Secreted antagonists of the Wnt signalling pathway

Wnt proteins are lipid-modified and can act as stem cell growth factors

Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257 · see citing works

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608 · see citing works

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591 · see citing works

LDL-receptor-related proteins in Wnt signal transduction

Tamai, K., Semënov, M. V., Kato, Y., Spokony, R. F., Liu, C., Katsuyama, Y., Hess, F. J., Saint‐Jeannet, J., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,334 · see citing works

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282 · see citing works

An LDL-receptor-related protein mediates Wnt signalling in mice

Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086 · see citing works

<i>Cbfa1</i>-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086 · see citing works

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042 · see citing works

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038 · see citing works

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013 · see citing works

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

Wehrli, M., Dougan, S. T., Caldwell, K. A., O’Keefe, L. V., Schwartz, S. L., Vaizel-Ohayon, D., Schejter, E. D., Tomlinson, A., & DiNardo, S. (2000) · Nature · doi:10.1038/35035110 · Cited by 871 · see citing works

The Wnt/Ca2+ pathway

Kühl, M., Sheldahl, L. C., Park, M., Miller, J. R., & Moon, R. T. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02028-x · Cited by 862 · see citing works

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

Suzuki, H., Gabrielson, E. W., Chen, W., Anbazhagan, R., van Engeland, M., Weijenberg, M. P., Herman, J. G., & Baylin, S. B. (2002) · Nature Genetics · doi:10.1038/ng892 · Cited by 858 · see citing works

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · see citing works

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T., & Robertis, E. M. D. (1999) · Nature · doi:10.1038/17820 · Cited by 832 · see citing works

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772 · see citing works

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759 · see citing works

A new secreted protein that binds to Wnt proteins and inhibits their activites

Hsieh, J.-C., Kodjabachian, L., Rebbert, M. L., Rattner, A., Smallwood, P. M., Samos, C. H., Nusse, R., Dawid, I. B., & Nathans, J. (1999) · Nature · doi:10.1038/18899 · Cited by 750 · see citing works

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

Leyns, L., Bouwmeester, T., Kim, S., Piccolo, S., & Robertis, E. M. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81921-2 · Cited by 736 · see citing works

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S. Y., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 700 · see citing works

Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

Mukhopadhyay, M., Shtrom, S., Rodrı́guez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S.-P., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00041-7 · Cited by 634 · see citing works

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

Rattner, A., Hsieh, J.-C., Smallwood, P. M., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2859 · Cited by 574 · see citing works

The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca 2+ Pathway To Antagonize Wnt/β-Catenin Signaling

Ishitani, T., Kishida, S., Hyodo‐Miura, J., Ueno, N., Yasuda, J., Waterman, M. L., Shibuyà, H., Moon, R. T., Ninomiya‐Tsuji, J., & Matsumoto, K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.131-139.2003 · Cited by 540 · see citing works

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

Pandur, P., Läsche, M., Eisenberg, L. M., & Kühl, M. (2002) · Nature · doi:10.1038/nature00921 · Cited by 536 · see citing works

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · see citing works

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

He, X., Saint‐Jeannet, J., Wang, Y., Nathans, J., Dawid, I. B., & VARMUS, H. E. (1997) · Science · doi:10.1126/science.275.5306.1652 · Cited by 493 · see citing works

Functional and structural diversity of the human Dickkopf gene family

Krupnik, V. E., Sharp, J., Jiang, C., Robison, K. E., Chickering, T. W., Amaravadi, L. S., Brown, D. E., Guyot, D. J., Mays, G. G., Leiby, K. R., et al. (1999) · Gene · doi:10.1016/s0378-1119(99)00365-0 · Cited by 490 · see citing works

Secreted Frizzled‐related proteins: searching for relationships and patterns

Jones, S. E., & Jomary, C. (2002) · BioEssays · doi:10.1002/bies.10136 · Cited by 427 · see citing works

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

Finch, P. W., He, X., Kelley, M. J., Üren, A., Schaudies, R. P., Popescu, N. C., Rudikoff, S., Aaronson, S. A., VARMUS, H. E., & Rubin, J. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6770 · Cited by 417 · see citing works

Wnt-mediated axon guidance via the Drosophila Derailed receptor

Yoshikawa, S., McKinnon, R. D., Kokel, M., & Thomas, J. B. (2003) · Nature · doi:10.1038/nature01522 · Cited by 416 · see citing works

Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling

Üren, A., Reichsman, F., Anest, V., Taylor, W. G., Muraiso, K., Bottaro, D. P., Cumberledge, S., & Rubin, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4374 · Cited by 408 · see citing works

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.

