The DOI matches its Crossref record.
Activation of immediate early genes after acute stress
Abstract
We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.
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“Indeed, various models of stress have been shown to activate neurons throughout the brain, including hypothalamus, amygdala, hippocampus and cortex.72,90, 91, 92, 93, 94, 95”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [95]
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Pattern and time course of immediate early gene expression in rat brain following acute stress
Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056
Heidbreder, C. A., & Groenewegen, H. J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.09.003 · Cited by 882
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118
Diamond, D. M., Park, C. R., & Woodson, J. C. (2004) · Hippocampus · doi:10.1002/hipo.10186 · Cited by 95
Metadata
- Authors
- Schreiber, S. S., Tocco, G., Shors, T. J., & Thompson, R. F.
- Affiliations
- University of Southern California (US)
- ORCID
- Shors, Tracey J.
- Venue
- NeuroReport
- Published
- 1991-01
- Volume
- 2
- Issue
- 1
- Pages
- 17-20
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1979367057
- Cited by
- 102
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08ns001337-04)
- National Institute on Aging (AG 05142, P50AG005142)
- National Institute of Neurological Disorders and Stroke (NS01337)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- immediate early genes, acute stress, c-fos, Zif268, neocortex, hippocampal CA1, restraint stress, tail shock, gene expression, stress response, rat brain
- MeSH terms
- Acute Disease, Animals, Brain, DNA-Binding Proteins, Electroshock, Gene Expression Regulation, Male, Nucleic Acid Hybridization, Restraint, Physical, RNA, Messenger, Stress, Physiological, Tail, Transcription Factors, Proto-Oncogene Proteins c-fos, Immediate-Early Proteins, Rats, Early Growth Response Protein 1
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