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Histologic Study of Artificial Skin Used in the Treatment of Full-Thickness Thermal Injury
Abstract
Integra artificial skin is an effective means of treatment for full-thickness burns. In extensive burn injury the use of such skin substitutes may become the treatment of choice. The artificial skin consists of a dermal substitute of bovine collagen and chondroitin-6-sulfate and an epidermal layer of synthetic polysiloxane polymer (Silastic). Serial biopsy specimens were obtained from 131 patients during a period of 7 days to 2 years after application. In this histologic study, six sequential phases of repair were discerned. In addition, there were occasional unusual histologic features, eosinophilic infiltration, and/or macrophage-derived giant cell formation in the wound area; however, such findings did not clinically correlate with a negative response to Integra artificial skin. Good repair was obtained, with rare exceptions. An intact dermis was achieved as well as definitive closure of a complete epidermal layer with a minimum of scarring.
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Cited by
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
A clinical trial of Integra Template for diabetic foot ulcer treatment
Driver, V. R., Lavery, L. A., Reyzelman, A. M., Dutra, T. G., Dove, C. R., Kotsis, S. V., Kim, H. M., & Chung, K. C. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12357 · Cited by 291
Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options
Debels, H., Hamdi, M., Abberton, K., & Morrison, W. (2015) · Plastic and Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000000219 · Cited by 227
Guo, X., Mu, D., & Gao, F. (2017) · International Journal of Surgery · doi:10.1016/j.ijsu.2017.02.008 · Cited by 80
Supp, D. M., & Boyce, S. T. (2002) · The Journal of Burn Care & Rehabilitation · doi:10.1097/00004630-200201000-00004 · Cited by 78
Metadata
- Authors
- Stern, R., McPherson, M., & Longaker, M. T.
- Venue
- Journal of Burn Care & Rehabilitation
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-01
- Volume
- 11
- Issue
- 1
- Pages
- 7-13
- ISSN
- 0273-8481 (ISSN-L)
- OpenAlex
- W1982105288
- Cited by
- 272
- References
- 0
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Histologic Study of Artificial Skin Used in the Treatment of Full-Thickness Thermal Injury. https://app.cochat.ai/papers/10.1097/00004630-199001000-00003
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- Stern, R., McPherson, M., & Longaker, M. T. (1990). Histologic Study of Artificial Skin Used in the Treatment of Full-Thickness Thermal Injury. Journal of Burn Care & Rehabilitation. https://doi.org/10.1097/00004630-199001000-00003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
