Cited by 249Sepsis Diagnosis and TreatmentTrauma, Hemostasis, Coagulopathy, ResuscitationHemodynamic Monitoring and Therapy

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Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: Improved short-term survival and acid-base balance with Hextend compared with saline

Kellum, John A.·2002·Critical Care Medicine

DOI 10.1097/00003246-200202000-00006

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Abstract

OBJECTIVE: To compare resuscitation with 0.9% saline with Hextend, a synthetic colloid in a balanced electrolyte solution, in terms of acid-base status and survival time in an experimental model of septic shock in the rat. DESIGN: Randomized, open-label, controlled experiment. SETTING: University research laboratory. SUBJECTS: Sixty adult, male Sprague-Dawley rats. INTERVENTION: Animals were studied for 12 hrs after intravenous infusion of Escherichia coli endotoxin (20 mg/kg). Animals were volume resuscitated to maintain a mean arterial pressure >60 mm Hg using either 0.9% saline (n = 25), Hextend (n = 25), or lactated Ringer's (n = 10). MEASUREMENTS: Arterial blood gases and electrolytes were measured before and after resuscitation (0, 180, 360, and 540 mins after endotoxin infusion). Survival time was measured, up to 12 hrs. RESULTS: Mean survival time among animals treated with saline or Ringer's was 45% less compared with Hextend-treated animals: 391 +/- 151 mins and 362 +/- 94 mins vs. 567 +/- 140 mins, respectively, p <.0001. Overall survival (at 12 hrs) was 0% with saline or Ringer's vs. 20% with Hextend, p =.05. After resuscitation with saline, arterial standard base excess and plasma apparent strong ion difference were both significantly lower (-19.3 +/- 5.2 vs. -12.1 +/- 5.7, p <.001, and 23.0 +/- 6.2 vs. 30.3 +/- 2.9, p <.0001, respectively) and plasma Cl(-) was significantly higher (123 +/- 7 vs. 115 +/- 3 mmol/L, p <.0001) compared with Hextend. Resuscitation with Ringer's solution resulted in a standard base excess, and Cl(-) between that of saline and Hextend (-15.4 +/- 3.1, and 117 +/- 3, respectively). CONCLUSION: Compared with 0.9% saline, volume resuscitation with Hextend was associated with less metabolic acidosis and longer survival in this experimental animal model of septic shock.

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Modern quantitative acid–base chemistry
Stewart, P. A. (1983) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y83-207 · Cited by 1,366
Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome
Hickling, K. G., Henderson, S. J., & Jackson, R. (1990) · Intensive Care Medicine · doi:10.1007/bf01735174 · Cited by 923
Rapid Saline Infusion Produces Hyperchloremic Acidosis in Patients Undergoing Gynecologic Surgery
Scheingraber, S., Rehm, M., Sehmisch, C., & FINSTERER, U. (1999) · Anesthesiology · doi:10.1097/00000542-199905000-00007 · Cited by 750
Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials
Schierhout, G., & Roberts, I. (1998) · BMJ · doi:10.1136/bmj.316.7136.961 · Cited by 639
The Effects of Balanced Versus Saline-Based Hetastarch and Crystalloid Solutions on Acid-Base and Electrolyte Status and Gastric Mucosal Perfusion in Elderly Surgical Patients
Wilkes, N. J., Woolf, R. L., Mutch, M., Mallett, S., Peachey, T., Stephens, R. C. M., & Mythen, M. G. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200110000-00003 · Cited by 458
Practice parameters for hemodynamic support of sepsis in adult patients in sepsis
(1999) · Critical Care Medicine · doi:10.1097/00003246-199903000-00049 · Cited by 434
The Effect of Fluid Loading, Blood Transfusion, and Catecholamine Infusion on Oxygen Delivery and Consumption in Patients with Sepsis
Gilbert, E. M., Haupt, M. T., Mandanas, R. Y., Huaringa, A. J., & Carlson, R. W. (1986) · American Review of Respiratory Disease · doi:10.1164/arrd.1986.134.5.873 · Cited by 363
Serum proteins and acid-base equilibria: a follow-up.
Figge, J. J., Mydosh, T., & Fencl, V. (1992) · PubMed · Cited by 349
Sodium Bicarbonate for the Treatment of Lactic Acidosis
Forsythe, S. M., & Schmidt, G. A. (2000) · CHEST Journal · doi:10.1378/chest.117.1.260 · Cited by 338
Strong ion gap: A methodology for exploring unexplained anions
Kellum, J. A., Kramer, D. J., & Pinsky, M. R. (1995) · Journal of Critical Care · doi:10.1016/0883-9441(95)90016-0 · Cited by 321
Self-citation

