Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning.
Abstract
Traditionally the auditory system was considered a hard-wired sensory system; this view has been challenged in recent years in light of the plasticity of other sensory systems, particularly the visual and somatosensory systems. Practical experience in clinical audiology together with the use of prosthetic devices, such as cochlear implants, contributed significantly to the present view on the plasticity of the central auditory system, which was originally based on data obtained in animal experiments. The loss of auditory receptors, the hair cells, results in profound changes in the structure and function of the central auditory system, typically demonstrated by a reorganization of the projection maps in the auditory cortex. These plastic changes occur not only as a consequence of mechanical lesions of the cochlea or biochemical lesions of the hair cells by ototoxic drugs, but also as a consequence of the loss of hair cells in connection with aging or noise exposure. In light of the aging world population and the increasing amount of noise in the modern world, understanding the plasticity of the central auditory system has its practical consequences and urgency. In most of these situations, a common denominator of central plastic changes is a deterioration of inhibition in the subcortical auditory nuclei and the auditory cortex. In addition to the processes that are elicited by decreased or lost receptor function, the function of nerve cells in the adult central auditory system may dynamically change in the process of learning. A better understanding of the plastic changes in the central auditory system after sensory deafferentation, sensory stimulation, and learning may contribute significantly to improvement in the rehabilitation of damaged or lost auditory function and consequently to improved speech processing and production.
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Overexposure to loud sounds can cause hearing loss and reduced afferent input in the auditory system.
“hearing loss and reduced afferent input in the auditory system (Syka, 2002).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Syka, 2002
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Ringing Ears: The Neuroscience of Tinnitus: Figure 1.
Roberts, L. E., Eggermont, J. J., Caspary, D. M., Shore, S. E., Melcher, J. R., & Kaltenbach, J. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4028-10.2010 · Cited by 584 · see citing works
“Partial deafferentation of the central auditory system due to aging, noise trauma, or other peripheral insults may produce plastic maladaptive compensatory changes resulting in net downregulation of functional inhibition (Syka, 2002; Dong et al., 2010; Eggermont, 2010).”
BackgroundCentral gain control in tinnitus and hyperacusis
Auerbach, B. D., Rodrigues, P. V., & Salvi, R. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00206 · Cited by 439 · see citing works
“Indeed, most sensory systems are known to exhibit long-term changes in function and connectivity in response to sensory deprivation (203–207) and auditory deprivation is known to result in alterations to neural activity in many brain areas (208).”
BackgroundWayne, R. V., & Johnsrude, I. S. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.06.002 · Cited by 453 · see citing works
“Research suggests that age-related or noise-induced hearing loss may also result in cortical changes (Gold and Bajo, 2014; Allman et al., 2009; Meredith et al., 2012; Pienkowski and Eggermont 2011; Caspary et al., 2005; Dietrich et al., 2001; Syka, 2002; Wang et al., 2011; Rajan, 1998), which could also affect cogniti…”
Seki, S., & Eggermont, J. J. (2003) · Hearing Research · doi:10.1016/s0378-5955(03)00074-1 · Cited by 329 · see citing works
Knipper, M., van Dijk, P., Nunes, I., Rüttiger, L., & Zimmermann, U. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.002 · Cited by 307 · see citing works
“…of excitatory and inhibitory inputs from the nuclei of the afferent auditory pathway, causing down-regulation of inhibition and an increase of excitability in several subcortical nuclei (Gerken, 1996; Salvi et al., 2000; Zacharek et al., 2002 ) and the auditory cortex (Rajan, 1998; Syka, 2002).”
Hearing Loss Raises Excitability in the Auditory Cortex
Kotak, V. C., Fujisawa, S., Lee, F. A., Karthikeyan, O., Aoki, C. J., & Sanes, D. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5169-04.2005 · Cited by 288 · see citing works
“Recordings from hearing-impaired animals have also revealed many profound changes in auditory processing (Syka, 2002).”
BackgroundHomeostatic plasticity drives tinnitus perception in an animal model
Yang, S., Weiner, B., Zhang, L. S., Cho, S., & Bao, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107998108 · Cited by 276 · see citing works
Underlying Mechanisms of Tinnitus: Review and Clinical Implications
Henry, J. A., Roberts, L. E., Caspary, D. M., Theodoroff, S. M., & Salvi, R. (2014) · Journal of the American Academy of Audiology · doi:10.3766/jaaa.25.1.2 · Cited by 268 · see citing works
“Evidence for increased gain in central auditory structures may account for reduced loudness tolerance reported in human tinnitus patients (see Syka, 2002, for a review).”
