The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Localisation of breast cancer resistance protein in microvessel endothelium of human brain
Abstract
Movement of substrates between blood and brain is known to be influenced by P-glycoprotein (P-gp) at the luminal surface of the endothelium lining brain microvessels and by multidrug resistance associated protein 1 (MRP1) at the basolateral surface of the choroid plexus epithelium. Here, using RT-PCR and Western blotting, we investigate other ABC transporters in both normal and tumour human brain tissue and demonstrate the presence of breast cancer resistance protein (BCRP). Immunofluorescence confocal microscopy demonstrates that BCRP is located at the blood-brain barrier, mainly at the luminal surface of microvessel endothelium. This localization closely resembles that of P-gp. BCRP has several substrates in common with P-gp and may pose an additional barrier to drug access to the brain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
P-Glycoprotein, a gatekeeper in the blood–brain barrier
Schinkel, A. H. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00085-4 · Cited by 960
Litman, T., Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D. D., Miyake, K., Resau, J. H., & Bates, S. E. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.2011 · Cited by 538
Sisodiya, S. M., Lin, W. ‐., Harding, B. N., Squier, M. V., & Thom, M. (2002) · Brain · doi:10.1093/brain/awf002 · Cited by 479
Wijnholds, J., de Lange, E. C. M., Scheffer, G. L., van den Berg, D.-J., Mol, C. A. A. M., van der Valk, M., Schinkel, A. H., Scheper, R. J., Breimer, D. D., & Borst, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8267 · Cited by 360
Regina, A., Koman, A., Piciotti, M., El Hafny, B., Center, M. S., Bergmann, R., Couraud, P., & Roux, F. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71020705.x · Cited by 266
Glucose transporter localization in brain using light and electron immunocytochemistry
Gerhart, D. Z., Levasseur, R. J., Broderius, M. A., & Drewes, L. R. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490220413 · Cited by 202
Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells
Huai-Yun, H., Secrest, D. T., Mark, K. S., Carney, D., Brandquist, C., Elmquist, W. F., & Miller, D. W. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.8132 · Cited by 199
Anticancer drug resistance in primary human brain tumors
Bredel, M. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00045-5 · Cited by 152
A new multidrug resistance protein at the blood–brain barrier
Eisenblaetter, T., & Galla, H. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00376-5 · Cited by 149
Seetharaman, S., Barrand, M. A., Maskell, L. B., & Scheper, R. J. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70031151.x · Cited by 137
Self-citation
Cited by
Targeting multidrug resistance in cancer
Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
Austin Doyle, L., & Ross, D. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206938 · Cited by 1,051
Overcoming the blood–brain tumor barrier for effective glioblastoma treatment
van Tellingen, O., Yetkin-Arik, B., de Gooijer, M. C., Wesseling, P., Wurdinger, T., & de Vries, H. E. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2015.02.002 · Cited by 1,035
Blood-brain barrier active efflux transporters: ATP-binding cassette gene family
Löscher, W., & Potschka, H. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.86 · Cited by 872
Helms, H. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P.-O., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16630991 · Cited by 843
Metadata
- Authors
- Cooray, H. C., Blackmore, C. G., Maskell, L., & Barrand, M. A.
- Venue
- NeuroReport
- Published
- 2002-11
- Volume
- 13
- Issue
- 16
- Pages
- 2059-2063
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2020441233
- Cited by
- 419
- References
- 14
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Localisation of breast cancer resistance protein in microvessel endothelium of human brain. https://app.cochat.ai/papers/10.1097/00001756-200211150-00014
- The paper
- Cooray, H. C., Blackmore, C. G., Maskell, L., & Barrand, M. A. (2002). Localisation of breast cancer resistance protein in microvessel endothelium of human brain. NeuroReport. https://doi.org/10.1097/00001756-200211150-00014
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