Show all 28 references

Research works printed but not linked: 3

Figge, 1992, J Lab Clin Med, 120, 713
Kellum, 1998, Kidney Int, 66, S81
Opie, 1965, J Appl Physiol, 209, 1975

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ETHYL PYRUVATE PREVENTS INFLAMMATORY RESPONSES AND ORGAN DAMAGE DURING RESUSCITATION IN PORCINE HEMORRHAGE
Dong, W., Cai, B., Peña, G., Pisarenko, V., Vida, G., Doucet, D. R., Lee, M., Sharpe, S., Lu, Q., Xu, D.-Z., et al. (2010) · Shock · doi:10.1097/shk.0b013e3181cc0c63 · Cited by 34
Cristaloides y coloides en la reanimación del paciente crítico
Garnacho‐Montero, J., Fernández‐Mondejar, E., Ferrer, R., Herrera-Gutiérrez, M. E., Lorente, J. A., Ruiz‐Santana, S., & Artigas, A. (2015) · Medicina Intensiva · doi:10.1016/j.medin.2014.12.007 · Cited by 37
Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy
Barhight, M. F., Lusk, J., Brinton, J. T., Stidham, T., Soranno, D. E., Faubel, S. G., Goebel, J., Mourani, P. M., & Gist, K. M. (2018) · Pediatric Nephrology · doi:10.1007/s00467-018-3898-2 · Cited by 34
Effects of two different strategies of fluid administration on inflammatory mediators, plasma electrolytes and acid/base disorders in patients undergoing major abdominal surgery: a randomized double blind study
Volta, C. A., Trentini, A., Farabegoli, L., Manfrinato, M. C., Alvisi, V., Dallocchio, F., Marangoni, E., Alvisi, R., & Bellini, T. (2013) · Journal of Inflammation · doi:10.1186/1476-9255-10-29 · Cited by 33
Qu'apporte le modèle de Stewart à l'interprétation des troubles de l'équilibre acide–base ?
Quintard, H., Hubert, S., & Ichaï, C. (2007) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2007.02.012 · Cited by 32
MONITORING SKELETAL MUSCLE AND SUBCUTANEOUS TISSUE ACID-BASE STATUS AND OXYGENATION DURING HEMORRHAGIC SHOCK AND RESUSCITATION
Clavijo‐Alvarez, J. A., Sims, C. A., Pinsky, M. R., & Puyana, J. C. (2005) · Shock · doi:10.1097/01.shk.0000172364.89128.28 · Cited by 31
Ethyl pyruvate improves survival in awake hemorrhage
Cai, B., Brunner, M., Wang, H., Wang, P., Deitch, E. A., & Ulloa, L. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0441-8 · Cited by 31
Lactated Ringer's vs normal saline for acute pancreatitis: An updated systematic review and meta-analysis
Aziz, M., Ahmed, Z., Weissman, S. I., Ghazaleh, S., Beran, A., Kamal, F., Lee‐Smith, W., Assaly, R., Nawras, A. T., Pandol, S. J., et al. (2021) · Pancreatology · doi:10.1016/j.pan.2021.06.002 · Cited by 30
The Importance of Intraoperative Hyperchloremia
Silva, J. M., Neves, E. F., Santana, T. C., Ferreira, U. P., Marti, Y. N., & Silva, J. M. C. (2009) · Brazilian Journal of Anesthesiology · doi:10.1590/s0034-70942009000300005 · Cited by 30
The Impact of Intravenous Fluid Therapy on Acid-Base Status of Critically Ill Adults: A Stewart Approach-Based Perspective
Kılıç, Ö., Yücel, G., & Yazıcı, S. (2020) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s266864 · Cited by 30
The acute effects of acetate-balanced colloid and crystalloid resuscitation on renal oxygenation in a rat model of hemorrhagic shock
Almac, E., Aksu, U., Bezemer, R., Jong, W. M. C., Kandil, A., Yürük, K., Demirci‐Tansel, C., & İnce, C. (2012) · Resuscitation · doi:10.1016/j.resuscitation.2012.02.011 · Cited by 28
Ab-normal saline in abnormal kidney function: risks and alternatives
Hayes, W. N. (2018) · Pediatric Nephrology · doi:10.1007/s00467-018-4008-1 · Cited by 29
Intravenous fluid therapy in sepsis
Seitz, K. P., Qian, E. T., & Semler, M. W. (2022) · Nutrition in Clinical Practice · doi:10.1002/ncp.10892 · Cited by 32
Acute Effects of Balanced Versus Unbalanced Colloid Resuscitation on Renal Macrocirculatory and Microcirculatory Perfusion During Endotoxemic Shock
Aksu, U., Bezemer, R., Demirci, C., & İnce, C. (2011) · Shock · doi:10.1097/shk.0b013e31823ca89c · Cited by 28
Detrimental effect of high volume fluid administration in acute pancreatitis – A retrospective analysis of 391 patients
Weitz, G., Woitalla, J., Wellhöner, P., Schmidt, K. J. W., Büning, J., & Fellermann, K. (2014) · Pancreatology · doi:10.1016/j.pan.2014.07.016 · Cited by 28
Balanced versus unbalanced salt solutions: What difference does it make?
Magder, S. A. (2014) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2014.07.001 · Cited by 27
Factors related to post‐operative metabolic acidosis following major abdominal surgery
Park, C., Chun, H.-K., Jeon, K., Suh, G. Y., Choi, D. W., & Kim, S. (2012) · ANZ Journal of Surgery · doi:10.1111/j.1445-2197.2012.06235.x · Cited by 27
Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage*
Cai, B., Chen, F., Lin, X., Miller, E. J., Szabó, C., Deithch, E. A., & Ulloa, L. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819b8237 · Cited by 27
Importance of intravenous fluid dose and composition in surgical ICU patients
Raghunathan, K., McGee, W. T., & Higgins, T. L. (2012) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e328355598c · Cited by 26
Cardiovascular aspects of septic shock: pathophysiology, monitoring, and treatment.
Bridges, E. J., & Dukes, S. F. (2005) · PubMed · Cited by 26
Cardiovascular Aspects of Septic Shock
Bridges, E. J., & Dukes, S. F. (2005) · Critical Care Nurse · doi:10.4037/ccn2005.25.2.14 · Cited by 26
Enhanced Recovery After Surgery
Simmons, J. W., Dobyns, J. B., & Paiste, J. (2018) · Surgical Clinics of North America · doi:10.1016/j.suc.2018.07.006 · Cited by 26
Early Chloride Intake Does Not Parallel That of Sodium in Extremely‐Low‐Birth‐Weight Infants and May Impair Neonatal Outcomes
Kermorvant‐Duchemin, E., Iacobelli, S., Trolli, S. E. D., Bonsante, F., Kermorvant, C., Sarfati, G., Gouyon, J., & Lapillonne, A. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318245b428 · Cited by 25
Saline versus balanced hydroxyethyl starch: does it matter?
Boldt, J. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32830dd05b · Cited by 25
Retracted

