Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater
Abstract
The presence of the neurotrophin, nerve growth factor, brain derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 (NGF, BDNF, NT-3 and NT-4) and their receptors of the tyrosine kinase family (trkA, trkB and trkC) have been investigated in the choroid plexus and dura mater of the adult rat by ribonuclease protection assay. The choroid plexus contained high levels of mRNAs for NGF and NT-4, and low levels of NT-3 and BDNF mRNA; and high levels of trkB mRNA, and undetectable levels of trkA and trkC mRNA. In the dura mater there were high levels of NT-3 and NGF, and low levels of BDNF and NT-4 mRNAs; and high levels of trkC mRNA, and relatively high amount of trkB mRNA, while levels of trkA mRNA was undetectable. The present analysis revealed a different distribution of neurotrophins and their related receptors in the choroid plexus and dura mater.
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TrkB, a transmembrane protein expressed in choroid plexus, is not detected in adult mouse cerebrospinal fluid.
“In contrast TrkB, also expressed in the choroid plexus (Timmusk et al., 1995), is not detected in the CSF sample (Fig. 2C).”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Timmusk et al., 1995
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- Authors
- Timmusk, T., Mudò, G., Metsis, M., & Belluardo, N.
- Affiliations
- Karolinska Institutet (SE)
- Venue
- NeuroReport
- Published
- 1995-10
- Volume
- 6
- Issue
- 15
- Pages
- 1997-2000
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2000206682
- Cited by
- 32
- References
- 0
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- neurotrophins, nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4, TrkA, TrkB receptor, TrkC receptor, choroid plexus, dura mater, mRNA expression
- MeSH terms
- Animals, Choroid Plexus, Dura Mater, Male, Nerve Growth Factors, Protein-Tyrosine Kinases, RNA, Messenger, Gene Expression, Rats, Wistar, Receptors, Nerve Growth Factor, Rats
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