Weiser, J. N. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001247 · Cited by 82 · see citing works
Self-citationMason, K. M., Bruggeman, M. E., Munson, R. S., & Bakaletz, L. O. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05460.x · Cited by 82 · see citing works
Brockson, M. E., Novotny, L. A., Mokrzan, E. M., Malhotra, S., Jurcisek, J. A., Akbar, R., Devaraj, A., Goodman, S. D., & Bakaletz, L. O. (2014) · Molecular Microbiology · doi:10.1111/mmi.12735 · Cited by 81 · see citing works
Intercellular adhesion and biocide resistance in nontypeable Haemophilus influenzae biofilms
Izano, E. A., Shah, S. M., & Kaplan, J. B. (2009) · Microbial Pathogenesis · doi:10.1016/j.micpath.2009.01.004 · Cited by 79 · see citing works
Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer
Moghaddam, S. J. (2011) · International Journal of COPD · doi:10.2147/copd.s15417 · Cited by 75 · see citing works
Prymula, R., Hanovcová, I., Špliňo, M., Kriz, P., Motlová, J., Lebedova, V., Lommel, P., Kaliskova, E., Pascal, T. G., & Borys, D. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.12.086 · Cited by 72 · see citing works
Mason, K. M., Raffel, F. K., Ray, W. C., & Bakaletz, L. O. (2011) · Journal of Bacteriology · doi:10.1128/jb.01313-10 · Cited by 72 · see citing works
Antiinflammatory Role of MUC1 Mucin during Infection with Nontypeable Haemophilus influenzae
Kyo, Y., Kato, K., Park, Y. S., Gajhate, S., Umehara, T., Lillehoj, E. P., Suzaki, H., & Kim, K. C. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0142oc · Cited by 70 · see citing works
A Mouse Model of Lethal Synergism Between Influenza Virus and Haemophilus influenzae
Lee, L. N., Dias, P. B., Han, D., Yoon, S., Shea, A., Zakharov, V., Parham, D. M., & Sarawar, S. R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090596 · Cited by 69 · see citing works
Identification of biofilm proteins in non-typeable Haemophilus Influenzae.
Gallaher, T. K., Wu, S., Webster, P. C., & Aguilera, R. (2006) · BMC Microbiology · doi:10.1186/1471-2180-6-65 · Cited by 68 · see citing works
Analysis of the Microbiota of Black Stain in the Primary Dentition
Li, Y., Zhang, Q., Zhang, F., Liu, R., He, L., & Chen, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137030 · Cited by 65 · see citing works
Jurcisek, J. A., Brockman, K. L., Novotny, L. A., Goodman, S. D., & Bakaletz, L. O. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705508114 · Cited by 62 · see citing works
Clementi, C. F., Håkansson, A., & Murphy, T. F. (2013) · Infection and Immunity · doi:10.1128/iai.00864-13 · Cited by 60 · see citing works
Self-citationSchutter, I. D., Dreesman, A., Soetens, O., Waele, M. D., Crokaert, F., Verhaegen, J., Piérard, D., & Malfroot, A. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-83 · Cited by 59 · see citing works
A review of the role of Haemophilus influenzae in community-acquired pneumonia
Slack, M. (2015) · Pneumonia · doi:10.15172/pneu.2015.6/520 · Cited by 62 · see citing works
Jones, M. B., Nasirikenari, M., Lugade, A. A., Thanavala, Y. M., & Lau, J. T. Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.345710 · Cited by 56 · see citing works
Pneumococcal Polysaccharide Protein D-Conjugate Vaccine (Synflorix™; PHiD-CV)
Croxtall, J. D., & Keating, G. M. (2009) · Pediatric Drugs · doi:10.2165/11202760-000000000-00000 · Cited by 54 · see citing works
Novotny, L. A., Adams, L. D., Kang, D., Wiet, G. J., Cai, X., Sethi, S., Murphy, T. F., & Bakaletz, L. O. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.08.017 · Cited by 54 · see citing works
Self-citationSriram, K. B., Cox, A. J., Clancy, R. L., Slack, M., & Cripps, A. W. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2017.1329274 · Cited by 54 · see citing works
Identification of a haem-utilization protein (Hup) in Haemophilus influenzae
Morton, D. J. (2004) · Microbiology · doi:10.1099/mic.0.27238-0 · Cited by 52 · see citing works
Zhu, B., Xiao, D., Zhang, H., Zhang, Y., Gao, Y., Xu, L., Lv, J., Wang, Y., Zhang, J., & Shao, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056139 · Cited by 52 · see citing works
Singh, B., Jalalvand, F., Mörgelin, M., Zipfel, P. F., Blom, A. M., & Riesbeck, K. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07678.x · Cited by 52 · see citing works