Connectionist models of development
Munakata, Y., & McClelland, J. L. (2003) · Developmental Science · doi:10.1111/1467-7687.00296 · Cited by 224 · see citing works
“In addition, there is substantial evidence for the biological plausibility of Hebbian learning (Ahissar, 1998; Syka, 2002).”
BackgroundRutkowski, R. G., & Weinberger, N. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506838102 · Cited by 217 · see citing works
Fetoni, A. R., Bartolo, P. D., Eramo, S. L. M., Rolesi, R., Paciello, F., Bergamini, C., Fato, R., Paludetti, G., Petrosini, L., & Troiani, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2282-12.2013 · Cited by 212 · see citing works
“There is growing evidence suggesting that NIHL can also induce homeostatic/maladaptive changes in the central auditory system (Syka, 2002; Pienkowski and Eggermont, 2011; Stolzberg et al., 2011; Wang et al., 2011).”
BackgroundCompensatory changes in cortical resource allocation in adults with hearing loss
Campbell, J., & Sharma, A. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00071 · Cited by 201 · see citing works
Engineer, N. D., Percaccio, C. R., Pandya, P. K., Moucha, R., Rathbun, D. L., & Kilgard, M. P. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00059.2004 · Cited by 198 · see citing works
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170 · see citing works
“, 1998), hearing loss and reduced afferent input in the auditory system (Syka, 2002).”
BackgroundCaspary, D. M., Schatteman, T. A., & Hughes, L. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2451-05.2005 · Cited by 174 · see citing works
“Age-related hearing loss (presbycusis) is a complex disorder that results in a slow deterioration of peripheral auditory input to auditory regions of the brain (Willott et al., 1991; Syka, 2002).”
BackgroundCochlear implants: cortical plasticity in congenital deprivation
Kral, A., Tillein, J., Heid, S., Klinke, R., & Hartmann, R. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)57018-9 · Cited by 170 · see citing works
“…central auditory system is shaped by acoustic experience (for review on owls spatial orientation, see Knudsen, 2004; for review on language-related aspects, see Skuse, 1993; Ruben, 1997; Kuhl, 2004; for review on auditory aspects and neurophysiology in mammals, see Kral et al., 2001; Syka, 2002).”
BackgroundWhy Do Hearing Aids Fail to Restore Normal Auditory Perception?
Lesica, N. A. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.01.008 · Cited by 157 · see citing works
“The plasticity that follows hearing loss may also impair the perception of speech in other ways [37]; for example, if the degree of hearing loss varies with frequency, as is often the case, plasticity can also result in a reorganization of the tonotopic maps within the brain, further distorting the representation of t…”
Ridder, D. D., Vanneste, S., Engineer, N. D., & Kilgard, M. P. (2013) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12127 · Cited by 154 · see citing works
Age-related changes in the central auditory system
Ouda, L., Profant, O., & Syka, J. (2015) · Cell and Tissue Research · doi:10.1007/s00441-014-2107-2 · Cited by 146 · see citing works
“…is thought to be significantly associated with age-related alterations in the processing of the temporal parameters of complex acoustical stimuli within the central auditory system, especially the IC and auditory cortex (for a review, see Syka 2002; Caspary et al. 2008; Frisina 2010; Walton 2010).”
BackgroundSelf-citationAge-related changes in GAD levels in the central auditory system of the rat
Burianova, J. S., Ouda, L., Profant, O., & Syka, J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.012 · Cited by 132 · see citing works
Self-citationTinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC)
Cheung, S. W., & Larson, P. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.007 · Cited by 120 · see citing works
Age-Related Hearing Loss: Quality of Care for Quality of Life
Li‐Korotky, H. (2012) · The Gerontologist · doi:10.1093/geront/gnr159 · Cited by 120 · see citing works
“Furthermore, intensive auditory and cognitive training may be effective in modifying the agingindependent brain plasticity, for example, by enhancing the selective attention in speech in noise, speech processing and discrimination, working memory, and executive functioning (Dahmen & King, 2007; Sweetow & Sabes, 2006;…”
BackgroundTinnitus and Neural Plasticity of the Brain
Bartels, H., Staal, M. J., & Albers, F. W. J. (2007) · Otology & Neurotology · doi:10.1097/mao.0b013e31802b3248 · Cited by 119 · see citing works
“Late Consequences of Neural Plasticity The functional organization of tonotopical maps is not statistically fixed but seems to alter and adapt dynamically in response to processes of neural plasticity (12,47, 49,55,59).”
