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Cited by 179Bone Tissue Engineering Materialsbiodegradable polymer synthesis and propertiesTissue Engineering and Regenerative Medicine

Use of polyphosphazenes for skeletal tissue regeneration

Laurencin, Cato T., Norman, Maria E., Elgendy, Hoda M., El‐Amin, Saadiq F., Allcock, Harry R., Pucher, Shawn R., Ambrosio, Archel A.·1993·Journal of Biomedical Materials Research
DOI 10.1002/jbm.820270716
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Abstract

The hydrolytically unstable polyphosphazenes, poly [(imidazolyl) (methylphenoxy) phosphazenes] and poly [ethyl (glycinato) (methylphenoxy) phosphazenes], were studied as potential polymeric supports for cells in tissue regeneration. For bone repair, their specific function would be to support osteoblast growth, forming a bone–polymer matrix. MC3T3–E1 cells (an osteogenic cell line) were seeded onto polymer matrices and cell adhesion and growth as well as polymer degradation were examined. Both imidazoly‐ and ethyl glycinato‐substituted polyphosphazenes supported the growth of MC3T3–E1 cells. An increase in the content of the imidazolyl side group resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer. In contrast, substitution with the ethyl glycinato group favored increased cell adhesion and growth and also an increase in the rate of degradation of the polymers. Thus, the polyphosphazenes represent a system whereby cell growth and degradation can be modulated by varying the nature of the hydrolytically unstable side chain. This in vitro evaluation suggests that the polyphosphazenes may be suitable candidate biomaterials for the construction of a cell–polymer matrix for tissue regeneration. © 1993 John Wiley & Sons, Inc.

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Crossref · 10.1002/jbm.820270716

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  • Increase in imidazolyl side groups in polyphosphazenes resulted in an increase in the rate of degradation of the polymer.

    “Increase in imidazolyl side groups resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer.”

    From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)

  • Substitution with ethylglycinato group in polyphosphazenes resulted in an increase in the rate of degradation of the polymers.

    “In contrast, substitution with ethylglycinato group favoured increased cell adhesion and growth and also an increase in the rate of degradation of the polymers.”

    From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)

  • Substitution with ethylglycinato group in polyphosphazenes favoured increased cell adhesion and growth.

    “In contrast, substitution with ethylglycinato group favoured increased cell adhesion and growth and also an increase in the rate of degradation of the polymers.”

    From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)

  • Both methylphenoxy and either imidazolyl or ethylglycinate substituted polyphosphazenes supported the growth of MC3T3-E1, an osteogenic cell line.

    “Both materials supported the growth of MC3T3-E1, an osteogenic cell line.”

    From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)

  • Increase in imidazolyl side groups in polyphosphazenes resulted in a reduction in cell attachment and growth on the polymer surface.

    “Increase in imidazolyl side groups resulted in a reduction in cell attachment and growth on the polymer surface and an increase in the rate of degradation of the polymer.”

    From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Laurencin et al. (1993)

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Authors
Laurencin, C. T., Norman, M. E., Elgendy, H. M., El‐Amin, S. F., Allcock, H. R., Pucher, S. R., & Ambrosio, A. A.
Affiliations
  • Harvard University (US)
  • Harvard–MIT Division of Health Sciences and Technology (US)
  • Pennsylvania State University (US)
Corresponding author
Laurencin, Cato T.
ORCID
Venue
Journal of Biomedical Materials Research
Publisher
Wiley
Published
1993-07
Volume
27
Issue
7
Pages
963-973
ISSN
  • 0021-9304 (ISSN-L)
  • 1097-4636
DOI
10.1002/jbm.820270716
OpenAlex
W2082515652
Cited by
179
References
31
Citations by year
2025: 2 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 10 · 2013: 13 · 2012: 3
FWCI
4.47
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4092 d)
Locations
  • Journal of Biomedical Materials Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
polyphosphazenes, bone regeneration, osteoblast proliferation, MC3T3-E1 cells, cell adhesion, polymer degradation, biomaterials
MeSH terms
Animals, Bone Regeneration, Cell Adhesion, Cell Division, Cell Line, Organophosphorus Compounds, Polymers, Mice

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