Synthetic Biodegradable Polymers for Orthopaedic Applications
Abstract
Synthetic biodegradable polymers offer an alternative to the use of autografts, allografts, and nondegradable materials for bone replacement. They can be synthesized with tailored mechanical and degradative properties. They also can be processed to porous scaffolds with desired pore morphologic features conducive to tissue ingrowth. Moreover, functionalized polymers can modulate cellular function and induce tissue ingrowth. This review focuses on four classes of polymers that hold promise for orthopaedic applications: poly alpha-hydroxy esters, polyphosphazenes, polyanhydrides, and polypropylene fumarate crosslinked networks.
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Major applications of biodegradable synthetic polymers include resorbable sutures, drug delivery systems and orthopaedic fixation devices such as pins, rods and screws.
“The major applications include resorbable sutures, drug delivery systems and orthopaedic fixation devices such as pins, rods and screws”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Behravesh et al., 1999
Incorporation of specific side groups such as amino acid esters, glucosyl, glyceyl, lactate, or imidazolyl units can render polyphosphazenes biodegradable.
“Although most polyphosphazenes are biostable, incorporation of specific side groups such as amino acid esters, glucosyl, glyceyl, lactate, or imidazolyl units can render polyphosphazenes biodegradable (Alcock, 1999;Behravesh et al., 1999;Qui and Zhu, 2000).”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Behravesh et al., 1999
Most polyphosphazenes are biostable.
“Although most polyphosphazenes are biostable, incorporation of specific side groups such as amino acid esters, glucosyl, glyceyl, lactate, or imidazolyl units can render polyphosphazenes biodegradable (Alcock, 1999;Behravesh et al., 1999;Qui and Zhu, 2000).”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Behravesh et al., 1999
Cites
Use of polyphosphazenes for skeletal tissue regeneration
Laurencin, C. T., Norman, M. E., Elgendy, H. M., El‐Amin, S. F., Allcock, H. R., Pucher, S. R., & Ambrosio, A. A. (1993) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820270716 · Cited by 179 · see citing works
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Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765 · see citing works
“The major applications include resorbable sutures, drug delivery systems and orthopaedic fixation devices such as pins, rods and screws (Behravesh et al., 1999; Middleton and Tipton, 2000).”
Background
- Authors
- Behravesh, E., Yasko, A. W., Engel, P. S., & Mikos, A. G.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Rice University (US)
- Corresponding author
- Behravesh, E.
- Yasko, A. W.
- Mikos, A. G.
- ORCID
- Mikos, A. G.
- Venue
- Clinical Orthopaedics and Related Research
- Published
- 1999-10
- Volume
- 367
- Issue
- 367 Suppl
- Pages
- S118-S129
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W1982461809
- Cited by
- 163
- References
- 1
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2022: 5 · 2021: 1 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 11
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Orthopaedics and Related Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ar042639-03, 5r01ar044381-04, 5r01de013031-05)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R29-AR42639, R01-AR44381)
- National Institute of Dental and Craniofacial Research (R01 DE13031)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Keywords
- biodegradable polymers, bone replacement, bone scaffolds, porous scaffolds, tissue ingrowth, polyphosphazenes, polyanhydrides, crosslinked polymer networks, polymer degradation, mechanical properties
- MeSH terms
- Animals, Biocompatible Materials, Biodegradation, Environmental, Biomechanical Phenomena, Humans, Orthopedics, Polymers, Prostheses and Implants
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