BackgroundPanza, F., Lozupone, M., Sardone, R., Battista, P., Piccininni, M., Dibello, V., Montagna, M. L., Stallone, R., Venezia, P., Liguori, A., et al. (2018) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622318811000 · Cited by 118 · see citing works
Noise exposure enhances auditory cortex responses related to hyperacusis behavior
Sun, W., Deng, A., Jayaram, A., & Gibson, B. (2012) · Brain Research · doi:10.1016/j.brainres.2012.02.008 · Cited by 117 · see citing works
The gap-startle paradigm for tinnitus screening in animal models: Limitations and optimization
Lobariñas, E., Hayes, S. H., & Allman, B. L. (2012) · Hearing Research · doi:10.1016/j.heares.2012.06.001 · Cited by 116 · see citing works
“Exposure to noise levels known to induce sensorineural hearing loss results in plasticity throughout the central auditory pathway (for review, see (Syka, 2002)) as well as in non-classical auditory structures such as those in the limbic system (Goble et al., 2009; Kraus et al., 2010;…”
BackgroundThe Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration
Pisani, A., Paciello, F., VECCHIO, V. D., Malesci, R., Corso, E. D., Cantone, E., & Fetoni, A. R. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13040652 · Cited by 120 · see citing works
PET evidence of neuroplasticity in adult auditory cortex of postlingual deafness.
Lee, J. S., Lee, D. S., Oh, S. H., Kim, C. S., Kim, J., Hwang, C. H., Koo, J., Kang, E., Chung, J., & Lee, M. C. (2003) · PubMed · Cited by 109 · see citing works
Hearing Loss Prevents the Maturation of GABAergic Transmission in the Auditory Cortex
Kotak, V. C., Takesian, A. E., & Sanes, D. H. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm233 · Cited by 108 · see citing works
Conductive Hearing Loss Disrupts Synaptic and Spike Adaptation in Developing Auditory Cortex
Xu, H., Kotak, V. C., & Sanes, D. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1992-07.2007 · Cited by 106 · see citing works
“However, it is well documented that developmental auditory deprivation leads to extensive changes in auditory processing (Sharma et al., 2002; Syka, 2002).”
BackgroundAcquired hearing loss and brain plasticity
Eggermont, J. J. (2016) · Hearing Research · doi:10.1016/j.heares.2016.05.008 · Cited by 99 · see citing works
“In contrast, recordings in normal adult cats typically showed only ~65% of A1 neurons excited by sound delivered to the ipsilateral ear, and thresholds to ipsilateral ear stimulation were significantly higher than thresholds to contralateral ear stimulation (as reviewed by Syka, 2002).”
Perceptual training improves syllable identification in new and experienced hearing aid users
Stecker, G. C., Bowman, G. A., Yund, E. W., Herron, T. J., Roup, C. M., & Woods, D. L. (2006) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2005.11.0171 · Cited by 96 · see citing works
“In cats with high-frequency hearing loss, neurons in auditory cortex originally tuned to high frequencies alter their tuning to process inputs from intact nearby portions of the cochlea [2,22].”
BackgroundThe emergence of a new paradigm in ape language research
Shanker, S. G., & King, B. J. (2002) · Behavioral and Brain Sciences · doi:10.1017/s0140525x02000110 · Cited by 98 · see citing works
Mahlke, C., & Wallhäußer-Franke, E. (2004) · Hearing Research · doi:10.1016/j.heares.2004.03.005 · Cited by 96 · see citing works
Wang, Y., & Manis, P. B. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00374.2005 · Cited by 93 · see citing works
“Since the principal neurons of the AVCN receive direct afferent innervation from the cochlea and provide essential timing information to other auditory centers for both sound localization and pitch detection, the effect of age-related hearing loss on synaptic transmission in these cells could have a profound impact on…”
BackgroundDubinsky, E., Wood, E. A., Nespoli, G., & Russo, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01153 · Cited by 75 · see citing works
“…to the degradation of neural mechanisms that relay sound information from the cochlea to the brain, resulting from longterm attenuation of neural input from the cochlea, as well as age-related changes in neuronal responses to sound (Syka, 2002; Frisina and Walton, 2006; Yamasoba et al., 2013).”
BackgroundKaltenbach, J. A. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)66009-9 · Cited by 90 · see citing works
Schofield, B. R., Motts, S. D., & Mellott, J. G. (2010) · Hearing Research · doi:10.1016/j.heares.2010.12.019 · Cited by 90 · see citing works
“ACh is also released in the auditory cortex (AC), where it modulates patterns of information flow and plays an important role in synaptic plasticity (e.g., Irvine, 2010; Metherate and Hsieh, 2004; Syka, 2002).”
