Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats
Abstract
Galanin-like peptide is a recently identified neuropeptide. We examined the effects of stressful stimuli on expression of c-Fos protein in galanin-like peptide neurons, and the effects of central infusion of galanin-like peptide on release of stress hormones, vasopressin, oxytocin and adrenocorticotropic hormone, in male rats. Foot shock stress induced expression of c-Fos protein in galanin-like peptide neurons in the hypothalamus. Intracerebroventricular injection of galanin-like peptide significantly increased plasma concentrations of vasopressin, oxytocin and adrenocorticotropic hormone. Galanin-like peptide also increased blood pressure, heart rates and plasma glucose concentrations, but significantly changed neither plasma osmolality nor blood haemoglobin concentration. A neuropeptide Y-Y1 receptor antagonist, BIBP3226, did not significantly change galanin-like peptide-induced hormone release. It is possible that galanin-like peptide is involved in vasopressin, oxytocin and adrenocorticotropic hormone release from the pituitary during stress.
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Intracerebroventricular injections of galanin-like peptides enhance the release of oxytocin.
“intracerebroventricular injections of galanin-like peptides enhance the release of oxytocin (Onaka et al., 2005).”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Onaka et al., 2005
Galanin-like peptides can be released by stress from neurons in the arcuate nucleus.
“galanin-like peptides can be released by stress from neurons in the arcuate nucleus”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Onaka et al., 2005
Cites
Isolation and cDNA Cloning of a Novel Galanin-like Peptide (GALP) from Porcine Hypothalamus
Ohtaki, T., Kumano, S., Ishibashi, Y., Ogi, K., Matsui, H., Harada, M., Kitada, C., Kurokawa, T., Onda, H., & Fujino, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37041 · Cited by 274 · see citing works
Release of oxytocin during suckling and parturition in the rat
Higuchi, T., Honda, K., Fukuoka, T., Negoro, H., & Wakabayashi, K. (1985) · Journal of Endocrinology · doi:10.1677/joe.0.1050339 · Cited by 247 · see citing works
Distribution of Galanin-Like Peptide in the Rat Brain
Takatsu, Y., Matsumoto, H., Ohtaki, T., Kumano, S., Kitada, C., Onda, H., Nishimura, O., & Fujino, M. (2001) · Endocrinology · doi:10.1210/endo.142.4.8089 · Cited by 154 · see citing works
Neural Pathways Controlling Central and Peripheral Oxytocin Release During Stress
Onaka, T. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01186.x · Cited by 130 · see citing works
Self-citationLarm, J. A., & Gundlach, A. L. (2000) · Neuroendocrinology · doi:10.1159/000054573 · Cited by 106 · see citing works
Hooi, S. C., Maiter, D. M., Martin, J. B., et al. (1990) · Endocrinology · doi:10.1210/endo-127-5-2281 · Cited by 91 · see citing works
Briski, K. P., & Gillen, E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00532-9 · Cited by 79 · see citing works
Differential effects of naloxone on neuroendocrine responses to fear-related emotional stress
Onaka, T., & Yagi, K. (1990) · Experimental Brain Research · doi:10.1007/bf00230100 · Cited by 77 · see citing works
Self-citationHawes, J. J., & Picciotto, M. R. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20329 · Cited by 76 · see citing works
Galanin-like peptide (GALP) is expressed in rat hypothalamus and pituitary, but not in DRG
Kerr, N. C. H., Holmes, F. E., & Wynick, D. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00060 · Cited by 72 · see citing works
Effects of Galanin-Like Peptide on Food Intake and the Hypothalamo-Pituitary-Thyroid Axis
Seth, A., Stanley, S. A., Dhillo, W. S., Murphy, K. G., Ghatei, M., & Bloom, S. R. (2003) · Neuroendocrinology · doi:10.1159/000068648 · Cited by 64 · see citing works
Lawrence, C. B., Williams, T., & Luckman, S. M. (2003) · Endocrinology · doi:10.1210/en.2003-0391 · Cited by 50 · see citing works
Parker, S. L., & Crowley, W. R. (1993) · Endocrinology · doi:10.1210/endo.132.2.8381069 · Cited by 48 · see citing works
Galanin‐Like Peptide as a Link Between Metabolism and Reproduction
Cunningham, M. J. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01221.x · Cited by 44 · see citing works
Gundlach, A. L., & Burazin, T. C. D. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10699.x · Cited by 41 · see citing works
Fujiwara, K., Adachi, S., Usui, K., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02445-4 · Cited by 40 · see citing works
Onaka, T., & Yagi, K. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00607.x · Cited by 39 · see citing works
Self-citationEffect of galanin on plasma levels of oxytocin and cholecystokinin
Björkstrand, E., Hulting, A.-L., Meister, B., & Uvnäs‐Moberg, K. (1993) · Neuroreport · doi:10.1097/00001756-199301000-00002 · Cited by 26 · see citing works
Kondo, K., Murase, T., Otake, K., Ito, M., Kurimoto, F., & Oiso, Y. (2008) · Neuroendocrinology · doi:10.1159/000126363 · Cited by 24 · see citing works
Chen, S., & Cheung, R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00576-6 · Cited by 20 · see citing works
Onaka, T., & Yagi, K. (1992) · Neuroscience Research · doi:10.1016/0168-0102(92)90005-w · Cited by 10 · see citing works
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Borroto-Escuela, D. O., Cuesta-Marti, C., Lopez-Salas, A., Chruścicka-Smaga, B., Crespo-Ramírez, M., Tesoro-Cruz, E., Palacios-Lagunas, D. A., Perez de la Mora, M., Schellekens, H., & Fuxe, K. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1055344 · Cited by 38 · see citing works
- Authors
- Onaka, T., Kuramochi, M., Saito, J., Ueta, Y., & Yada, T.
- Affiliations
- Jichi Medical University (JP)
- University of Occupational and Environmental Health Japan (JP)
- Venue
- Neuroreport
- Published
- 2005-02
- Volume
- 16
- Issue
- 3
- Pages
- 243-247
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2055331707
- Cited by
- 17
- References
- 21
- Citations by year
- 2026: 1 · 2022: 2 · 2019: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- galanin-like peptide, vasopressin, oxytocin, ACTH, stress hormones, hypothalamic neurons, Fos expression, footshock stress, Y1 receptor, pituitary hormone secretion, blood pressure, plasma glucose
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Blood Glucose, Cell Count, Dose-Response Relationship, Drug, Drug Interactions, Electroshock, Hypothalamus, Immunohistochemistry, Injections, Intraventricular, Male, Neurons, Osmolar Concentration, Oxytocin, Time Factors, Vasopressins, Proto-Oncogene Proteins c-fos, Rats, Wistar, Receptors, Neuropeptide Y, Galanin-Like Peptide, Rats
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