The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss.
Abstract
Guinea-pigs were exposed to a traumatic sound inducing up to 80 dB hearing loss. Beside the well described mechanical damage to outer hair cells, a total disruption of inner hair cell (IHC)-auditory nerve synapses was acutely observed within the traumatized area. To test the hypothesis that synaptic damage is due to an excessive release of glutamate by the IHCs, we examined the protective effect of the glutamate antagonist kynurenate on noise-induced hearing loss. The high degree of protection observed with kynurenate attests that dendritic damage is an important component in noise-induced hearing loss. Moreover, we demonstrate that a synaptic repair mechanism occurring within the first few days post-exposure is partly responsible for the recovery of temporary threshold shifts after an acoustic trauma.
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“Overexposure to loud sounds can cause hair cell damage (Puel et al., 1998)”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Puel et al., 1998
Citations
Cites
Neurotransmitters and neuromodulators of the mammalian cochlea.
Eybalin, M. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.309 · Cited by 548
Primary Structural Changes in the Organ of Corti After Acoustic Overstimulation
Spoendlin, H. H. (1971) · Acta Oto-Laryngologica · doi:10.3109/00016487109125346 · Cited by 332
Chemical synaptic transmission in the cochlea
Puel, J. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00028-3 · Cited by 278
Self-citationFunctional significance of dendritic swelling after loud sounds in the guinea pig cochlea
Robertson, D. (1983) · Hearing Research · doi:10.1016/0378-5955(83)90031-x · Cited by 255
Beagley, H. A. (1965) · Acta Oto-Laryngologica · doi:10.3109/00016486509127031 · Cited by 86
Bobbin, R. P., & Ceasar, G. (1987) · Hearing Research · doi:10.1016/0378-5955(87)90081-5 · Cited by 51
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The Role of Oxidative Stress in Noise-Induced Hearing Loss
Henderson, D., Bielefeld, E. C., Harris, K. C., & Hu, B. H. (2006) · Ear & Hearing · doi:10.1097/01.aud.0000191942.36672.f3 · Cited by 879
Syka, J. (2002) · Physiological Reviews · doi:10.1152/physrev.00002.2002 · Cited by 369
Brown, K. D., Maqsood, S., Huang, J.-Y., Pan, Y., Harkcom, W., Li, W., Sauve, A., Verdin, E., & Jaffrey, S. R. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.003 · Cited by 277
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170
Metadata
- Authors
- Puel, J.-L., Ruel, J., dʼAldin, C. G., & Pujol, R.
- Affiliations
- Inserm (FR)
- Venue
- NeuroReport
- Published
- 1998-06
- Volume
- 9
- Issue
- 9
- Pages
- 2109-2114
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2014428504
- Cited by
- 425
- References
- 6
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 28 · 2023: 24 · 2022: 10 · 2021: 19 · 2020: 22 · 2019: 20 · 2018: 19 · 2017: 10 · 2016: 14 · 2015: 24 · 2014: 20 · 2013: 16 · 2012: 15
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Health Sciences › Health Professions › Speech and Hearing › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- noise-induced hearing loss, excitotoxicity, cochlear synapses, inner hair cells, auditory nerve, glutamate release, kynurenic acid, temporary threshold shift, outer hair cells, guinea pig
- MeSH terms
- Animals, Cochlea, Dendrites, Electrodes, Implanted, Electrophysiology, Guinea Pigs, Hearing Loss, Noise-Induced, Kynurenic Acid, Synapses, Excitatory Amino Acid Antagonists, In Vitro Techniques
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