BackgroundAge-related GABAA receptor changes in rat auditory cortex
Caspary, D. M., Hughes, L. F., & Ling, L. L. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.009 · Cited by 86 · see citing works
Dong, S., Mulders, W. H. A. M., Rodger, J., & Robertson, D. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.043 · Cited by 85 · see citing works
Auditory system dysfunction in Alzheimer disease and its prodromal states: A review
Swords, G. M., Nguyen, L. T., Mudar, R. A., & Llano, D. A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.001 · Cited by 83 · see citing works
Buckiová, D., Ranjan, S. K., Newman, T. A., Johnston, A. H., Sood, R., Kinnunen, P. K. J., Popelář, J., Chumak, T., & Syka, J. (2012) · Nanomedicine · doi:10.2217/nnm.12.5 · Cited by 83 · see citing works
Self-citationThe Fischer 344 rat as a model of presbycusis
Syka, J. (2009) · Hearing Research · doi:10.1016/j.heares.2009.11.003 · Cited by 82 · see citing works
“For further information about the effects of aging on the rat auditory system, reviews by Caspary et al. (1995, 2008), Syka (2002), Frisina (2001), Salvi et al. (2001), and Willott (2001) can be consulted.”
MethodSelf-citationGröschel, M., Götze, R., Ernst, A., & Basta, D. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1246 · Cited by 80 · see citing works
“Moreover, one characteristic feature of plasticity of the central auditory system is the deterioration of inhibition of the subcortical auditory nuclei and the auditory cortex, which can change dynamically (Syka, 2002).”
Developmental Hearing Loss Disrupts Synaptic Inhibition: Implications for Auditory Processing
Takesian, A. E., Kotak, V. C., & Sanes, D. H. (2009) · Future Neurology · doi:10.2217/fnl.09.5 · Cited by 79 · see citing works
Holt, A. G., Asako, M., Lomax, C. A., MacDonald, J. W., Tong, L., Lomax, M. I., & Altschuler, R. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03090.x · Cited by 79 · see citing works
“Deafness (full or partial) and noise over-stimulation have been shown to lead to plastic changes in the mature central auditory pathways (Syka 2002; Moller 2005).”
BackgroundIs the din really harmless? Long-term effects of non-traumatic noise on the adult auditory system
Gourévitch, B., Edeline, J., Occelli, F., & Eggermont, J. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3744 · Cited by 79 · see citing works
Deafness Disrupts Chloride Transporter Function and Inhibitory Synaptic Transmission
Vale, C., Schoorlemmer, J., & Sanes, D. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07516.2003 · Cited by 78 · see citing works
“An understanding of these changes seems particularly important in light of the compensatory changes that accompany peripheral injury (Pallas et al., 1999; Gold and Knudsen, 2000; Syka, 2002) and the potential to restore stimulation with prosthetic devices (Klinke et al., 1999; Kral et al., 2002).”
Whiting, B. A., Moiseff, A., & Rubio, M. E. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.049 · Cited by 76 · see citing works
Insult-induced adaptive plasticity of the auditory system
Gold, J., & Bajo, V. M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00110 · Cited by 76 · see citing works
Carpenter-Thompson, J. R., Akrofi, K., Schmidt, S. A., Dolcos, F., & Husain, F. T. (2014) · Brain Research · doi:10.1016/j.brainres.2014.04.024 · Cited by 73 · see citing works
“…was the effect of hearing loss, which has been shown to cause reorganization and decreased inhibitory input of the central auditory pathway (Brozoski et al., 2002, 2007; Dong et al., 2009; Kim et al., 1997; Syka, 2002; Szczepaniak and Moller, 1996), and may affect processing of affective sounds.”
BackgroundThe Efficacy of Auditory Perceptual Training for Tinnitus: A Systematic Review
Hoare, D. J., Stacey, P. C., & Hall, D. A. (2010) · Annals of Behavioral Medicine · doi:10.1007/s12160-010-9213-5 · Cited by 73 · see citing works
“Several other animal experiments have confirmed that auditory training is associated with plastic changes in neural representations [28–31].”