Toxin-antitoxin systems in bacterial pathogenesis
Sonika, S., Singh, S., Mishra, S., & Verma, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14220 · Cited by 49 · see citing works
Construction of non-polar mutants in Haemophilus influenzae using FLP recombinase technology
Tracy, E. N., Ye, F., Baker, B. D., & Munson, R. S. (2008) · BMC Molecular Biology · doi:10.1186/1471-2199-9-101 · Cited by 49 · see citing works
Fernaays, M. M., Lesse, A. J., Cai, X., & Murphy, T. F. (2006) · Infection and Immunity · doi:10.1128/iai.00796-06 · Cited by 48 · see citing works
Self-citationMurphy, T. F., Kirkham, C., & Lesse, A. J. (2006) · Infection and Immunity · doi:10.1128/iai.00692-06 · Cited by 47 · see citing works
Self-citationRosadini, C. V., Ram, S., & Akerley, B. J. (2013) · Infection and Immunity · doi:10.1128/iai.01224-13 · Cited by 47 · see citing works
Novotny, L. A., & Bakaletz, L. O. (2016) · Cellular Microbiology · doi:10.1111/cmi.12575 · Cited by 46 · see citing works
Fernaays, M. M., Lesse, A. J., Sethi, S., Cai, X., & Murphy, T. F. (2006) · Infection and Immunity · doi:10.1128/iai.01904-05 · Cited by 47 · see citing works
Self-citationMokrzan, E. M., Novotny, L. A., Brockman, K. L., & Bakaletz, L. O. (2018) · mBio · doi:10.1128/mbio.02423-18 · Cited by 45 · see citing works
Health and economic impact of PHiD-CV in Canada and the UK: a Markov modelling exercise
Knerer, G., Ismaila, A., & Pearce, D. (2011) · Journal of Medical Economics · doi:10.3111/13696998.2011.622323 · Cited by 40 · see citing works
Szelestey, B. R., Heimlich, D. R., Raffel, F. K., Justice, S. S., & Mason, K. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003709 · Cited by 40 · see citing works
Harrison, A., Hardison, R. L., Wallace, R. M., Fitch, J., Heimlich, D. R., Bryan, M. O., Dubois, L. G., John‐Williams, L. S., Sebra, R., White, P., et al. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-019-0105-6 · Cited by 40 · see citing works
Rosadini, C. V., Gawronski, J. D., Raimunda, D., Argüello, J. M., & Akerley, B. J. (2011) · Infection and Immunity · doi:10.1128/iai.05135-11 · Cited by 38 · see citing works
Hare, K. M., Binks, M., Grimwood, K., Chang, A. B., Leach, A. J., & Smith‐Vaughan, H. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.00566-12 · Cited by 38 · see citing works
Kaur, R., Chang, A. J., Xu, Q., Casey, J. R., & Pichichero, M. E. (2011) · Journal of Medical Microbiology · doi:10.1099/jmm.0.034041-0 · Cited by 38 · see citing works
Hotomi, M., Arai, J., Billal, D. S., Takei, S., Ikeda, Y., Ogami, M., Kono, M., BEDER, L. B., Toya, K., Kimura, M., et al. (2009) · Auris Nasus Larynx · doi:10.1016/j.anl.2009.03.012 · Cited by 38 · see citing works
Berglund, J. S., Vink, P., Silva, F. T. D., Lestrate, P., & Boutriau, D. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00430-13 · Cited by 38 · see citing works
Murphy, T. F., & Brauer, A. L. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-183 · Cited by 38 · see citing works
Self-citationProtein E ofHaemophilus influenzaeIs a Ubiquitous Highly Conserved Adhesin
Singh, B., Brant, M., Kilian, M., Hallström, B. M., & Riesbeck, K. (2009) · The Journal of Infectious Diseases · doi:10.1086/649782 · Cited by 38 · see citing works
Zhao, L., Xia, J., Li, T., Zhou, H., Ouyang, W., Hong, Z., Ke, Y., Qian, J., & Xu, F. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw205 · Cited by 37 · see citing works
The Haemophilus influenzae Sap Transporter Mediates Bacterium-Epithelial Cell Homeostasis
Raffel, F. K., Szelestey, B. R., Beatty, W. L., & Mason, K. M. (2012) · Infection and Immunity · doi:10.1128/iai.00942-12 · Cited by 36 · see citing works
Vogel, A. R., Szelestey, B. R., Raffel, F. K., Sharpe, S. W., Gearinger, R. L., Justice, S. S., & Mason, K. M. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00042 · Cited by 35 · see citing works
Vesikari, T., Karvonen, A., Lindblad, N., Korhonen, T., Lommel, P., Willems, P., Dieussaert, I., & Schuerman, L. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181dffabf · Cited by 33 · see citing works