Torres, M. A., Yang-Snyder, J., Purcell, S. M., DeMarais, A. A., McGrew, L. L., & Moon, R. T. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.5.1123 · Cited by 405 · see citing works

Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling

Bafico, A., Gazit, A., Tata, P., Finch, P. W., Yaniv, A., & Aaronson, S. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16180 · Cited by 353 · see citing works

Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling

Mao, B., & Niehrs, C. (2003) · Gene · doi:10.1016/s0378-1119(02)01106-x · Cited by 325 · see citing works

SARPs: A family of secreted apoptosis-related proteins

Melkonyan, H. S., Chang, W. C., Shapiro, J. P., Mahadevappa, M., Fitzpatrick, P., Kiefer, M. C., Tomei, L., & Umansky, S. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13636 · Cited by 322 · see citing works

Heads or tails: Wnts and anterior–posterior patterning

Yamaguchi, T. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00417-1 · Cited by 276 · see citing works

The Wnts.

Miller, J. R. (2001) · Genome biology · doi:10.1186/gb-2001-3-1-reviews3001 · Cited by 275 · see citing works

Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling

Fedi, P., Bafico, A., Nieto, A., Burgess, W. H., Miki, T., Bottaro, D. P., Kraus, M. H., & Aaronson, S. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19465 · Cited by 274 · see citing works

The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling

Lin, K., Wang, S., Julius, M. A., Kitajewski, J., Moos, M. C., & Luyten, F. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11196 · Cited by 251 · see citing works

Primary Structure and Tissue Distribution of FRZB, a Novel Protein Related to Drosophila Frizzled, Suggest a Role in Skeletal Morphogenesis

Hoang, B. H., Moos, M. C., Vukičević, S., & Luyten, F. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26131 · Cited by 248 · see citing works

Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins

Brott, B. K., & Sokol, S. Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6100-6110.2002 · Cited by 234 · see citing works

Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca2+ signaling

Kühl, M., Geis, K., Sheldahl, L. C., Pukrop, T., Moon, R. T., & Wedlich, D. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00416-6 · Cited by 219 · see citing works

The NTR module: Domains of netrins, secreted frizzled related proteins, and type I procollagen C‐proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases

Bányai, L., & Patthy, L. (1999) · Protein Science · doi:10.1110/ps.8.8.1636 · Cited by 195 · see citing works

A REIC Gene Shows Down-Regulation in Human Immortalized Cells and Human Tumor-Derived Cell Lines

Tsuji, T., Miyazaki, M., Sakaguchi, M., Inoue, Y., & Namba, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2067 · Cited by 191 · see citing works

Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule

Biben, C., Stanley, E. G., Fabri, L., Kotecha, S., Rhinn, M., Drinkwater, C. C., Lah, M. S., Wang, C.-C., Nash, A. D., Hilton, D. J., et al. (1998) · Developmental Biology · doi:10.1006/dbio.1997.8812 · Cited by 183 · see citing works

Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling

Wu, W., Glinka, A., Delius, H., & Niehrs, C. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00868-x · Cited by 183 · see citing works

WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

Ugolini, F., Charafe‐Jauffret, E., Bardou, V., Geneix, J., Adélaı̈de, J., Labat-Moleur, F., Penault-Llorca, F. M., Longy, M., Jacquemier, J. D., Birnbaum, D., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204706 · Cited by 176 · see citing works

Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells

Roth, W., Wild‐Bode, C., Platten, M., Grimmel, C., Melkonyan, H. S., DICHGANS, J., & Weller, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203783 · Cited by 169 · see citing works

Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled

Li, L., Mao, J., Sun, L., Liu, W., & Wu, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111131200 · Cited by 168 · see citing works

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

Shou, J., Ali‐Osman, F., Multani, A. S., Pathak, S., Fedi, P., & Srivenugopal, K. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205138 · Cited by 164 · see citing works

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53

Wang, J., Shou, J., & Chen, X. (2000) · Oncogene · doi:10.1038/sj.onc.1203503 · Cited by 159 · see citing works

Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos

Salic, A. N., Kroll, K. L., Esvans, L. M., & Kirschner, M. W. (1997) · Development · doi:10.1242/dev.124.23.4739 · Cited by 159 · see citing works

Cloning and Expression of the Wnt Antagonists Sfrp-2 and Frzb during Chick Development

Ladher, R. K., CHURCH, V. L., Allen, S., Robson, L. G., Abdelfattah, A., Brown, N. A., Hattersley, G., Rosen, V., Luyten, F. P., Dale, L., et al. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9586 · Cited by 157 · see citing works

Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning

Davidson, G. R., Mao, B., Barrantes, I. D. B., & Niehrs, C. (2002) · Development · doi:10.1242/dev.00154 · Cited by 149 · see citing works

Cell fate specification and competence by Coco, a maternal BMP, TGFβand Wnt inhibitor

Bell, E. J. D. H., Muñoz-Sanjuán, I., Altmann, C. R., Vonica, A., & Brivanlou, A. H. (2003) · Development · doi:10.1242/dev.00344 · Cited by 149 · see citing works

Antiproliferative Activity of REIC/Dkk-3 and Its Significant Down-Regulation in Non-Small-Cell Lung Carcinomas

Tsuji, T., Nozaki, I., Miyazaki, M., Sakaguchi, M., Pu, H., Hamazaki, Y., Iijima, O., & Namba, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5972 · Cited by 124 · see citing works

Secreted Frizzled-related proteins can regulate metanephric development

Yoshino, K., Rubin, J. S., Higinbotham, K. G., Üren, A., Anest, V., Plisov, S. Y., & Perantoni, A. O. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00282-9 · Cited by 118 · see citing works

A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1

Pera, E. M., & Robertis, E. M. D. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00394-4 · Cited by 117 · see citing works

Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist

Xu, Q., D'Amore, P. A., & Sokol, S. Y. (1998) · Development · doi:10.1242/dev.125.23.4767 · Cited by 114 · see citing works

Frzb-1, an Antagonist of Wnt-1 and Wnt-8, Does Not Block Signaling by Wnts -3A, -5A, or -11

Wang, S., Krinks, M. H., & Moos, M. C. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6995 · Cited by 113 · see citing works

FrzA, a Secreted Frizzled Related Protein, Induced Angiogenic Response

Dufourcq, P., Couffinhal, T., Ezan, J., et al. (2002) · Circulation · doi:10.1161/01.cir.0000039342.85015.5c · Cited by 103 · see citing works

Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon

Kim, A. S., Lowenstein, D. H., & Pleasure, S. J. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00342-2 · Cited by 102 · see citing works

Colipase: structure and interaction with pancreatic lipase

TILBEURGH, H. V., Bezzine, S., Cambillau, C., et al. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00149-3 · Cited by 99 · see citing works

FrzA, a Secreted Frizzled Related Protein, Induced Angiogenic Response

PascaleDufourcq, Couffinhal, T., Ezan, J., et al. (2002) · Circulation · Cited by 92 · see citing works

Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy.

Abu‐Jawdeh, G. M., Comella, N., Tomita, Y., et al. (1999) · PubMed · Cited by 88 · see citing works

The WIF module

Patthy, L. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01504-2 · Cited by 82 · see citing works

The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm

Collavin, L., & Kirschner, M. W. (2003) · Development · doi:10.1242/dev.00306 · Cited by 77 · see citing works

Frequent loss of heterozygosity and three critical regions on the short arm of chromosome 8 in ovarian adenocarcinomas

Wright, K., Wilson, P. J., Kerr, J., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202028 · Cited by 68 · see citing works

A colipase fold in the carboxy-terminal domain of the Wnt antagonists – the Dickkopfs

Aravind, L., & Koonin, E. V. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70309-4 · Cited by 67 · see citing works

The synthetic multivulval genes ofC. elegans: functional redundancy, Ras-antagonism, and cell fate determination

Fay, D. S., & Han, M. (2000) · genesis · doi:10.1002/(sici)1526-968x(200004)26:4 · Cited by 66 · see citing works

Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis.