BackgroundMacová, I., Pysanenko, K., Chumak, T., Dvořáková, M., Bohuslavová, R., Syka, J., Fritzsch, B., & Pavlínková, G. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-18.2018 · Cited by 72 · see citing works
“Indeed, the auditory system is well known for having a high level of plastic changes throughout life (Syka, 2002; Eggermont, 2017) but how embryonic development affects and possibly limits these later plastic changes remains unclear because of the lack of models (Kral et al., 2016) beyond simply…”
BackgroundSelf-citationBrain Plasticity under Cochlear Implant Stimulation
Kral, A., & Tillein, J. (2006) · Advances in oto-rhino-laryngology · doi:10.1159/000094647 · Cited by 72 · see citing works
Cochlear implants: the view from the brain
Middlebrooks, J. C., Bierer, J. A., & Snyder, R. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.06.004 · Cited by 72 · see citing works
Environmental Enrichment and Successful Aging
Leon, M., & Woo, C. C. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00155 · Cited by 71 · see citing works
“, 2008) and hearing sensitivity declines two times faster in men than in women, with diminished sensitivity observed in males as early as age 30 years (Syka, 2002).”
InfluentialObject identification and attention training for treating tinnitus
Searchfield, G. D., Morrison-Low, J., & Wise, K. J. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)66043-9 · Cited by 70 · see citing works
Central Compensation in Auditory Brainstem after Damaging Noise Exposure
Schrode, K. M., Muniak, M. A., Kim, Y.-H., & Lauer, A. M. (2018) · eNeuro · doi:10.1523/eneuro.0250-18.2018 · Cited by 68 · see citing works
“Other forms of peripheral damage are also associated with decreases in inhibitory protein immunolabeling and concentrations of inhibitory amino acid in the VCN (Syka, 2002; Asako et al., 2005; Godfrey et al., 2005, 2008; Lu et al., 2008; Gold and Bajo, 2014).”
BackgroundEnhancement of steady‐state auditory evoked magnetic fields in tinnitus
Diesch, E., Struve, M., Rupp, A., Ritter, S., Hülse, M., & Flor, H. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03191.x · Cited by 68 · see citing works
Age-related changes in cochlear and brainstem auditory functions in Fischer 344 rats
Popelář, J., Groh, D., Pelánová, J., Canlon, B., & Syka, J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.001 · Cited by 68 · see citing works
Self-citationVale, C., Juiz, J. M., Moore, D. R., & Sanes, D. H. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03679.x · Cited by 67 · see citing works
Discrimination Task Reveals Differences in Neural Bases of Tinnitus and Hearing Impairment
Husain, F. T., Pajor, N. M., Smith, J. F., Kim, H. J., Rudy, S., Zalewski, C. K., Brewer, C. C., & Horwitz, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026639 · Cited by 66 · see citing works
“Whereas peripheral hearing loss may be the most prominent trigger for tinnitus, pathophysiology resulting in tinnitus may be quite different than in hearing loss without tinnitus [59,60].”
BackgroundSchatteman, T. A., Hughes, L. F., & Caspary, D. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.025 · Cited by 66 · see citing works
A Sensitive Period for the Impact of Hearing Loss on Auditory Perception
Buran, B. N., Sarro, E. C., Manno, F. A. M., Kang, R. S., Caras, M. L., & Sanes, D. H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0647-13.2014 · Cited by 61 · see citing works
“DOI:10.1523/JNEUROSCI.0647-13.2014 Copyright © 2014 the authors 0270-6474/14/342276-09$15.00/0 (Syka, 2002; de Villers-Sidani and Merzenich, 2011; Kral and Sharma, 2012), we controlled for the onset age, magnitude, and duration of CHL.”
BackgroundInfluentialZwergal, A., Schlichtiger, J., Xiong, G., Beck, R., Gunther, L. M., Schniepp, R., Schöberl, F., Jahn, K., Brandt, T., Strupp, M. L., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0899-1 · Cited by 65 · see citing works
Structural alterations of brain grey and white matter in early deaf adults
Hribar, M., Šuput, D., Carvalho, A. A., Battelino, S., & Vovk, A. (2014) · Hearing Research · doi:10.1016/j.heares.2014.09.008 · Cited by 65 · see citing works
Learning-Induced Plasticity in Auditory Spatial Representations Revealed by Electrical Neuroimaging
Spierer, L., Tardif, É., Sperdin, H. F., Murray, M. M., & Clarke, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0764-07.2007 · Cited by 65 · see citing works
“Previous studies have demonstrated plastic changes within the “what” stream as subjects learned to discriminate between frequency, duration, or intensity of sounds or between semantic features of complex environmental sounds or speech (Tremblay et al., 1998; Jäncke et al., 2001; Syka, 2002; Bergerbest et al., 2004; Go…”
BackgroundAlvarado, J. C., Fuentes‐Santamaría, V., Melgar–Rojas, P., Valero, M. L., Gabaldón-Ull, M. C., Miller, J. M., & Juiz, J. M. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00086 · Cited by 61 · see citing works
Wistar rats: a forgotten model of age-related hearing loss
Alvarado, J. C., Fuentes‐Santamaría, V., Gabaldón-Ull, M. C., Blanco, J. L., & Juiz, J. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00029 · Cited by 61 · see citing works
“…histological, genetic, and molecular mechanisms involved in presbyacusis have been obtained from studies performed in rodents, including guinea pigs, chinchillas, Mongolian gerbils, mice, and rats (Syka, 2002, 2010; Ohlemiller, 2006; Bielefeld et al., 2008, 2010; Fetoni et al., 2011).”