Sun, D., Matsune, S., Ohori, J., Fukuiwa, T., Ushikai, M., & Kurono, Y. (2005) · Auris Nasus Larynx · doi:10.1016/j.anl.2005.01.004 · Cited by 31 · see citing works
Lagos, R., Muñoz, A., Levine, M. M., Lepetic, A., François, N., Yarzábal, J. P., & Schuerman, L. (2011) · Human Vaccines · doi:10.4161/hv.7.5.14634 · Cited by 30 · see citing works
Microbiology of non-CF bronchiectasis
Foweraker, J. E., & Wat, D. (2011) · European Respiratory Society eBooks · doi:10.1183/1025448x.10003610 · Cited by 31 · see citing works
By, Å., Sobocki, P., Forsgren, A., & Silfverdal, S. (2012) · Clinical Therapeutics · doi:10.1016/j.clinthera.2011.12.007 · Cited by 30 · see citing works
Shukla, S. D., Sohal, S. S., O’Toole, R., Eapen, M. S., & Walters, E. H. (2015) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2015.1070673 · Cited by 29 · see citing works
Noda, K., Kodama, S., Umemoto, S., Abe, N., Hirano, T., & Suzuki, M. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.05.005 · Cited by 29 · see citing works
Noda, K., Kodama, S., Umemoto, S., Nomi, N., Hirano, T., & Suzuki, M. (2011) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2011.00352.x · Cited by 28 · see citing works
Endotoxin Up-regulates Interleukin-18
Kelly, D. M., Greene, C. M., Meachery, G. J., O’Mahony, M. J., Gallagher, P. M., Taggart, C. C., O'Neill, S. J., & McElvaney, N. G. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200411-1594oc · Cited by 28 · see citing works
Abe, N., Kodama, S., Hirano, T., Eto, M., & Suzuki, M. (2006) · The Laryngoscope · doi:10.1097/01.mlg.0000199740.04730.d4 · Cited by 28 · see citing works
Otitis media: concepts and controversies
Darrow, D. H., Dash, N., & Derkay, C. S. (2003) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/00020840-200312000-00002 · Cited by 28 · see citing works
Watanabe, H., Hoshino, K., Sugita, R., Asoh, N., Watanabe, K., Oishi, K., & Nagatake, T. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.1.362-365.2004 · Cited by 28 · see citing works
Buchinsky, F. J., Forbes, M. L., Hayes, J. D., Shen, K., Ezzo, S., Compliment, J. M., Hogg, J., Hiller, N. L., Hu, F. Z., Post, J. C., et al. (2007) · BMC Microbiology · doi:10.1186/1471-2180-7-56 · Cited by 27 · see citing works
Biofilm Biology and Vaccine Strategies for Otitis Media Due to Nontypeable Haemophilus influenzae
Novotny, L. A., Brockman, K. L., Mokrzan, E. M., Jurcisek, J. A., & Bakaletz, L. O. (2018) · Journal of Pediatric Infectious Diseases · doi:10.1055/s-0038-1660818 · Cited by 24 · see citing works
Nontypeable Haemophilus influenzae Genetic Islands Associated with Chronic Pulmonary Infection
Zhang, L., Xie, J., PATEL, M. J., Bakhtyar, A., Ehrlich, G. D., Ahmed, A., Earl, J., Marrs, C. F., Clemans, D. L., Murphy, T. F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044730 · Cited by 25 · see citing works
Self-citationUnderstanding nontypeable Haemophilus influenzae and chronic obstructive pulmonary disease
Alikhan, M. M., & Lee, F. E.-H. (2014) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000023 · Cited by 24 · see citing works
Kong, M. M., Yang, B., Gong, C. J., Wang, H., Li, X., Zhao, K., Li, J. J., Wu, F., Liu, X., & Hu, Z. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13489 · Cited by 23 · see citing works
A murine model of ulcerative colitis: induced with sinusitis-derived superantigen and food allergen
Yang, P., Wang, C., & An, Z.-Y. (2005) · BMC Gastroenterology · doi:10.1186/1471-230x-5-6 · Cited by 23 · see citing works
Hardison, R. L., Harrison, A., Wallace, R. M., Heimlich, D. R., O’Bryan, M. E., Sebra, R., Pinkett, H. W., Justice, S. S., & Mason, K. M. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007355 · Cited by 22 · see citing works
Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System
Bertelsen, M. B., Senissar, M., Nielsen, M., Bisiak, F., Cunha, M. V., Molinaro, A. L., Daines, D. A., & Brodersen, D. E. (2020) · Structure · doi:10.1016/j.str.2020.10.002 · Cited by 21 · see citing works
Satola, S. W., Napier, B. A., & Farley, M. M. (2008) · Infection and Immunity · doi:10.1128/iai.00672-08 · Cited by 21 · see citing works
Vaccine Candidates against Nontypeable Haemophilus influenzae: a Review
