The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Different mechanisms in the tumorigenesis of proximal and distal colon cancers
Abstract
Environment or genetic constitutions can lead to an increase of genetic or epigenetic events and increase the risk for malignancy. Genomic instability is seen in most types of malignancies. Two forms of genetic instability have been described in colorectal cancer: chromosomal instability (CIN), and microsatellite instability (MIN). Almost all sporadic MIN tumors occur in the proximal colon, whereas most sporadic CIN tumors are distributed in the distal colon. The two familial syndromes, familial adenomatous polyposis and Lynch syndrome, constitute models for the different carcinogenic mechanisms in CIN and MIN tumors, respectively. This article reviews the principal differences between CIN and MIN tumors, evidence for a proximal and distal route in carcinogenesis, gender differences, and aspects of methylation in CIN and MIN colorectal tumorigenesis.
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Cites
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Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
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Activating SRC mutation in a subset of advanced human colon cancers
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Cited by
Caught up in a Wnt storm: Wnt signaling in cancer
Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482
Are there two sides to colorectal cancer?
Iacopetta, B. (2002) · International Journal of Cancer · doi:10.1002/ijc.10635 · Cited by 782
Huycke, M. M., Abrams, V., & Moore, D. R. (2002) · Carcinogenesis · doi:10.1093/carcin/23.3.529 · Cited by 489
Mechanisms of PTEN loss in cancer: It’s all about diversity
Álvarez-Garcia, V., Tawil, Y., Wise, H. M., & Leslie, N. R. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.02.001 · Cited by 401
Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?
Yuhara, H., Steinmaus, C., Cohen, S. E., Corley, D. A., Tei, Y., & Buffler, P. A. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.301 · Cited by 377
Metadata
- Authors
- Lindblom, A.
- Venue
- Current Opinion in Oncology
- Published
- 2001-01
- Volume
- 13
- Issue
- 1
- Pages
- 63-69
- ISSN
- 1040-8746 (ISSN-L)
- OpenAlex
- W2000170100
- Cited by
- 212
- References
- 5
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
