Cited by 99Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVasculitis and related conditions

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Pathogenic mechanisms mediating antiphospholipid syndrome

Meroni, Pier Luigi, Riboldi, Piersandro·2001·Current Opinion in Rheumatology

DOI 10.1097/00002281-200109000-00006

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Abstract

Antiphospholipid antibodies are the marker for antiphospholipid syndrome. There is evidence that these autoantibodies lead to both thrombotic diathesis and obstetrical manifestations. Besides the known interaction with soluble coagulation factors, in vitro and in vivo experimental models and studies in humans recently have shown the ability of antiphospholipid antibodies to modulate functions of cells involved in coagulation homeostasis. These findings support a new hypothesis to explain the paradox of the prolongation of coagulation assays in vitro and the association with thrombophilic diathesis in vivo. Obstetrical manifestations have been linked to a direct antibody effect on the trophoblast leading to defective placentation that is not necessarily associated with thrombotic phenomena. Phospholipid binding proteins such as beta 2 -glycoprotein I appear to behave as a bridge between circulating antiphospholipid antibodies and cellular targets.

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1 retracted

Monocyte Tissue Factor Induction by Activation of β2-Glycoprotein-I-Specific T Lymphocytes Is Associated with Thrombosis and Fetal Loss in Patients with Antiphospholipid Antibodies
Visvanathan, S., Geczy, C. L., Harmer, J. A., & McNeil, H. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.2258 · Cited by 22
Retracted
In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
Combes, V., Simon, A.-C., Grau, G. E., Arnoux, D., Camoin‐Jau, L., Sabatier, F., Mutin, M., Sanmarco, M., Sampol, J., & Dignat‐George, F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4985 · Cited by 731
Antiphospholipid Antibodies From Antiphospholipid Syndrome Patients Activate Endothelial Cells In Vitro and In Vivo
Pierangeli, S. S., Colden‐Stanfield, M., Liu, X., Barker, J. H., Anderson, G. L., & Harris, E. N. (1999) · Circulation · doi:10.1161/01.cir.99.15.1997 · Cited by 323
The Role of the Tissue Factor Pathway in the Hypercoagulable State in Patients with the Antiphospholipid Syndrome
Amengual, O., Atsumi, T., Hughes, G. R. V., et al. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614977 · Cited by 270
Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases: Antinucleosome antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus
Amoura, Z., Koutouzov, S., Chabre, H., Cacoub, P., Amoura, I., Musset, L., Bach, J., & Pietté, J. C. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 243
Thrombogenic Effects of Antiphospholipid Antibodies Are Mediated by Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and P-Selectin
Pierangeli, S. S., Espinola, R. G., Liu, X., & Harris, E. N. (2001) · Circulation Research · doi:10.1161/01.res.88.2.245 · Cited by 187
Adoptive Transfer of β 2 -Glycoprotein I–Reactive Lymphocytes Enhances Early Atherosclerosis in LDL Receptor–Deficient Mice
George, J., Harats, D., Gilburd, B., et al. (2000) · Circulation · doi:10.1161/01.cir.102.15.1822 · Cited by 168
Action of anticardiolipin and antibodies to β2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death
Chamley, L., Duncalf, A. M., Mitchell, M. D., & Johnson, P. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60080-3 · Cited by 165
Endothelial Activation by aPL: A Potential Pathogenetic Mechanism for the Clinical Manifestations of the Syndrome
Meroni, P. L., Raschi, E., Camera, M., Testoni, C., Nicoletti, F., Tincani, A., Khamashta, M. A., Balestrieri, G., Tremoli, E., & Hess, D. C. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0412 · Cited by 163
Self-citation
Increased Levels of Tissue Factor mRNA in Mononuclear Blood Cells of Patients with Primary Antiphospholipid Syndrome
López-Pedrera, C., Velasco, F., Aguirre, M. A., et al. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614881 · Cited by 122
Differential Effects of Anti–β2-Glycoprotein I and Antiprothrombin Antibodies on the Anticoagulant Activity of Activated Protein C
Galli, M., Ruggeri, L., & Barbui, T. (1998) · Blood · doi:10.1182/blood.v91.6.1999 · Cited by 116
Human beta 2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-beta 2-glycoprotein I antibodies.
Papa, N. D., Sheng, Y., Raschi, E., et al. (1998) · PubMed · Cited by 114
Human β2-Glycoprotein I Binds to Endothelial Cells Through a Cluster of Lysine Residues That Are Critical for Anionic Phospholipid Binding and Offers Epitopes for Anti-β2-Glycoprotein I Antibodies
Papa, N. D., Sheng, Y., Raschi, E., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5572 · Cited by 105
The Role of Placental Trophoblast in the Pathophysiology of the Antiphospholipid Antibody Syndrome
Rote, N. S., Vogt, E., Devere, G., et al. (1998) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1998.tb00344.x · Cited by 98
Antiphospholipid Antibody-mediated Disruption of the Annexin-V Antithrombotic Shield: a Thrombogenic Mechanism for the Antiphospholipid Syndrome
Rand, J. H. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0410 · Cited by 87
Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus
Male, C., Mitchell, L. G., Julian, J. A., et al. (2001) · Blood · doi:10.1182/blood.v97.4.844 · Cited by 77
Reduced factor XII levels in patients with the antiphospholipid syndrome are associated with antibodies to factor XII
Jones, D. W., Gallimore, M. J., Mackie, I. J., et al. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02251.x · Cited by 73
Interaction of Anti-Phospholipid Antibodies With Late Endosomes of Human Endothelial Cells
Rochemonteix, B. G.-D., Kobayashi, T., Rosnoblet, C., Lindsay, M. R., Parton, R. G., Reber, G., de Maistre, E., Wahl, D. G., Kruithof, E. K. O., Grüenberg, J., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.563 · Cited by 73
Binding of anticardiolipin antibodies to protein C via β2-glycoprotein I (β2-GPI): a possible mechanism in the inhibitory effect of antiphospholipid antibodies on the protein C system
Atsumi, T., Khamashta, M. A., Amengual, O., et al. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00582.x · Cited by 64
Endothelial Cells as a Target for Antiphospholipid Antibodies: Role of Anti‐Beta 2 Glycoprotein I Antibodies
Papa, N. D., Raschi, E., Catelli, L., et al. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00301.x · Cited by 59
Competition of Annexin V and Anticardiolipin Antibodies for Binding to Phosphatidylserine Containing Membranes
Willems, G. M., Janssen, M. P., Comfurius, P., Galli, M., Zwaal, R. F. A., & Bevers, E. M. (2000) · Biochemistry · doi:10.1021/bi9921081 · Cited by 58
Autoantibodies associated with atherosclerosis.
Shoenfeld, Y., Sherer, Y., George, J., et al. (2000) · PubMed · Cited by 58
Experimental Thrombosis and Antiphospholipid Antibodies: New Insights
Pierangeli, S. S., Gharavi, A. E., & Harris, E. N. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0420 · Cited by 56
Anti-β2-glycoprotein I (GPI) autoantibodies, annexin V binding and the anti-phospholipid syndrome
Hanly, J. G., & Smith, S. A. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01248.x · Cited by 54
Effect of anticardiolipin/beta2-glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome.
Robbins, D. L., Leung, S., Miller-Blair, D. J., et al. (1998) · PubMed · Cited by 54
Increased endothelial cell expression of a3β1 integrin in cardiac valvulopathy in the primary (Hughes) and secondary antiphospholipid syndrome
Afek, A. B., Shoenfeld, Y., Manor, R. S., Goldberg, I., Ziporen, L., George, J., Polak‐Charcon, S., Amigo, M., Garcia-Torres, R., Segal, R., et al. (1999) · Lupus · doi:10.1191/096120399678840873 · Cited by 52
Tissue Factor Pathway and the Antiphospholipid Syndrome
Roubey, R. A. S. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0397 · Cited by 51
Nuclear antigen histone H1 is primarily involved in lupus erythematosus cell formation
Schett, G. A., Steiner, G. E., & Smolen, J. S. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199808)41:8 · Cited by 44
Placentation, antiphospholipid syndrome and pregnancy outcome
Stone, S., Khamashta, M. A., & Poston, L. (2001) · Lupus · doi:10.1191/096120301667486047 · Cited by 39
The Putative Mechanism of Thrombosis in Antiphospholipid Syndrome: Impairment of the Protein C and the Fibrinolytic Systems by Monoclonal Anticardiolipin Antibodies
Ieko, M., Sawada, K., Koike, T., Notoya, A., Mukai, M., Kohno, M., Wada, N., Itoh, T., & Yoshioka, N. (1999) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-994958 · Cited by 33
Analysis of Prothrombotic Effects of two Human Monoclonal IgG Antiphospholipid Antibodies of Apparently Similar Specificity
von Landenberg, C., Barlage, S., Schmitz, G., et al. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613867 · Cited by 29
Long-term Prognosis of Antiphospholipid Syndrome in Patients with Systemic Lupus Erythematosus
Alarcón-Segovia, D., Pérez-Ruiz, A., & Villa, A. R. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0402 · Cited by 25
β2 glycoprotein I containing immune-complexes in lupus patients: association with thrombocytopenia and lipoprotein (a) levels
George, J., Gilburd, B., Langevitz, P., et al. (1999) · Lupus · doi:10.1191/096120399678847470 · Cited by 23
IgG from patients with antiphospholipid syndrome binds to platelets without induction of platelet activation
Ford, Urbaniak, & Greaves (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00841.x · Cited by 21
Platelet activation markers and the primary antiphospholipid syndrome (PAPS)
Joseph, J. E., Harrison, P. J., Ij, M., et al. (1998) · Lupus · doi:10.1177/096120339800700212 · Cited by 21
Affinity purified human antiphospholipid antibodies bind normal term placenta
Donohoe, S., Kingdom, J. C., & Mackie, I. J. (1999) · Lupus · doi:10.1191/096120399678840756 · Cited by 17
Antiphospholipid syndrome: insights from animal models
Sherer, Y., & Shoenfeld, Y. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200009000-00011 · Cited by 16
Plasma contact system, kallikrein–kinin system and antiphospholipid-protein antibodies in thrombosis and pregnancy
Sugi, T., & Makino, T. (2000) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(00)00061-9 · Cited by 13
Untitled work
Wilson (1999) · doi:10.1002/1529-0131(199907)42:7
Untitled work
Lawrence (1998) · doi:10.1002/1529-0131(199805)41:5

