The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Chronic morphine treatment inhibits oxytocin synthesis in rats
Abstract
The changes of oxytocin content and mRNA expression in some nuclei were investigated in morphine-dependent rats using radioimmunoassay (RIA) and in situ hybridization (ISH). After chronic administration of morphine, the oxytocin content in supraoptic nucleus (SON) and nucleus accumbens (NAc) decreased, and increased in the ventral tegment area (VTA) and locus coeruleus (LC), but did not change in other nuclei including the paraventricular nucleus (PVN), lateral septum (SEPTUM), raphe magnus nucleus (NRM) and periaquaductal gray (PAG). In morphine-L dependent rats, naloxone increased the levels of oxytocin in SON and PVN, but decreased that in LC. ISH first showed that chronic morphine treatment inhibited the oxytocin synthesis in SON but not in PVN. The present study demonstrates that chronic morphine treatment alters the brain oxytocin system, suggesting that oxytocin might contribute to the behavioral and neuroendocrine responses to morphine.
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“The chronic administration of morphine, a prototypical μ-opioid receptor agonist, also influences both the synthesis and secretion of OT (25).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [25]
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Cites
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Breaking the loop: Oxytocin as a potential treatment for drug addiction
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Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
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Metadata
- Authors
- You, Z.-D., Li, J.-H., Song, C.-Y., Wang, C.-H., & Lu, C.-L.
- Affiliations
- Second Military Medical University (CN)
- Venue
- Neuroreport
- Published
- 2000-09
- Volume
- 11
- Issue
- 14
- Pages
- 3113-3116
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1985852293
- Cited by
- 45
- References
- 14
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2017: 7 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- chronic morphine administration, morphine dependence, supraoptic nucleus, paraventricular nucleus, nucleus accumbens, ventral tegmental area, locus coeruleus, naloxone
- MeSH terms
- Animals, Brain, Drug Administration Schedule, Hypothalamo-Hypophyseal System, Male, Morphine, Morphine Dependence, Naloxone, Neurons, Oxytocin, RNA, Messenger, Substance Withdrawal Syndrome, Supraoptic Nucleus, Rats, Sprague-Dawley, Rats
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