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Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit
Abstract
We retrospectively studied relations between age, pre-existing chronic disease, sepsis, organ system failure, and mortality in 487 patients from a medical ICU. Single organ system failure (SOSF) occurred in 136 (28%) and multiple (greater than or equal to 2) organ system failure (MOSF) in 187 (38%) patients. Cardiovascular and pulmonary failure predominated. Overall mortality was 27%. SOSF mortality was 16% and for MOSF 58%. Eighty-three percent of nonsurvivors had MOSF. Hence, MOSF is common and a major cause of death in critically ill medical patients. Advancing age and prior chronic disease may diminish physiologic reserve and predispose to sepsis and MOSF. Although sepsis is a major risk factor for MOSF, a nonspecific host response to critical illness may contribute to the syndrome in 35% of patients. Advancing age, chronic disease, and the number of failing organs, particularly failure of cardiovascular, pulmonary, renal, and neurologic systems, are major determinants of overall mortality, but sepsis is not an independent contributor.
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Citations
Cited by
Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients
Ferreira, F. L. (2001) · JAMA · doi:10.1001/jama.286.14.1754 · Cited by 2,862
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays
Wang, C., Qi, B., Lin, M., Zhang, Z., Makihata, M., Liu, B., Zhou, S., Huang, Y.-H., Hu, H., Gu, Y., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00763-4 · Cited by 274
Chronic Medical Conditions and Risk of Sepsis
Wang, H. E., Shapiro, N. I., Griffin, R., Safford, M. M., Judd, S., & Howard, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048307 · Cited by 142
Candidemia as a cause of septic shock and multiple organ failure in nonimmunocompromised patients
Hadley, S., Lee, W. W., Ruthazer, R., & Nasraway, S. A. (2002) · Critical Care Medicine · doi:10.1097/00003246-200208000-00023 · Cited by 46
Metadata
- Authors
- TRAN, D. D., JOHAN GROENEVELD, A. B., DER MEULEN, J. V., NAUTA, J. J. P., STRACK VAN SCHIJNDEL, R. J. M., & THUS, L. G.
- Venue
- Critical Care Medicine
- Published
- 1990-05
- Volume
- 18
- Issue
- 5
- Pages
- 474-479
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2075023013
- Cited by
- 362
- References
- 0
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- TRAN, D. D., JOHAN GROENEVELD, A. B., DER MEULEN, J. V., NAUTA, J. J. P., STRACK VAN SCHIJNDEL, R. J. M., & THUS, L. G. (1990). Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Critical Care Medicine. https://doi.org/10.1097/00003246-199005000-00002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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