The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Modulated expression of secreted Frizzledrelated proteins in human retinal degeneration
Abstract
Inherited retinal degenerations such as retinitis pigmentosa (RP) are characterized by progressive loss of photoreceptors, apparently by apoptosis, and our recent report of increased secreted Frizzled-related protein-2 (SFRP2) in RP retinas suggests altered Wnt signalling may be a component of the degenerative process. The present study shows that levels of SFRPI, SFRP3 and SFRP5 mRNAs are also abnormal in RP, giving rise to idiosyncratic expression patterns. In highly degenerative retinas, the SFRP proteins localize mainly to the inner limiting membrane, but in a well-preserved retina SFRPI and SFRP5 are notably localized to the surviving photoreceptors. Together with increased c-jun mRNA expression in all cases examined, these results support the notion that disruptions of Wnt network signalling are involved retinal neurodegeneration.
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In the citing paper
“abnormal Wnt/frizzled signaling in the RPE may be responsible for photoreceptor degeneration”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Jones et al., 2000
In the citing paper
“Aberrations in the Wnt/frizzled signaling pathway have been implicated in photoreceptor degeneration in retinitis pigmentosa patients”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Jones et al., 2000
Citations
Cites
Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice
Chang, G.-Q., Hao, Y., & Wong, F. (1993) · Neuron · doi:10.1016/0896-6273(93)90072-y · Cited by 647
Weber, U., Paricio, N., & Mlodzik, M. (2000) · Development · doi:10.1242/dev.127.16.3619 · Cited by 197
Linkage of photoreceptor degeneration by apoptosis with inherited defect in phototransduction.
Lolley, R. N., Rong, H.-M., & Craft, C. M. (1994) · PubMed · Cited by 192
Mechanisms of Cell Death in the Inherited Retinal Degenerations
Travis, G. H. (1998) · The American Journal of Human Genetics · doi:10.1086/301772 · Cited by 140
Wnt signalling: pathway or network?
Arias, A. M., Browntand, A. M., & Brennan, K. R. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80068-9 · Cited by 97
Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa
Jones, S. E., Jomary, C., & Neal, M. J. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00951-1 · Cited by 36
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- 1994, Invest Ophthalmol Vis Sci, 35, 358
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Secreted antagonists of the Wnt signalling pathway
Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584
Chong, Z. Z., Li, F., & Maiese, K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.004 · Cited by 536
Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163
Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6
Kameya, S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.16.1879 · Cited by 134
Metadata
- Authors
- Jones, S. E., Jomary, C., Grist, J., Stewart, H. J., & Neal, M. J.
- Affiliations
- St Thomas' Hospital (GB)
- ORCID
- Grist, John
- Venue
- Neuroreport
- Published
- 2000-12
- Volume
- 11
- Issue
- 18
- Pages
- 3963-3967
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2006467537
- Cited by
- 51
- References
- 6
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- retinitis pigmentosa, retinal degeneration, secreted frizzled-related proteins, SFRP2, SFRP1, SFRP3, SFRP5, Wnt signaling, photoreceptor apoptosis, internal limiting membrane, c-Jun, gene expression, retinal neurodegeneration
- MeSH terms
- Secreted Frizzled-Related Proteins, Frizzled-Related Proteins, Aged, Aged, 80 and over, Eye Proteins, Female, Humans, Male, Membrane Proteins, Middle Aged, Proteins, Proto-Oncogene Proteins, Retinitis Pigmentosa, RNA, Messenger, Signal Transduction, Photoreceptor Cells, Vertebrate, Zebrafish Proteins, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Wnt Proteins
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