BackgroundMethodResultInfluentialDeep Brain Stimulation in Area LC Controllably Triggers Auditory Phantom Percepts
Larson, P., & Cheung, S. W. (2011) · Neurosurgery · doi:10.1227/neu.0b013e3182320ab5 · Cited by 59 · see citing works
Popelář, J., Grécová, J., Rybalko, N., & Syka, J. (2008) · Hearing Research · doi:10.1016/j.heares.2008.09.002 · Cited by 59 · see citing works
“Injury of the periphery is reflected in a hearing threshold shift and in weaker responses to sound at many levels of the central auditory system, from the cochlear nucleus to the auditory cortex (see Syka, 1989, 2002, for review).”
Self-citationHuxlin, K. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg106 · Cited by 59 · see citing works
“However, most of this information comes from work in motor (e.g. Nudo et al., 1996; Hallett, 2001; see review by Taub et al., 2002), somatosensory (e.g. Recanzone et al., 1992b; Xerri et al., 1996) or auditory (Recanzone et al., 1993; Syka, 2002) systems.”
Munro, K. J. (2008) · Trends in Amplification · doi:10.1177/1084713808323483 · Cited by 57 · see citing works
“In relatively recent times, it has become clear that the sensory areas in the brain of adult humans retain a significant degree of plasticity (Buonomano & Merzenich, 1998; Syka, 2002).”
BackgroundThe FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes
Cai, R., Montgomery, S. C., Graves, K. A., Caspary, D. M., & Cox, B. C. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.034 · Cited by 57 · see citing works
“…and at higher levels resulting in larger than expected super-threshold responses at multiple levels of the CANS with age (Willott, Milbrandt et al. 1997, Amenedo and Diaz 1998, Syka 2002, Caspary, Ling et al. 2008, Burianova, Ouda et al. 2009, Wang, Turner et al. 2009, Gold and Bajo 2014).”
BackgroundEnvironmental Enrichment Increases Paired-Pulse Depression in Rat Auditory Cortex
Percaccio, C. R., Engineer, N. D., Pruette, A. L., Pandya, P. K., Moucha, R., Rathbun, D. L., & Kilgard, M. P. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00433.2005 · Cited by 55 · see citing works
“However, the degree of paired-pulse depression was different depending on the method of data recording.”
Paciello, F., Rinaudo, M., Longo, V., Cocco, S., Conforto, G., Pisani, A., Podda, M. V., Fetoni, A. R., Paludetti, G., & Grassi, C. (2021) · eLife · doi:10.7554/elife.70908 · Cited by 53 · see citing works
“Sensory disruption due to damage of the organ of Corti may trigger central mechanisms of homeostatic plasticity (Rauschecker, 1999; Syka, 2002; Caspary et al., 2008; Wang et al., 2011; Yang et al., 2011) and changes in excitatory, inhibitory, and neuromodulatory networks along the central auditory…”
BackgroundManagement of auditory processing disorders
Bamiou, D., Campbell, N., & Sirimanna, T. (2006) · Hearing Balance and Communication · doi:10.1080/16513860600630498 · Cited by 52 · see citing works
“Plasticity is underpinned by neurochemical, physiological as well as structural changes and may also be associated with behavioural change (6,7).”
BackgroundBDNF mRNA expression and protein localization are changed in age-related hearing loss
Rüttiger, L., Panford-Walsh, R., Schimmang, T., Tan, J., Zimmermann, U., Rohbock, K., Köpschall, I., Limberger, A., Müller, M. C., Fraenzer, J.-T., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.02.008 · Cited by 50 · see citing works
Benson, R. R., Gattu, R., & Cacace, A. T. (2013) · Hearing Research · doi:10.1016/j.heares.2013.10.005 · Cited by 50 · see citing works
“…auditory nerve discharge properties (e.g., Liberman and Kiang, 1978; Henderson et al., 2011; Kujawa and Liberman, 2009) and secondary anatomical and physiological effects in the central auditory nervous system (e.g., Morest et al., 1998; Salvi et al., 2000; Syka, 2002; Schreiner and Cheung, 2004).”
