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Cited by 43Endometrial and Cervical Cancer TreatmentsCervical Cancer and HPV ResearchNeuroendocrine Tumor Research Advances

Dissociated Expression of Bcl-2 and Ki-67 in Endometrial Lesions: Diagnostic and Histogenetic Implications

Risberg, Bj??rn, Karlsson, Kerstin, Abeler, Vera, Lagrelius, Anders, Davidson, Ben, Karlsson, Mats G.·2002·International Journal of Gynecological Pathology
DOI 10.1097/00004347-200204000-00008
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Abstract

The objective of the present study was to analyze the expression of the proliferation marker, Ki-67, and the anti-apoptotic protein, bcl-2, in various endometrial lesions. Ki-67 and bcl-2 expressions were studied in 194 specimens of endometrial hyperplasia, polyps, carcinomas, and cyclic endometrium from a defined geographic area. Results were statistically analyzed with respect to marker expression, localization to the stromal or glandular component, and intraglandular topography. The lowest glandular Ki-67 expression was seen in secretory endometrium, in polyps, and in atypical hyperplasia. The Ki-67 score was significantly higher and less heterogeneous in endometrial carcinomas than in hyperplasia (p<0.001). Endometrial hyperplasia of all types was characterized by a markedly heterogeneous glandular expression of Ki-67. The glandular expression of bcl-2 was highest in proliferative endometrium and polyps. Bcl-2 expression was significantly lower in adenocarcinomas than in hyperplastic lesions (p=0.002). Ki-67 and bcl-2 expression showed a significant association in proliferative endometrium (p=0.003). Endometrial polyps demonstrated a unique pattern of very low expression of Ki-67 and high bcl-2 expression in both stroma and glands. Our findings indicate that an imbalance between proliferation and apoptosis may be an important factor in the development of different endometrial lesions, benign as well as malignant. The specific finding of inter- and intraglandular Ki-67 heterogeneity may be valuable as an adjunct to morphology in the differential diagnosis of endometrial hyperplasia.

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  • Bcl-2 inhibits apoptosis in the endometrium and endometrial lesions.

    “Bcl-2 is a regulator of the programmed cell death process and inhibits apoptosis in the endometrium and the endometrial lesions.28,29”

    From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [29]

  • Both Ki-67 and Bcl-2 expression have been closely linked to estrogen receptor level.

    “Both Ki-67 and Bcl-2 expression have been closely linked to estrogen receptor level.29”

    From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [29]

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Authors
Risberg, B., Karlsson, K., Abeler, V., Lagrelius, A., Davidson, B., & Karlsson, M. G.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Risberg, Bj??rn
ORCID
Venue
International Journal of Gynecological Pathology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-04
Volume
21
Issue
2
Pages
155-160
ISSN
0277-1691 (ISSN-L)
DOI
10.1097/00004347-200204000-00008
OpenAlex
W2076087067
Cited by
43
References
30
Citations by year
2026: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
1.88
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Gynecological Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
Bcl-2, Ki-67, endometrial lesions, endometrial hyperplasia, endometrial cancer, endometrial polyps, atypical hyperplasia, apoptosis, endometrial adenocarcinoma, differential diagnosis, endometrial stroma
MeSH terms
Adenocarcinoma, Adolescent, Adult, Aged, Cell Division, Diagnosis, Differential, Endometrial Hyperplasia, Endometrium, Female, Humans, Immunohistochemistry, Middle Aged, Polyps, Endometrial Neoplasms, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Ki-67 Antigen

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