The DOI matches its Crossref record.
Localization of leptin receptor mRNA expression in mouse brain
Abstract
The distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method. Leptin receptor mRNA expression was highest in the arcuate nucleus and median eminence of the hypothalamus, but it was also abundant in hippocampus, primarily in the dentate gyrus and CA1, and was detected at low levels in piriform cortex and the medial margin of the medial habenular nucleus. The localization of leptin receptor-containing neurones in the present study indicates the possibility that the leptin receptor is expressed on neuropeptide Y-containing neurones.
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“Leptin may also modulate sensory processing at higher gustatory and olfactory processing steps, as indicated by the presence of leptin receptors and leptin-induced Fos expression in the nucleus of the solitary tract, parabrachial nucleus, olfactory bulb, and insular and piriform cortices of rodents”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [86]
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Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horváth, T. L., & Kalra, P. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0357 · Cited by 1,564
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902
“Further work, including the cloning of Lepr (Chen et al., 1996; Tartaglia et al., 1995), demonstrated that the ventral hypothalamus (arcuate nucleus) is an important mediator of the actions of leptin in the brain (Elmquist et al., 1998; Huang et al., 1996 ).”
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
Håkansson, M., Brown, H., Ghilardi, N., Skoda, R. C., & Meister, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00559.1998 · Cited by 741
“This distribution pattern is in agreement with the recently described distribution of LR mRNA, as shown by in situ hybridization (Håkansson et al., 1996; Huang et al., 1996; Mercer et al., 1996a).”
BackgroundResultLeptin's Actions on the Reproductive Axis: Perspectives and Mechanisms
Cunningham, M. J., Clifton, D. K., & Steiner, R. A. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.216 · Cited by 532
“Distribution of Ob-R and its mRNA has been examined in several species, including the mouse [63, 65, 78–81], rat [82–87], monkey [49], and human [88–90].”
BackgroundLeptin targets in the mouse brain
Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M., & Elmquist, J. K. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22025 · Cited by 484
“While several studies have attempted to define the sites of LepRb in rodent brain (Huang et al., 1996; Mercer et al., 1996a, 1998) the relatively low abundance of LepRb mRNA and the absence of selective leptin receptor antibodies have hindered a comprehensive description of LepRb distribution in…”
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Metadata
- Authors
- Huang, X. F., Koutcherov, I., Lin, S., Wang, H. Q., & Storlien, L.
- Affiliations
- University of Wollongong (AU)
- ORCID
- Venue
- NeuroReport
- Published
- 1996-11
- Volume
- 7
- Issue
- 15
- Pages
- 2635-2638
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2061211669
- Cited by
- 160
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 10 · 2013: 2 · 2012: 9
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- leptin receptor, mRNA expression, brain localization, hypothalamus, arcuate nucleus, median eminence, hippocampus, dentate gyrus, CA1, piriform cortex, medial habenula, neuropeptide Y neurons, C57 mice
- MeSH terms
- Animals, Base Sequence, Brain, Carrier Proteins, Female, Male, Mice, Inbred C57BL, Molecular Sequence Data, Receptors, Cell Surface, In Situ Hybridization, Mice, Receptors, Leptin
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