Pfeffer, P., Robertis, E. D., & Izpisúa-Belmonte, J. (1997) · International Journal of Developmental Biology · doi:10.1387/ijdb.9240561 · Cited by 66 · see citing works

Fritz: a secreted frizzled-related protein that inhibits Wnt activity

Mayr, T., Deutsch, U., Kühl, M., Drexler, H. C. A., Lottspeich, F., Deutzmann, R., Wedlich, D., & Risau, W. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00035-x · Cited by 63 · see citing works

Different Activities of the Frizzled-Related Proteins frzb2 and sizzled2 during Xenopus Anteroposterior Patterning

Bradley, L., Sun, B. I., Collins‐Racie, L. A., LaVallie, E., McCoy, J. M., & Sive, H. L. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9873 · Cited by 59 · see citing works

Human Secreted Frizzled-Related Protein Is Down-regulated and Induces Apoptosis in Human Cervical Cancer

KO, J., RYU, K., LEE, Y., et al. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5649 · Cited by 57 · see citing works

Identification and Cloning of a Secreted Protein Related to the Cysteine-Rich Domain of Frizzled

Duplàa, C., Jaspard‐Vinassa, B., Moreau, C., & D'Amore, P. A. (1999) · Circulation Research · doi:10.1161/01.res.84.12.1433 · Cited by 56 · see citing works

Bmp, Fgf and Wnt signalling in programmed cell death and chondrogenesis during vertebrate limb development: the role of Dickkopf-1

Grotewold, L., & Rüther, U. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12455632 · Cited by 52 · see citing works

Modulated expression of secreted Frizzledrelated proteins in human retinal degeneration

Jones, S. E., Jomary, C., Grist, J., Stewart, H. J., & Neal, M. J. (2000) · Neuroreport · doi:10.1097/00001756-200012180-00012 · Cited by 51 · see citing works

Dickkopf1 and the Spemann-Mangold head organizer

Niehrs, C., Kazanskaya, O., Wu, W., & Glinka, A. (2001) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11291852 · Cited by 49 · see citing works

Soggy, a spermatocyte-specific gene, lies 3.8 kb upstream of and antipodal to TEAD-2, a transcription factor expressed at the beginning of mouse development

Kaneko, K. J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.20.3982 · Cited by 40 · see citing works

Adenoviral-mediated expression of antisense RNA to fibroblast growth factors disrupts murine vascular development

Leconte, I., Fox, J. C., Baldwin, H. S., Buck, C. A., & Swain, J. L. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199812)213:4 · Cited by 38 · see citing works

Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase

Mulvaney, P. T., Stracke, M. L., Nam, S. W., Woodhouse, E. C., O'Keefe, M., Clair, T., Liotta, L. A., Kaddurah-Daouk, R. F., & Schiffmann, E. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980925)78:1 · Cited by 24 · see citing works

Cloning and developmental expression of a novel, secreted frizzled-related protein from the sea urchin, Strongylocentrotus purpuratus

Illies, M. R., Peeler, M. T., Dechtiaruk, A., & Ettensohn, C. A. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00657-8 · Cited by 17 · see citing works

Wnt signal transduction pathways

Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works

Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

Gaur, T., Lengner, C. J., Hovhannisyan, H., Bhat, R. A., Bodine, P. V. N., Komm, B. S., Javed, A., van Wijnen, A. J., Stein, J. L., Stein, G. S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500608200 · Cited by 1,170 · see citing works

Skeletal muscle hypertrophy and atrophy signaling pathways

Glass, D. J. (2005) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2005.04.018 · Cited by 1,106 · see citing works

Function and biological roles of the Dickkopf family of Wnt modulators

Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995 · see citing works

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN <i>XENOPUS</i> EMBRYOS

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Secreted and transmembrane wnt inhibitors and activators

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Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization

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Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight

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Wnt/β-Catenin Signaling Mediates Osteoblast Differentiation Triggered by Peptide-induced α5β1 Integrin Priming in Mesenchymal Skeletal Cells

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Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats.

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MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer

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WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

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A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model

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sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss

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Impact of an Altered Wnt1/β-Catenin Expression on Clinicopathology and Prognosis in Clear Cell Renal Cell Carcinoma

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Two Wnt genes regulate the expression levels of antimicrobial peptides during Vibrio infection in Macrobrachium nipponense

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A Novel Set of Wnt-Frizzled Fusion Proteins Identifies Receptor Components That Activate β-Catenin-dependent Signaling

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A model for signaling specificity of Wnt/Frizzled combinations through co‐receptor recruitment

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