Cited by 32Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsPain Mechanisms and Treatments

Expression of mRNAs for neurotrophins and their receptors in the rat choroid plexus and dura mater

Timmusk, Tönis, Mudò, Giuseppa, Metsis, Madis, Belluardo, Natale·1995·NeuroReport

Abstract

The presence of the neurotrophin, nerve growth factor, brain derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 (NGF, BDNF, NT-3 and NT-4) and their receptors of the tyrosine kinase family (trkA, trkB and trkC) have been investigated in the choroid plexus and dura mater of the adult rat by ribonuclease protection assay. The choroid plexus contained high levels of mRNAs for NGF and NT-4, and low levels of NT-3 and BDNF mRNA; and high levels of trkB mRNA, and undetectable levels of trkA and trkC mRNA. In the dura mater there were high levels of NT-3 and NGF, and low levels of BDNF and NT-4 mRNAs; and high levels of trkC mRNA, and relatively high amount of trkB mRNA, while levels of trkA mRNA was undetectable. The present analysis revealed a different distribution of neurotrophins and their related receptors in the choroid plexus and dura mater.

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Crossref · 10.1097/00001756-199510010-00011

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Authors
Timmusk, T., Mudò, G., Metsis, M., & Belluardo, N.
Affiliations
Karolinska Institutet (SE)
Venue
NeuroReport
Published
1995-10
Volume
6
Issue
15
Pages
1997-2000
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2000206682
Cited by
32
References
0
Citations by year
2022: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
FWCI
0.53
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
neurotrophins, nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4, TrkA, TrkB receptor, TrkC receptor, choroid plexus, dura mater, mRNA expression
MeSH terms
Animals, Choroid Plexus, Dura Mater, Male, Nerve Growth Factors, Protein-Tyrosine Kinases, RNA, Messenger, Gene Expression, Rats, Wistar, Receptors, Nerve Growth Factor, Rats

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