The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of Bone Substitutes
Abstract
Approximately 500 million years ago, the Paleozoic era heralded an evolutionary marvel: the skeleton. Unique to this evolutionary development was the capacity for regeneration: the physiologic renewal of embryologically derived tissue. Many of the cellular and molecular components for bone regeneration have been identified (bone morphogenetic proteins), and their therapeutic manipulation will become common clinical practice. Moreover, synthetic materials produced in the laboratory and novel bone derivatives will be used to exploit the skeleton's capacity to regenerate and repair. The concept of repair may be viewed as the restoration of form and function to deficient osseous tissue. Materials that provoke repair can be categorized broadly as bone substitutes. In this review, bone substitutes are grouped into 2 categories, polymers and ceramics, and each is subclassified as biodegradable or nonbiodegradable. Examples of these materials are provided as well as some of their liabilities and virtues.
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Cites
Use of polyphosphazenes for skeletal tissue regeneration
Laurencin, C. T., Norman, M. E., Elgendy, H. M., El‐Amin, S. F., Allcock, H. R., Pucher, S. R., & Ambrosio, A. A. (1993) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820270716 · Cited by 179
Cited by
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
Giannoudis, P. V., Dinopoulos, H., & Tsiridis, E. (2005) · Injury · doi:10.1016/j.injury.2005.07.029 · Cited by 2,078
Functionalized silk-based biomaterials for bone formation
Sofia, S., McCarthy, M. B., Gronowicz, G., & Kaplan, D. L. (2001) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(200101)54:1<139::aid-jbm17>3.0.co;2-7 · Cited by 819
Water‐Stable Silk Films with Reduced β‐Sheet Content
Jin, H. ‐., Park, J., Karageorgiou, V., Kim, U. ‐., Valluzzi, R., Cebe, P., & Kaplan, D. L. (2005) · Advanced Functional Materials · doi:10.1002/adfm.200400405 · Cited by 614
Engineering Bone Regeneration with Bioabsorbable Scaffolds with Novel Microarchitecture
Whang, K., Healy, K. E., Elenz, D. R., Nam, E. K., Tsai, D. C., Thomas, C. H., Nuber, G. W., Glorieux, F. H., Travers, R., & Sprague, S. M. (1999) · Tissue Engineering · doi:10.1089/ten.1999.5.35 · Cited by 405
Metadata
- Authors
- Hollinger, J. O., Brekke, J., Gruskin, E., & Lee, D.
- Venue
- Clinical Orthopaedics and Related Research
- Published
- 1996-03
- Volume
- 324
- Issue
- 324
- Pages
- 55-65
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W2089273654
- Cited by
- 405
- References
- 1
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Role of Bone Substitutes. https://app.cochat.ai/papers/10.1097/00003086-199603000-00008
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- Hollinger, J. O., Brekke, J., Gruskin, E., & Lee, D. (1996). Role of Bone Substitutes. Clinical Orthopaedics and Related Research. https://doi.org/10.1097/00003086-199603000-00008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