Is Cognitive Function in Adults with Hearing Impairment Improved by the Use of Hearing Aids?
Choi, A. Y., Shim, H. J., Lee, S. H., Yoon, S. W., & Joo, E.-J. (2011) · Clinical and Experimental Otorhinolaryngology · doi:10.3342/ceo.2011.4.2.72 · Cited by 50 · see citing works
“The dominant components of presbycusis are the gradual degeneration of hair cells (mainly in the basal part of the cochlea) and atrophy of the stria vascularis and spiral ganglion cells; however, sclerotic changes in the brain are attributed as a central component (4).”
BackgroundRegulation of auditory plasticity during critical periods and following hearing loss
Persic, D., Thomas, M. E., Pelekanos, V., Ryugo, D. K., Takesian, A. E., Krumbholz, K., & Pyott, S. J. (2020) · Hearing Research · doi:10.1016/j.heares.2020.107976 · Cited by 51 · see citing works
“Alternative mechanisms, such as the unmasking of silent synapses and Hebbian strengthening of weak synapses (Syka, 2002) as well as neuronal adaptation and both short- and long-term potentiation (Froemke and Schreiner, 2015) may be involved in reorganization of cortical”
BackgroundDoes long-term unilateral deafness change auditory evoked potential asymmetries?
Hine, J. E., Thornton, R., Davis, A. E., & Debener, S. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.11.010 · Cited by 49 · see citing works
“Animal studies have clearly shown that unilateral deafness results in profound changes in the structure and function of the central auditory system that modify the asymmetric cortical response patterns of the auditory cortex (Syka, 2002).”
BackgroundPlasticity in neuromagnetic cortical responses suggests enhanced auditory object representation
Roß, B., Jamali, S., & Tremblay, K. L. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-151 · Cited by 49 · see citing works
“As an example, early sensory processing occurs in separated frequency bands [10].”
BackgroundObjective evidence of temporal processing deficits in older adults
Anderson, S., & Karawani, H. (2020) · Hearing Research · doi:10.1016/j.heares.2020.108053 · Cited by 48 · see citing works
“(2019) studies, an inefficient use of cognitive resources may be a factor in over-representation of the speech envelope in older listeners, and 3) Reduced neural inhibition noted in animal models (Cisneros-Franco et al., 2018; de Villers-Sidani et al., 2010; Hughes et al., 2010; Syka, 2002) or redundant local processi…”
BackgroundImmunocytochemical profiles of inferior colliculus neurons in the rat and their changes with aging
Ouda, L., & Syka, J. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00068 · Cited by 47 · see citing works
“Both temporal parameter processing and GABA-mediated inhibition are known to be altered in aged rats (Syka, 2002; Caspary et al., 2008; Frisina, 2010).”
BackgroundInfluentialSelf-citationLong-term treatment with aldosterone slows the progression of age-related hearing loss
Halonen, J. D., Hinton, A. S., Frisina, R. D., Ding, B., Zhu, X., & Walton, J. P. (2016) · Hearing Research · doi:10.1016/j.heares.2016.05.001 · Cited by 48 · see citing works
“…difficulties in suprathreshold hearing faced by older listeners likely develop not only from impaired cochlear function, but also from age-related physiological changes in the parts of the brain used for hearing e central auditory system (Frisina and Frisina, 1997; Syka, 2002; Willott, 1991, 1996).”
BackgroundPersistent effects of early augmented acoustic environment on the auditory brainstem
Oliver, D. L., Izquierdo, M. A., & Malmierca, M. S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.001 · Cited by 47 · see citing works
Vallabha, G. K., & McClelland, J. L. (2007) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.7.1.53 · Cited by 47 · see citing works
Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus
Asako, M., Holt, A. G., Griffith, R. D., Buras, E. D., & Altschuler, R. A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20542 · Cited by 47 · see citing works
“…Inc. Key words: hearing; auditory; ablation; neurotransmitter There is increasing evidence of plasticity in the mature auditory system, with decreased activity from deafness or increased activity from noise overstimulation capable of inducing marked changes (recently reviewed by Syka, 2002).”
BackgroundFuentes‐Santamaría, V., Alvarado, J. C., Taylor, A. R., Brunso‐Bechtold, J. K., & Henkel, C. K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20437 · Cited by 47 · see citing works
“Loss of cochlear integrity has been shown to result in a variety of morphological, biochemical, and metabolic changes throughout the auditory brainstem (Sie and Rubel, 1992; Potashner et al, 1997; Illing et al., 2000; Tucci et al., 2001; Syka, 2002).”
