The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Pathogenic mechanisms mediating antiphospholipid syndrome
Abstract
Antiphospholipid antibodies are the marker for antiphospholipid syndrome. There is evidence that these autoantibodies lead to both thrombotic diathesis and obstetrical manifestations. Besides the known interaction with soluble coagulation factors, in vitro and in vivo experimental models and studies in humans recently have shown the ability of antiphospholipid antibodies to modulate functions of cells involved in coagulation homeostasis. These findings support a new hypothesis to explain the paradox of the prolongation of coagulation assays in vitro and the association with thrombophilic diathesis in vivo. Obstetrical manifestations have been linked to a direct antibody effect on the trophoblast leading to defective placentation that is not necessarily associated with thrombotic phenomena. Phospholipid binding proteins such as beta 2 -glycoprotein I appear to behave as a bridge between circulating antiphospholipid antibodies and cellular targets.
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In the citing paper
“Antiphospholipid antibodies (aPL Abs) play an active role in the pathogenesis of the antiphospholipid syndrome (APLS).”
In the citing paper
“However, aPL Abs alone are not sufficient, and may persist for a long time before the 2nd hit results in the actual thrombotic event (1, 2).”
In the citing paper
“According to the two-hit hypothesis, the presence of antiphospholipid antibodies (aPL Abs) is necessary to create a prothrombotic state (1st hit).”
Citations
Cites
1 retracted
Visvanathan, S., Geczy, C. L., Harmer, J. A., & McNeil, H. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.2258 · Cited by 22
RetractedCombes, V., Simon, A.-C., Grau, G. E., Arnoux, D., Camoin‐Jau, L., Sabatier, F., Mutin, M., Sanmarco, M., Sampol, J., & Dignat‐George, F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4985 · Cited by 731
Pierangeli, S. S., Colden‐Stanfield, M., Liu, X., Barker, J. H., Anderson, G. L., & Harris, E. N. (1999) · Circulation · doi:10.1161/01.cir.99.15.1997 · Cited by 323
Amengual, O., Atsumi, T., Hughes, G. R. V., et al. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614977 · Cited by 270
Amoura, Z., Koutouzov, S., Chabre, H., Cacoub, P., Amoura, I., Musset, L., Bach, J., & Pietté, J. C. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 243
Pierangeli, S. S., Espinola, R. G., Liu, X., & Harris, E. N. (2001) · Circulation Research · doi:10.1161/01.res.88.2.245 · Cited by 187
George, J., Harats, D., Gilburd, B., et al. (2000) · Circulation · doi:10.1161/01.cir.102.15.1822 · Cited by 168
Chamley, L., Duncalf, A. M., Mitchell, M. D., & Johnson, P. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60080-3 · Cited by 165
Meroni, P. L., Raschi, E., Camera, M., Testoni, C., Nicoletti, F., Tincani, A., Khamashta, M. A., Balestrieri, G., Tremoli, E., & Hess, D. C. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0412 · Cited by 163
Self-citationLópez-Pedrera, C., Velasco, F., Aguirre, M. A., et al. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614881 · Cited by 122
Research works printed but not linked: 4
- Keying, 2000, J Biol Chem, 20, 15541
- Shoenfeld, 2000, Ann Med, 32, 37
- Robbins, 1998, J Rheumatol, 25, 51
- Di Simone, 2000, Arthritis Rheum, 43, 140, 10.1002/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P · DOI
Cited by
Sorted by citations
BRODER, A., & PUTTERMAN, C. (2013) · The Journal of Rheumatology · doi:10.3899/jrheum.120157 · Cited by 102
“LAC+ and/or at least 1 aPL ≥ 40 U 25 (28) 20 (22) 17 (19) LAC+ and aPL ≥ 40 U 7 (8) 4 (4) 4 (4) LAC– and aPL ≥ 40 U 6 (7) 2 (2) 1 (1) LAC+ and aPL < 40 U 1 (1) 3 (3) 1 (1) LAC unknown and aPL ≥ 40 U 11 (12) 11 (12) 7 (8) LAC unknown and aPL < 40 U 37 (41) 28 (31) 24 (27) At least 1 aPL ≥ 40 U 24 (27) 17 (19) 16 (18) A…”
Bordin, G., Boldorini, R., & Meroni, P. L. (2003) · Lupus · doi:10.1191/0961203303lu445cr · Cited by 33
Self-citation
Metadata
- Authors
- Meroni, P. L., & Riboldi, P.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Meroni, Pier Luigi
- ORCID
- Meroni, Pier Luigi
- Venue
- Current Opinion in Rheumatology
- Published
- 2001-09
- Volume
- 13
- Issue
- 5
- Pages
- 377-382
- ISSN
- 1040-8711 (ISSN-L)
- OpenAlex
- W2330553074
- Cited by
- 99
- References
- 40
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 7
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, antiphospholipid antibodies, thrombophilia, thrombotic diathesis, beta2-glycoprotein I, phospholipid-binding proteins, trophoblast
- MeSH terms
- Animals, Disease Models, Animal, Female, Fetal Death, Humans, Pregnancy, Pregnancy Complications, Hematologic, Thrombosis, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, Mice, In Vitro Techniques
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