Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer's disease
Abstract
Cell-cycle dysregulation might be critically involved in the process of neurodegeneration in Alzheimer's disease (AD). We now provide evidence for a dysfunction of the cell division cycle as a more general cellular phenomenon of the disease. Peripheral blood lymphocytes, stimulated with mitogenic compounds, were less able to express CD69, an early proliferation marker, in AD patients than in age-matched controls. Expression levels of CD69 of both T-cells and B-cells correlated inversely with the Mini-mental Scale. The results suggest that a systemic failure of cellular proliferation control might be of critical importance for the pathomechanism of AD.
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A cell cycle regulatory failure occurs in lymphocytes as it was observed in neurons.
“Nevertheless, despite these several defence mechanisms, authors showed a cell cycle regulatory failure in lymphocytes as it was observed in neurons [130–132, 168, 169].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [169]
Cites
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works
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PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · see citing works
- Authors
- Stieler, J. T., Lederer, C., Brückner, M. K., Wolf, H., Holzer, M., Gertz, H.-J., & Arendt, T.
- Affiliations
- Leipzig University (DE)
- Venue
- Neuroreport
- Published
- 2001-12
- Volume
- 12
- Issue
- 18
- Pages
- 3969-3972
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1975330896
- Cited by
- 43
- References
- 1
- Citations by year
- 2026: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, peripheral blood lymphocytes, mitogen stimulation, CD69, cell proliferation, cell cycle dysregulation, T cells, B cells, Mini-Mental State Examination, neurodegeneration, immunosenescence
- MeSH terms
- CD69 Antigens, Aged, Aged, 80 and over, Alzheimer Disease, Antigens, Differentiation, T-Lymphocyte, Apolipoproteins E, B-Lymphocytes, Cell Division, Flow Cytometry, Genotype, Humans, Mitogens, T-Lymphocytes, Antigens, CD, Lectins, C-Type
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