BackgroundAge-related changes in the response properties of cartwheel cells in rat dorsal cochlear nucleus
Caspary, D. M., Hughes, L. F., Schatteman, T. A., & Turner, J. G. (2006) · Hearing Research · doi:10.1016/j.heares.2006.03.005 · Cited by 46 · see citing works
Auditory Cortex Electrical Stimulation Suppresses Tinnitus in Rats
Zhang, J., Zhang, Y., & Zhang, X. (2010) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-010-0246-z · Cited by 46 · see citing works
Noise trauma induced plastic changes in brain regions outside the classical auditory pathway
Chen, G.-D., Sheppard, A., & Salvi, R. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.005 · Cited by 46 · see citing works
“…hyperactivity due to noise trauma or other forms of cochlear pathology tends to progressively increase along the caudal-rostral axis (Popelar et al., 1987, Qiu et al., 2000, Salvi et al., 2000, Syka and Rybalko, 2000, Syka, 2002, Popelar et al., 2008, Auerbach et al., 2014, Chen et al., 2015).”
BackgroundAtorvastatin slows down the deterioration of inner ear function with age in mice
Syka, J., Ouda, L., Nachtigal, P., Solichová, D., & Semecký, V. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.032 · Cited by 46 · see citing works
Self-citationHolt, A. G., Asako, M., Duncan, R. K., Lomax, C. A., Juiz, J. M., & Altschuler, R. A. (2006) · Hearing Research · doi:10.1016/j.heares.2006.03.009 · Cited by 45 · see citing works
“…(Francis and Manis, 2000; Kaltenbach and Afman, 2000; Kanold and Manis, 2005; Wang and Manis, 2005) and inferior colliculus (Bledsoe et al., 1995, 1997; Mossop et al., 2000; Salvi et al., 2000; Syka and Rybalko, 2000; Vale and Sanes, 2002; Vale et al., 2004) (for reviews Moller, 2005; Syka, 2002).”
BackgroundArgence, M., Sáez, I., Sassu, R., Vassias, I., Vidal, P. P., & de Waele, C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.058 · Cited by 45 · see citing works
Cochlear Injury and Adaptive Plasticity of the Auditory Cortex
Fetoni, A. R., Troiani, D., Petrosini, L., & Paludetti, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00008 · Cited by 44 · see citing works
“The current state of presbycusis and NIHL research suggests that sensory disruption due to damage of the organ of corti may trigger central mechanisms of homeostatic/maladaptive plasticity (Rauschecker, 1999; Syka, 2002; Caspary et al., 2008; Wang et al., 2011; Yang et al., 2011).”
BackgroundAge-related changes in auditory temporal processing in the rat
Šuta, D., Rybalko, N., Pelánová, J., Popelář, J., & Syka, J. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.05.004 · Cited by 44 · see citing works
Self-citationDeafness associated changes in two-pore domain potassium channels in the rat inferior colliculus
Cui, Y. L., Holt, A. G., Lomax, C. A., & Altschuler, R. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.054 · Cited by 42 · see citing works
“Decreases in inhibitory influences, such as GABA input, have been suggested as a mechanism for the increased neuronal excitability in the IC after deafness (Bledsoe et al., 1995, 1997; Mossop et al 2000; Salvi et al., 2000; Syka, 2002).”
BackgroundInfluentialGrécová, J., Bureš, Z., Popelář, J., Šuta, D., & Syka, J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06739.x · Cited by 42 · see citing works
Self-citation
- Authors
- Syka, J.
- Affiliations
- Czech Academy of Sciences (CZ)
- Corresponding author
- Syka, Josef
- ORCID
- Syka, Josef
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2002-01-07
- Volume
- 82
- Issue
- 3
- Pages
- 601-636
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2116004651
- Cited by
- 369
- References
- 398
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 16 · 2023: 7 · 2022: 10 · 2021: 15 · 2020: 19 · 2019: 18 · 2018: 15 · 2017: 15 · 2016: 17 · 2015: 25 · 2014: 22 · 2013: 14 · 2012: 17
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- hearing loss, auditory cortex, cochlear implants, sensory deafferentation, auditory cortex reorganization, noise-induced hearing loss, auditory learning, hearing rehabilitation, speech processing, cochlear hair cell loss, ototoxic drugs
- MeSH terms
- Animals, Auditory Cortex, Hearing Loss, Sensorineural, Humans, Learning, Neuronal Plasticity, Recovery of Function
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