Research works printed but not linked: 4

Keying, 2000, J Biol Chem, 20, 15541
Shoenfeld, 2000, Ann Med, 32, 37
Robbins, 1998, J Rheumatol, 25, 51
Di Simone, 2000, Arthritis Rheum, 43, 140, 10.1002/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P · DOI

Sorted by citations

Hydroxychloroquine Use Is Associated with Lower Odds of Persistently Positive Antiphospholipid Antibodies and/or Lupus Anticoagulant in Systemic Lupus Erythematosus
BRODER, A., & PUTTERMAN, C. (2013) · The Journal of Rheumatology · doi:10.3899/jrheum.120157 · Cited by 102
“LAC+ and/or at least 1 aPL ≥ 40 U 25 (28) 20 (22) 17 (19) LAC+ and aPL ≥ 40 U 7 (8) 4 (4) 4 (4) LAC– and aPL ≥ 40 U 6 (7) 2 (2) 1 (1) LAC+ and aPL < 40 U 1 (1) 3 (3) 1 (1) LAC unknown and aPL ≥ 40 U 11 (12) 11 (12) 7 (8) LAC unknown and aPL < 40 U 37 (41) 28 (31) 24 (27) At least 1 aPL ≥ 40 U 24 (27) 17 (19) 16 (18) A…”
The two hit hypothesis in the antiphospholipid syndrome: acute ischaemic heart involvement after valvular replacement despite anticoagulation in a patient with secondary APS
Bordin, G., Boldorini, R., & Meroni, P. L. (2003) · Lupus · doi:10.1191/0961203303lu445cr · Cited by 33
Self-citation

See all 99

Authors: Meroni, P. L., & Riboldi, P.
Affiliations: University of Milan (IT)
Corresponding author: Meroni, Pier Luigi
ORCID: Meroni, Pier Luigi
Venue: Current Opinion in Rheumatology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-09
Volume: 13
Issue: 5
Pages: 377-382
ISSN: 1040-8711 (ISSN-L)
DOI: 10.1097/00002281-200109000-00006
OpenAlex: W2330553074
Cited by: 99
References: 40
Citations by year: 2026: 5 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 7
FWCI: 1.59
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Rheumatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
Keywords: antiphospholipid syndrome, antiphospholipid antibodies, thrombophilia, thrombotic diathesis, beta2-glycoprotein I, phospholipid-binding proteins, trophoblast
MeSH terms: Animals, Disease Models, Animal, Female, Fetal Death, Humans, Pregnancy, Pregnancy Complications, Hematologic, Thrombosis, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, Mice, In Vitro Techniques

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Pathogenic mechanisms mediating antiphospholipid syndrome

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