The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
L-arginine: Nitric oxide pathway in endotoxemia and human septic shock
Abstract
OBJECTIVE: To investigate the relationship between nitric oxide production, endotoxemia, and hemodynamic alterations in human septic shock. DESIGN: Prospective study. SETTING: A 32-bed intensive care unit in a university referral hospital. PATIENTS: Two groups of septic patients with shock (n = 13) or without shock (n = 16) and an additional group of nonseptic patients as control group (n = 25). MEASUREMENTS: Plasma nitrite and nitrate concentrations were measured as an index of nitric oxide generation. Nitrite and nitrate concentrations were correlated with plasma endotoxin and hemodynamic variables. MAIN RESULTS: Increased plasma nitrite and nitrate concentrations were found in patients with septic shock (p < .01). Nitrite and nitrate correlated directly with endotoxin concentration (r2 = .21, p < .05) and cardiac output (r2 = .49, p < .05), and inversely with systolic blood pressure (r2 = .24, p < .01). CONCLUSIONS: This study demonstrated the activation of the L-arginine:nitric oxide pathway in human endotoxemic septic shock, suggesting that nitric oxide may be an important mediator of the hemodynamic disturbances in this pathophysiologic situation.
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Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Self-citationStuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126
Cited by
Briegel, J., Forst, H., Haller, M., Schelling, G., Kilger, E., Kuprat, G., Hemmer, B., Hummel, T., Lenhart, A., Heyduck, M., et al. (1999) · Critical Care Medicine · doi:10.1097/00003246-199904000-00025 · Cited by 889
Endotoxin and immune activation in chronic heart failure: a prospective cohort study
Niebauer, J., Volk, H.-D., Kemp, M., Dominguez, M., Schumann, R. R., Rauchhaus, M., Poole-Wilson, P. A., Coats, A. J., & Anker, S. D. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09286-1 · Cited by 877
Titheradge, M. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00031-6 · Cited by 457
Kynurenine is an endothelium-derived relaxing factor produced during inflammation
Wang, Y., Liu, H., McKenzie, G., Witting, P. K., Stasch, J.-P., Hahn, M., Changsirivathanathamrong, D., Wu, B. J., Ball, H. J., Thomas, S. R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2092 · Cited by 446
de Werra, I., Jaccard, C., Corradin, S. B., Chiolero, R., Yersin, B., Gallati, H., Assicot, M., Bohuon, C., Baumgartner, J.-D., Glauser, M. P., et al. (1997) · Critical Care Medicine · doi:10.1097/00003246-199704000-00009 · Cited by 388
Metadata
- Authors
- Gomez-Jimenez, J., Salgado, A., Mourelle, M., Martin, M. C., Segura, R. M., Peracaula, R., & Moncada, S.
- Venue
- Critical Care Medicine
- Published
- 1995-02
- Volume
- 23
- Issue
- 2
- Pages
- 253-258
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2012100682
- Cited by
- 205
- References
- 2
- FWCI
- 20.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gomez-Jimenez, J., Salgado, A., Mourelle, M., Martin, M. C., Segura, R. M., Peracaula, R., & Moncada, S. (1995). L-arginine: Nitric oxide pathway in endotoxemia and human septic shock. Critical Care Medicine. https://doi.org/10.1097/00003246-199502000-00009
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