Behrouzi, A., Vaziri, F., Jamnani, F. R., Afrough, P., Rahbar, M., Satarian, F., & Siadat, S. D. (2017) · Iranian Biomedical Journal · doi:10.18869/acadpub.ibj.21.2.69 · Cited by 21 · see citing works
Aziz, A., Sarovich, D. S., Nosworthy, E., Beissbarth, J., Chang, A. B., Smith‐Vaughan, H., Price, E. P., & Harris, T. M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01622 · Cited by 21 · see citing works
Characterization of the Haemophilus influenzae tehB gene and its role in virulence
Whitby, P. W., Seale, T. W., Morton, D. J., VanWagoner, T. M., & Stull, T. L. (2010) · Microbiology · doi:10.1099/mic.0.036400-0 · Cited by 20 · see citing works
Identification and Characterization of msf, a Novel Virulence Factor in Haemophilus influenzae
Kress-Bennett, J. M., Hiller, N. L., Eutsey, R. A., Powell, E., Longwell, M. J., Hillman, T. A., Blackwell, T., Byers, B., Mell, J. C., Post, J. C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149891 · Cited by 20 · see citing works
Recombinant Sialyltransferase Infusion Mitigates Infection-Driven Acute Lung Inflammation
Nasirikenari, M., Lugade, A. A., Neelamegham, S., Gao, Z., Moremen, K. W., Bogner, P. N., Thanavala, Y. M., & Lau, J. T. Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00048 · Cited by 20 · see citing works
Kodama, S., Hirano, T., Noda, K., Umemoto, S., & Suzuki, M. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.12.129 · Cited by 19 · see citing works
Dietert, R. R. (2008) · Current Drug Safety · doi:10.2174/157488608785699450 · Cited by 19 · see citing works
Murine Model of Chronic Respiratory Inflammation
Lugade, A. A., Bogner, P. N., & Thanavala, Y. M. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5632-3_11 · Cited by 18 · see citing works
Clinical and Laboratory Evidence for Neisseria Meningitidis Biofilms
Neil, R. B., & Apicella, M. A. (2009) · Future Microbiology · doi:10.2217/fmb.09.27 · Cited by 17 · see citing works
Andersson, M., Resman, F., Eitrem, R., Drobni, P., Riesbeck, K., Kahlmeter, G., & Sundqvist, M. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-1319-8 · Cited by 17 · see citing works
Kodama, S., Hirano, T., Noda, K., Abe, N., & Suzuki, M. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.01.043 · Cited by 17 · see citing works
Kosikowska, U., Malm, A., Pitucha, M., Rajtar, B., & Polz‐Dacewicz, M. (2013) · Medicinal Chemistry Research · doi:10.1007/s00044-013-0700-7 · Cited by 17 · see citing works
McCrea, K. W., Xie, J., Marrs, C. F., & Gilsdorf, J. R. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-286 · Cited by 17 · see citing works
Haro, K., Ogawa, M., Saito, M., Kusuhara, K., & Fukuda, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-77271-z · Cited by 16 · see citing works
Wu, T.-H., Chen, J., Murphy, T. F., Green, B. A., & Gu, X. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.06.014 · Cited by 16 · see citing works
Self-citationNürnberg, S., Claus, H., Krone, M., Vogel, U. F., & Lâm, T. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa557 · Cited by 15 · see citing works
Kodama, S., Abe, N., Hirano, T., & Suzuki, M. (2011) · Acta Oto-Laryngologica · doi:10.3109/00016489.2011.576429 · Cited by 15 · see citing works
- Authors
- Murphy, T. F.
- Affiliations
- Buffalo VA Medical Center (US)
- Corresponding author
- Murphy, Timothy F.
- ORCID
- Murphy, Timothy F.
- Venue
- Current Opinion in Infectious Diseases
- Published
- 2003-04
- Volume
- 16
- Issue
- 2
- Pages
- 129-134
- ISSN
- 0951-7375 (ISSN-L)
- OpenAlex
- W1977497036
- Cited by
- 165
- References
- 75
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 14
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- nontypeable Haemophilus influenzae, respiratory infections, otitis media, sinusitis, pneumonia, chronic obstructive pulmonary disease, beta-lactamase, biofilm, intracellular infection, lipooligosaccharide, virulence factors, host-pathogen interaction, immune response, vaccine development, vaccine antigens, antimicrobial susceptibility
- MeSH terms
- Adult, Anti-Bacterial Agents, Child, Haemophilus Infections, Haemophilus influenzae, Humans, Lipopolysaccharides, Nasopharynx, Otitis Media, Respiratory Tract Infections, Pulmonary Disease, Chronic Obstructive
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