Authors: Kellum, J. A.
Affiliations: University of Pittsburgh Medical Center (US)
Corresponding author: Kellum, John A.
ORCID: Kellum, John A.
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-02
Volume: 30
Issue: 2
Pages: 300-305
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/00003246-200202000-00006
OpenAlex: W2091601305
Cited by: 249
References: 28
Citations by year: 2026: 6 · 2025: 4 · 2024: 4 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 2 · 2019: 4 · 2018: 18 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 12 · 2013: 8 · 2012: 6
FWCI: 10.05
Type: journal article
Language: en
Open access: closed
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Center, University of Pittsburgh
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords: fluid resuscitation, hyperchloremic metabolic acidosis, septic shock, Hextend, synthetic colloids, 0.9% saline, lactated Ringer's solution, endotoxin, acid-base balance, strong ion difference, base excess, plasma chloride, short-term survival, rats, electrolyte balance
MeSH terms: Acid-Base Equilibrium, Acidosis, Analysis of Variance, Animals, Fluid Therapy, Hydroxyethyl Starch Derivatives, Male, Plasma Substitutes, Random Allocation, Shock, Septic, Sodium Chloride, Survival Analysis, Rats, Sprague-Dawley, Rats

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Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: Improved short-term survival and acid-base balance with Hextend compared with saline

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