The DOI matches its Crossref record.
Treatment of intestinal microsporidiosis with albendazole in patients with AIDS
Abstract
OBJECTIVE: To determine the clinical and parasitological response to treatment of intestinal microsporidiosis with albendazole. DESIGN: Open prospective study. SETTING: Hospital-based HIV/genito-urinary medicine unit. PATIENTS, PARTICIPANTS: Six consecutive AIDS patients with small intestinal microsporidiosis as the only identified cause of diarrhoea after intensive gastrointestinal investigations. RESULTS: Diarrhoea resolved completely in all patients within 1 week of starting treatment, and body weight stabilized or increased. Four patients who relapsed at 19-31 days after the cessation of treatment responded to a second course of albendazole. Degenerative changes occurred in the parasites after treatment, which had not been seen either in pre-treatment biopsies or, in four patients, following therapy with other drugs. CONCLUSIONS: Albenazole is a useful palliative treatment for microsporidial diarrhoea.
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“The therapeutic efficacy of albendazole (800 mg daily for 28 days) against human microsporidiosis due to Enterocytozoon bieneusi was first suggested by Blanshard et al. [290] in 1992.”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [290]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence
Katiyar, S. K., Gordon, V. R., McLaughlin, G. L., & Edlind, T. D. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.9.2086 · Cited by 217
Activity of Benzimidazoles against Cryptosporidiosis in Neonatal BALB/c Mice
Fayer, R., & Fetterer, R. (1995) · The Journal of Parasitology · doi:10.2307/3283980 · Cited by 31
Metadata
- Authors
- Blanshard, C., Ellis, D. S., Tovey, D. G., Dowell, S., & Gazzard, B. G.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- ORCID
- Blanshard, Christine
- Venue
- AIDS
- Published
- 1992-03
- Volume
- 6
- Issue
- 3
- Pages
- 311-314
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2040860941
- Cited by
- 145
- References
- 0
- Citations by year
- 2025: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 6
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Keywords
- intestinal microsporidiosis, albendazole, HIV-associated diarrhea, parasitological response, treatment relapse, palliative care
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, Animals, Diarrhea, Humans, Male, Middle Aged, Prospective Studies, Albendazole, Microsporida, Microsporidiosis
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Treatment of intestinal microsporidiosis with albendazole in patients with AIDS. https://app.cochat.ai/papers/10.1097/00002030-199203000-00009
- The paper
- Blanshard, C., Ellis, D. S., Tovey, D. G., Dowell, S., & Gazzard, B. G. (1992). Treatment of intestinal microsporidiosis with albendazole in patients with AIDS. AIDS. https://doi.org/10.1097/00002030-199203000-00009
